Hypertrophic osteoarthropathy associated with lung cancer: a case report

Abstract

Malignant neoplasms are sometimes associated with a variety of paraneoplastic rheumatic syndromes. Hypertrophic osteoarthropathy is one of these syndromes and the vast majority of cases are associated with intra thoracic neoplasms mainly broncogenic cancer. Hypertrophic osteoarthropathy (HOA) is characterized by clubbed fingers and periosteal new bone formation. Etio logically, it can be divided into primary and secondary HOA. The major clinical manifestation was severe bilateral leg pain. The pathogenesis of the disease remains unclear. Bone scintigraphy is a sensitive method to detect HOA. In this case, a 49-yea r-old man who had hypertrophic pulmonary osteoarthropathy associated with advanced stage non-small cell lung carcinoma is presented and a review of the literature is performed.

Keywords

• Lung Neoplasms,Osteoarthropathy, Primary Hypertrophic,Osteoarthropathy, Secondary Hypertrophic,Middle Aged,Male,Tomography, X-Ray Computed,Carcinoma, Non-Small-Cell Lung

Akciğer kanserine bağlı hipertrofik osteoartropati: Olgu sunumu

Öz

Malign hastalıklar çeşitli paraneoplastik romatolojik sendromlara yol açabilir. Bu sendromlardan biri olan hipertrofik osteoartropati (HPO) çoğunlukla toraks içi malignitelere ve en sık olarak da akciğer kanserine bağlı olarak ortaya çıkar. Hipertrofik osteoartropati çomak parmak ve periostal yeni kemik oluşumu ile kendini gösterir. En önemli klinik bulgusu bilateral bacak ağrısıdır. Hastalığın patogenezi henüz aydınlanmamıştır. Kemik sintigrafisi tanı için duyarlı bir yöntemdir. Bu yazıda, ileri evre küçük hücreli dışı akciğer kanseri tanılı 49 yaşındaki bir erkek hastanın hipertrofik pulmoner oseoartropati bulguları bildirilmiş ve bu konudaki literatür bilgisi özetlenmiştir.

Anahtar Kelimeler

• Akciğer kanseri, hipertrofik osteoartropati, periostal yeni kemik oluşumu

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