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Pediatric Hodgkin lymphoma: epidemiologic characteristics and early treatment results in a new oncology center

Year 2007, Volume: 22 Issue: 3, 118 - 126, 01.04.2007

Görkem Aksu Merdan Fayda Funda Çorapçıoğlu Eviç Başar Nagihan İnan Cengiz Erçin

Abstract

OBJECTIVES To evaluate patient characteristics and treatment results of pediatric patients with Hodgkin lymphoma. METHODS Hodgkin lymphoma patients (9 males, 4 females; mean age 9.2±3.5; range 4 to 15 years) at pediatric age group (

Keywords

Hodgkin Disease Lymphoma Prognosis Retrospective Studies Survival Rate Child

References

  • 1. Pötter R. Paediatric Hodgkin’s disease. Eur J Cancer 1999;35(10):1466-76.
  • 2. Büyükpamukçu M, Atahan L, Ca¤lar M, Kutluk T, Akyüz C, Hazar V. Hodgkin’s disease in Turkish children: clinical characteristics and treatment results of 210 patients. Pediatr Hematol Oncol 1999;16(2):11 9 - 2 9 .
  • 3. Hudson MM, Onciu M, Donaldson SS. Hodgkin lymphoma. In: Pizzo PA, Poplack DG, editors. Principles and practice of pediatric oncology. 5th ed. Philedelphia: Lippincott Williams&Wilkins; 2005. p. 694-721.
  • 4. Oguz A, Karadeniz C, Okur FV, Citak EC, Pinarli FG, Bora H, et al. Prognostic factors and treatment outcome in childhood Hodgkin disease. Pediatr Blood Cancer 2005;45(5):670-5.
  • 5. Arya LS, Dinand V. Current strategies in the treatment of childhood Hodgkins disease. Indian Pediatr 2005;42(11):1115-28.
  • 6. Rühl U, Albrecht M, Dieckmann K, Lüders H, Marciniak H, Schellenberg D, et al. Response-adapted radiotherapy in the treatment of pediatric Hodgkin’s disease: an interim report at 5 years of the German GPOH-HD 95 trial. Int J Radiat Oncol Biol Phys 2001;51(5):1209-18.
  • 7. Hsu SC, Metzger ML, Hudson MM, Pedrosa F, Lins M, Pedrosa M, et al. Comparison of treatment outcomes of childhood Hodgkin lymphoma in two US centers and a center in Recife, Brazil. Pediatr Blood Cancer 2007;49(2):139-44.
  • 8. Harris NL, Jaffe ES, Diebold J, Flandrin G, MullerHermelink HK, Vardiman J, et al. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Vi rginia, November 1997. J Clin Oncol 1999;17(12):3835-49.
  • 9. Hiçsönmez G, Büyükpamukçu M. Pediatric hematology and oncology in Turkey. Ph/o Forum 1994;1:4-8.
  • 10.Cavdar AO, Pamir A, Gözdafloglu S, Babacan E, Yavuz G, Unal E, et al. Hodgkin disease in children: clinicoepidemiologic and viral (Epstein-Barr virus) analyses. Med Pediatr Oncol 1999;32(1):18-24.
  • 11. Correa P, O'Conor GT. Epidemiologic patterns of Hodgkin’s disease. Int J Cancer 1971;8(2):192-201.
  • 12.Cavdar AO, Tacoy A, Babacan E, Gözdaflo¤lu S, Arcasoy A, Topuz U, et al. Hodgkin’s disease in Turkish children: a clinical and histopathologic analysis. J Natl Cancer Inst 1977;58(3):479-81.
  • 13. Sachdeva A, Wallace WHB. Hodgkin’s lymphomacurrent concepts. In: Agarwal BR, Perilongo G, Rogers P, Strahlendorf C, Eden OB, editors. International Society of Paediatric Oncology education book. 2005. p. 87-99.
  • 14. Norum J, Wist E. Hodgkin disease treated at the Tromsø regional hospital 1985-93. Diagnosis, treatment, prognosis, quality of life and costs of a decentralized treatment. [Article in Norwegian] Tidsskr Nor Laegeforen 1997;117(1):23-6. [Abstract]
  • 15.Chang ET, Zheng T, Weir EG, Borowitz M, Mann RB, Spiegelman D, et al. Childhood social environment and Hodgkin’s lymphoma: new findings from a population-based case-control study. Cancer Epidemiol Biomarkers Prev 2004;13(8):1361-70.
  • 16. Lanzkowsky P. Pediatric hematology and oncology. 4th ed. Burlington, MA: Elsevier Academic Press; 2005. p. 453-90.
  • 17.Carbone PP, Kaplan HS, Musshoff K, Smithers DW, Tubiana M. Report of the Committee on Hodgkin’s Disease Staging Classification. Cancer Res 1971;31(11):1860-1.
  • 18. Lukes RJ, Butler JJ. The pathology and nomenclature of Hodgkin’s disease. Cancer Res 1966;26(6):1063-83.
  • 19. Kung FH, Schwartz CL, Ferree CR, London WB, Ternberg JL, Behm FG, et al. POG 8625: a randomized trial comparing chemotherapy with chemoradiotherapy for children and adolescents with Stages I, IIA, IIIA1 Hodgkin Disease: a report from the Children's Oncology Group. J Pediatr Hematol Oncol 2006;28(6):362-8.
  • 20.Carde P, Koscielny S, Franklin J, Axdorph U, Raemaekers J, Diehl V, et al. Early response to chemotherapy: a surrogate for final outcome of Hodgkin’s disease patients that should influence initial treatment length and intensity? Ann Oncol 2002;13 Suppl 1:86-91.
  • 21. Nachman JB, Sposto R, Herzog P, Gilchrist GS, Wolden SL, Thomson J, et al. Randomized comparison of low-dose involved-field radiotherapy and no radiotherapy for children with Hodgkin’s disease who achieve a complete response to chemotherapy. J Clin Oncol 2002;20(18):3765-71.
  • 22. Henry-Amar M, Joly F. Late complications after H o d g k i n’s disease. Ann Oncol 1996;7 Suppl 4:11 5 - 2 6 .
  • 2 3 . H u dson MM, Poquette CA, Lee J, Greenwald CA, Shah A, Luo X, et al. Increased mortality after successful treatment for Hodgkin’s disease. J Clin Oncol 1998;16(11):3592-600.
  • 24. Herbertson R, Hancock BW. Hodgkin Lymphoma in adolescents. Cancer Treat Rev 2005;31(5):339-60.
  • 25.Corapçioglu F, Sarper N, Berk F, Sahin T, Zengin E, Demir H. Evaluation of anthracycline-induced early left ventricular dysfunction in children with cancer: a comparative study with echocardiography and multigated radionuclide angiography. Pediatr Hematol Oncol 2006;23(1):71-80.
  • 26. Treatment strategies for pediatric nodular lymphocyte predominant Hodgkin’s lymphoma. Leuk Ly m p h 2006;47(8):1450-1.

Pediatrik Hodgkin lenfoma: Yeni yapılanmakta olan bir onkoloji merkezinde epidemiyolojik özellikler ve erken tedavi sonuçları

Year 2007, Volume: 22 Issue: 3, 118 - 126, 01.04.2007

Görkem Aksu Merdan Fayda Funda Çorapçıoğlu Eviç Başar Nagihan İnan Cengiz Erçin

Abstract

AMAÇ Pediatrik Hodgkin lenfoma tanılı hastaların karakteristikleri ve tedavi yanıtlarının incelenmesi. GEREÇ VE YÖNTEM 2003-2006 yılları arasında Kocaeli Üniversitesi Pediatrik Onkoloji Grubu tarafından tedavi edilen Hodgkin lenfoma tanılı 18 yaş altı hastalar (9 erkek, 4 kız; ort. yaş 9.2±3.5; dağılım 4-15) geriye dönük olarak değerlendirildi. BULGULAR En sık saptanan histopatolojik alt tip (%54) mikst selüler Hodgkin lenfoma idi. Olguların %69'u erken evre hastalıkla (evre I, II) başvurmuşlardı. On iki olguya ABVD, bir hastaya ise OEPA/COPP rejimi uygulandı. Hastaların %83'ünde 2. kürden sonra tam yanıt elde edildi. Olguların 11'ine kemoterapi sonrası tutulu alan radyoterapisi, 2 olguya ise “bulky” bölgeye radyoterapi uygulandı. Radyoterapi dozları evreye ve kemoterapi cevabına göre değişmekle birlikte ortanca 2000 (1500-3000) cGy'di. Dört yıllık genel ve olaysız sağkalım oranları %87.5 olarak saptandı. SONUÇ Merkezimizde uygulanan evre ve KT yanıtına dayalı kombine tedavi modelimizin erken sonuçları, diğer merkezlerin sonuçlarıyla benzer oranda başarılıdır.

Keywords

Çocuk Hodgkin hastalığı/ilaç tedavisi/patoloji/radyoterapi prognoz geriye dönük çalışma sağkalım oranı

References

  • 1. Pötter R. Paediatric Hodgkin’s disease. Eur J Cancer 1999;35(10):1466-76.
  • 2. Büyükpamukçu M, Atahan L, Ca¤lar M, Kutluk T, Akyüz C, Hazar V. Hodgkin’s disease in Turkish children: clinical characteristics and treatment results of 210 patients. Pediatr Hematol Oncol 1999;16(2):11 9 - 2 9 .
  • 3. Hudson MM, Onciu M, Donaldson SS. Hodgkin lymphoma. In: Pizzo PA, Poplack DG, editors. Principles and practice of pediatric oncology. 5th ed. Philedelphia: Lippincott Williams&Wilkins; 2005. p. 694-721.
  • 4. Oguz A, Karadeniz C, Okur FV, Citak EC, Pinarli FG, Bora H, et al. Prognostic factors and treatment outcome in childhood Hodgkin disease. Pediatr Blood Cancer 2005;45(5):670-5.
  • 5. Arya LS, Dinand V. Current strategies in the treatment of childhood Hodgkins disease. Indian Pediatr 2005;42(11):1115-28.
  • 6. Rühl U, Albrecht M, Dieckmann K, Lüders H, Marciniak H, Schellenberg D, et al. Response-adapted radiotherapy in the treatment of pediatric Hodgkin’s disease: an interim report at 5 years of the German GPOH-HD 95 trial. Int J Radiat Oncol Biol Phys 2001;51(5):1209-18.
  • 7. Hsu SC, Metzger ML, Hudson MM, Pedrosa F, Lins M, Pedrosa M, et al. Comparison of treatment outcomes of childhood Hodgkin lymphoma in two US centers and a center in Recife, Brazil. Pediatr Blood Cancer 2007;49(2):139-44.
  • 8. Harris NL, Jaffe ES, Diebold J, Flandrin G, MullerHermelink HK, Vardiman J, et al. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Vi rginia, November 1997. J Clin Oncol 1999;17(12):3835-49.
  • 9. Hiçsönmez G, Büyükpamukçu M. Pediatric hematology and oncology in Turkey. Ph/o Forum 1994;1:4-8.
  • 10.Cavdar AO, Pamir A, Gözdafloglu S, Babacan E, Yavuz G, Unal E, et al. Hodgkin disease in children: clinicoepidemiologic and viral (Epstein-Barr virus) analyses. Med Pediatr Oncol 1999;32(1):18-24.
  • 11. Correa P, O'Conor GT. Epidemiologic patterns of Hodgkin’s disease. Int J Cancer 1971;8(2):192-201.
  • 12.Cavdar AO, Tacoy A, Babacan E, Gözdaflo¤lu S, Arcasoy A, Topuz U, et al. Hodgkin’s disease in Turkish children: a clinical and histopathologic analysis. J Natl Cancer Inst 1977;58(3):479-81.
  • 13. Sachdeva A, Wallace WHB. Hodgkin’s lymphomacurrent concepts. In: Agarwal BR, Perilongo G, Rogers P, Strahlendorf C, Eden OB, editors. International Society of Paediatric Oncology education book. 2005. p. 87-99.
  • 14. Norum J, Wist E. Hodgkin disease treated at the Tromsø regional hospital 1985-93. Diagnosis, treatment, prognosis, quality of life and costs of a decentralized treatment. [Article in Norwegian] Tidsskr Nor Laegeforen 1997;117(1):23-6. [Abstract]
  • 15.Chang ET, Zheng T, Weir EG, Borowitz M, Mann RB, Spiegelman D, et al. Childhood social environment and Hodgkin’s lymphoma: new findings from a population-based case-control study. Cancer Epidemiol Biomarkers Prev 2004;13(8):1361-70.
  • 16. Lanzkowsky P. Pediatric hematology and oncology. 4th ed. Burlington, MA: Elsevier Academic Press; 2005. p. 453-90.
  • 17.Carbone PP, Kaplan HS, Musshoff K, Smithers DW, Tubiana M. Report of the Committee on Hodgkin’s Disease Staging Classification. Cancer Res 1971;31(11):1860-1.
  • 18. Lukes RJ, Butler JJ. The pathology and nomenclature of Hodgkin’s disease. Cancer Res 1966;26(6):1063-83.
  • 19. Kung FH, Schwartz CL, Ferree CR, London WB, Ternberg JL, Behm FG, et al. POG 8625: a randomized trial comparing chemotherapy with chemoradiotherapy for children and adolescents with Stages I, IIA, IIIA1 Hodgkin Disease: a report from the Children's Oncology Group. J Pediatr Hematol Oncol 2006;28(6):362-8.
  • 20.Carde P, Koscielny S, Franklin J, Axdorph U, Raemaekers J, Diehl V, et al. Early response to chemotherapy: a surrogate for final outcome of Hodgkin’s disease patients that should influence initial treatment length and intensity? Ann Oncol 2002;13 Suppl 1:86-91.
  • 21. Nachman JB, Sposto R, Herzog P, Gilchrist GS, Wolden SL, Thomson J, et al. Randomized comparison of low-dose involved-field radiotherapy and no radiotherapy for children with Hodgkin’s disease who achieve a complete response to chemotherapy. J Clin Oncol 2002;20(18):3765-71.
  • 22. Henry-Amar M, Joly F. Late complications after H o d g k i n’s disease. Ann Oncol 1996;7 Suppl 4:11 5 - 2 6 .
  • 2 3 . H u dson MM, Poquette CA, Lee J, Greenwald CA, Shah A, Luo X, et al. Increased mortality after successful treatment for Hodgkin’s disease. J Clin Oncol 1998;16(11):3592-600.
  • 24. Herbertson R, Hancock BW. Hodgkin Lymphoma in adolescents. Cancer Treat Rev 2005;31(5):339-60.
  • 25.Corapçioglu F, Sarper N, Berk F, Sahin T, Zengin E, Demir H. Evaluation of anthracycline-induced early left ventricular dysfunction in children with cancer: a comparative study with echocardiography and multigated radionuclide angiography. Pediatr Hematol Oncol 2006;23(1):71-80.
  • 26. Treatment strategies for pediatric nodular lymphocyte predominant Hodgkin’s lymphoma. Leuk Ly m p h 2006;47(8):1450-1.
There are 26 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Görkem Aksu This is me

Merdan Fayda This is me

Funda Çorapçıoğlu This is me

Eviç Başar This is me

Nagihan İnan This is me

Cengiz Erçin This is me

Publication Date April 1, 2007
Published in Issue Year 2007 Volume: 22 Issue: 3

Cite

APA Aksu, G., Fayda, M., Çorapçıoğlu, F., Başar, E., et al. (2007). Pediatrik Hodgkin lenfoma: Yeni yapılanmakta olan bir onkoloji merkezinde epidemiyolojik özellikler ve erken tedavi sonuçları. Türk Onkoloji Dergisi, 22(3), 118-126.
AMA Aksu G, Fayda M, Çorapçıoğlu F, Başar E, İnan N, Erçin C. Pediatrik Hodgkin lenfoma: Yeni yapılanmakta olan bir onkoloji merkezinde epidemiyolojik özellikler ve erken tedavi sonuçları. Türk Onkoloji Dergisi. April 2007;22(3):118-126.
Chicago Aksu, Görkem, Merdan Fayda, Funda Çorapçıoğlu, Eviç Başar, Nagihan İnan, and Cengiz Erçin. “Pediatrik Hodgkin Lenfoma: Yeni yapılanmakta Olan Bir Onkoloji Merkezinde Epidemiyolojik özellikler Ve Erken Tedavi sonuçları”. Türk Onkoloji Dergisi 22, no. 3 (April 2007): 118-26.
EndNote Aksu G, Fayda M, Çorapçıoğlu F, Başar E, İnan N, Erçin C (April 1, 2007) Pediatrik Hodgkin lenfoma: Yeni yapılanmakta olan bir onkoloji merkezinde epidemiyolojik özellikler ve erken tedavi sonuçları. Türk Onkoloji Dergisi 22 3 118–126.
IEEE G. Aksu, M. Fayda, F. Çorapçıoğlu, E. Başar, N. İnan, and C. Erçin, “Pediatrik Hodgkin lenfoma: Yeni yapılanmakta olan bir onkoloji merkezinde epidemiyolojik özellikler ve erken tedavi sonuçları”, Türk Onkoloji Dergisi, vol. 22, no. 3, pp. 118–126, 2007.
ISNAD Aksu, Görkem et al. “Pediatrik Hodgkin Lenfoma: Yeni yapılanmakta Olan Bir Onkoloji Merkezinde Epidemiyolojik özellikler Ve Erken Tedavi sonuçları”. Türk Onkoloji Dergisi 22/3 (April 2007), 118-126.
JAMA Aksu G, Fayda M, Çorapçıoğlu F, Başar E, İnan N, Erçin C. Pediatrik Hodgkin lenfoma: Yeni yapılanmakta olan bir onkoloji merkezinde epidemiyolojik özellikler ve erken tedavi sonuçları. Türk Onkoloji Dergisi. 2007;22:118–126.
MLA Aksu, Görkem et al. “Pediatrik Hodgkin Lenfoma: Yeni yapılanmakta Olan Bir Onkoloji Merkezinde Epidemiyolojik özellikler Ve Erken Tedavi sonuçları”. Türk Onkoloji Dergisi, vol. 22, no. 3, 2007, pp. 118-26.
Vancouver Aksu G, Fayda M, Çorapçıoğlu F, Başar E, İnan N, Erçin C. Pediatrik Hodgkin lenfoma: Yeni yapılanmakta olan bir onkoloji merkezinde epidemiyolojik özellikler ve erken tedavi sonuçları. Türk Onkoloji Dergisi. 2007;22(3):118-26.