The role of postoperative radiotherapy in treatment of soft tissue sarcomas

Abstract

Soft-tissue sarcomas account for approximately 1% of adult malignancies and they occur in up to 50% of cases in the extremities, followed by visceral/retroperitoneal regions. Different histological subtypes exist and primary therapy is predicated on surgical resection with an adequate margin of normal tissue. İn most of the extremity tumors, limb-sparing surgery is possible. Local recurrence rates vary depending on the anatomic site and for high-risk patients, identified by tumor grade, size and site, local control is clearly improved with postoperative adjuvant radiation. In this review, the role of radiotherapy in the treatment of soft tissue sarcomas are analyzed regarding the recent literature.

Keywords

• Sarcoma,Positron-Emission Tomography,Epidemiology,Etiology,Risk Factors,Diagnosis,Neoplasm Staging,Therapy,Radiotherapy

Yumuşak doku sarkomlarının tedavisinde radyoterapinin rolü

Abstract

Yumuşak doku sarkomları, yetişkin malignitelerinin %1'ini oluşturmaktadır ve yaklaşık %50'si ekstremite yerleşimli olup, takiben viseral ve retroperitoneal bölgelerde yerleşmektedirler. Çeşitli histolojik alt tipleri vardır ve primer tedavi; uygun cerrahi sınırlar oluşturacak şekilde uygulanan cerrahi rezeksiyondur. Ekstremite yerleşimli tümörlerin çoğunda organ koruyucu cerrahi yaklaşımlar mümkün olmaktadır. Lokal nüks oranları anatomik lokalizasyonlara göre değişkenlik göstermekte ve tümör gradı, boyut ve anatomik lokalizasyon açısından yüksek riskli hastalarda lokal kontrol oranları, ameliyat sonrası adjuvan radyoterapi ile belirgin şekilde artış göstermektedir. Bu yazıda literatürdeki son gelişmelerin ışığı altında, yumuşak doku sarkomlarda radyoterapinin rolü incelendi.

Keywords

• Yumuşak doku sarkomları/tedavi/radyoterapi/cerrahi, pozitron emisyon tomografisi

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