Prognostic factors effecting the survival in patients with initially metastatic breast cancer

Abstract

OBJECTIVES There have not been much data in literature related to the prognostic factors effecting survival in patients with initially metastatic breast cancer. METHODS To evaluate these factors, 44 patients with initially metastatic breast cancer who had adequate clinical and follow-up records were involved into this study. The biological characteristics of primary tumor were investigated by using immuno-histochemical methods. And also, the effects of histological and nuclear grade of the tumor, patients' age, visceral metastasis and performance status on survival were investigated. Median overall survival was 39 months (%95 confidential interval: 27.6-50.4). Lower performance status and presence of visceral metastasis were found to be the factors effecting the survival in univariate analysis (p≤0.05). CONCLUSION Lower performance status, hormone receptor negativity and presence of visceral metastasis were found to be as negative factors effecting overall survival in multivariate analysis (p≤0.05).

Keywords

• Breast Neoplasms,Carcinoma, Ductal, Breast,Neoplasm Metastasis,Prognosis,Time Factors,Survival Analysis

İlk tanıda metastatik meme kanseri ile başvuran hastaların sağkalımını etkileyen prognostik faktörler

Öz

AMAÇ İlk tanıda metastatik hastalık saptanan meme kanserli hastalarda sağkalımı etkileyen prognostik faktörler araştırıldı. GEREÇ VE YÖNTEM Bu çalışmaya ilk tanı anında metastaz saptanan, yeterli klinik ve izlem verisi bulunan meme kanserli toplam 44 hasta alındı. Primer tümörün biyolojik özellikleri immunohistokimyasal yöntemle değerlendirildi. Ayrıca histolojik ve nükleer derece, hasta yaşı, viseral metastaz durumu ve performans durumu gibi parametrelerin sağkalım üzerine etkisi araştırıldı. BULGULAR Medyan genel sağkalım süresi 39 ay (%95 güven aralığı: 27.6-50.4) bulundu. Tek değişkenli analizde genel sağkalımı olumsuz etkileyen faktörlerin düşük performans durumu ve viseral metastaz görülmesi olduğu saptandı (p < =0.05). SONUÇ Genel sağkalım için yapılan çok değişkenli analizde, genel sağkalımı olumsuz etkileyen en önemli faktörlerin düşük performans durumu, hormon reseptör negatifliği ve viseral metastaz varlığının olduğu gösterildi (p < = 0.05).

Anahtar Kelimeler

• Kanser, kanal, meme, meme neoplazi/mortalite/patoloji/terapi, neoplazi metastaz, prognoz, zaman faktörü, sağkalım analizi

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