Research Article
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Year 2023, Volume: 53 Issue: 1, 30 - 38, 28.04.2023

Abstract

Supporting Institution

Çukurova üniversitesi

Project Number

TSA-2019-11424

References

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  • Bozkurt, A. E., & Terzioğlu, S. (2017). The aromatic-medicinal plant taxa of pure scots pine stands in Sürmene-Camburnu (Trab- zon). International Journal of Secondary Metabolite, 4(3, Special Issue 2), 517-529.
  • Bradley, A. F., Loftsgaarden, D. O., & Steele, R. (1992). Constructing and testing logistic regression models for binary data: Applications to the National Fire Danger Rating System (pp. 284-287). US De- partment of Agriculture, Forest Service, Intermountain Research Station.
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  • Demirci, S., & Özhatay, N. (2012). An ethnobotanical study in Kahramanmaraş (Turkey); wild plants used for medicinal purpose in Andirin, Kahramanmaraş. Turk J Pharm Sci, 9(1), 75-92.
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  • Eminağaoğlu, Ö., Göktürk, T., & Akyıldırım Beğen, H. A. Y. A. L. (2017). Traditional uses of medicinal plants and animals of Ha- tila Valley National Park, Artvin. Biological Diversity and Conserva- tion, 10(3), 33-42.
  • Erol, I., Üstündağ Okur, N., Orak, D., Sipahi, H., Aydın, A., & Özer, Ö. (2020). Tazarotene-loaded in situ gels for potential management of psoriasis: biocompatibility, anti-inflammatory and analgesic ef- fect. Pharmaceutical Development and Technology, 25(8), 909-918.
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  • Güner, Ö., Selvi, S. (2016). Balıkesir aktarlarında satılan yabani tıbbi bitkiler ve kullanım özellikleri [Wild medicinal plants sold in Balıkesir/Turkey herbal markets and their using properties]. Bio- logical Diversity and Conservation, 9(2), 96-101 .
  • Güneş, F. (2018). Edirne’nin İpsala ilçesinde halk ilacı olarak kullanılan bitkiler. Research Journal of Biology Sciences, 11(1), 29-37.
  • Güneş, S., Savran, A., Paksoy, M. Y., Koşar, M., & Çakılcıoğlu, U. (2017). Ethnopharmacological survey of medicinal plants in Karaisalı and its surrounding (Adana-Turkey). Journal of Herbal Medicine, 8, 68-75.
  • Güngör, S., Erdal, M. F., & Aksu, B. (2013). New Formulation Strate- gies in Topical Antifungal Therapy. Journal of Cosmetics. Derma- tological Sciences and Applications, 3, 56-65.
  • Güven, U. M., Berkman, M. S., Şenel, B., & Yazan, Y. (2019). Develop- ment and in vitro/in vivo evaluation of thermo-sensitive in situ gelling systems for ocular allergy. Brazilian Journal of Pharmaceuti- cal Sciences, 55.
  • Hashemi, Z., Ebrahimzadeh, M. A., & Khalili, M. (2019). Sun pro- tection factor, total phenol, flavonoid contents and antioxidant activity of medicinal plants from Iran. Trop. J. Pharm. Res, 18, 1443- 1448.
  • Hudson, S. P., Langer, R., Fink, G. R., & Kohane, D. S. (2010). Inject- able in situ cross-linking hydrogels for local antifungal therapy. Biomaterials, 31(6), 1444-1452.
  • Ivanova, D., Tasinov, O., & Kiselova-Kaneva, Y. (2014). Improved lipid profile and increased serum antioxidant capacity in healthy volunteers after Sambucus ebulus L. fruit infusion consumption. International journal of food sciences and nutrition, 65(6), 740-744.
  • Jabbari, M., Daneshfard, B., Emtiazy, M., Khiveh, A., & Hashempur,
  • M. H. (2017). Biological effects and clinical applications of dwarf elder (Sambucus ebulus L): A review. Journal of evidence-based complementary & alternative medicine, 22(4), 996-1001.
  • Kaileh, M., Berghe, W. V., Boone, E., Essawi, T., & Haegeman, G. (2007). Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity. Journal of eth- nopharmacology, 113(3), 510-516.
  • Kang, F., & Singh, J. (2005). In vitro release of insulin and biocom- patibility of in situ forming gel systems. International Journal of Pharmaceutics, 304(1-2), 83-90.
  • Karaköse, M., & Karaköse, G. Ç. (2017). Medicinal and Aromatic Plants of Esenli (Giresun) Forest Planning Unit. International Jour- nal of Secondary Metabolite, 4(3), 285-305.
  • Karcı, E., Gürbüz, İ., Akaydın, G., & Günbatan, T. (2017). Folk medi- cines of Bafra (Samsun-Turkey). Turkish Journal of Biochemis- try, 42(4), 381-399.
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Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract

Year 2023, Volume: 53 Issue: 1, 30 - 38, 28.04.2023

Abstract

Background and Aims: Sambucus ebulus L. has been used to treat inflammation-related gastrointestinal disorders, influen- za, kidney ailments, lung diseases, rheumatoid arthritis, and snake and insect bites. Our study provides important ethnobo- tanical information about S. ebulus with the aim of developing a formulation with increased extract bioavailability, diminished side effects, and easy drug loading and dose adjustment as an effective local therapy for dermatologic diseases.
Methods: Twelve in-situ gels with S. ebulus were prepared as antifungal treatments in accordance with the cold method and formulated using poloxamer and hydroxypropyl methylcellulose (HPMC). The formulations were characterized in terms of pH, gelling capacity, swelling degree, spreadability, and rheological properties.
Results: Among the prepared in situ gel formulations, the Poloxamer 407 and 407-HPMC mixtures of P14H1 and P15 demon- strated acceptable gelation temperatures for dermal use.
Conclusion: Thermosensitive in-situ gels containing S. ebulus may be a viable alternative for treating fungal diseases.

Project Number

TSA-2019-11424

References

  • Agrawal, A. K., Das, M., & Jain, S. (2012). In situ gel systems as ‘smart’ carriers for sustained ocular drug delivery. Expert Opinion on Drug Delivery, 9(4), 383-402.
  • Ahmadiani, A., Fereidoni, M., Semnanian, S., Kamalinejad, M., & Saremi, S. (1998). Antinociceptive and anti-inflammatory effects of Sambucus ebulus rhizome extract in rats. Journal of Ethnophar- macology, 61(3), 229-235.
  • Atay, I., Kirmizibekmez, H., Gören, A. C., & Yeşilada, E. (2015). Sec- ondary metabolites from Sambucus ebulus. Turkish Journal of Chemistry, 39(1), 34-41.
  • Aydın, A, Yeşil, Y. (2018). İkizce Ordu-Türkiye ilçesinde etnobotanik bir ön çalışma [An ethnobotanical preliminary study in İkizce (Or- du-Turkey) district]. Bağbahçe Bilim Dergisi, 5(3), 25-43 .
  • Bhattaccharjee, S., Beck-Broichsitter, M., & Banga, A. K. (2020). In situ gel formation in microporated skin for enhanced topical de- livery of niacinamide. Pharmaceutics, 12(5), 472.
  • Bozkurt, A. E., & Terzioğlu, S. (2017). The aromatic-medicinal plant taxa of pure scots pine stands in Sürmene-Camburnu (Trab- zon). International Journal of Secondary Metabolite, 4(3, Special Issue 2), 517-529.
  • Bradley, A. F., Loftsgaarden, D. O., & Steele, R. (1992). Constructing and testing logistic regression models for binary data: Applications to the National Fire Danger Rating System (pp. 284-287). US De- partment of Agriculture, Forest Service, Intermountain Research Station.
  • Charlebois, D., Byers, P. L., Finn, C. E., & Thomas, A. L. (2010). Elder- berry: Botany, Horticulture, Potential. Horticultural Reviews, 37(4), 214-280.
  • Chaudhary, B., & Verma, S. (2014). Preparation and evaluation of novel in situ gels containing acyclovir for the treatment of oral her- pes simplex virus infections. The Scientific World Journal, 2014, 1-7.
  • Chirigiu, L., Chirigiu, R. G., Tircomnicu, V., & Bubulica, M. V. (2011). GC-MS analysis of chemical composition of Sambucus ebulus leaves. Chemistry of natural compounds, 47(1), 126-127.
  • Choi, H. G., Jung, J. H., Ryu, J. M., Yoon, S. J., Oh, Y. K., & Kim, C. K. 36
  • (1998). Development of in situ-gelling and mucoadhesive acet- aminophen liquid suppository. International Journal of Pharma- ceutics, 165(1), 33-44.
  • Cvetanović, A. (2020). Sambucus ebulus L., antioxidants and poten- tial in disease. In Pathology (pp. 321-333). Academic Press.
  • Demirci, S., & Özhatay, N. (2012). An ethnobotanical study in Kahramanmaraş (Turkey); wild plants used for medicinal purpose in Andirin, Kahramanmaraş. Turk J Pharm Sci, 9(1), 75-92.
  • Ebrahimzadeh, M., Mahmoudi, M., & Salimi, E. (2006). Antiinflam- matory activity of Sambucus ebulus hexane extracts. Fitoterapia, 77(2), 146-148.
  • Eminağaoğlu, Ö., Göktürk, T., & Akyıldırım Beğen, H. A. Y. A. L. (2017). Traditional uses of medicinal plants and animals of Ha- tila Valley National Park, Artvin. Biological Diversity and Conserva- tion, 10(3), 33-42.
  • Erol, I., Üstündağ Okur, N., Orak, D., Sipahi, H., Aydın, A., & Özer, Ö. (2020). Tazarotene-loaded in situ gels for potential management of psoriasis: biocompatibility, anti-inflammatory and analgesic ef- fect. Pharmaceutical Development and Technology, 25(8), 909-918.
  • Göç, F., Mat, A. (2019). Türkiye’de Yanık Tedavisinde Geleneksel Olarak Kullanılan Bitkiler [Plants Traditionally Used in the Treat- ment of Burns in Turkey]. Journal of Advanced Research in Health Sciences, 2(1), 15-35.
  • Gugleva, V., Titeva, S., Ermenlieva, N., Tsibranska, S., Tcholakova, S., Rangelov, S., & Momekova, D. (2020). Development and evalu- ation of doxycycline niosomal thermoresponsive in situ gel for ophthalmic delivery. International Journal of Pharmaceutics, 591, 1-11.
  • Gül, V., & Dİnler, B. S. (2016). Some medical and aromatic plants growing naturally in Kumru Region (Ordu). Ziraat Fakültesi Dergisi- Süleyman Demirel Üniversitesi, 11(1), 146-156.
  • Güner, Ö., Selvi, S. (2016). Balıkesir aktarlarında satılan yabani tıbbi bitkiler ve kullanım özellikleri [Wild medicinal plants sold in Balıkesir/Turkey herbal markets and their using properties]. Bio- logical Diversity and Conservation, 9(2), 96-101 .
  • Güneş, F. (2018). Edirne’nin İpsala ilçesinde halk ilacı olarak kullanılan bitkiler. Research Journal of Biology Sciences, 11(1), 29-37.
  • Güneş, S., Savran, A., Paksoy, M. Y., Koşar, M., & Çakılcıoğlu, U. (2017). Ethnopharmacological survey of medicinal plants in Karaisalı and its surrounding (Adana-Turkey). Journal of Herbal Medicine, 8, 68-75.
  • Güngör, S., Erdal, M. F., & Aksu, B. (2013). New Formulation Strate- gies in Topical Antifungal Therapy. Journal of Cosmetics. Derma- tological Sciences and Applications, 3, 56-65.
  • Güven, U. M., Berkman, M. S., Şenel, B., & Yazan, Y. (2019). Develop- ment and in vitro/in vivo evaluation of thermo-sensitive in situ gelling systems for ocular allergy. Brazilian Journal of Pharmaceuti- cal Sciences, 55.
  • Hashemi, Z., Ebrahimzadeh, M. A., & Khalili, M. (2019). Sun pro- tection factor, total phenol, flavonoid contents and antioxidant activity of medicinal plants from Iran. Trop. J. Pharm. Res, 18, 1443- 1448.
  • Hudson, S. P., Langer, R., Fink, G. R., & Kohane, D. S. (2010). Inject- able in situ cross-linking hydrogels for local antifungal therapy. Biomaterials, 31(6), 1444-1452.
  • Ivanova, D., Tasinov, O., & Kiselova-Kaneva, Y. (2014). Improved lipid profile and increased serum antioxidant capacity in healthy volunteers after Sambucus ebulus L. fruit infusion consumption. International journal of food sciences and nutrition, 65(6), 740-744.
  • Jabbari, M., Daneshfard, B., Emtiazy, M., Khiveh, A., & Hashempur,
  • M. H. (2017). Biological effects and clinical applications of dwarf elder (Sambucus ebulus L): A review. Journal of evidence-based complementary & alternative medicine, 22(4), 996-1001.
  • Kaileh, M., Berghe, W. V., Boone, E., Essawi, T., & Haegeman, G. (2007). Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity. Journal of eth- nopharmacology, 113(3), 510-516.
  • Kang, F., & Singh, J. (2005). In vitro release of insulin and biocom- patibility of in situ forming gel systems. International Journal of Pharmaceutics, 304(1-2), 83-90.
  • Karaköse, M., & Karaköse, G. Ç. (2017). Medicinal and Aromatic Plants of Esenli (Giresun) Forest Planning Unit. International Jour- nal of Secondary Metabolite, 4(3), 285-305.
  • Karcı, E., Gürbüz, İ., Akaydın, G., & Günbatan, T. (2017). Folk medi- cines of Bafra (Samsun-Turkey). Turkish Journal of Biochemis- try, 42(4), 381-399.
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There are 75 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences
Journal Section Original Article
Authors

Umay Merve Güven 0000-0003-1547-0817

Yusuf Yakut 0000-0003-0992-9986

Nurdan Çakır 0000-0001-8559-2305

Serpil Demirci Kayıran 0000-0001-8340-3347

Project Number TSA-2019-11424
Publication Date April 28, 2023
Submission Date February 1, 2022
Published in Issue Year 2023 Volume: 53 Issue: 1

Cite

APA Güven, U. M., Yakut, Y., Çakır, N., Demirci Kayıran, S. (2023). Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract. İstanbul Journal of Pharmacy, 53(1), 30-38.
AMA Güven UM, Yakut Y, Çakır N, Demirci Kayıran S. Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract. iujp. April 2023;53(1):30-38.
Chicago Güven, Umay Merve, Yusuf Yakut, Nurdan Çakır, and Serpil Demirci Kayıran. “Thermosensitive in Situ Gel Formulation and Characterization Studies of Sambucus Ebulus L. Extract”. İstanbul Journal of Pharmacy 53, no. 1 (April 2023): 30-38.
EndNote Güven UM, Yakut Y, Çakır N, Demirci Kayıran S (April 1, 2023) Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract. İstanbul Journal of Pharmacy 53 1 30–38.
IEEE U. M. Güven, Y. Yakut, N. Çakır, and S. Demirci Kayıran, “Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract”, iujp, vol. 53, no. 1, pp. 30–38, 2023.
ISNAD Güven, Umay Merve et al. “Thermosensitive in Situ Gel Formulation and Characterization Studies of Sambucus Ebulus L. Extract”. İstanbul Journal of Pharmacy 53/1 (April 2023), 30-38.
JAMA Güven UM, Yakut Y, Çakır N, Demirci Kayıran S. Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract. iujp. 2023;53:30–38.
MLA Güven, Umay Merve et al. “Thermosensitive in Situ Gel Formulation and Characterization Studies of Sambucus Ebulus L. Extract”. İstanbul Journal of Pharmacy, vol. 53, no. 1, 2023, pp. 30-38.
Vancouver Güven UM, Yakut Y, Çakır N, Demirci Kayıran S. Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract. iujp. 2023;53(1):30-8.