Radiotherapy results of patients with oral cavity and oropharynx tumours

Abstract

OBJECTIVES To evaluate patients with oral cavity (OC) and oropharynx (OP) tumours treated with definitive radiotherapy (±chemotherapy) and adjuvant radiotherapy according to treatment protocol of Dokuz Eylul Head and Neck Cancer Group (DEBBKG) between August 1991 and June 2003. METHODS In total 148 patients (50 females, 98 males; median age 60; range 24 to 90 years) (128 (86%) OC; 20 (14%) OP) were evaluated. Stage distribution is as follows; stage-I: 15 (10%); stage-II: 14 (9%); stage-III: 35 (24%); stage-IV: 84 (57%). Adjuvant radiotherapy performed in 67 (45%) patients; definitive radiotherapy in 81 (55%) patients. Twenty seven (18%) patients received concomittant boost radiotherapy and 23 (16%) received concomittant cisplatin. Median total dose was 70 Gy (35-78) in the definitive setting and 51 Gy (21-70) in the adjuvant setting. RESULTS Median follow-up was 25 (3-158) months. In patients receiving adjuvant radiotherapy, 2 and 5 years overall survival (OS) and disease free interval (DFI) rates were respectively; 75%; 61% and 75%; 64%. In definitive setting 2 and 5 years OS rates were 48%; 28% and DFI rates were 36%; 24% for OC; 2 and 5 years OS rates were 54%; 18% and DFI rates were 46%; 46% for OP cancer patients. CONCLUSION It is potentially possible to achive better results with combined treatment modalities in especially locally advanced OC and OP tumours.

Keywords

• Oropharyngeal Neoplasms,Mouth Neoplasms,Neoplasm Staging,Radiotherapy, Adjuvant,Survival Rate

Radyoterapi uygulanmış oral kavite ve orofarenks kanserli hastalarda tedavi sonuçlarımız

Öz

AMAÇ Ağustos 1991-Haziran 2003 tarihleri arasında Dokuz Eylül Baş-Boyun Kanserleri Grubu protokolüne uygun definitif (±kemoterapi) ve adjuvan radyoterapi uygulanan oral kavite (OK) ve orofarenks (OF) kanserli hastalarda tedavi sonuçları değerlendirildi. GEREÇ VE YÖNTEM Toplam 148 hasta (50 kadın, 98 erkek; medyan yaş 60; dağılım 24-90) (128 (%86) OK; 20 (%14) OF) değerlendirilmiştir. Evre dağılımı; evre-I: 15 (%10); evre-II: 14 (%9); evre-III: 35 (%24); evre-IV: 84 (%57) şeklindedir. Adjuvan radyoterapi 67 (%45); definitif radyoterapi 81 (%55) hastaya uygulanmıştır. Konkomitan boost tekniği 27 (%18); eş zamanlı sisplatin 23 (%16) hastaya uygulanmıştır. Definitif radyoterapide medyan doz 70 Gy (35-78), adjuvan radyoterapide 51 Gy (21- 70)'dir. BULGULAR Medyan izlem süresi 25 (3-158) aydır. Adjuvan radyoterapi uygulananlarda 2 ve 5 yıllık genel sağkalım (GSK) oranları sırasıyla %75; %61; hastalıksız aralık (HA) oranları ise %75; %64'dür. Definitif radyoterapi uygulanan OK hastalarında 2 ve 5 yıllık GSK oranları sırasıyla %48; %28; HA oranları ise %36; %24 iken OF kanserli hastalar için 2 ve 5 yıllık GSK oranları %54; %18; HA oranları ise %46; 46'dır. SONUÇ Özellikle yerel ileri evre OK ve OF tümörlerinde kombine tedavi yaklaşımları ile daha iyi sonuçlar alınmaktadır.

Anahtar Kelimeler

• Baş-boyun kanserleri/mortalite/radyoterapi, radyoterapi/yan etki/yöntem, oral kavite kanseri, orofarenks kanseri, sağkalım oranı

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