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The effects of radiation on the fetus

Year 2009, Volume: 24 Issue: 4, 185 - 190, 01.05.2009

Beyhan Ceylaner Bıçakçı

Abstract

Ionizing radiation can directly affect fetal development in several ways. Radiation dose and the time of exposure are critically important in the development of these effects. The most sensitive cells to ionizing radiation are those that are rapidly dividing or in the mitotic phase. Radiation can cause fetal death or congenital anomalies, growth deficiencies or several structural and/or functional development abnormalities. In this review, the relationship between radiation and pregnancy is evaluated in view of the recent literature.

Keywords

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References

  • 1. Dunn K, Yoshimaru H, Otake M, Annegers JF, Schull WJ. Prenatal exposure to ionizing radiation and subsequent development of seizures. Am J Epidemiol 1990;131(1):114-23.
  • 2. Özalpman A. Radyasyonun embriyo ve fetus üzerine etkileri. Temel Radyobiyoloji 2001;20:308-30.
  • 3. Kıraç FS, Yüksel D. İnsan fötüsüne radyasyonun zararlı etkileri. Radyasyon Biyolojisi 2001;9:95-102.
  • 4. Valentine J. International commission on radiological protection pregnancy and medical radiation. ICRP Publication 84. Ann ICRP 2000;30:1-43.
  • 5. Valentine J. Biological effects after prenatal irradiation (embryo and fetus). ICRP Publication 90. Ann ICRP 2003;33:1-200.
  • 6. Hall EJ, Giaccia AJ. Effects of radiation on the embryo and fetus. Radiobiology for the radiologist. 6th ed. Philadelphia: Lippicott; 2006. p. 168-80.
  • 7. Wagner LK, Lester RG, Saldana LR. Exposure of the pregnant patient to diagnostic radiations. 2nd ed. Medical Physics Publishing; Madison, Wisconcin: 1997.
  • 8. Friedberg W, Faulkner DN, Neas BR, Hanneman GD, Darden EB Jr, Deal RB Jr, et al. Dose-incidence relationships for exencephalia, anophthalmia and prenatal mortality in mouse embryos irradiated with fission neutrons or 250 kV X-rays. Int J Radiat Biol Relat Stud Phys Chem Med 1987;52(2):223-36.
  • 9. Miller RW. Discussion: severe mental retardation and cancer among atomic bomb survivors exposed in utero. Teratology 1999;59(4):234-5.
  • 10. Mole RH. Irradiation of the embryo and fetus. Br J Radiol 1987;60(709):17-31.
  • 11. Mole RH. The effect of prenatal radiation exposure on the developing human brain. Int J Radiat Biol 1990;57(4):647-63.
  • 12. Otake M, Schull WJ, Yoshimaru H. A review of fortyfive years study of Hiroshima and Nagasaki atomic bomb survivors. Brain damage among the prenatally exposed. J Radiat Res (Tokyo) 1991;32 Suppl:249-64.
  • 13. Otake M, Schull WJ. Radiation-related brain damage and growth retardation among the prenatally exposed atomic bomb survivors. Int J Radiat Biol 1998;74(2):159-71.
  • 14. Fattibene P, Mazzei F, Nuccetelli C, Risica S. Prenatal exposure to ionizing radiation: sources, effects and regulatory aspects. Acta Paediatr 1999;88(7):693-702.
  • 15. Russell LB, Russell WL. An analysis of the changing radiation response of the developing mouse embryo. J Cell Physiol Suppl 1954;43(Suppl. 1):103-49.
  • 16. Rugh R. Radiation biology of the fetal and juvenil mammal. In: usaec conference. Us Atomic Energy Commission; Washington: 1969. p. 381.
  • 17. Hammer-Jacobsen E. Therapeutic abortion on account of x-ray examination during pregnancy. Dan Med Bull 1959;6(4):113-22.
  • 18. Schull WJ, Otake M. Cognitive function and prenatal exposure to ionizing radiation. Teratology 1999;59(4):222-6.
  • 19. BEIR. Health effects of exposure to low levels of ıonizing radiation. National Academy Pres; Washington, D.C: 1990.
  • 20. Mole RH. The biology and radiobiology of in utero development in relation to radiological protection. Br J Radiol 1993;66(792):1095-102.
  • 21. Yoshimoto Y. Cancer risk among children of atomic bomb survivors. A review of RERF epidemiologic studies. Radiation Effects Research Foundation. JAMA 1990;264(5):596-600.
  • 22. Stewart A, Kneale GW. Radiation dose effects in relation to obstetric x-rays and childhood cancers. Lancet 1970;1(7658):1185-8.
  • 23. Meinert R, Kaletsch U, Kaatsch P, Schüz J, Michaelis J. Associations between childhood cancer and ionizing radiation: results of a population-based case-control study in Germany. Cancer Epidemiol Biomarkers Prev 1999;8(9):793-9.
  • 24. Astakhova LN, Anspaugh LR, Beebe GW, Bouville A, Drozdovitch VV, Garber V, et al. Chernobyl-related thyroid cancer in children of Belarus: a case-control study. Radiat Res 1998;150(3):349-56.
  • 25. Tuttle RM, Becker DV. The Chernobyl accident and its consequences: update at the millennium. Semin Nucl Med 2000;30(2):133-40.
  • 26. Adalı F, Adalı E. Gebelikte tanısal görüntüleme yöntemlerinin fetusa etkisi. Van Tıp Dergisi 2008;15(2):64-9.
  • 27. Mayr NA, Wen BC, Saw CB. Radiation therapy during pregnancy. Obstet Gynecol Clin North Am 1998;25(2):301-21.
  • 28. ACOG Committee on Obstetric Practice. ACOG Committee Opinion. Number 299, September 2004 (replaces No. 158, September 1995). Guidelines for diagnostic imaging during pregnancy. Obstet Gynecol 2004;104(3):647-51.
  • 29. Barnett SB, Maulik D; International Perinatal Doppler Society. Guidelines and recommendations for safe use of Doppler ultrasound in perinatal applications. J Matern Fetal Med 2001;10(2):75-84.
  • 30. Guo Y, Luo BN. The state of the art of fetal magnetic resonance imaging. Chin Med J (Engl) 2006;119(15):1294-9.
  • 31. Sandrasegaran K, Lall CG, Aisen AA. Fetal magnetic resonance imaging. Curr Opin Obstet Gynecol 2006;18(6):605-12.
  • 32. Coakley FV, Glenn OA, Qayyum A, Barkovich AJ, Goldstein R, Filly RA. Fetal MRI: a developing technique for the developing patient. AJR Am J Roentgenol 2004;182(1):243-52.
  • 33. Stovall M, Blackwell CR, Cundiff J, Novack DH, Palta JR, Wagner LK, et al. Fetal dose from radiotherapy with photon beams: report of AAPM Radiation Therapy Committee Task Group No. 36. Med Phys 1995;22(1):63-82.
  • 34. Nuyttens JJ, Prado KL, Jenrette JM, Williams TE. Fetal dose during radiotherapy: clinical implementation and review of the literature. Cancer Radiother 2002;6(6):352-7.

Radyasyonun fetus üzerine etkileri

Year 2009, Volume: 24 Issue: 4, 185 - 190, 01.05.2009

Beyhan Ceylaner Bıçakçı

Abstract

İyonizan radyasyon, fetus gelişimini direkt olarak çeşitli mekanizmalarla etkileyebilir. Radyasyon dozu ve maruziyet zamanı, bu etkilerin gelişiminde kritik şekilde önemlidir. İyonize edici radyasyona en hassas hücreler hızlı bölünen ve mitotik fazdaki hücrelerdir. Radyasyonun organizma üzerine etkileri doğum öncesi veya doğum sonrası ölümle sonuçlanabileceği gibi, doğumsal anomaliler, büyüme bozuklukları ve çeşitli yapısal ve fonksiyonel gerilikler olarak da karşımıza çıkabilir. Bu yazıda, radyasyon ve hamilelik arasındaki ilişki, son literatür bilgileri eşliğinde değerlendirildi.

Keywords

Fetus hamilelik radyasyon radyoterapi

References

  • 1. Dunn K, Yoshimaru H, Otake M, Annegers JF, Schull WJ. Prenatal exposure to ionizing radiation and subsequent development of seizures. Am J Epidemiol 1990;131(1):114-23.
  • 2. Özalpman A. Radyasyonun embriyo ve fetus üzerine etkileri. Temel Radyobiyoloji 2001;20:308-30.
  • 3. Kıraç FS, Yüksel D. İnsan fötüsüne radyasyonun zararlı etkileri. Radyasyon Biyolojisi 2001;9:95-102.
  • 4. Valentine J. International commission on radiological protection pregnancy and medical radiation. ICRP Publication 84. Ann ICRP 2000;30:1-43.
  • 5. Valentine J. Biological effects after prenatal irradiation (embryo and fetus). ICRP Publication 90. Ann ICRP 2003;33:1-200.
  • 6. Hall EJ, Giaccia AJ. Effects of radiation on the embryo and fetus. Radiobiology for the radiologist. 6th ed. Philadelphia: Lippicott; 2006. p. 168-80.
  • 7. Wagner LK, Lester RG, Saldana LR. Exposure of the pregnant patient to diagnostic radiations. 2nd ed. Medical Physics Publishing; Madison, Wisconcin: 1997.
  • 8. Friedberg W, Faulkner DN, Neas BR, Hanneman GD, Darden EB Jr, Deal RB Jr, et al. Dose-incidence relationships for exencephalia, anophthalmia and prenatal mortality in mouse embryos irradiated with fission neutrons or 250 kV X-rays. Int J Radiat Biol Relat Stud Phys Chem Med 1987;52(2):223-36.
  • 9. Miller RW. Discussion: severe mental retardation and cancer among atomic bomb survivors exposed in utero. Teratology 1999;59(4):234-5.
  • 10. Mole RH. Irradiation of the embryo and fetus. Br J Radiol 1987;60(709):17-31.
  • 11. Mole RH. The effect of prenatal radiation exposure on the developing human brain. Int J Radiat Biol 1990;57(4):647-63.
  • 12. Otake M, Schull WJ, Yoshimaru H. A review of fortyfive years study of Hiroshima and Nagasaki atomic bomb survivors. Brain damage among the prenatally exposed. J Radiat Res (Tokyo) 1991;32 Suppl:249-64.
  • 13. Otake M, Schull WJ. Radiation-related brain damage and growth retardation among the prenatally exposed atomic bomb survivors. Int J Radiat Biol 1998;74(2):159-71.
  • 14. Fattibene P, Mazzei F, Nuccetelli C, Risica S. Prenatal exposure to ionizing radiation: sources, effects and regulatory aspects. Acta Paediatr 1999;88(7):693-702.
  • 15. Russell LB, Russell WL. An analysis of the changing radiation response of the developing mouse embryo. J Cell Physiol Suppl 1954;43(Suppl. 1):103-49.
  • 16. Rugh R. Radiation biology of the fetal and juvenil mammal. In: usaec conference. Us Atomic Energy Commission; Washington: 1969. p. 381.
  • 17. Hammer-Jacobsen E. Therapeutic abortion on account of x-ray examination during pregnancy. Dan Med Bull 1959;6(4):113-22.
  • 18. Schull WJ, Otake M. Cognitive function and prenatal exposure to ionizing radiation. Teratology 1999;59(4):222-6.
  • 19. BEIR. Health effects of exposure to low levels of ıonizing radiation. National Academy Pres; Washington, D.C: 1990.
  • 20. Mole RH. The biology and radiobiology of in utero development in relation to radiological protection. Br J Radiol 1993;66(792):1095-102.
  • 21. Yoshimoto Y. Cancer risk among children of atomic bomb survivors. A review of RERF epidemiologic studies. Radiation Effects Research Foundation. JAMA 1990;264(5):596-600.
  • 22. Stewart A, Kneale GW. Radiation dose effects in relation to obstetric x-rays and childhood cancers. Lancet 1970;1(7658):1185-8.
  • 23. Meinert R, Kaletsch U, Kaatsch P, Schüz J, Michaelis J. Associations between childhood cancer and ionizing radiation: results of a population-based case-control study in Germany. Cancer Epidemiol Biomarkers Prev 1999;8(9):793-9.
  • 24. Astakhova LN, Anspaugh LR, Beebe GW, Bouville A, Drozdovitch VV, Garber V, et al. Chernobyl-related thyroid cancer in children of Belarus: a case-control study. Radiat Res 1998;150(3):349-56.
  • 25. Tuttle RM, Becker DV. The Chernobyl accident and its consequences: update at the millennium. Semin Nucl Med 2000;30(2):133-40.
  • 26. Adalı F, Adalı E. Gebelikte tanısal görüntüleme yöntemlerinin fetusa etkisi. Van Tıp Dergisi 2008;15(2):64-9.
  • 27. Mayr NA, Wen BC, Saw CB. Radiation therapy during pregnancy. Obstet Gynecol Clin North Am 1998;25(2):301-21.
  • 28. ACOG Committee on Obstetric Practice. ACOG Committee Opinion. Number 299, September 2004 (replaces No. 158, September 1995). Guidelines for diagnostic imaging during pregnancy. Obstet Gynecol 2004;104(3):647-51.
  • 29. Barnett SB, Maulik D; International Perinatal Doppler Society. Guidelines and recommendations for safe use of Doppler ultrasound in perinatal applications. J Matern Fetal Med 2001;10(2):75-84.
  • 30. Guo Y, Luo BN. The state of the art of fetal magnetic resonance imaging. Chin Med J (Engl) 2006;119(15):1294-9.
  • 31. Sandrasegaran K, Lall CG, Aisen AA. Fetal magnetic resonance imaging. Curr Opin Obstet Gynecol 2006;18(6):605-12.
  • 32. Coakley FV, Glenn OA, Qayyum A, Barkovich AJ, Goldstein R, Filly RA. Fetal MRI: a developing technique for the developing patient. AJR Am J Roentgenol 2004;182(1):243-52.
  • 33. Stovall M, Blackwell CR, Cundiff J, Novack DH, Palta JR, Wagner LK, et al. Fetal dose from radiotherapy with photon beams: report of AAPM Radiation Therapy Committee Task Group No. 36. Med Phys 1995;22(1):63-82.
  • 34. Nuyttens JJ, Prado KL, Jenrette JM, Williams TE. Fetal dose during radiotherapy: clinical implementation and review of the literature. Cancer Radiother 2002;6(6):352-7.
There are 34 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Beyhan Ceylaner Bıçakçı This is me

Publication Date May 1, 2009
Published in Issue Year 2009 Volume: 24 Issue: 4

Cite

APA Bıçakçı, B. C. (2009). Radyasyonun fetus üzerine etkileri. Türk Onkoloji Dergisi, 24(4), 185-190.
AMA Bıçakçı BC. Radyasyonun fetus üzerine etkileri. Türk Onkoloji Dergisi. May 2009;24(4):185-190.
Chicago Bıçakçı, Beyhan Ceylaner. “Radyasyonun Fetus üzerine Etkileri”. Türk Onkoloji Dergisi 24, no. 4 (May 2009): 185-90.
EndNote Bıçakçı BC (May 1, 2009) Radyasyonun fetus üzerine etkileri. Türk Onkoloji Dergisi 24 4 185–190.
IEEE B. C. Bıçakçı, “Radyasyonun fetus üzerine etkileri”, Türk Onkoloji Dergisi, vol. 24, no. 4, pp. 185–190, 2009.
ISNAD Bıçakçı, Beyhan Ceylaner. “Radyasyonun Fetus üzerine Etkileri”. Türk Onkoloji Dergisi 24/4 (May 2009), 185-190.
JAMA Bıçakçı BC. Radyasyonun fetus üzerine etkileri. Türk Onkoloji Dergisi. 2009;24:185–190.
MLA Bıçakçı, Beyhan Ceylaner. “Radyasyonun Fetus üzerine Etkileri”. Türk Onkoloji Dergisi, vol. 24, no. 4, 2009, pp. 185-90.
Vancouver Bıçakçı BC. Radyasyonun fetus üzerine etkileri. Türk Onkoloji Dergisi. 2009;24(4):185-90.