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Antioxidant activity and three phenolic compounds from the roots of Taraxacum gracilens Dahlst.

Year 2022, Volume 52, Issue 1, 69 - 72, 28.04.2022
https://doi.org/10.26650/IstanbulJPharm.2022.894762

Abstract

Background and Aims: The genus Taraxacum is a member of the family Asteraceae. Taraxacum species are widely distributed in the warmer temperate zones of the Northern Hemisphere. The aim of this study was to evaluate the phenolic contents and antioxidant activity of the ethanol extract and its chloroform and ethyl acetate fractions from the roots of Taraxacum gracilens Dahlst. and isolate some of its phenolic compounds.
Methods: The roots of T. gracilens Dahlst. werefirst macerated with EtOH and fractionated to obtain chloroform and ethyl acetate fractions, and then phenolic compounds were isolated by column chromatography. The polyphenolic contents and antioxidant activities of the fractions were evaluated by measuring their abilities to inhibit lipid peroxidation induced by Fe3+- ascorbate, their reducing powers, and their hydrogen-donor activities.
Results: Three phenolic compounds [vanillic acid (1), caffeic acid (2) and luteolin (3)] were isolated from the roots of T. grac- ilens Dahlst. The ethyl acetate fraction from the ethanol extract of T. gracilens Dahlst. roots showed the highest antioxidant activity due to its richest phenolic contents, whereas the ethanol extract containing the least phenolics was the weakest in activity.
Conclusion: The fractions have potential to act as antioxidant agents. T. gracilens Dahlst. roots were investigated for the first time in literature data in terms of phenolic contents and antioxidant activity.

References

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  • Brand-Williams, W., Cuvelier, M., & Berset, C. (1995). Use of a free radical method to evaluate antioxidant activity. Lebensmittel-Wis- senschaft Und Technologie, 28, 25–30.
  • Budzianowski, J. (1997). Coumarins, Caffeoyltartaric acids and their artifactual methyl esters from taraxacum officinale Leaves. Planta Medica, 63(03), 288–288. https://doi.org/10.1055/s-2006-957681
  • Duh, P.-D., Tu, Y.-Y., & Yen, G.-C. (1999). Antioxidant activity of wa- ter extract of Harng Jyur (Chrysanthemum morifolium ramat). Lebensmıttel-Wıssenschaft Und Technologıe, 32, 269–277.
  • Hu, C. (2018). Taraxacum: Phytochemistry and health benefits. Chi- nese Herbal Medicines, 10(4), 353–361. https://doi.org/10.1016/j. chmed.2018.08.003
  • Ivanov, I. G. (2014). polyphenols content and antioxidant activities of taraxacum officinale F.H. Wigg (Dandelion) Leaves. Available Online on Www.Ijppr.Com International Journal of Pharmacognosy and Phytochemical Research, 6(4). Retrieved from www.ijppr.com
  • Jedrejek, D., Lis, B., Rolnik, A., Stochmal, A., & Olas, B. (2019). Com- parative phytochemical, cytotoxicity, antioxidant and haemo- static studies of Taraxacum officinale root preparations. Food and Chemical Toxicology, 126, 233–247. https://doi.org/10.1016/J. FCT.2019.02.017
  • Kenny, O., Smyth, T. J., Hewage, C. M., Brunton, N. P., & McLough- lin, P. (2014). 4-Hydroxyphenylacetic acid derivatives of inositol from dandelion (Taraxacum officinale) root characterised using LC-SPE-NMR and LC-MS techniques. Phytochemistry, 98, 197–203.https://doi.org/10.1016/j.phytochem.2013.11.022
  • Kenny, Owen, J Smyth, T., M Hewage, C., & P Brunton, N. (2014). Antioxidant properties and quantitative UPLC-MS/MS analysis of phenolic compounds in dandelion (Taraxacum officinale) root extracts. Free Radicals and Antioxidants, 4(1), 55–61. https://doi. org/10.5530/fra.2014.1.9
  • Kenny, Owen, Smyth, T. J., Hewage, C. M., & Brunton, N. P. (2015). Quantitative UPLC-MS/MS analysis of chlorogenic acid deriva- tives in antioxidant fractionates from dandelion (Taraxacum of- ficinale) root. International Journal of Food Science and Technology, 50(3), 766–773. https://doi.org/10.1111/ijfs.12668
  • Leu, Y. L., Wang, Y. L., Huang, S. C., & Shi, L. S. (2005). Chemical constituents from roots of Taraxacum formosanum. Chemical and Pharmaceutical Bulletin, 53(7), 853–855. https://doi.org/10.1248/ cpb.53.853
  • Martinez, M., Poirrier, P., Chamy, R., Prüfer, D., Schulze-Gronover, C., Jorquera, L., & Ruiz, G. (2015). Taraxacum officinale and related species - An ethnopharmacological review and its potential as a commercial medicinal plant. Journal of Ethnopharmacology, 169, 244–262. https://doi.org/10.1016/j.jep.2015.03.067
  • Pratt, D. E. (1976). Food Flavors. In G. Charalambous & I. Katz (Eds.), Phenolic, Sulfur and Nitrogen Compounds. Washington, DC.: Amer- ican Chemical Society.
  • Schütz, K., Carle, R., & Schieber, A. (2006, October 11). Taraxacum- A review on its phytochemical and pharmacological profile. Journal of Ethnopharmacology, Vol. 107, pp. 313–323. https://doi. org/10.1016/j.jep.2006.07.021
  • Slinkard, K., & Singleton, V. (1977). Total phenol analyses: automa- tion and comparison with manual methods. American Journal of Enology and Viticulture, 28, 49–55.
  • Stefano, L. G., Bruna, E., Virginia, F., & Giuliano Bonanomi, L. (2019). Common dandelion: a review of its botanical, phytochemical and pharmacological profiles. Phytochemistry Reviews, 1–18. https:// doi.org/10.1007/s11101-019-09622-2
  • Williams, C. A., Goldstone, F., & Greenham, J. (1996). Flavonoids, cinnamic acids and coumarins from the different tissues and me- dicinal preparations of Taraxacum officinale. Phytochemistry, 42(1), 121–127. https://doi.org/10.1016/0031-9422(95)00865-9

Year 2022, Volume 52, Issue 1, 69 - 72, 28.04.2022
https://doi.org/10.26650/IstanbulJPharm.2022.894762

Abstract

References

  • Benzie, I., & Strain, J. (1996). The ferric reducing ability of plasma (FRAP) as a measure of antioxidant power: The FRAP assay. Ana- lytical Biochemistry, 239, 70–76.
  • Brand-Williams, W., Cuvelier, M., & Berset, C. (1995). Use of a free radical method to evaluate antioxidant activity. Lebensmittel-Wis- senschaft Und Technologie, 28, 25–30.
  • Budzianowski, J. (1997). Coumarins, Caffeoyltartaric acids and their artifactual methyl esters from taraxacum officinale Leaves. Planta Medica, 63(03), 288–288. https://doi.org/10.1055/s-2006-957681
  • Duh, P.-D., Tu, Y.-Y., & Yen, G.-C. (1999). Antioxidant activity of wa- ter extract of Harng Jyur (Chrysanthemum morifolium ramat). Lebensmıttel-Wıssenschaft Und Technologıe, 32, 269–277.
  • Hu, C. (2018). Taraxacum: Phytochemistry and health benefits. Chi- nese Herbal Medicines, 10(4), 353–361. https://doi.org/10.1016/j. chmed.2018.08.003
  • Ivanov, I. G. (2014). polyphenols content and antioxidant activities of taraxacum officinale F.H. Wigg (Dandelion) Leaves. Available Online on Www.Ijppr.Com International Journal of Pharmacognosy and Phytochemical Research, 6(4). Retrieved from www.ijppr.com
  • Jedrejek, D., Lis, B., Rolnik, A., Stochmal, A., & Olas, B. (2019). Com- parative phytochemical, cytotoxicity, antioxidant and haemo- static studies of Taraxacum officinale root preparations. Food and Chemical Toxicology, 126, 233–247. https://doi.org/10.1016/J. FCT.2019.02.017
  • Kenny, O., Smyth, T. J., Hewage, C. M., Brunton, N. P., & McLough- lin, P. (2014). 4-Hydroxyphenylacetic acid derivatives of inositol from dandelion (Taraxacum officinale) root characterised using LC-SPE-NMR and LC-MS techniques. Phytochemistry, 98, 197–203.https://doi.org/10.1016/j.phytochem.2013.11.022
  • Kenny, Owen, J Smyth, T., M Hewage, C., & P Brunton, N. (2014). Antioxidant properties and quantitative UPLC-MS/MS analysis of phenolic compounds in dandelion (Taraxacum officinale) root extracts. Free Radicals and Antioxidants, 4(1), 55–61. https://doi. org/10.5530/fra.2014.1.9
  • Kenny, Owen, Smyth, T. J., Hewage, C. M., & Brunton, N. P. (2015). Quantitative UPLC-MS/MS analysis of chlorogenic acid deriva- tives in antioxidant fractionates from dandelion (Taraxacum of- ficinale) root. International Journal of Food Science and Technology, 50(3), 766–773. https://doi.org/10.1111/ijfs.12668
  • Leu, Y. L., Wang, Y. L., Huang, S. C., & Shi, L. S. (2005). Chemical constituents from roots of Taraxacum formosanum. Chemical and Pharmaceutical Bulletin, 53(7), 853–855. https://doi.org/10.1248/ cpb.53.853
  • Martinez, M., Poirrier, P., Chamy, R., Prüfer, D., Schulze-Gronover, C., Jorquera, L., & Ruiz, G. (2015). Taraxacum officinale and related species - An ethnopharmacological review and its potential as a commercial medicinal plant. Journal of Ethnopharmacology, 169, 244–262. https://doi.org/10.1016/j.jep.2015.03.067
  • Pratt, D. E. (1976). Food Flavors. In G. Charalambous & I. Katz (Eds.), Phenolic, Sulfur and Nitrogen Compounds. Washington, DC.: Amer- ican Chemical Society.
  • Schütz, K., Carle, R., & Schieber, A. (2006, October 11). Taraxacum- A review on its phytochemical and pharmacological profile. Journal of Ethnopharmacology, Vol. 107, pp. 313–323. https://doi. org/10.1016/j.jep.2006.07.021
  • Slinkard, K., & Singleton, V. (1977). Total phenol analyses: automa- tion and comparison with manual methods. American Journal of Enology and Viticulture, 28, 49–55.
  • Stefano, L. G., Bruna, E., Virginia, F., & Giuliano Bonanomi, L. (2019). Common dandelion: a review of its botanical, phytochemical and pharmacological profiles. Phytochemistry Reviews, 1–18. https:// doi.org/10.1007/s11101-019-09622-2
  • Williams, C. A., Goldstone, F., & Greenham, J. (1996). Flavonoids, cinnamic acids and coumarins from the different tissues and me- dicinal preparations of Taraxacum officinale. Phytochemistry, 42(1), 121–127. https://doi.org/10.1016/0031-9422(95)00865-9

Details

Primary Language English
Subjects Pharmacology and Pharmacy
Journal Section Original Article
Authors

Seçil KARAHÜSEYİN> (Primary Author)
İstanbul Üniversitesi Eczacılık Fakültesi Eczacılık Meslek Bilimleri Bölümü
0000-0002-3515-2974
Türkiye


Aynur SARI>
İstanbul Üniversitesi Eczacılık Fakültesi Farmakognozi AD
0000-0001-8116-7053
Türkiye


Nurten OZSOY>
İstanbul Üniversitesi Eczacılık Fakültesi Biyokimya AD
0000-0002-2419-9128
Türkiye

Supporting Institution Scientific Research Projects Unit of Istanbul University
Project Number 45560
Publication Date April 28, 2022
Application Date March 11, 2021
Acceptance Date February 23, 2022
Published in Issue Year 2022, Volume 52, Issue 1

Cite

Bibtex @research article { iujp894762, journal = {İstanbul Journal of Pharmacy}, eissn = {2587-2087}, address = {İstanbul Üniversitesi Eczacılık Fakültesi Farmasötik Botanik AD}, publisher = {Istanbul University}, year = {2022}, volume = {52}, number = {1}, pages = {69 - 72}, doi = {10.26650/IstanbulJPharm.2022.894762}, title = {Antioxidant activity and three phenolic compounds from the roots of Taraxacum gracilens Dahlst.}, key = {cite}, author = {Karahüseyin, Seçil and Sarı, Aynur and Ozsoy, Nurten} }
APA Karahüseyin, S. , Sarı, A. & Ozsoy, N. (2022). Antioxidant activity and three phenolic compounds from the roots of Taraxacum gracilens Dahlst. . İstanbul Journal of Pharmacy , 52 (1) , 69-72 . DOI: 10.26650/IstanbulJPharm.2022.894762
MLA Karahüseyin, S. , Sarı, A. , Ozsoy, N. "Antioxidant activity and three phenolic compounds from the roots of Taraxacum gracilens Dahlst." . İstanbul Journal of Pharmacy 52 (2022 ): 69-72 <https://dergipark.org.tr/en/pub/iujp/issue/69658/894762>
Chicago Karahüseyin, S. , Sarı, A. , Ozsoy, N. "Antioxidant activity and three phenolic compounds from the roots of Taraxacum gracilens Dahlst.". İstanbul Journal of Pharmacy 52 (2022 ): 69-72
RIS TY - JOUR T1 - Antioxidant activity and three phenolic compounds from the roots of Taraxacum gracilens Dahlst. AU - SeçilKarahüseyin, AynurSarı, NurtenOzsoy Y1 - 2022 PY - 2022 N1 - doi: 10.26650/IstanbulJPharm.2022.894762 DO - 10.26650/IstanbulJPharm.2022.894762 T2 - İstanbul Journal of Pharmacy JF - Journal JO - JOR SP - 69 EP - 72 VL - 52 IS - 1 SN - -2587-2087 M3 - doi: 10.26650/IstanbulJPharm.2022.894762 UR - https://doi.org/10.26650/IstanbulJPharm.2022.894762 Y2 - 2022 ER -
EndNote %0 İstanbul Journal of Pharmacy Antioxidant activity and three phenolic compounds from the roots of Taraxacum gracilens Dahlst. %A Seçil Karahüseyin , Aynur Sarı , Nurten Ozsoy %T Antioxidant activity and three phenolic compounds from the roots of Taraxacum gracilens Dahlst. %D 2022 %J İstanbul Journal of Pharmacy %P -2587-2087 %V 52 %N 1 %R doi: 10.26650/IstanbulJPharm.2022.894762 %U 10.26650/IstanbulJPharm.2022.894762
ISNAD Karahüseyin, Seçil , Sarı, Aynur , Ozsoy, Nurten . "Antioxidant activity and three phenolic compounds from the roots of Taraxacum gracilens Dahlst.". İstanbul Journal of Pharmacy 52 / 1 (April 2022): 69-72 . https://doi.org/10.26650/IstanbulJPharm.2022.894762
AMA Karahüseyin S. , Sarı A. , Ozsoy N. Antioxidant activity and three phenolic compounds from the roots of Taraxacum gracilens Dahlst.. iujp. 2022; 52(1): 69-72.
Vancouver Karahüseyin S. , Sarı A. , Ozsoy N. Antioxidant activity and three phenolic compounds from the roots of Taraxacum gracilens Dahlst.. İstanbul Journal of Pharmacy. 2022; 52(1): 69-72.
IEEE S. Karahüseyin , A. Sarı and N. Ozsoy , "Antioxidant activity and three phenolic compounds from the roots of Taraxacum gracilens Dahlst.", İstanbul Journal of Pharmacy, vol. 52, no. 1, pp. 69-72, Apr. 2022, doi:10.26650/IstanbulJPharm.2022.894762