Matrix metalloproteinases and lung cancer

Abstract

OBJECTIVES The aim of this study was to determine the pretreatment levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase 1 (TIMP-1) in lung cancer patients. METHODS We investigated the serum MMP-9 and TIMP-1 values in 20 lung cancer patients by ELISA and the results were compared with the controls (n=20). RESULTS MMP-9 (p

Keywords

• Lung Neoplasms,Matrix Metalloproteinase 9,Tissue Inhibitor of Metalloproteinase-1,Enzyme-Linked Immunosorbent Assay

Matriks metalloproteinazlar ve akciğer kanseri

Öz

AMAÇ Bu çalışmada akciğer kanserli hastalarda matriks metalloproteinaz- 9 (MMP-9) ve doku matriks metalloproteinaz inhibitörü- 1'in (TIMP-1) tedavi öncesi düzeylerinin belirlenmesi amaçlandı. GEREÇ VE YÖNTEM Çalışmamızda cerrahi ve radyoterapi uygulanmamış 20 akciğer kanserli hastada MMP-9 ve TIMP-1 değerleri ELISA yöntemi ile belirlendi ve sağlıklı kontrol grubu ile karşılaştırıldı (n=20). BULGULAR Hastaların MMP-9 (p

Anahtar Kelimeler

• Jelatinaz B, akciğer kanseri, akciğer/metabolizma/radyasyon etkileri, akciğer neoplazisi/kan/enzimoloji/radyoterapi, Matriks Metalloproteinaz, MMP 9, doku matriks metalloproteinaz inhibitörü-1.

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