Research Article
BibTex RIS Cite

Anti-inflammatory activity of a novel lectin isolated from Pleurotus eryngii var. ferulae mushroom

Year 2024, Volume: 54 Issue: 2, 195 - 204, 26.08.2024

Thoiba Mogahid Hussein Seliman , Gülsüm Altıparmak Ülbegi , Nurten Özsoy , Hevidar Alp Kavlo , Pınar Aksoy Sağırlı

https://doi.org/10.26650/IstanbulJPharm.2024.1322171

Abstract

Background and Aims: Pleurotus species are edible mushrooms with important economic and medicinal value. Many phar macological properties of these species, such as anticancer, immunomodulating, and anti-inflammatory activities, have been attributed to lectin. The aim of this study was to purify a novel lectin from Pleurotus eryngii var. ferulae (PEFL) and investigate its anti-inflammatory activity.

Methods:PEFLwaspurifiedby80%ammoniumsulphatefractionation,diethylaminoethyl(DEAE)-Sepharose-4Banionexchange, and Sephadex G-100 gel filtration chromatography. The molar mass of the purified lectin was determined by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) under denaturing conditions. Inhibition of lectin-induced haemagglu tination by several carbohydrates and one glycoprotein (ovalbumin) was also performed using the haemagglutination inhibition activity test. The anti-inflammatory effect of PEFL was tested in a lipopolysaccharide (LPS)-induced inflammation model in mouse macrophage cells (RAW 264.7). The levels of prostaglandin (PG)-E2, tumour necrosis factor-alpha (TNF-𝛼), interleukin 1-beta (IL-1𝛽), interleukin-6 (IL-6), interleukin-10 (IL-10), and interferon-gamma (IFN-𝛾) were determined using enzyme-linked immunosorbent assay (ELISA) kits. Furthermore, the expression of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) was estimated by western blot analysis.

Results: PEFL wasobtained in 16%yield. The specific activity of PEFL was calculated as 1280 haemagglutinating units (HU)/mg protein and was inhibited only by D-galactose. The molecular weight was determined to be 46 kDa. PEFL showed an anti inflammatory effect by reducing the production of pro-inflammatory PGs through COX-2 inhibition, as well as reducing iNOS expression. Furthermore, our findings reported that PEFL has a protective effect on inflammation by decreasing the production of pro-inflammatory cytokines and increasing the production of the anti-inflammatory cytokine (IL-10).

Conclusion:The results suggest that PEFL can be considered as a potential therapeutic agent in the development of new therapeutic strategies for inflammatory diseases.

Keywords

Cytokines Lectin Lipopolysaccharide Mushroom Pleurotus eryngii var. ferulae RAW 264.7 macrophage

Supporting Institution

Scientific Research Projects Coordination Unit of Istanbul University

Project Number

37626

References

  • Akyüz, M. & Kırbağ, S. (2007). Ülkemizde sebze ve meyvelerin yanı sıra alternatif besin kaynağı: yabani mantar (Pleurotus eryngii var. ferulae). Artvin Çoruh Üniversitesi Orman Fakültesi Dergisi 8(1), 26-36. http://ofd.artvin.edu.tr/download/article-file/25715 google scholar
  • Anjana, S.H. & Savita, J.A. (2017). Oyster mushroom: answer to human ailments. Asian Journal of Phar-maceutical and Clinical Research, 10(4), 24-27. https://doi.org/10.22159/ajpcr.2017.v10i4.16867 google scholar
  • Bobek, P., Nosalova, V. & Cerna, S. (2001). Effect of pleuran (beta-glucan from Pleurotus ostreatus) in diet or drinking fluid on colitis in rats. Nahrung, 45(5), 360-363. https://doi.org/10.1002/1521-3803(20011001)45:5<360::AID-FOOD360>3.0.CO;2-C google scholar
  • Choi, D. B., Cha, W. S., Kang, S. H. & Lee, B. R. (2004). Effect of Pleurotus ferulae extracts on viability of human lung cancer and cervical cancer cell lines. Biotechnology and Bioprocess Engi-neering, 9, 356-361. https://doi.org/10.1007/BF02933057 google scholar
  • Choi, J.H., Kim, D.W., Kim, S., & Kim, S.J. (2017). In vitro antioxidant and in vivo hypolipidemic effects of the king oyster culinary-medicinal mushroom, Pleurotus eryngii var. ferulae DDL01 (Agaricomycetes), in rats with high-fat diet-induced fatty liver and hyperlipidemia. Interna-tional Journal of Medicinal Mushrooms, 19(2), 107-119. https://doi.org/10.1615/IntJMedMushrooms.v19.i2.20 google scholar
  • Coelho, L.C.B.B., Silva, P.M.S., Lima, V.L.M., Pontual, E.V., Paiva, P.M.G., Napoleao,T.H. & Correia, M.T.S. (2017). Lectins, interconnecting proteins with biotechnologi-cal/pharmacological and therapeutic applications. Evidence-Based Complementary and Alternative Medicine, 1594074, 1-22. http://dx.doi.org/10.1155/2017/1594074 google scholar
  • Dan, X., Liu, W. & Ng, T.B. (2015). Development and applications of lectins as biological tools in biomedi-cal research. Medicinal Research Reviews, 36(2), 221-247. https://doi.org/10.1002/med.21363 google scholar
  • El-Deeb, N.M., El-Adawi, H.I., El-Wahab, A.E.A., Haddad, A.M., El Enshasy, H.A.,He, Y.- W. & Davis, K.R. (2019). Modulation of NKG2D, KIR2DL and cytokine production by Pleurotus os-treatus glucan enhances natural killer cell cytotoxicity toward cancer cells. Frontiers in Cell Developmental Biology, 7, 165. https://doi.org/10.3389/fcell.2019.00165. google scholar
  • Elhusseiny, S.M., El-Mahdy, T.S., Elleboudy, N.S., Yahia, I.S., Farag, M.M., Ismail, N.S., Yassien, M.A. & Aboshanab, K.M. (2022). In vitro anti SARS-CoV-2 activity and docking analysis of Pleu-rotus ostreatus, Lentinula edodes and Agaricus bisporus edi-ble mushrooms. Infection and Drug Resistance, 15, 3459-3475. https://doi.org/10.2147/IDR.S362823 google scholar
  • Guillot, J. & Konska, G. (1997). Lectins in higher fungi. Biochemical Systematics and Ecology, 25, 203-230.https://doi.org/10.1016/S0305-1978(96)00110-X google scholar
  • Hassan, M.A.A., Rouf, R., Tiralongo, E., May, T.W. & Tiralongo, J. (2015). Mushroom lectins: Specificity, structure and bioactivity relevant to human disease. International Journal of Molecular Sci-ences, 16(4), 7802-7838. https://doi.org/10.3390/ijms16047802 google scholar
  • Hu, S.H., Lien, J.L., Hsieh, S.L., Wang, J.C. & Chang, S.J. (2009). Antioxidant and antigenotoxicity activities of extracts from liquid submerged culture of culinary-medicinal ferula oyster mushroom, Pleurotus eryngii (DC.) Quel. var. ferulae (Lanzi) Sacc. (Agari-comycetideae). International Journal of Medicinal Mushrooms, 11(4), 395-408. https://doi.org/10.1615/IntJMedMushr.v11.i4.60 google scholar
  • Jedinak, A., Dudhgaonkar, S., Wu, Q.L., Simon, J. & Sliva, D. (2011). Anti-inflammatory activity of edible oyster mushroom is mediated through the inhibition of NF-kB and AP-1 signaling. Nutrition Journal, 10, 1-10. https://doi.org/10.1186/1475-2891-10-52 google scholar
  • Jo, K.-J., Ghim, J., Kim, J., Lee, H., Lee, T. G., Kim, J.-I., Kim, Y., Byun, J.W., Min, B.S., Son, J.S., Shim, S.G., Cheon, W.J. & Ryu, S.H. (2019). Water extract of Pleurotus eryngii var. ferulae prevents high-fat diet-induced obesity by inhibiting pancreatic lipase. Journal of Medicinal Food, 22(2), 178-185. https://doi.org/10.1089/jmf.2018.4255 google scholar
  • Jose, N., Ajith, T.A. & Janardhanan, K.K. (2004). Methanol extract of the oyster mushroom, Pleurotus florida, inhibits inflammation and platelet aggregation. Phytotherapy Research, 18(1), 43-46. https://doi.org/10.1002/ptr.1355 google scholar
  • Khan, M.A. & Tania, M. (2012). Nutritional and medicinal importance of Pleurotus mushroom: An overview. Food Reviews International, 28(3), 313-329. https://doi.org/10.1080/87559129.2011.637267 google scholar
  • Laemmli, U.K. (1970). Cleavage of structural proteins during the as-sembly of the head of bacteriophage T4. Nature, 227, 680-685. https://doi.org/10.1038/227680a0 google scholar
  • Li, Y. R., Liu, Q. H., Wang, H. X. & Ng, T. B. (2008). A novel lectin with potent antitumor, mitogenic and HIV-1 reverse transcriptase inhibitory activities from the edible mushroom Pleurotus citrinopileatus. Biochimica et Biophysica Acta (BBA)-General Subjects, 1780(1), 51-57. https://doi.org/10.1016/j.bbagen.2007.09.004 google scholar
  • Lis, H. & Sharon, N. (1972). Soybean (Glycine max) agglutinin. Meth-ods in Enzymology, 28, 360-365. https://doi.org/10.1016/0076-6879(72)28046-6 google scholar
  • Lull, C., Wichers, H.J. & Savelkoul, H.F.J. (2005). An-tiinflammatory and immunomodulating properties of fun-gal metabolites. Mediators of Inflammation, 2005(2), 63-80. https://doi.org/10.1155/MI.2005.63 google scholar
  • Ma, G., Yang, W., Zhao, L., Pei, F., Fang, D. & Hu, Q. (2018). A critical review on the health promoting effects of mushrooms nutraceuticals. Food Science and Human Wellness, 7, 125-133. https://doi.org/10.1016/j.fshw.2018.05.002 google scholar
  • Minato, K.-i., Laan, L.C., van Die, I. & Mizuno, M. (2019). Pleu-rotus citrinopileatus polysaccharide stimulates anti-inflammatory properties during monocyte-to-macrophage differentiation. Inter-national Journal of Biological Macromolecules, 122, 705-712. https://doi.org/10.1016/j.ijbiomac.2018.10.157. google scholar
  • Mori, K., Kobayashi, C., Tomita, T., Inatomi, S. & Ikeda, M. (2008). Antiatherosclerotic effect of the edible mush-rooms Pleurotus eryngii (Eringi), Grifola frondosa (Maitake), and Hypsizygus marmoreus (Bunashimeji) in apolipopro-tein E-deficient mice. Nutrition Research, 28(5), 335-342. https://doi.org/10.1016/j.nutres.2008.03.010 google scholar
  • Motta, F., Gershwin, M.E. & Selmi, C. (2021). Mushrooms and immunity. Journal of Autoimmunity, 117, 102576. https://doi.org/10.1016/j.jaut.2020.102576 google scholar
  • Muramoto, K. (2017). Lectins as bioactive proteins in foods and feeds. Food Science and Technology Research, 23(4), 487-494. https://doi.org/ 10.3136/fstr.23.487 google scholar
  • Muszynska, B., Grzywacz-Kisielewska, A., Kala, K. & Gdula-Argasinska, J. (2018). Anti-inflammatory properties of edi-ble mushrooms: A review. Food Chemistry, 243, 373-381. https://doi.org/10.1016/j.foodchem.2017.09.149 google scholar
  • Ngai, P.H. & Ng, T.B. (2006). A hemolysin from the mushroom Pleu-rotus eryngii. Applied Microbiology and Biotechnology, 72, 11851191. https://doi.org/10.1007/s00253-006-0406-6 google scholar
  • Nozaki, H., Itonori, S., Sugita, M., Nakamura, K., Ohba, K., Suzuki, A. & Kushi, Y. (2008). Mushroom acidic glycosphingolipid induc-tion of cytokine secretion from murine T cells and proliferation of NK1.1 alpha/beta TCR-double positive cells in vitro. Biochem-ical and Biophysical Research Communications, 373, 435-439. https://doi.org/10.1016/j.bbrc.2008.06.047. google scholar
  • Patel, Y., Naraian, R. & Singh, V.K. (2012). Medicinal prop-erties of Pleurotus species (oyster mushroom): A review. World Journal of Fungal and Plant Biology, 3(1), 1-12. https://doi.org/10.5829/idosi.wjfpb.2012.3.1.303 google scholar
  • Santos, A.F.S., da Silva, M.D.C., Napoleâo, T.H., Paiva, P.M.G., Correia, S. & Coelho, L.C.B.B. (2014). Lectins: Function, structure, biological properties and potential applications. Cur-rent Topics in Peptide & Protein Research, 15, 41-62. https://doi.org/10.1016/j.carres.2021.108367 google scholar
  • Sharon, N. & Lis, H. (1972). Lectins: cell-agglutinating and sugar-specific proteins. Science, 177, 949-958. https://doi.org/10.1126/science.177.4053.949 google scholar
  • Sharon, N. & Lis, H. (2004). History of lectins: From hemagglutinins to biological recognition molecules. Glycobiology, 14, 53R-62R. https://doi.org/10.1093/glycob/cwh122 google scholar
  • Shibata, T., Kudou, M., Hoshi, Y., Kudo, A., Nanashima, N. & Miyairi, K. (2010). Isolation and characterization of a novel two-component hemolysin, erylysin A and B, from an edi-ble mushroom, Pleurotus eryngii. Toxicon, 56(8), 1436-1442. https://doi.org/10.1016/j.toxicon.2010.08.010 google scholar
  • Singh, R. S., Bhari, R. & Kaur, H.P. (2010). Mushroom lectins: current status and future perspectives. Critical Reviews in Biotechnology, 30(2), 99-126. https://doi.org/10.3109/07388550903365048 google scholar
  • Singh, S.S., Wang, H., Chan, Y.S., Pan, W., Dan, X., Yin, C.M., Akkouh, O. & Ng, T.B. (2015). Lectins from edible mushrooms. Molecules, 20, 446-469. https://doi.org/10.3390/molecules20010446 google scholar
  • Smiderle, F.R., Olsen, L.M., Carbonero, E.R., Baggio, C.H., Freitas, C.S., Marcon, R., Santos, A.R.S., Gorin, P.A.J., Iacomini, M. google scholar
  • (2008). Anti-inflammatory and analgesic properties in a rodent model of a (1->3),(1->6)-linked beta-glucan isolated from Pleu-rotus pulmonarius. European Journal of Pharmacology, 597(1-3), 86-91. https://doi.org/10.1016/j.ejphar.2008.08.028 google scholar
  • Sun, Y., Hu, X., &Li,W. (2017). Antioxidant, antitumor and immunos-timulatory activities of the polypeptide from Pleurotus eryngii mycelium. International Journal of Biological Macromolecules, 97, 323-330. https://doi.org/10.1016/j.ijbiomac.2017.01.043 google scholar
  • Tanaka, A., Nishimura, M., Sato, Y., Sato, H. & Nishihira, J. (2016). Enhancement of the Th1-phenotype immune system by the in-take of oyster mushroom (Tamogitake) extract in a double-blind, placebo-controlled study. Journal of Traditional and Complemen-tary Medicine, 6, 424-430. https://doi.org/10.1016/j.jtcme.2015. 11.004 google scholar
  • Wang, H., Ng, T.B. & Ooi, V.E.C. (1998). Lectins from mushrooms. Mycolocigal Research, 102 (8), 897-906. https://doi.org/10.1017/S0953756298006200 google scholar
  • Wang, H., Gao, J. & Ng, T.B. (2000). A new lectin with highly potent antihepatoma and antisarcoma activities from the oyster mushroom Pleurotus ostreatus. Biochemi-cal and Biophyical Research Communications, 275, 810-816. https://doi.org/10.1006/bbrc.2000.3373 google scholar
  • Wang, H. &Ng. T.B. (2003). Isolation of a novel N-acetylglucosamine-specific lectin from fresh sclerotia of the edible mushroom Pleu-rotus tuber-regium. Protein Expression and Purification, 29(2), 156-160. https://doi.org/10.1016/S1046-5928(03)00059-7 google scholar
  • Xu, C.-J., Wang, Y.-X., Niu, B.-N., Liu, B., Li, Y.-B., Wang, X.-M. & Lu, S.-L. (2014). Isolation and characterization of a novel lectin with mitogenic activity from Pleurotus ferulae. Pakistan Journal of Pharmaceutical Sciences, 27 (4), 983-989. google scholar
  • Yoon, S.-B., Lee, Y.- J., Park, S.-K., Kim, H.-C., Bae, H., Kim, H. M., Ko, S.-G., Choi, H.Y., Oh, M.S. & Park, W. (2009). Anti-inflammatory effects of Scutellaria baicalensis water extract on LPS-activated RAW 264.7 macrophages. Journal of Ethnopharmacology, 125(2), 286-290. https://doi.org/10.1016/j.jep.2009.06.027 google scholar
  • Yuan, B., Ma, Ning, Zhao, L., Zhao, E., Gao, Z., Wang, W., Song, M., Zhang, G., Hu, Q. & Xiao, H. (2017a). In vitro and in vivo inhibitory effects of a Pleurotus eryngii protein on colon cancer cells. Food and Function, 8, 3553-3562. https://doi.org/10.1039/c7fo00895c google scholar
  • Yuan, B., Zhao, L., Rakariyatham, K., Han, Y., Gao, Z., Kimatu, B.M., Hu, Q. & Xiao, H. (2017b). Isolation of a novel bioac-tive protein from an edible mushroom Pleurotus eryngii and its inflammatory potential. Food and Function, 8, 2175-2183. http://dx.doi.org/10.1039/c7fo00244k google scholar
  • Zaidman, B.-Z., Yassin, M., Mahajna, J. & Wasser, S.P. (2005). Medic-inal mushroom modulators of molecular targets as cancer thera-peutics. Applied Microbiology and Biotechnology, 67, 453-468. http://dx.doi.org/10.1007/s00253-004-1787-z google scholar

Year 2024, Volume: 54 Issue: 2, 195 - 204, 26.08.2024

Thoiba Mogahid Hussein Seliman , Gülsüm Altıparmak Ülbegi , Nurten Özsoy , Hevidar Alp Kavlo , Pınar Aksoy Sağırlı

https://doi.org/10.26650/IstanbulJPharm.2024.1322171

Abstract

Project Number

37626

References

  • Akyüz, M. & Kırbağ, S. (2007). Ülkemizde sebze ve meyvelerin yanı sıra alternatif besin kaynağı: yabani mantar (Pleurotus eryngii var. ferulae). Artvin Çoruh Üniversitesi Orman Fakültesi Dergisi 8(1), 26-36. http://ofd.artvin.edu.tr/download/article-file/25715 google scholar
  • Anjana, S.H. & Savita, J.A. (2017). Oyster mushroom: answer to human ailments. Asian Journal of Phar-maceutical and Clinical Research, 10(4), 24-27. https://doi.org/10.22159/ajpcr.2017.v10i4.16867 google scholar
  • Bobek, P., Nosalova, V. & Cerna, S. (2001). Effect of pleuran (beta-glucan from Pleurotus ostreatus) in diet or drinking fluid on colitis in rats. Nahrung, 45(5), 360-363. https://doi.org/10.1002/1521-3803(20011001)45:5<360::AID-FOOD360>3.0.CO;2-C google scholar
  • Choi, D. B., Cha, W. S., Kang, S. H. & Lee, B. R. (2004). Effect of Pleurotus ferulae extracts on viability of human lung cancer and cervical cancer cell lines. Biotechnology and Bioprocess Engi-neering, 9, 356-361. https://doi.org/10.1007/BF02933057 google scholar
  • Choi, J.H., Kim, D.W., Kim, S., & Kim, S.J. (2017). In vitro antioxidant and in vivo hypolipidemic effects of the king oyster culinary-medicinal mushroom, Pleurotus eryngii var. ferulae DDL01 (Agaricomycetes), in rats with high-fat diet-induced fatty liver and hyperlipidemia. Interna-tional Journal of Medicinal Mushrooms, 19(2), 107-119. https://doi.org/10.1615/IntJMedMushrooms.v19.i2.20 google scholar
  • Coelho, L.C.B.B., Silva, P.M.S., Lima, V.L.M., Pontual, E.V., Paiva, P.M.G., Napoleao,T.H. & Correia, M.T.S. (2017). Lectins, interconnecting proteins with biotechnologi-cal/pharmacological and therapeutic applications. Evidence-Based Complementary and Alternative Medicine, 1594074, 1-22. http://dx.doi.org/10.1155/2017/1594074 google scholar
  • Dan, X., Liu, W. & Ng, T.B. (2015). Development and applications of lectins as biological tools in biomedi-cal research. Medicinal Research Reviews, 36(2), 221-247. https://doi.org/10.1002/med.21363 google scholar
  • El-Deeb, N.M., El-Adawi, H.I., El-Wahab, A.E.A., Haddad, A.M., El Enshasy, H.A.,He, Y.- W. & Davis, K.R. (2019). Modulation of NKG2D, KIR2DL and cytokine production by Pleurotus os-treatus glucan enhances natural killer cell cytotoxicity toward cancer cells. Frontiers in Cell Developmental Biology, 7, 165. https://doi.org/10.3389/fcell.2019.00165. google scholar
  • Elhusseiny, S.M., El-Mahdy, T.S., Elleboudy, N.S., Yahia, I.S., Farag, M.M., Ismail, N.S., Yassien, M.A. & Aboshanab, K.M. (2022). In vitro anti SARS-CoV-2 activity and docking analysis of Pleu-rotus ostreatus, Lentinula edodes and Agaricus bisporus edi-ble mushrooms. Infection and Drug Resistance, 15, 3459-3475. https://doi.org/10.2147/IDR.S362823 google scholar
  • Guillot, J. & Konska, G. (1997). Lectins in higher fungi. Biochemical Systematics and Ecology, 25, 203-230.https://doi.org/10.1016/S0305-1978(96)00110-X google scholar
  • Hassan, M.A.A., Rouf, R., Tiralongo, E., May, T.W. & Tiralongo, J. (2015). Mushroom lectins: Specificity, structure and bioactivity relevant to human disease. International Journal of Molecular Sci-ences, 16(4), 7802-7838. https://doi.org/10.3390/ijms16047802 google scholar
  • Hu, S.H., Lien, J.L., Hsieh, S.L., Wang, J.C. & Chang, S.J. (2009). Antioxidant and antigenotoxicity activities of extracts from liquid submerged culture of culinary-medicinal ferula oyster mushroom, Pleurotus eryngii (DC.) Quel. var. ferulae (Lanzi) Sacc. (Agari-comycetideae). International Journal of Medicinal Mushrooms, 11(4), 395-408. https://doi.org/10.1615/IntJMedMushr.v11.i4.60 google scholar
  • Jedinak, A., Dudhgaonkar, S., Wu, Q.L., Simon, J. & Sliva, D. (2011). Anti-inflammatory activity of edible oyster mushroom is mediated through the inhibition of NF-kB and AP-1 signaling. Nutrition Journal, 10, 1-10. https://doi.org/10.1186/1475-2891-10-52 google scholar
  • Jo, K.-J., Ghim, J., Kim, J., Lee, H., Lee, T. G., Kim, J.-I., Kim, Y., Byun, J.W., Min, B.S., Son, J.S., Shim, S.G., Cheon, W.J. & Ryu, S.H. (2019). Water extract of Pleurotus eryngii var. ferulae prevents high-fat diet-induced obesity by inhibiting pancreatic lipase. Journal of Medicinal Food, 22(2), 178-185. https://doi.org/10.1089/jmf.2018.4255 google scholar
  • Jose, N., Ajith, T.A. & Janardhanan, K.K. (2004). Methanol extract of the oyster mushroom, Pleurotus florida, inhibits inflammation and platelet aggregation. Phytotherapy Research, 18(1), 43-46. https://doi.org/10.1002/ptr.1355 google scholar
  • Khan, M.A. & Tania, M. (2012). Nutritional and medicinal importance of Pleurotus mushroom: An overview. Food Reviews International, 28(3), 313-329. https://doi.org/10.1080/87559129.2011.637267 google scholar
  • Laemmli, U.K. (1970). Cleavage of structural proteins during the as-sembly of the head of bacteriophage T4. Nature, 227, 680-685. https://doi.org/10.1038/227680a0 google scholar
  • Li, Y. R., Liu, Q. H., Wang, H. X. & Ng, T. B. (2008). A novel lectin with potent antitumor, mitogenic and HIV-1 reverse transcriptase inhibitory activities from the edible mushroom Pleurotus citrinopileatus. Biochimica et Biophysica Acta (BBA)-General Subjects, 1780(1), 51-57. https://doi.org/10.1016/j.bbagen.2007.09.004 google scholar
  • Lis, H. & Sharon, N. (1972). Soybean (Glycine max) agglutinin. Meth-ods in Enzymology, 28, 360-365. https://doi.org/10.1016/0076-6879(72)28046-6 google scholar
  • Lull, C., Wichers, H.J. & Savelkoul, H.F.J. (2005). An-tiinflammatory and immunomodulating properties of fun-gal metabolites. Mediators of Inflammation, 2005(2), 63-80. https://doi.org/10.1155/MI.2005.63 google scholar
  • Ma, G., Yang, W., Zhao, L., Pei, F., Fang, D. & Hu, Q. (2018). A critical review on the health promoting effects of mushrooms nutraceuticals. Food Science and Human Wellness, 7, 125-133. https://doi.org/10.1016/j.fshw.2018.05.002 google scholar
  • Minato, K.-i., Laan, L.C., van Die, I. & Mizuno, M. (2019). Pleu-rotus citrinopileatus polysaccharide stimulates anti-inflammatory properties during monocyte-to-macrophage differentiation. Inter-national Journal of Biological Macromolecules, 122, 705-712. https://doi.org/10.1016/j.ijbiomac.2018.10.157. google scholar
  • Mori, K., Kobayashi, C., Tomita, T., Inatomi, S. & Ikeda, M. (2008). Antiatherosclerotic effect of the edible mush-rooms Pleurotus eryngii (Eringi), Grifola frondosa (Maitake), and Hypsizygus marmoreus (Bunashimeji) in apolipopro-tein E-deficient mice. Nutrition Research, 28(5), 335-342. https://doi.org/10.1016/j.nutres.2008.03.010 google scholar
  • Motta, F., Gershwin, M.E. & Selmi, C. (2021). Mushrooms and immunity. Journal of Autoimmunity, 117, 102576. https://doi.org/10.1016/j.jaut.2020.102576 google scholar
  • Muramoto, K. (2017). Lectins as bioactive proteins in foods and feeds. Food Science and Technology Research, 23(4), 487-494. https://doi.org/ 10.3136/fstr.23.487 google scholar
  • Muszynska, B., Grzywacz-Kisielewska, A., Kala, K. & Gdula-Argasinska, J. (2018). Anti-inflammatory properties of edi-ble mushrooms: A review. Food Chemistry, 243, 373-381. https://doi.org/10.1016/j.foodchem.2017.09.149 google scholar
  • Ngai, P.H. & Ng, T.B. (2006). A hemolysin from the mushroom Pleu-rotus eryngii. Applied Microbiology and Biotechnology, 72, 11851191. https://doi.org/10.1007/s00253-006-0406-6 google scholar
  • Nozaki, H., Itonori, S., Sugita, M., Nakamura, K., Ohba, K., Suzuki, A. & Kushi, Y. (2008). Mushroom acidic glycosphingolipid induc-tion of cytokine secretion from murine T cells and proliferation of NK1.1 alpha/beta TCR-double positive cells in vitro. Biochem-ical and Biophysical Research Communications, 373, 435-439. https://doi.org/10.1016/j.bbrc.2008.06.047. google scholar
  • Patel, Y., Naraian, R. & Singh, V.K. (2012). Medicinal prop-erties of Pleurotus species (oyster mushroom): A review. World Journal of Fungal and Plant Biology, 3(1), 1-12. https://doi.org/10.5829/idosi.wjfpb.2012.3.1.303 google scholar
  • Santos, A.F.S., da Silva, M.D.C., Napoleâo, T.H., Paiva, P.M.G., Correia, S. & Coelho, L.C.B.B. (2014). Lectins: Function, structure, biological properties and potential applications. Cur-rent Topics in Peptide & Protein Research, 15, 41-62. https://doi.org/10.1016/j.carres.2021.108367 google scholar
  • Sharon, N. & Lis, H. (1972). Lectins: cell-agglutinating and sugar-specific proteins. Science, 177, 949-958. https://doi.org/10.1126/science.177.4053.949 google scholar
  • Sharon, N. & Lis, H. (2004). History of lectins: From hemagglutinins to biological recognition molecules. Glycobiology, 14, 53R-62R. https://doi.org/10.1093/glycob/cwh122 google scholar
  • Shibata, T., Kudou, M., Hoshi, Y., Kudo, A., Nanashima, N. & Miyairi, K. (2010). Isolation and characterization of a novel two-component hemolysin, erylysin A and B, from an edi-ble mushroom, Pleurotus eryngii. Toxicon, 56(8), 1436-1442. https://doi.org/10.1016/j.toxicon.2010.08.010 google scholar
  • Singh, R. S., Bhari, R. & Kaur, H.P. (2010). Mushroom lectins: current status and future perspectives. Critical Reviews in Biotechnology, 30(2), 99-126. https://doi.org/10.3109/07388550903365048 google scholar
  • Singh, S.S., Wang, H., Chan, Y.S., Pan, W., Dan, X., Yin, C.M., Akkouh, O. & Ng, T.B. (2015). Lectins from edible mushrooms. Molecules, 20, 446-469. https://doi.org/10.3390/molecules20010446 google scholar
  • Smiderle, F.R., Olsen, L.M., Carbonero, E.R., Baggio, C.H., Freitas, C.S., Marcon, R., Santos, A.R.S., Gorin, P.A.J., Iacomini, M. google scholar
  • (2008). Anti-inflammatory and analgesic properties in a rodent model of a (1->3),(1->6)-linked beta-glucan isolated from Pleu-rotus pulmonarius. European Journal of Pharmacology, 597(1-3), 86-91. https://doi.org/10.1016/j.ejphar.2008.08.028 google scholar
  • Sun, Y., Hu, X., &Li,W. (2017). Antioxidant, antitumor and immunos-timulatory activities of the polypeptide from Pleurotus eryngii mycelium. International Journal of Biological Macromolecules, 97, 323-330. https://doi.org/10.1016/j.ijbiomac.2017.01.043 google scholar
  • Tanaka, A., Nishimura, M., Sato, Y., Sato, H. & Nishihira, J. (2016). Enhancement of the Th1-phenotype immune system by the in-take of oyster mushroom (Tamogitake) extract in a double-blind, placebo-controlled study. Journal of Traditional and Complemen-tary Medicine, 6, 424-430. https://doi.org/10.1016/j.jtcme.2015. 11.004 google scholar
  • Wang, H., Ng, T.B. & Ooi, V.E.C. (1998). Lectins from mushrooms. Mycolocigal Research, 102 (8), 897-906. https://doi.org/10.1017/S0953756298006200 google scholar
  • Wang, H., Gao, J. & Ng, T.B. (2000). A new lectin with highly potent antihepatoma and antisarcoma activities from the oyster mushroom Pleurotus ostreatus. Biochemi-cal and Biophyical Research Communications, 275, 810-816. https://doi.org/10.1006/bbrc.2000.3373 google scholar
  • Wang, H. &Ng. T.B. (2003). Isolation of a novel N-acetylglucosamine-specific lectin from fresh sclerotia of the edible mushroom Pleu-rotus tuber-regium. Protein Expression and Purification, 29(2), 156-160. https://doi.org/10.1016/S1046-5928(03)00059-7 google scholar
  • Xu, C.-J., Wang, Y.-X., Niu, B.-N., Liu, B., Li, Y.-B., Wang, X.-M. & Lu, S.-L. (2014). Isolation and characterization of a novel lectin with mitogenic activity from Pleurotus ferulae. Pakistan Journal of Pharmaceutical Sciences, 27 (4), 983-989. google scholar
  • Yoon, S.-B., Lee, Y.- J., Park, S.-K., Kim, H.-C., Bae, H., Kim, H. M., Ko, S.-G., Choi, H.Y., Oh, M.S. & Park, W. (2009). Anti-inflammatory effects of Scutellaria baicalensis water extract on LPS-activated RAW 264.7 macrophages. Journal of Ethnopharmacology, 125(2), 286-290. https://doi.org/10.1016/j.jep.2009.06.027 google scholar
  • Yuan, B., Ma, Ning, Zhao, L., Zhao, E., Gao, Z., Wang, W., Song, M., Zhang, G., Hu, Q. & Xiao, H. (2017a). In vitro and in vivo inhibitory effects of a Pleurotus eryngii protein on colon cancer cells. Food and Function, 8, 3553-3562. https://doi.org/10.1039/c7fo00895c google scholar
  • Yuan, B., Zhao, L., Rakariyatham, K., Han, Y., Gao, Z., Kimatu, B.M., Hu, Q. & Xiao, H. (2017b). Isolation of a novel bioac-tive protein from an edible mushroom Pleurotus eryngii and its inflammatory potential. Food and Function, 8, 2175-2183. http://dx.doi.org/10.1039/c7fo00244k google scholar
  • Zaidman, B.-Z., Yassin, M., Mahajna, J. & Wasser, S.P. (2005). Medic-inal mushroom modulators of molecular targets as cancer thera-peutics. Applied Microbiology and Biotechnology, 67, 453-468. http://dx.doi.org/10.1007/s00253-004-1787-z google scholar
There are 47 citations in total.

Details

Primary Language English
Subjects Pharmaceutical Biochemistry
Journal Section Original Article
Authors

Thoiba Mogahid Hussein Seliman 0000-0002-9193-1833

Gülsüm Altıparmak Ülbegi 0000-0002-2585-1931

Nurten Özsoy 0000-0002-2419-9128

Hevidar Alp Kavlo 0000-0001-9167-5844

Pınar Aksoy Sağırlı 0000-0002-9432-3163

Project Number 37626
Publication Date August 26, 2024
Submission Date July 4, 2023
Published in Issue Year 2024 Volume: 54 Issue: 2

Cite

APA Mogahid Hussein Seliman, T., Altıparmak Ülbegi, G., Özsoy, N., Alp Kavlo, H., et al. (2024). Anti-inflammatory activity of a novel lectin isolated from Pleurotus eryngii var. ferulae mushroom. İstanbul Journal of Pharmacy, 54(2), 195-204. https://doi.org/10.26650/IstanbulJPharm.2024.1322171
AMA Mogahid Hussein Seliman T, Altıparmak Ülbegi G, Özsoy N, Alp Kavlo H, Aksoy Sağırlı P. Anti-inflammatory activity of a novel lectin isolated from Pleurotus eryngii var. ferulae mushroom. iujp. August 2024;54(2):195-204. doi:10.26650/IstanbulJPharm.2024.1322171
Chicago Mogahid Hussein Seliman, Thoiba, Gülsüm Altıparmak Ülbegi, Nurten Özsoy, Hevidar Alp Kavlo, and Pınar Aksoy Sağırlı. “Anti-Inflammatory Activity of a Novel Lectin Isolated from Pleurotus Eryngii Var. Ferulae Mushroom”. İstanbul Journal of Pharmacy 54, no. 2 (August 2024): 195-204. https://doi.org/10.26650/IstanbulJPharm.2024.1322171.
EndNote Mogahid Hussein Seliman T, Altıparmak Ülbegi G, Özsoy N, Alp Kavlo H, Aksoy Sağırlı P (August 1, 2024) Anti-inflammatory activity of a novel lectin isolated from Pleurotus eryngii var. ferulae mushroom. İstanbul Journal of Pharmacy 54 2 195–204.
IEEE T. Mogahid Hussein Seliman, G. Altıparmak Ülbegi, N. Özsoy, H. Alp Kavlo, and P. Aksoy Sağırlı, “Anti-inflammatory activity of a novel lectin isolated from Pleurotus eryngii var. ferulae mushroom”, iujp, vol. 54, no. 2, pp. 195–204, 2024, doi: 10.26650/IstanbulJPharm.2024.1322171.
ISNAD Mogahid Hussein Seliman, Thoiba et al. “Anti-Inflammatory Activity of a Novel Lectin Isolated from Pleurotus Eryngii Var. Ferulae Mushroom”. İstanbul Journal of Pharmacy 54/2 (August 2024), 195-204. https://doi.org/10.26650/IstanbulJPharm.2024.1322171.
JAMA Mogahid Hussein Seliman T, Altıparmak Ülbegi G, Özsoy N, Alp Kavlo H, Aksoy Sağırlı P. Anti-inflammatory activity of a novel lectin isolated from Pleurotus eryngii var. ferulae mushroom. iujp. 2024;54:195–204.
MLA Mogahid Hussein Seliman, Thoiba et al. “Anti-Inflammatory Activity of a Novel Lectin Isolated from Pleurotus Eryngii Var. Ferulae Mushroom”. İstanbul Journal of Pharmacy, vol. 54, no. 2, 2024, pp. 195-04, doi:10.26650/IstanbulJPharm.2024.1322171.
Vancouver Mogahid Hussein Seliman T, Altıparmak Ülbegi G, Özsoy N, Alp Kavlo H, Aksoy Sağırlı P. Anti-inflammatory activity of a novel lectin isolated from Pleurotus eryngii var. ferulae mushroom. iujp. 2024;54(2):195-204.
 Download Cover Image