A new approach for the synthesis of N,N’-bis(phenoxyacetyl)hydrazines

Year 2019, Volume: 49 Issue: 2, 61 - 63, 01.08.2019

Çağla Begüm Apaydın , Zafer Cesur

Abstract

DOI: 10.26650/IstanbulJPharm.2019.19002

This report is about an unexpected
formation of N,N’-bis(substituted phenoxyacetyl) hydrazine derivatives. The
reaction between N’-(4-ethylcyclohexylidene)phenoxyacetohydrazide with sulfanyl
acids to obtain 4-thiazolidinones s, 
gave an unexpected product, N,N’-bis(phenoxyacetyl)hydrazine, with high
purity instead of the expected cyclocondensation product.  When repeating the reaction with p-toluenesulfonic
acid under the same conditions, the reaction resulted in the same compound.
This indicates that two molecules of
N’-(4-ethylcyclohexylidene)phenoxyacetohydrazide were involved in the reaction.
The reaction can be applied as a different and new procedure for the synthesis
of several N,N’-bis(substituted phenoxyacetyl)hydrazine derivatives. 

Cite this article as: Apaydın ÇB, Cesur Z
(2019). A new approach for the synthesis of N,N’-bis(phenoxyacetyl)hydrazines.
Istanbul J Pharm 49 (2): 61-63.

Keywords

Diacylhydrazines, sulfanyl acid, reaction mechanism

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