Toxic epidermal necrolysis after cranial radiotherapy and anticonvulsant treatment: a case report

Abstract

Toxic epidermal necrolysis (TEN) is rare, but, it has been known life treating reaction. It's a mucocutaneous reaction resulting from hypersensitivity to a variety of agents including most anticonvulsants. We report a case of TEN whit occured in a patient with metastatic non-small cell lung carcinona before whole-brain radiation therapy (WBRT) and then received phenytoin (300 mg day-1).

Keywords

• Middle Aged,Female,Epidermal Necrolysis, Toxic,Lung Neoplasms,Carcinoma, Small Cell,Drug Hypersensitivity,Drug Toxicity,Anticonvulsants,Adverse effects

Kraniyal radyoterapi ve antikonvülsan tedavi sonrası gelişen toksik epidermal nekroliz: Olgu sunumu

Öz

Toksik epidermal nekroliz (TEN), nadir görünen fakat yaşamı tehdit eden bir reaksiyondur. Pek çok ajan tarafından başlatılabilen bir hirpersensitive reaksiyonu olduğu düşünülmektedir. Bu yazıda, metastatik küçük hücreli dışı akciğer kanseri tanısı ile tüm beyin radyoterapisi (TBRT) uygulandıktan sonra Epdantoin (300 mg/gün) başlanan ve 5. günde TEN gelişen bir olgu sunuldu.

Anahtar Kelimeler

• Antikonvülsanlar/yan etki, toksik epidermal nekroliz/sınıflama/etyoloji

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