Akciğer kanserine bağlı hipertrofik osteoartropati: Olgu sunumu

Alaattin Özen; Mert Saynak; Zafer Koçak; Gülden Bayır Argın; Burcu Üregen; Ruşen Coşar Alas; Cem Uzal; İrfan Çiçin

Hypertrophic osteoarthropathy associated with lung cancer: a case report

Year 2007, Volume: 22 Issue: 3, 141 - 145, 01.04.2007

Alaattin Özen Mert Saynak Zafer Koçak Gülden Bayır Argın Burcu Üregen Ruşen Coşar Alas Cem Uzal İrfan Çiçin

Abstract

Malignant neoplasms are sometimes associated with a variety of paraneoplastic rheumatic syndromes. Hypertrophic osteoarthropathy is one of these syndromes and the vast majority of cases are associated with intra thoracic neoplasms mainly broncogenic cancer. Hypertrophic osteoarthropathy (HOA) is characterized by clubbed fingers and periosteal new bone formation. Etio logically, it can be divided into primary and secondary HOA. The major clinical manifestation was severe bilateral leg pain. The pathogenesis of the disease remains unclear. Bone scintigraphy is a sensitive method to detect HOA. In this case, a 49-yea r-old man who had hypertrophic pulmonary osteoarthropathy associated with advanced stage non-small cell lung carcinoma is presented and a review of the literature is performed.

Keywords

Lung Neoplasms, Osteoarthropathy, Primary Hypertrophic, Osteoarthropathy, Secondary Hypertrophic, Middle Aged, Male, Tomography, X-Ray Computed, Carcinoma, Non-Small-Cell Lung

References

1. McNaughton DA, Nguyen BD. AJR teaching file: Cavitated mass with hypertrophic osteoarthropathy
AJR Am J Roentgenol 2007;188(3 Suppl):S7-9
2. von Bamberger E. Veranderungen der rohrrenknochen bei bronchiektasie. Wien Klin Wochenschr 1889;2:226
3. Marie P. De l’osteo-arthropathie hypertrophiante pneumique. Rev Med Paris 1890;10:1-36
4. Vogl A, Goldfischer S. Pachydermoperiostosis
Primary or idiopathic hypertrophic osteoarthropathy
Am J Med 1962;33:166-87
5. Martinez-Lavin M. Cardiogenic hypertrophic osteoarthropathy. Clin Exp Rheumatol 1992;10 Suppl 7:19-21
6. Yang WC, Lin SC, Liu TC, Chen CJ, Yen JH, Ou TT, et al. Clubbed fingers and hypertrophic osteoarthropathy in a patient with squamous cell carcinoma of the lung. Kaohsiung J Med Sci 2003;19:183-7
7. Gerber RB, Mazzone P, Arroliga AC. Paraneoplastic syndromes associated with bronchogenic carcinoma
Clin Chest Med 2002;23:257-64
8. Kurzrock R, Cohen PR. Cutaneous paraneoplastic syndromes in solid tumors. Am J Med 1995;99:662-71
9. Nashitz JE, Rosner I, Rozenbaum M, Elias N, Yeshurun D. Cancer-associated rheumatic disorders: clues to occult neoplasia. Semin Arthritis Rheum 1995;24:231-41
10.Wegrowski Y, Gillery P, Serpier H, Georges N, Combemale P, Kalis B, et al. Alteration of matrix macromolecule synthesis by fibroblasts from a patient with pachydermoperiostosis. J Invest Dermatol 1996;106:70-4
11.Matucci-Cerinic M, Martinez-Lavin M, Rojo F, Fonseca C, Kahaleh BM. von Willebrand factor antigen in hypertrophic osteoarthropathy. J Rheumatol 1992;19:765-7
12. Silveira LH, Martínez-Lavín M, Pineda C, Fonseca MC, Navarro C, Nava A. Vascular endothelial growth factor and hypertrophic osteoarthropathy. Clin Exp Rheumatol 2000;18:57-62
13. Kroon HM, Pauwels EK. Bone scintigraphy for the detection and follow-up of hypertrophic osteoarthropathy. Diagn Imaging 1982;51:47-55
14.Albrecht S, Keller A. Postchemotherapeutic reversibility of hypertrophic osteoarthropathy in a patient with bronchogenic adenocarcinoma. Clin Nucl Med 2003;28:463-6
15. Shih WJ. Pulmonary hypertrophic osteoarthropathy and its resolution. Semin Nucl Med 2004;34:159-63
16. Amital H, Applbaum YH, Vasiliev L, Rubinow A.Hypertrophic pulmonary osteoarthropathy: control of pain and symptoms with pamidronate. Clin Rheumatol 2004;23:330-2
17. Blackwell N, Bangham L, Hughes M, Melzack D, Trotman I. Treatment of resistant pain in hypertrophic pulmonary arthropathy with ketorolac. Thorax 1993;48:401
18. Kozak KR, Milne GL, Morrow JD, Cuiffo BP
Hypertrophic osteoarthropathy pathogenesis: a case highlighting the potential role for cyclo-oxygenase-2 derived prostaglandin E2. Nat Clin Pract Rheumatol 2006;2:452-6
19. Ooi A, Saad RA, Moorjani N, Amer KM. Effective symptomatic relief of hypertrophic pulmonary osteoarthropathy by video-assisted thoracic surgery truncal vagotomy. Ann Thorac Surg 2007;83:684-5

Akciğer kanserine bağlı hipertrofik osteoartropati: Olgu sunumu

Year 2007, Volume: 22 Issue: 3, 141 - 145, 01.04.2007

Alaattin Özen Mert Saynak Zafer Koçak Gülden Bayır Argın Burcu Üregen Ruşen Coşar Alas Cem Uzal İrfan Çiçin

Abstract

Malign hastalıklar çeşitli paraneoplastik romatolojik sendromlara yol açabilir. Bu sendromlardan biri olan hipertrofik osteoartropati (HPO) çoğunlukla toraks içi malignitelere ve en sık olarak da akciğer kanserine bağlı olarak ortaya çıkar. Hipertrofik osteoartropati çomak parmak ve periostal yeni kemik oluşumu ile kendini gösterir. En önemli klinik bulgusu bilateral bacak ağrısıdır. Hastalığın patogenezi henüz aydınlanmamıştır. Kemik sintigrafisi tanı için duyarlı bir yöntemdir. Bu yazıda, ileri evre küçük hücreli dışı akciğer kanseri tanılı 49 yaşındaki bir erkek hastanın hipertrofik pulmoner oseoartropati bulguları bildirilmiş ve bu konudaki literatür bilgisi özetlenmiştir.

Keywords

Akciğer kanseri, hipertrofik osteoartropati, periostal yeni kemik oluşumu

References

1. McNaughton DA, Nguyen BD. AJR teaching file: Cavitated mass with hypertrophic osteoarthropathy
AJR Am J Roentgenol 2007;188(3 Suppl):S7-9
2. von Bamberger E. Veranderungen der rohrrenknochen bei bronchiektasie. Wien Klin Wochenschr 1889;2:226
3. Marie P. De l’osteo-arthropathie hypertrophiante pneumique. Rev Med Paris 1890;10:1-36
4. Vogl A, Goldfischer S. Pachydermoperiostosis
Primary or idiopathic hypertrophic osteoarthropathy
Am J Med 1962;33:166-87
5. Martinez-Lavin M. Cardiogenic hypertrophic osteoarthropathy. Clin Exp Rheumatol 1992;10 Suppl 7:19-21
6. Yang WC, Lin SC, Liu TC, Chen CJ, Yen JH, Ou TT, et al. Clubbed fingers and hypertrophic osteoarthropathy in a patient with squamous cell carcinoma of the lung. Kaohsiung J Med Sci 2003;19:183-7
7. Gerber RB, Mazzone P, Arroliga AC. Paraneoplastic syndromes associated with bronchogenic carcinoma
Clin Chest Med 2002;23:257-64
8. Kurzrock R, Cohen PR. Cutaneous paraneoplastic syndromes in solid tumors. Am J Med 1995;99:662-71
9. Nashitz JE, Rosner I, Rozenbaum M, Elias N, Yeshurun D. Cancer-associated rheumatic disorders: clues to occult neoplasia. Semin Arthritis Rheum 1995;24:231-41
10.Wegrowski Y, Gillery P, Serpier H, Georges N, Combemale P, Kalis B, et al. Alteration of matrix macromolecule synthesis by fibroblasts from a patient with pachydermoperiostosis. J Invest Dermatol 1996;106:70-4
11.Matucci-Cerinic M, Martinez-Lavin M, Rojo F, Fonseca C, Kahaleh BM. von Willebrand factor antigen in hypertrophic osteoarthropathy. J Rheumatol 1992;19:765-7
12. Silveira LH, Martínez-Lavín M, Pineda C, Fonseca MC, Navarro C, Nava A. Vascular endothelial growth factor and hypertrophic osteoarthropathy. Clin Exp Rheumatol 2000;18:57-62
13. Kroon HM, Pauwels EK. Bone scintigraphy for the detection and follow-up of hypertrophic osteoarthropathy. Diagn Imaging 1982;51:47-55
14.Albrecht S, Keller A. Postchemotherapeutic reversibility of hypertrophic osteoarthropathy in a patient with bronchogenic adenocarcinoma. Clin Nucl Med 2003;28:463-6
15. Shih WJ. Pulmonary hypertrophic osteoarthropathy and its resolution. Semin Nucl Med 2004;34:159-63
16. Amital H, Applbaum YH, Vasiliev L, Rubinow A.Hypertrophic pulmonary osteoarthropathy: control of pain and symptoms with pamidronate. Clin Rheumatol 2004;23:330-2
17. Blackwell N, Bangham L, Hughes M, Melzack D, Trotman I. Treatment of resistant pain in hypertrophic pulmonary arthropathy with ketorolac. Thorax 1993;48:401
18. Kozak KR, Milne GL, Morrow JD, Cuiffo BP
Hypertrophic osteoarthropathy pathogenesis: a case highlighting the potential role for cyclo-oxygenase-2 derived prostaglandin E2. Nat Clin Pract Rheumatol 2006;2:452-6
19. Ooi A, Saad RA, Moorjani N, Amer KM. Effective symptomatic relief of hypertrophic pulmonary osteoarthropathy by video-assisted thoracic surgery truncal vagotomy. Ann Thorac Surg 2007;83:684-5

There are 24 citations in total.

Details

Primary Language	Turkish
Journal Section	Articles
Authors	Alaattin Özen This is me Mert Saynak This is me Zafer Koçak This is me Gülden Bayır Argın This is me Burcu Üregen This is me Ruşen Coşar Alas This is me Cem Uzal This is me İrfan Çiçin This is me
Publication Date	April 1, 2007
Published in Issue	Year 2007 Volume: 22 Issue: 3

Cite

APA	Özen, A., Saynak, M., Koçak, Z., Argın, G. B., et al. (2007). Akciğer kanserine bağlı hipertrofik osteoartropati: Olgu sunumu. Türk Onkoloji Dergisi, 22(3), 141-145.
AMA	Özen A, Saynak M, Koçak Z, Argın GB, Üregen B, Alas RC, Uzal C, Çiçin İ. Akciğer kanserine bağlı hipertrofik osteoartropati: Olgu sunumu. Türk Onkoloji Dergisi. April 2007;22(3):141-145.
Chicago	Özen, Alaattin, Mert Saynak, Zafer Koçak, Gülden Bayır Argın, Burcu Üregen, Ruşen Coşar Alas, Cem Uzal, and İrfan Çiçin. “Akciğer Kanserine bağlı Hipertrofik Osteoartropati: Olgu Sunumu”. Türk Onkoloji Dergisi 22, no. 3 (April 2007): 141-45.
EndNote	Özen A, Saynak M, Koçak Z, Argın GB, Üregen B, Alas RC, Uzal C, Çiçin İ (April 1, 2007) Akciğer kanserine bağlı hipertrofik osteoartropati: Olgu sunumu. Türk Onkoloji Dergisi 22 3 141–145.
IEEE	A. Özen, M. Saynak, Z. Koçak, G. B. Argın, B. Üregen, R. C. Alas, C. Uzal, and İ. Çiçin, “Akciğer kanserine bağlı hipertrofik osteoartropati: Olgu sunumu”, Türk Onkoloji Dergisi, vol. 22, no. 3, pp. 141–145, 2007.
ISNAD	Özen, Alaattin et al. “Akciğer Kanserine bağlı Hipertrofik Osteoartropati: Olgu Sunumu”. Türk Onkoloji Dergisi 22/3 (April 2007), 141-145.
JAMA	Özen A, Saynak M, Koçak Z, Argın GB, Üregen B, Alas RC, Uzal C, Çiçin İ. Akciğer kanserine bağlı hipertrofik osteoartropati: Olgu sunumu. Türk Onkoloji Dergisi. 2007;22:141–145.
MLA	Özen, Alaattin et al. “Akciğer Kanserine bağlı Hipertrofik Osteoartropati: Olgu Sunumu”. Türk Onkoloji Dergisi, vol. 22, no. 3, 2007, pp. 141-5.
Vancouver	Özen A, Saynak M, Koçak Z, Argın GB, Üregen B, Alas RC, Uzal C, Çiçin İ. Akciğer kanserine bağlı hipertrofik osteoartropati: Olgu sunumu. Türk Onkoloji Dergisi. 2007;22(3):141-5.

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