The fatigue rate and association with serum cytokine and leptin levels in breast cancer patients undergoing postmastectomy radiotherapy: a prospective evaluation

Abstract

OBJECTIVES To investigate the fatigue rate during postmastectomy radiotherapy (RT) and the correlation between fatigue and serum cytokines and leptin levels. METHODS Thirty-eight, stage II-III breast cancer patients undergoing RT were evaluated with quality of life, Cancer Fatigue Scale, Visual Analogue Scale, Hospital Anxiety and Depression Scale, and the serum inflammatory cytokine and leptin levels were measured. The association of serum marker levels with fatigue was analyzed. RESULTS The fatigue rate increased during RT and decreased to pretreatment levels at 2 months following RT. Serum cytokine levels were not significantly changed with RT and was not found to be correlated with fatigue. Fatigue rate was found to be increased in cases with high leptin levels. A correlation was determined between preRT serum leptin levels and postRT fatigue rates (p=0.01). CONCLUSION It is found that fatigue increases during RT; fatigue is correlated with high serum leptin levels and decreases to pretreatment levels at 2 months following RT.

Keywords

• Prospective Studies,Mastectomy,Breast Neoplasms,Radiotherapy,Cytokines,Fatigue,Leptin,Psychological Tests,Test Anxiety Scale

Postmastektomi radyoterapi uygulanan meme kanserli olgularda gelişen yorgunluğun derecesi, serum sitokin ve leptin düzeyleri ile ilişkisi: Prospektif değerlendirme

Abstract

AMAÇ Postmastektomi radyoterapi (RT) sırasında gelişen yorgunluğun derecesi ve yorgunluğun serum sitokinleri ve leptin düzeyleri ile ilişkisi araştırıldı. GEREÇ VE YÖNTEM Evre II-III meme kanseri tanısıyla RT programına alınan 38 olgu; RT başı, sonu ve RT sonrası ikinci ayda yaşam kalitesi, Kanser Yorgunluk Skalası ve Görsel Analog Skalası, Hastane Anksiyete ve Depresyon Skalası ile değerlendirildi; serum inflamatuvar sitokin ve leptin düzeyleri ölçüldü. Serum belirteç düzeylerinin yorgunlukla ilişkisi araştırıldı. BULGULAR Yorgunluk derecesi RT sırasında arttı ve RT sonrası ikinci ayda tedavi başı değerlere düştü. Serum sitokin düzeyleri RT'yle anlamlı değişmedi, yorgunlukla bağlantılı bulunmadı. Leptin düzeyi yüksek olanlarda daha fazla oranda yorgunluk saptandı. RT başındaki serum leptin düzeyleri ile RT sonu yorgunluk düzeyleri arasında bağlantı saptandı (p=0.01). SONUÇ Meme kanserli olgularda RT sırasında yorgunlukta artma olduğu, gelişen yorgunluğun yüksek serum leptin düzeyleri ile bağlantılı olduğu ve RT sonrası ikinci ayda tedavi öncesi değerlere düştüğü bulunmuştur.

Keywords

• Meme kanseri/radyoterapi, sitokin, yorgunluk/etyoloji, leptin, radyoterapi.

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