Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin

Year 2021, Volume: 51 Issue: 1, 26 - 34, 30.04.2021

Sinem Şahin Burcu Mesut M. Ezgi Durgun Esher Özçelik Yıldız Özsoy

Abstract

Background and Aims: The study aimed to design a Fixed-dose tablet formulation of Metformine and Repaglinide. Methods: Wet granulation method was used to prepare tablet formulations. Characterization studies and dissolution studies were performed. Results: A stable formulation was developed according to the requirements of the pharmacopoeia criteria. This new formulsation dissolution results showed that Repaglinide and Metformin HCl dissolved more than 85% from film tablets at 15 minutes. Conclusion: Thus, an alternative product to the market product was developed.

Keywords

Fixed-Dose Tablet, Metformin, Repaglinide

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