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In vitro evaluation of antimicrobial activity of Distemonanthus benthamianus chewing stick extract mouthwash

Year 2021, Volume: 51 Issue: 1, 105 - 110, 30.04.2021

Abstract

Background and Aims: Mouthwashes are oral home care product used to treat mouth infections and to maintain satisfactory oral hygiene. The use of effective mouthwash is a reasonable means to prevent dental caries and oro-dental infections. The aim of this study was to evaluate the antimicrobial potential of Distemonanthus benthamianus chewing stick extract formulated as a mouthwash against some microorganisms associated with oro-dental infections in comparison with two commercial brand mouthwashes. Methods: The chewing stick was extracted with methanol and used to formulate mouthwash. Phytochemical screening was done to test for the presence of secondary metabolites. Antimicrobial activity of the crude extract and the formulated mouthwash on Staphylococcus aureus, Streptococcus mutans and Candida albicans was evaluated. The physical characteristics, pH and the stability of the mouthwashes were determined. Results: The extract contains alkaloids, saponins flavonoids, steroids and tannins. The crude extract and the formulated mouthwashes showed significant difference in activity against the test microorganisms in the following order Candida albicans > Staphylococcus aureus > Streptococcus mutans. At high concentrations of the extract (0.3%W/V and 0.5%W/V) in formulations, antibacterial activities were significantly higher against Streptococcus mutans and Staphylococcus aureus when compared with the commercial brands. The pH of the mouthwashes ranged from 5.2 - 7.4. The stability of formulation F5 was maintained for 12 weeks. Conclusion: The use of Distemonanthus benthamianus chewing stick extract mouthwash is safer, cheaper, and more effective in preventing dental caries and oro-dental infections compared to the commercial brand mouthwashes.

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There are 27 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences, Health Care Administration
Journal Section Original Article
Authors

Mbang Nyong Femi-oyewo This is me 0000-0003-0025-2227

Olutayo Ademola Adeleye This is me 0000-0001-8716-4064

Caroline Olufunke Babalola This is me

Olufemi Babatunde Banjo This is me 0000-0002-6970-516X

Modupe Nofisat Adebowale This is me 0000-0002-0944-0702

Florence Olubola Odeleye This is me

Publication Date April 30, 2021
Submission Date June 14, 2020
Published in Issue Year 2021 Volume: 51 Issue: 1

Cite

APA Femi-oyewo, M. N., Adeleye, O. A., Babalola, C. O., Banjo, O. B., et al. (2021). In vitro evaluation of antimicrobial activity of Distemonanthus benthamianus chewing stick extract mouthwash. İstanbul Journal of Pharmacy, 51(1), 105-110.
AMA Femi-oyewo MN, Adeleye OA, Babalola CO, Banjo OB, Adebowale MN, Odeleye FO. In vitro evaluation of antimicrobial activity of Distemonanthus benthamianus chewing stick extract mouthwash. iujp. April 2021;51(1):105-110.
Chicago Femi-oyewo, Mbang Nyong, Olutayo Ademola Adeleye, Caroline Olufunke Babalola, Olufemi Babatunde Banjo, Modupe Nofisat Adebowale, and Florence Olubola Odeleye. “In Vitro Evaluation of Antimicrobial Activity of Distemonanthus Benthamianus Chewing Stick Extract Mouthwash”. İstanbul Journal of Pharmacy 51, no. 1 (April 2021): 105-10.
EndNote Femi-oyewo MN, Adeleye OA, Babalola CO, Banjo OB, Adebowale MN, Odeleye FO (April 1, 2021) In vitro evaluation of antimicrobial activity of Distemonanthus benthamianus chewing stick extract mouthwash. İstanbul Journal of Pharmacy 51 1 105–110.
IEEE M. N. Femi-oyewo, O. A. Adeleye, C. O. Babalola, O. B. Banjo, M. N. Adebowale, and F. O. Odeleye, “In vitro evaluation of antimicrobial activity of Distemonanthus benthamianus chewing stick extract mouthwash”, iujp, vol. 51, no. 1, pp. 105–110, 2021.
ISNAD Femi-oyewo, Mbang Nyong et al. “In Vitro Evaluation of Antimicrobial Activity of Distemonanthus Benthamianus Chewing Stick Extract Mouthwash”. İstanbul Journal of Pharmacy 51/1 (April 2021), 105-110.
JAMA Femi-oyewo MN, Adeleye OA, Babalola CO, Banjo OB, Adebowale MN, Odeleye FO. In vitro evaluation of antimicrobial activity of Distemonanthus benthamianus chewing stick extract mouthwash. iujp. 2021;51:105–110.
MLA Femi-oyewo, Mbang Nyong et al. “In Vitro Evaluation of Antimicrobial Activity of Distemonanthus Benthamianus Chewing Stick Extract Mouthwash”. İstanbul Journal of Pharmacy, vol. 51, no. 1, 2021, pp. 105-10.
Vancouver Femi-oyewo MN, Adeleye OA, Babalola CO, Banjo OB, Adebowale MN, Odeleye FO. In vitro evaluation of antimicrobial activity of Distemonanthus benthamianus chewing stick extract mouthwash. iujp. 2021;51(1):105-10.