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Toxicity of serotonin-norepinephrine reuptake inhibitors (SNRIs) during pregnancy and lactation

Year 2024, Volume: 54 Issue: 2, 255 - 267, 26.08.2024

Göksu Canıtez , Rahime Şimşek , Deniz Arca Çakır , Hülya Tezel Yalçın , Terken Baydar , Pınar Erkekoğlu

https://doi.org/10.26650/IstanbulJPharm.2024.1359269

Abstract

Major depressive disorder (depression) is a severe mood disorder. Lifestyle changes during the COVID-19 pandemic contributed to the high incidence of depression in the population. The primary care treatment is provided by both psychotherapy and antidepressants. In the last 35years,selective serotoninreuptakeinhibitors (SSRIs)were used because of lower adverse effects when compared to tricyclic antidepressants and monoamine oxidase (MAO) inhibitors. However, selective serotonin–norepinephrine reuptake inhibitors (SNRIs), which are second-generation antidepressants, are preferred over first-generation antidepressants by some physicians as they have broad uses nowadays. Anxiety disorders, depression, social phobia, attention-deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), fibromyalgia syndrome, chronic neuropathic pain, and menopausal symptoms are among the conditions that can be treated with SNRIs. Although the effects of genetic factors and family history on these diseases, especially recurrence, are undeniable, these drugs provide a great deal of improvement. However, the use of SNRIs during pregnancy and lactation is still a debate. There is no definite judgment on whether a pregnant woman should use these drugs during pregnancy or not. As the rate of depression among pregnant women increases, this issue becomes more serious. A definitive answer has not been reached yet because studies on pregnant women cannot be carried out within the framework of ethical rules. In this review, the effects, toxicity, and safety of SNRIs during pregnancy and lactation are discussed.

Keywords

SNRI antidepressant serotonin norepinephrine pregnancy lactation

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Year 2024, Volume: 54 Issue: 2, 255 - 267, 26.08.2024

Göksu Canıtez , Rahime Şimşek , Deniz Arca Çakır , Hülya Tezel Yalçın , Terken Baydar , Pınar Erkekoğlu

https://doi.org/10.26650/IstanbulJPharm.2024.1359269

Abstract

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There are 75 citations in total.

Details

Primary Language English
Subjects Pharmaceutical Toxicology
Journal Section Review
Authors

Göksu Canıtez 0009-0006-0672-2022

Rahime Şimşek 0000-0002-8467-6336

Deniz Arca Çakır 0000-0002-6110-1775

Hülya Tezel Yalçın 0000-0002-1843-3424

Terken Baydar 0000-0002-5497-9600

Pınar Erkekoğlu 0000-0003-4713-7672

Publication Date August 26, 2024
Submission Date September 12, 2023
Published in Issue Year 2024 Volume: 54 Issue: 2

Cite

APA Canıtez, G., Şimşek, R., Çakır, D. A., Tezel Yalçın, H., et al. (2024). Toxicity of serotonin-norepinephrine reuptake inhibitors (SNRIs) during pregnancy and lactation. İstanbul Journal of Pharmacy, 54(2), 255-267. https://doi.org/10.26650/IstanbulJPharm.2024.1359269
AMA Canıtez G, Şimşek R, Çakır DA, Tezel Yalçın H, Baydar T, Erkekoğlu P. Toxicity of serotonin-norepinephrine reuptake inhibitors (SNRIs) during pregnancy and lactation. iujp. August 2024;54(2):255-267. doi:10.26650/IstanbulJPharm.2024.1359269
Chicago Canıtez, Göksu, Rahime Şimşek, Deniz Arca Çakır, Hülya Tezel Yalçın, Terken Baydar, and Pınar Erkekoğlu. “Toxicity of Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) During Pregnancy and Lactation”. İstanbul Journal of Pharmacy 54, no. 2 (August 2024): 255-67. https://doi.org/10.26650/IstanbulJPharm.2024.1359269.
EndNote Canıtez G, Şimşek R, Çakır DA, Tezel Yalçın H, Baydar T, Erkekoğlu P (August 1, 2024) Toxicity of serotonin-norepinephrine reuptake inhibitors (SNRIs) during pregnancy and lactation. İstanbul Journal of Pharmacy 54 2 255–267.
IEEE G. Canıtez, R. Şimşek, D. A. Çakır, H. Tezel Yalçın, T. Baydar, and P. Erkekoğlu, “Toxicity of serotonin-norepinephrine reuptake inhibitors (SNRIs) during pregnancy and lactation”, iujp, vol. 54, no. 2, pp. 255–267, 2024, doi: 10.26650/IstanbulJPharm.2024.1359269.
ISNAD Canıtez, Göksu et al. “Toxicity of Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) During Pregnancy and Lactation”. İstanbul Journal of Pharmacy 54/2 (August 2024), 255-267. https://doi.org/10.26650/IstanbulJPharm.2024.1359269.
JAMA Canıtez G, Şimşek R, Çakır DA, Tezel Yalçın H, Baydar T, Erkekoğlu P. Toxicity of serotonin-norepinephrine reuptake inhibitors (SNRIs) during pregnancy and lactation. iujp. 2024;54:255–267.
MLA Canıtez, Göksu et al. “Toxicity of Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) During Pregnancy and Lactation”. İstanbul Journal of Pharmacy, vol. 54, no. 2, 2024, pp. 255-67, doi:10.26650/IstanbulJPharm.2024.1359269.
Vancouver Canıtez G, Şimşek R, Çakır DA, Tezel Yalçın H, Baydar T, Erkekoğlu P. Toxicity of serotonin-norepinephrine reuptake inhibitors (SNRIs) during pregnancy and lactation. iujp. 2024;54(2):255-67.
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