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Year 2020, Volume: 50 Issue: 1, 49 - 53, 01.04.2020

Abstract

References

  • • Al-Soud, Y. A., Al-Dweri, M. N., & Al-Masoudi, N. A. (2004). Synthesis, antitumor and antiviral properties of some 1,2,4-triazole derivatives. Farmaco, 59(10), 775–783.
  • • Boraei, A. T. A., Singh, P. K., Sechi, M., & Satta, S. (2019). Discovery of novel functionalized 1,2,4-triazoles as PARP-1 inhibitors in breast cancer: Design, synthesis and antitumor activity evaluation. European Journal of Medicinal Chemistry, 182, 111621.
  • • Çapan, G., Ergenç, N., & Ötük, G. (1990-92). Synthesis and biological evaluation of 4-alkyl/aryl-1-(2-furoyl)-3-thiosemicarbazides and 4-alkyl/aryl-2,4-dihydro-5-(2-furyl)-3H-1,2,4-triazole-3-thiones. Journal of Faculty of Pharmacy of Istanbul, 26-28, 23–30.
  • • Çapan, G., Ergenç, N., & Ötük, G. (1993). Synthesis, characterization and biological evaluation of 1,2,4-triazole-3-mercaptoacetic acid derivatives. Acta Pharmaceutica Turcica, 35, 51–58.
  • • Çapan, G., Ulusoy, N., Ergenç, N., & Kiraz, M. (1999). New 6-phenylimidazo[2,1-b]thiazole derivatives: Synthesis and antifungal activity. Monatshefte fur Chemie, 130(11), 1399–1407.
  • • Demirbaş, N., Karaoğlu, S. A., Demirbaş, A., & Sancak, K. (2004). Synthesis and antimicrobial activities of some new 1-(5-phenylamino-[1,3,4] thiadiazol-2-yl)methyl-5-oxo-[1,2,4]triazole and 1-(4-phenyl-5-thioxo-[1,2,4] triazol-3-yl)methyl-5-oxo-[1,2,4]triazole derivatives. European Journal of Medicinal Chemistry, 39(9), 793-804.
  • • Dimmock, J. R., Vashishtha, S. C., & Stables, J. P. (2000). Anticonvulsant properties of various acetylhydrazones, oxamoylhydrazones and semicarbazones derived from aromatic and unsaturated carbonyl compounds. European Journal of Medicinal Chemistry, 35(2), 241–248.
  • • El-Sherief, H. A. M., Youssif, B. G. M., Abbas Bukhari, S. N., Abdelazeem, A. H., Abdel-Aziz, M., & Abdel-Rahman, H. M. (2018). Synthesis, anticancer activity and molecular modeling studies of 1,2,4-triazole derivatives as EGFR inhibitors. European Journal of Medicinal Chemistry, 156, 774–789.
  • • Ergenç, N., Ulusoy, N., Çapan, G., Sanis, G. Ö., & Kiraz, M. (1996). Synthesis and antimicrobial properties of new 4-(alkylidene/ arylidene)-amino-5-(2-furanyl)-2,4-dihydro-3H-1,2,4-triazole-3thiones and 6-aryl-3-(2-furanyl)-7H-1,2,4-triazolo[3,4-b][1,3,4] thiadiazines. Archiv der Pharmazie, 329(8–9), 427–430.
  • • Fernández-Torres, B., Cabañes, F. J., Carrillo-Muñoz, A. J., Esteban, A., Inza, I., Abarca, L., & Guarro, J. (2002). Collaborative evaluation of optimal antifungal susceptibility testing conditions for dermatophytes. Journal of Clinical Microbiology, 40(11), 3999–4003.
  • • Günay, N. S., Çapan, G., Ulusoy, N., Ergenç, N., Ötük, G., & Kaya, D. (1999). 5-Nitroimidazole derivatives as possible antibacterial and antifungal agents. Farmaco, 54(11-12), 826–831.
  • • Holla, S., B., Veerendra, B., Shivananda, M. K., & Poojary, B. (2003). Synthesis characterization and anticancer activity studies on some Mannich bases derived from 1,2,4-triazoles. European Journal of Medicinal Chemistry, 38(7-8), 759–767.
  • • İlhan, E. Ergenç, N., Ulusoy, N., & Ötük Sanış, G., (1996). Synthese und antimikrobielle Untersuchung einiger 4-Arylidenamino-3(α,α-diphenyl-α-hydroxymethyl)-1,4-dihydro-5H-1,2,4-Triazol5-thione und 6-Aryl-3-(α,α-diphenyl-α-hydroxymethyl)-7H-sTriazolo[3,4-b][1,3,4]thiadiazine. Die Pharmazie, 51(2), 123–124.
  • • Imramovský, A., Polanc, S., Vinšová, J., Kočevar, M., Jampílek, J., Rečková, Z., & Kaustová, J. (2007). A new modification of antitubercular active molecules. Bioorganic and Medicinal Chemistry, 15(7), 2551–2559.
  • • Koçyiğit Kaymakçıoğlu, B., Oruç, E., Ünsalan, S., Kandemirli, F., Shvets, N., Rollas, S., & Dimoglo, A. (2006). Synthesis and characterization of novel hydrazide-hydrazones and the study of their structure-antituberculosis activity. European Journal of Medicinal Chemistry, 41(11), 1253–1261.
  • • Mustafa, M., Abdelhamid, D., Abdelhafez, E. S. M. N., Ibrahim, M. A. A., Gamal-Eldeen, A. M., & Aly, O. M. (2017). Synthesis, antiproliferative, anti-tubulin activity, and docking study of new 1,2,4-triazoles as potential combretastatin analogues. European Journal of Medicinal Chemistry, 141, 293–305.
  • • Mustafa, M., Anwar, S., Elgamal, F., Ahmed, E. R., & Aly, O. M. (2019). Potent combretastatin A-4 analogs containing 1,2,4-triazole: Synthesis, antiproliferative, anti-tubulin activity, and docking study. European Journal of Medicinal Chemistry, 183, 111697.
  • • Özkırımlı, S., Kazan, F., & Tunalı, Y. (2009). Synthesis, antibacterial and antifungal activities of 3-(1,2,4-triazol-3- yl)-4-thiazolidinones. Journal of Enzyme Inhibition and Medicinal Chemistry, 24(2), 447–452.
  • • Rollas, S., Gülerman, N., & Erdeniz, H. (2002). Synthesis and antimicrobial activity of some new hydrazones of 4-fluorobenzoic acid hydrazide and 3-acetyl-2,5-disubstituted-1,3,4-oxadiazolines. Farmaco, 57(2), 171–174.
  • • Salgın-Gökşen, U., Gökhan-Kelekçi, N., Göktaş, Ö., Köysal, Y., Kılıç, E., Işık, Ş., Aktay, G. & Özalp, M. (2007). 1-Acylthiosemicarbazides, 1,2,4-triazole-5(4H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: Synthesis, analgesicanti-inflammatory and antimicrobial activities. Bioorganic and Medicinal Chemistry, 15(17), 5738–5751.
  • • Savini, L., Chiasserini, L., Travagli, V., Pellerano, C., Novellino, E., Cosentino, S., & Pisano, M. B. (2004). New α-(N)-heterocyclichydrazones: Evaluation of anticancer, anti-HIV and antimicrobial activity. European Journal of Medicinal Chemistry, 39(2), 113–122.
  • • Sztanke, K., Tuzimski, T., Rzymowska, J., Pasternak, K., & KandeferSzerszeń, M. (2008). Synthesis, determination of the lipophilicity, anticancer and antimicrobial properties of some fused 1,2,4-triazole derivatives. European Journal of Medicinal Chemistry, 43(2), 404–419.
  • • Tozkoparan, B., Gökhan, N., Aktay, G., Yeşilada, E., & Ertan, M. (2000). 6-Benzylidenethiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones substituted with ibuprofen: Synthesis, characterization and evaluation of anti-inflammatory activity. European Journal of Medicinal Chemistry, 35(7), 743–750.
  • • Turan-Zitouni, G., Kaplancıklı, Z. A., Erol, K., & Kılıç, F. S. (1999). Synthesis and analgesic activity of some triazoles and triazolothiadiazines. Farmaco, 54(4), 218–223.
  • • Turan-Zitouni, G., Kaplancıklı, Z. A., Yıldız, M. T., Chevallet, P., & Kaya, D. (2005). Synthesis and antimicrobial activity of 4-phenyl/cyclohexyl-5-(1-phenoxyethyl)-3-[N-(2-thiazolyl)acetamido]thio-4H1,2,4-triazole derivatives. European Journal of Medicinal Chemistry, 40(6), 607–613.
  • • Ulusoy Güzeldemirci, N., & Küçükbasmacı, Ö. (2010). Synthesis and antimicrobial activity evaluation of new 1,2,4-triazoles and 1,3,4-thiadiazoles bearing imidazo[2,1-b]thiazole moiety. European Journal of Medicinal Chemistry, 45(1), 63–68.
  • • Ulusoy Güzeldemirci, N., Şatana, D., & Küçükbasmacı, Ö. (2013). Synthesis, characterization, and antimicrobial evaluation of some new hydrazinecarbothioamide, 1,2,4-triazole and 1,3,4-thiadiazole derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry, 28(5), 968–973.
  • • Ulusoy, N., Ateş, Ö., Küçükbasmacı, Ö., Kiraz, M., & Yemenoğlu, Y. (2003). Synthesis, Characterization, and Evaluation of Antimicrobial Activity of Some 1,2,4-Triazole Derivatives Bearing an Antipyryl Moiety. Monatshefte für Chemie, 134(3), 465–474.
  • • Ulusoy, N., Ergenç, N., Ötük, G., & Kiraz, M. (2001a). Synthesis of some 4-(alkylidene/arylidene)amino-2,4-dihydro-5-(2thienyl)-3H-1,2,4-triazole-3-thiones tested for antimicrobial activity. Bollettino Chimico Farmaceutico, 140(6), 417–421.
  • • Ulusoy, N., Gürsoy, A., & Ötük, G. (2001b). Synthesis and antimicrobial activity of some 1,2,4-triazole-3-mercaptoacetic acid derivatives. Farmaco, 56(12), 947–952.
  • • Wayne, P. A. (2005). Clinical and Laboratory Standards Institute. Performance standards for antimicrobial testing, 15th informational supplement. M100-S15. Clinical and Laboratory Standards Institute.
  • • Wayne, P. A. (2002a). National Committee for Clinical Laboratory Standards. Reference method for broth dilution antifungal susceptibility testing of yeasts; Approved standard-2nd Edition. M27-A2. Clinical and Laboratory Standards Institute.
  • • Wayne, P. A. (2002b). National Committee for Clinical Laboratory Standards. Reference method for broth dilution an antifungal susceptibility testing filamentous fungi; Approved standard M38A2. Clinical and Laboratory Standards Institute.
  • • Weng, Q., Huang, J., Zeng, Y., Deng, Y., & Hu, M. (2012). Synthesis and herbicidal activity evaluation of novel β-carboline derivatives. Molecules, 17(4), 3969–3980.
  • • Završnik, D., Muratović, S., Makuc, D., Plavec, J., Cetina, M., Nagl, A., Clercq, E. D., Balzarini, J., & Mintas, M. (2011). Benzylidene-bis-(4hydroxycoumarin) and benzopyrano-coumarin derivatives: Synthesis, 1H/13C-NMR conformational and X-ray crystal structure studies and in vitro antiviral activity evaluations. Molecules, 16(7), 6023–6040.

Synthesis and antimicrobial activity evaluation of new hydrazide-hydrazones derived from 1,2,4-triazole

Year 2020, Volume: 50 Issue: 1, 49 - 53, 01.04.2020

Abstract

Background and Aims: The aim in this study was to synthesize new 2-[[4-(4-chlorophenyl)-5-(furan-2-yl)-4H-1,2,4-triazol3-yl]sulfanyl]-N’-[(substituted phenyl/furanyl)methylidene]acetohydrazides and screen for their in vitro antimicrobial activity. Methods: Novel compounds (6a-g) were synthesized starting with furan-2-carbohydrazide (1) using five step reactions. The structures of the the resulting compounds were characterized by IR, 1H-NMR and elemental analysis. All compounds were evaluated for antibacterial and antifungal activities against Staphylococcus aureus ATCC 29213, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Candida albicans ATCC 10231, Candida krusei ATCC 6258, Candida parapsilosis ATCC 22019, Microsporum gypseum NCPF 580, Trichophyton mentagrophytes var. erinacei NCPF 375 and Trichophyton tonsurans NCPF 245 using a microbroth dilution method. Results: The biological assay results showed that all of the compounds displayed varying degrees of antimicrobial activity in this series. Conclusion: The preliminary results revealed that some of the new synthesized derivatives exhibited promising antimicrobial activities. Further investigation may be completed on similar molecules in the future.

References

  • • Al-Soud, Y. A., Al-Dweri, M. N., & Al-Masoudi, N. A. (2004). Synthesis, antitumor and antiviral properties of some 1,2,4-triazole derivatives. Farmaco, 59(10), 775–783.
  • • Boraei, A. T. A., Singh, P. K., Sechi, M., & Satta, S. (2019). Discovery of novel functionalized 1,2,4-triazoles as PARP-1 inhibitors in breast cancer: Design, synthesis and antitumor activity evaluation. European Journal of Medicinal Chemistry, 182, 111621.
  • • Çapan, G., Ergenç, N., & Ötük, G. (1990-92). Synthesis and biological evaluation of 4-alkyl/aryl-1-(2-furoyl)-3-thiosemicarbazides and 4-alkyl/aryl-2,4-dihydro-5-(2-furyl)-3H-1,2,4-triazole-3-thiones. Journal of Faculty of Pharmacy of Istanbul, 26-28, 23–30.
  • • Çapan, G., Ergenç, N., & Ötük, G. (1993). Synthesis, characterization and biological evaluation of 1,2,4-triazole-3-mercaptoacetic acid derivatives. Acta Pharmaceutica Turcica, 35, 51–58.
  • • Çapan, G., Ulusoy, N., Ergenç, N., & Kiraz, M. (1999). New 6-phenylimidazo[2,1-b]thiazole derivatives: Synthesis and antifungal activity. Monatshefte fur Chemie, 130(11), 1399–1407.
  • • Demirbaş, N., Karaoğlu, S. A., Demirbaş, A., & Sancak, K. (2004). Synthesis and antimicrobial activities of some new 1-(5-phenylamino-[1,3,4] thiadiazol-2-yl)methyl-5-oxo-[1,2,4]triazole and 1-(4-phenyl-5-thioxo-[1,2,4] triazol-3-yl)methyl-5-oxo-[1,2,4]triazole derivatives. European Journal of Medicinal Chemistry, 39(9), 793-804.
  • • Dimmock, J. R., Vashishtha, S. C., & Stables, J. P. (2000). Anticonvulsant properties of various acetylhydrazones, oxamoylhydrazones and semicarbazones derived from aromatic and unsaturated carbonyl compounds. European Journal of Medicinal Chemistry, 35(2), 241–248.
  • • El-Sherief, H. A. M., Youssif, B. G. M., Abbas Bukhari, S. N., Abdelazeem, A. H., Abdel-Aziz, M., & Abdel-Rahman, H. M. (2018). Synthesis, anticancer activity and molecular modeling studies of 1,2,4-triazole derivatives as EGFR inhibitors. European Journal of Medicinal Chemistry, 156, 774–789.
  • • Ergenç, N., Ulusoy, N., Çapan, G., Sanis, G. Ö., & Kiraz, M. (1996). Synthesis and antimicrobial properties of new 4-(alkylidene/ arylidene)-amino-5-(2-furanyl)-2,4-dihydro-3H-1,2,4-triazole-3thiones and 6-aryl-3-(2-furanyl)-7H-1,2,4-triazolo[3,4-b][1,3,4] thiadiazines. Archiv der Pharmazie, 329(8–9), 427–430.
  • • Fernández-Torres, B., Cabañes, F. J., Carrillo-Muñoz, A. J., Esteban, A., Inza, I., Abarca, L., & Guarro, J. (2002). Collaborative evaluation of optimal antifungal susceptibility testing conditions for dermatophytes. Journal of Clinical Microbiology, 40(11), 3999–4003.
  • • Günay, N. S., Çapan, G., Ulusoy, N., Ergenç, N., Ötük, G., & Kaya, D. (1999). 5-Nitroimidazole derivatives as possible antibacterial and antifungal agents. Farmaco, 54(11-12), 826–831.
  • • Holla, S., B., Veerendra, B., Shivananda, M. K., & Poojary, B. (2003). Synthesis characterization and anticancer activity studies on some Mannich bases derived from 1,2,4-triazoles. European Journal of Medicinal Chemistry, 38(7-8), 759–767.
  • • İlhan, E. Ergenç, N., Ulusoy, N., & Ötük Sanış, G., (1996). Synthese und antimikrobielle Untersuchung einiger 4-Arylidenamino-3(α,α-diphenyl-α-hydroxymethyl)-1,4-dihydro-5H-1,2,4-Triazol5-thione und 6-Aryl-3-(α,α-diphenyl-α-hydroxymethyl)-7H-sTriazolo[3,4-b][1,3,4]thiadiazine. Die Pharmazie, 51(2), 123–124.
  • • Imramovský, A., Polanc, S., Vinšová, J., Kočevar, M., Jampílek, J., Rečková, Z., & Kaustová, J. (2007). A new modification of antitubercular active molecules. Bioorganic and Medicinal Chemistry, 15(7), 2551–2559.
  • • Koçyiğit Kaymakçıoğlu, B., Oruç, E., Ünsalan, S., Kandemirli, F., Shvets, N., Rollas, S., & Dimoglo, A. (2006). Synthesis and characterization of novel hydrazide-hydrazones and the study of their structure-antituberculosis activity. European Journal of Medicinal Chemistry, 41(11), 1253–1261.
  • • Mustafa, M., Abdelhamid, D., Abdelhafez, E. S. M. N., Ibrahim, M. A. A., Gamal-Eldeen, A. M., & Aly, O. M. (2017). Synthesis, antiproliferative, anti-tubulin activity, and docking study of new 1,2,4-triazoles as potential combretastatin analogues. European Journal of Medicinal Chemistry, 141, 293–305.
  • • Mustafa, M., Anwar, S., Elgamal, F., Ahmed, E. R., & Aly, O. M. (2019). Potent combretastatin A-4 analogs containing 1,2,4-triazole: Synthesis, antiproliferative, anti-tubulin activity, and docking study. European Journal of Medicinal Chemistry, 183, 111697.
  • • Özkırımlı, S., Kazan, F., & Tunalı, Y. (2009). Synthesis, antibacterial and antifungal activities of 3-(1,2,4-triazol-3- yl)-4-thiazolidinones. Journal of Enzyme Inhibition and Medicinal Chemistry, 24(2), 447–452.
  • • Rollas, S., Gülerman, N., & Erdeniz, H. (2002). Synthesis and antimicrobial activity of some new hydrazones of 4-fluorobenzoic acid hydrazide and 3-acetyl-2,5-disubstituted-1,3,4-oxadiazolines. Farmaco, 57(2), 171–174.
  • • Salgın-Gökşen, U., Gökhan-Kelekçi, N., Göktaş, Ö., Köysal, Y., Kılıç, E., Işık, Ş., Aktay, G. & Özalp, M. (2007). 1-Acylthiosemicarbazides, 1,2,4-triazole-5(4H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: Synthesis, analgesicanti-inflammatory and antimicrobial activities. Bioorganic and Medicinal Chemistry, 15(17), 5738–5751.
  • • Savini, L., Chiasserini, L., Travagli, V., Pellerano, C., Novellino, E., Cosentino, S., & Pisano, M. B. (2004). New α-(N)-heterocyclichydrazones: Evaluation of anticancer, anti-HIV and antimicrobial activity. European Journal of Medicinal Chemistry, 39(2), 113–122.
  • • Sztanke, K., Tuzimski, T., Rzymowska, J., Pasternak, K., & KandeferSzerszeń, M. (2008). Synthesis, determination of the lipophilicity, anticancer and antimicrobial properties of some fused 1,2,4-triazole derivatives. European Journal of Medicinal Chemistry, 43(2), 404–419.
  • • Tozkoparan, B., Gökhan, N., Aktay, G., Yeşilada, E., & Ertan, M. (2000). 6-Benzylidenethiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones substituted with ibuprofen: Synthesis, characterization and evaluation of anti-inflammatory activity. European Journal of Medicinal Chemistry, 35(7), 743–750.
  • • Turan-Zitouni, G., Kaplancıklı, Z. A., Erol, K., & Kılıç, F. S. (1999). Synthesis and analgesic activity of some triazoles and triazolothiadiazines. Farmaco, 54(4), 218–223.
  • • Turan-Zitouni, G., Kaplancıklı, Z. A., Yıldız, M. T., Chevallet, P., & Kaya, D. (2005). Synthesis and antimicrobial activity of 4-phenyl/cyclohexyl-5-(1-phenoxyethyl)-3-[N-(2-thiazolyl)acetamido]thio-4H1,2,4-triazole derivatives. European Journal of Medicinal Chemistry, 40(6), 607–613.
  • • Ulusoy Güzeldemirci, N., & Küçükbasmacı, Ö. (2010). Synthesis and antimicrobial activity evaluation of new 1,2,4-triazoles and 1,3,4-thiadiazoles bearing imidazo[2,1-b]thiazole moiety. European Journal of Medicinal Chemistry, 45(1), 63–68.
  • • Ulusoy Güzeldemirci, N., Şatana, D., & Küçükbasmacı, Ö. (2013). Synthesis, characterization, and antimicrobial evaluation of some new hydrazinecarbothioamide, 1,2,4-triazole and 1,3,4-thiadiazole derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry, 28(5), 968–973.
  • • Ulusoy, N., Ateş, Ö., Küçükbasmacı, Ö., Kiraz, M., & Yemenoğlu, Y. (2003). Synthesis, Characterization, and Evaluation of Antimicrobial Activity of Some 1,2,4-Triazole Derivatives Bearing an Antipyryl Moiety. Monatshefte für Chemie, 134(3), 465–474.
  • • Ulusoy, N., Ergenç, N., Ötük, G., & Kiraz, M. (2001a). Synthesis of some 4-(alkylidene/arylidene)amino-2,4-dihydro-5-(2thienyl)-3H-1,2,4-triazole-3-thiones tested for antimicrobial activity. Bollettino Chimico Farmaceutico, 140(6), 417–421.
  • • Ulusoy, N., Gürsoy, A., & Ötük, G. (2001b). Synthesis and antimicrobial activity of some 1,2,4-triazole-3-mercaptoacetic acid derivatives. Farmaco, 56(12), 947–952.
  • • Wayne, P. A. (2005). Clinical and Laboratory Standards Institute. Performance standards for antimicrobial testing, 15th informational supplement. M100-S15. Clinical and Laboratory Standards Institute.
  • • Wayne, P. A. (2002a). National Committee for Clinical Laboratory Standards. Reference method for broth dilution antifungal susceptibility testing of yeasts; Approved standard-2nd Edition. M27-A2. Clinical and Laboratory Standards Institute.
  • • Wayne, P. A. (2002b). National Committee for Clinical Laboratory Standards. Reference method for broth dilution an antifungal susceptibility testing filamentous fungi; Approved standard M38A2. Clinical and Laboratory Standards Institute.
  • • Weng, Q., Huang, J., Zeng, Y., Deng, Y., & Hu, M. (2012). Synthesis and herbicidal activity evaluation of novel β-carboline derivatives. Molecules, 17(4), 3969–3980.
  • • Završnik, D., Muratović, S., Makuc, D., Plavec, J., Cetina, M., Nagl, A., Clercq, E. D., Balzarini, J., & Mintas, M. (2011). Benzylidene-bis-(4hydroxycoumarin) and benzopyrano-coumarin derivatives: Synthesis, 1H/13C-NMR conformational and X-ray crystal structure studies and in vitro antiviral activity evaluations. Molecules, 16(7), 6023–6040.
There are 35 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences, Health Care Administration
Journal Section Original Article
Authors

Nuray Ulusoy Güzeldemirci This is me 0000-0002-4495-4282

Dilek Şatana This is me 0000-0002-8827-1504

Ömer Küçükbasmacı This is me 0000-0002-8678-4218

Publication Date April 1, 2020
Submission Date July 3, 2019
Published in Issue Year 2020 Volume: 50 Issue: 1

Cite

APA Ulusoy Güzeldemirci, N., Şatana, D., & Küçükbasmacı, Ö. (2020). Synthesis and antimicrobial activity evaluation of new hydrazide-hydrazones derived from 1,2,4-triazole. İstanbul Journal of Pharmacy, 50(1), 49-53.
AMA Ulusoy Güzeldemirci N, Şatana D, Küçükbasmacı Ö. Synthesis and antimicrobial activity evaluation of new hydrazide-hydrazones derived from 1,2,4-triazole. iujp. April 2020;50(1):49-53.
Chicago Ulusoy Güzeldemirci, Nuray, Dilek Şatana, and Ömer Küçükbasmacı. “Synthesis and Antimicrobial Activity Evaluation of New Hydrazide-Hydrazones Derived from 1,2,4-Triazole”. İstanbul Journal of Pharmacy 50, no. 1 (April 2020): 49-53.
EndNote Ulusoy Güzeldemirci N, Şatana D, Küçükbasmacı Ö (April 1, 2020) Synthesis and antimicrobial activity evaluation of new hydrazide-hydrazones derived from 1,2,4-triazole. İstanbul Journal of Pharmacy 50 1 49–53.
IEEE N. Ulusoy Güzeldemirci, D. Şatana, and Ö. Küçükbasmacı, “Synthesis and antimicrobial activity evaluation of new hydrazide-hydrazones derived from 1,2,4-triazole”, iujp, vol. 50, no. 1, pp. 49–53, 2020.
ISNAD Ulusoy Güzeldemirci, Nuray et al. “Synthesis and Antimicrobial Activity Evaluation of New Hydrazide-Hydrazones Derived from 1,2,4-Triazole”. İstanbul Journal of Pharmacy 50/1 (April 2020), 49-53.
JAMA Ulusoy Güzeldemirci N, Şatana D, Küçükbasmacı Ö. Synthesis and antimicrobial activity evaluation of new hydrazide-hydrazones derived from 1,2,4-triazole. iujp. 2020;50:49–53.
MLA Ulusoy Güzeldemirci, Nuray et al. “Synthesis and Antimicrobial Activity Evaluation of New Hydrazide-Hydrazones Derived from 1,2,4-Triazole”. İstanbul Journal of Pharmacy, vol. 50, no. 1, 2020, pp. 49-53.
Vancouver Ulusoy Güzeldemirci N, Şatana D, Küçükbasmacı Ö. Synthesis and antimicrobial activity evaluation of new hydrazide-hydrazones derived from 1,2,4-triazole. iujp. 2020;50(1):49-53.