Biyokimyasal Özellikleri ile L - Karnitin

Halil Yavuz; Firuze Kurtoğlu

doi:10.16988/iuvfd.34399

Biyokimyasal Özellikleri ile L - Karnitin

Abstract

ÖZET

Karnitin, organizmada yağların enerjiye dönüşümünü sağlayan bir maddedir. Karaciğer ve böbrekte sentezlenerek, iskelet kasları, kalp, beyin gibi dokularda depolanır. Genellikle canlı organizma kendisine yetecek oranda karnitini sentezleyebilir. Ancak bazı organizmalarda ise bu sentez miktarı ya da kullanılabilecek oranda karnitin dokulara transferi yeterli olamayabilir. Karnitin, oksidatif stresi azaltan bir faktör olarak değişik şartlarda tedavi edici bir faktör olarak etkindir ve doktor kontrollü olmak üzere geleneksel tedavide ilave ajanlar olarak kullanılabilmektedir. Yorgunluk, fiziksel performansın artırılması, kalp - damar sisteminin korunması gibi farklı amaçlarla karnitin kullanımı güvenli ve pozitif etkilere sahip gibi görünmektedir.

Anahtar Kelimeler: Karnitin, biyokimyasal fonksiyon, medikal kullanım

ABSTRACT

L - CARNITINE AND BIOCHEMICAL CHARACTERISTICS

Carnitine is a nutrient that helps the body turn fat into energy. It is produced by the body in the liver and kidneys and stored in the skeletal muscles, heart and brain. Usually, the body can make all the carnitine it needs. However, some organisms may be deficient in carnitine because their bodies cannot make enough carnitine or transport it into tissues so it can be used. Carnitine has been proposed as a treatment for many conditions because it helps reduce oxidative stress. Some of the conditions carnitine may help treat are serious, and it should be take the supplement under the supervision of doctor, as an adjunct therapy to conventional medicine. For other conditions, such as fatigue or improving exercise performance, protection of heart diseases, carnitine appears safe and seems to have positive effects.

Key Words: Carnitine, biochemical function, medical usage

Keywords

Karnitin, biyokimyasal fonksiyon, medikal kullanım

References

Abd-Allah, A.R., Helal, G.K., Al-Yahya, A.A., Aleisa, A.M., Al-Rejaie, S.S., Al-Bakheet, S.A., 2009. Pro-inflammatory and oxidative stress pathways which compromise sperm motility and survival may be altered by L- carnitine. Oxidative Medicine and Cellular Longevity 2, 73-81.
Arduini, A., 1992. Carnitine and its acetyl esters as secondary antioxidants? American Heart Journal 123, 1726-1727.
Arockia Rani, P.J., Panneerselvam, C . , 2001. L- carnitine as a free radical scavenger in aging. Experimental Gerontology 36, 1713-1726.
Arrigoni-Martelli, E . , Caso, V., 2001. Carnitine protects mitocondria and removes toxic acyls from xenobiotics. Drugs Under Experimental and Clinical Research 27(1), 27-49.
Balercia, G., Regoli, F . , Armeni, T., Koverech, A., Mantero, F . , Boscaro, M., 2005. Placebo- controlled double-blind randomized trial on the use of L-carnitine, L-acetylcarnitine, or combined L-carnitine and L-acetylcarnitine in men with idiopathic asthenozoospermia. Fertility and Sterility 84, 662-671.
Banji, M.S., 1984. Nutrition and healt implications of lysin-carnitine relationship. World Review of Nutrition and Dietetics 44, 185-211.
Bartelloni, M., Canale, D., Izzo, P.L., Giorgi, P.M., Meschini, P., Menchini-Fabris, G.F., 1987. L - Carnitine and acetylcarnitine in human sperm with normal and reduced motility. Acta Europaea Fertilitatis 18, 29-31.
Baruksal, G., 2010. L-Karnitinin yaşlı sıçanlarda kalp, karaciğer, beyin ve plazma yağ aisdi profillerine ve kalp fonksiyonlarına etkisi. Yüksek Lisans Tezi, İstanbul Üniversitesi Sağlık Bilimleri Enstitüsü, İstanbul.

Başpınar, N., Kurtoğlu, F . , 2003. Vitaminler. ISBN 975-448-168-7. Selçuk Üniversitesi Veteriner Fakültesi Yayın Ünitesi, Konya.
Binienda, Z.K., Ali, S.F., 2001. Neuroprotective role of L-carnitine in the 3-nitropropionic acid induced neurotoxicity. Toxicology Letters 125, 67-73.
Borum, P.R., 1983. Carnitine. The Annual Review of Nutrition 3, 233-259.
Bremer, J . , 1983. Carnitine-metabolism and functions. Physiology Review 63, 1420-1480.
Bremer, J . , 1990. The role of carnitine in intracelluler metabolism. Journal of Clinical Chemistry Clinical Biochemistry 28, 297-301.
Brevetti, G., Diehm, C., Lambert, D., 1999. European multicenter study on propionyl-L-carnitine in intermittent claudication. Journal of the American College of Cardiology 34 (5), 1618ı 1624.
Brevetti, G., Perna, S., 1992. Metabolic and Clinical Effects of L-carnitine in Peripheral Vascular Disease. In: Ferrari, R., DiMauro, S., Sherwood, G. (Eds.), L-carnitine and Its Role in Medicine: From Function to Therapy. Academic Press, London, pp. 359-378.
Brooks, D.E., 1979. Carnitine in the male reproductive tract and its relation to the motabolism of the epididymis and spermatozoa. Proceding of Virginia Biochemistry Symposium pp. 219-235.
Burns, K.A., Casillas, E.R., 1989. The metabolism of acetylcarnitine and acetate by bovine and hamster epididymal spermatozoa. Biology of Reproduction 41, 218-226.
Carter, H.E., Bhattacharya, P.K., Weidman, K.R., Fraenkel, G., 1952. Chemical studies on vitamin BT-isolation and characterization as carnitine. Archives of Biochemistry and Biophysics 38, 405-416.
Cerretelli, P., Marconi, C., 1990. L-Carnitine supplementation in humans. The effects of physical performance. International Journal of Sports Medicine 11, 1-14.
Chen, W., Huang, Y . C . , Shultz, T.D., Mitchell, M.E., 1998. Urinary, plasma, and erythrocyte carnitine concentrations during transition to a lactoovovegetarian diet with vitamin B-6 depletion and epletion in young adult women. American Journal of Clinical Nutrition 67, 221ı 230.
Çitil, M., 2002. Veteriner hekimlikte karnitin. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 8 (1), 77-82.
Coşkun, Ö., Öter, Ş., Korkmaz, A., Sezen, Ş., Öztaş, E . , Cıncık, M., 2000. Yoğun egzersiz ile iskelet kasında oluşan glikojen azalması, laktik asit birikmesi ve morfolojik değişikliklere, karnitinin etkisi. Türkiye Klinikleri Tıp Bilimleri Dergisi 20, 325-333.
Costell, M., O'Connor, J . E . , Grisolia, S., 1989. Age- dependent decrease of L-carnitine content in muscle of mice and humans. Biochemical and Biophysical Research Communication 161 (3), 1135-1143.
Da Torre, S.D., Creer, M.H., Progwizd, S.M., Corr, P.B., 1991. Amphipathic lipid metabolites and their relation to arrhythmogenesis in ischemic heart. Journal of Molecular and Cellular Cardiology 23 (1), 11-22.
De Vivo, D.C., Tein, I., 1990. Primary and secondary disorders of carnitine metabolism. International Pediatry 5, 134-141.
Deniz, G., 1999. Karnitin: Sentez, Metabolizma, Fonksiyon ve İskemik Kalpte Terapötik Önemi. Türkiye Klinikleri Tıp Bilimleri 19, 55-62.
Duran, M., Loof, N.E., Dorland, L . , 1990. Secondary carnitine deficiency. Journal of Clinical Chemistry and Clinical Biochemistry 28, 359ı 363.
Engel, A.G., Rebouche, C . J . , 1983. Carnitine metabolism and inborne errors. Journal of Inherited Metabolic Disease 7, 38-43.
Erfle, J.D., Fisher, L . J . , Sauer, F.D., 1971. Effect of infusion of carnitine and glucose on blood glucose, ketones, and free fatty acides of ketotic cows. Journal of Dairy Science 54, 673-680.
Evans, A., 2003. Dialysis-related carnitine disorder and levocarnitine pharmacology. The American Journal of Kidney Diseases 41 (suppl. 4), S13- S26.
Fabriello, R.G., Calabrese, F . , 1988. Prevention of ischemia induced increase in M D A by acetyl carnitine. Annals of Neurology 24, 114-118.
Feller, A.G., Rudman, D., 2002. Role of carnitine in human nutrition. Journal of Nutrition 118, 541ı 547.
Fujisawa, S., Kobayashi, A., Hironoko, Y . , 1992. Effect of L-carnitine and its acyl derivatives in the ischemic heart. Japanese Heart Journal 33 (5), 693-705.
Garzya, G., Corallo, D., Fiore, A., 1990. Evaluation of the effects of L-acetylcarnitine on senile patients suffering form depression. Drugs Under Experimental and Clinical Research 16, 101ı 106.
Gülçin, I., 2006. Antioxidant and antiradical activities of L-Carnitine. Life Sciences 78, 803-811.
Hagen, T., Liu, J . , Lykkesfeldt, J . , 2002. Feeding acetyl-L-carnitine and lipoic acid to old rats significiantly improves metabolic function while decreasing oxidative stress. Proceedings of the National Academy of Sciences 99 (4), 1870-1875.
Harmeyer, J . , Schlumbohm, C., 1997. Die physiologische Bedeutung von L-Carnitin und Effekte von Carnitinzulagen bei Haustieren. In: Proc. Vitamine und Zusatztoffe in der Erna hrung von Mensch und Tier. 6. Symposium, Jena/Thüringen, pp. 42-46.
Heinonen, O.J., 1996. Carnitine and physical exercise. Sports Medicine 22, 109-132.
Kalaycıoğlu, L . , Serpek, B., Nizamlıoğlu, M., Başpınar, N., Tiftik, M.A., 2010. Biyokimya. 4. Baskı. Nobel Yayınevi ISBN: 978-975-591ı 131-1.
Kayaalp, O.S., 1993. Rasyonel Tedavi Yönünden Tıbbi Farmakoloji, 6. baskı. Ankara: Feryal Basımevi 3, pp. 2505-2511.
Kopec, B., Fritz, I.B., 1973. Comparison of properties of carnitine palmitoyltransferase I with dose of carnitine palmitoyltransferase II, and prepations of antibodies to carnitine palmitoyltransferases. The Journal of Biological Chemistry 248, 4069ı 4079.
Koudelova, J . , Mourek, J . , Drahota, Z., Rauchova, H., 1994. Protective effect of carnitine on lipoperoxide formation in rat brain. Physiological Research 43, 387-389.
Kudo, N., Barr, A.J., Barr, R . L . , Desai, S., Lopaschuk, G.D., 1995. High rates of fatty acid oxydation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5- AMP activated protein kinase inhibition of acetly-CoA carboxylase. The Journal of Biological Chemistry 270 (229), 17513-17520.
L i , B.U.K., Lloyd, M.L., Gudjonsson, H., Shug, A.L., Olsen, W.A., 1992. The effect of enteral carnitine administration in humans. American Journal of Clinical Nutrition 55, 838-845.
Lopaschuk, G., 2002. Regulation of carbohydrate metabolism in ischemia and perfusion. American Heart Journal 139 (2-3), 115-119.
Malone, J.I., Schocken, D.D., Morrison, A.D., Gilbertbarness, E . , 1999. Diabetic cardiomyopathy and carnitine deficiencies. Journal of Diabetes and Its Complications 13 (2), 86-90.
Mansour, H.H., 2006. Protective role of carnitine ester against radiation-induced oxidative stres in rats. Pharmacological Research 54 (3), 165-171.
Marcuus, R., Coulston, A.M., 1990. Water Soluble Vitamins. In: Gilman, A.G., Rall, T.W., Nies, S.A., (Eds.). The Pharmacological Basis of Therapeatics, 8t h ed., Macmillan press, pp. 1545-1547.
Matalliotakis, I . , Koumantaki, Y . , Evageliou, A., Matalliotakis, G., Goumenou, A., Koumantakis, E . , 2000. L-carnitine levels in the seminal plasma of fertile and infertile men: Correlation with sperm quality. International Journal of Fertility 45 (3), 236-240.
McGarry, J.D., Sen, A., Esser, V., Woeltje, K . F . , Weis, B., Foster, D.W., 1991. New insights into mitochondrial carnitine palmitoyl transferase enzyme system. Biochimie 73, 77ı 84.
Meier, P.J., 1987. D-Carnitin, harmlos? In: Gitzelmann, R., Baerlocher, K., Steinmann, B., (Hrsg.): Carnitin in der medizin. Schattauer, Stutgart, New York, pp. 101-104.
Moradi, M., Moradi, A., Alemi, M., Ahmadnia, H., Abdi, H., Ahmadi, A., Bazargan-Hejazi, S., 2010. Safety and efficacy of clomiphene citrate and L-carnitine in idiopathic male infertility: a comparative study. Urology Journal 7, 188-193.
Mroczkowska, J . E . , Gala, H.J., Nalecz, M.J., Nalecz, K.A., 1997. Evidence for an asymmetrical uptake of L-carnitine in the blood-brain barrier in vitro. Biochemistry and Biophysics Research Communication 241, 127-131.
Nalecz, K.A., Nalecz, M.J.I., 1996. Carnitine-a known compound, a novel function in neural cells. Acta Neurobiologiae Experimentalis 56, 597ı 609.
Newton, G., Burtle, G.H., 1992. Carnitine in Food Animal Production. In, Carter, A.L. (Ed). Current Concepts in Carnitine Research. Boca Raton, F.L., CRC Press Inc., pp. 59-76.
Pepine, C . J . , 1991. The Therapeutic potential of carnitine in cardiovasculer disorders. Clinical Therapeutics 13, 2-21.
Pettegrew, J . , W, Klunk, W.E., Panchalingham, K., Kanfer, J.N., Mcclure, R . J . , 1995. Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease. Neurobiology of Aging 16 (1), 1-4.
Rauchova, H., Dobesova, Z., Drahota, Z., Zicha, J . , Kunes, J . , 1998. The effect of chronic L - carnitine treatment on blood pressure and plasma lipids in spontaneously hypertensive rats. European Journal of Pharmacology 342, 235-239.
Rebouche, C . J . , 1987. Carnitine metabolism and human nutrition. The Journal of Applied Nutrition 117, 1024-1031.
Rebouche, C.J., 1999. Carnitine. In: Shils M.E., Olson J.A., Shike M . , Ross A.C., (Eds.) Nutrition in Health and Disease. 9th ed. Baltimore: Williams and Wilkins, pp. 505-512.
Rebouche, C.J., Engel, A.G., 1980. Tissue distribution of carnitine biosynthetic enzymes in man. Biochimica et Biophysica Acta 630, 22-29.
Rebouche, C . J . , Paulson, D.J., 1986. Carnitine metabolism and function in humans. The Annual Review of Nutrition 6, 41-66.
Rodrigues, B., Xiang, H., McNeill, J.H., 1988. Effect of L-Carnitine treatment on lipid metabolism and cardiac performance in chronically diabetic rats. Diabetes 37, 1358-1364.
Sahlin, K., 1990. Muscle carnitine metabolism during incremental dynamic exercise in humans. Acta Physiologic Scandinavica 138, 259-262.
Schnackenberg, C.G., Wilcox, C., 2001. The SOD mimetic tempol restores vasodilation in affernt arterioles of experimental diabetes. Kidney International 59, 1859-1864.
Scholte, H.R., Jonge, P.C., 1987. Metabolism, Function and Transport Carnitine in Health and Disease. In: Gitzelmann, R., Baerlocher, K., Steinman, B., (Hrsg.). Carnitin in der medizin, Schattauer, Stutgart, New York, pp. 21-59.
Scholte, H.R., Pereira, R.R., De Jang, P.C., Luyt Houwen, I.E.M., Verduin, M.H.M., Ross, J.D., 1990. Primary carnitine deficiency. Journal of Clinical Chemistry and Clinical Biochemistry 28, 351-357.
Shug, A.L., Schmidt, M.J., Golden, G.T., Fariello, R.T., 1982. The distribution and role of carnitine in the mammalian brain. Life Sciences 31, 2869-2874.
Şıktar, E . , 2008. Hipertermik ve hipotermik su sıcaklıklarında yorucu yüzme egzersizi yaptırılan ratlarda L-karnitinin ve termal stresin serbest radikal ve antioksidan düzeylere etkisi. Doktora Tezi, Gazi Üniversitesi Sağlık Bilimleri Enstitüsü, Ankara.
Siliprandi, N., 1982. Carnitine as a Drug Affecting Lipid Metabolism: General Consideration. In: Paoletti, R., (Ed.), Hypolipidemic drugs; Therapeutic Selectivity and Risk/Benefit Assessment. Raven Press, New York, pp. 265ı 268.
Treem, W.R., Stanley, C.A., Finegold, D.N., Hale, D.E., Coates, P.M., 1998. Primary carnitine deficiency due to a failure of carnitine transport in kidney, muscle, and fibroblast. The New England Journal of Medicine 319, 1331-1336.
Vacha, G.M., Giorcelli, G., Siliprandi, N., Corsi, M., 1983. Favorable effects of L-carnitine treatment on hypertriglyceridemia in hemodialysis patients: decisive role of low levels of high- density lipoproteincholesterol. The American Journal of Clinical Nutrition 38, 532-540.
Vesela, E . , Racek, J . , Trefil, L . , Jankovych, V., Pojer, M., 2001. Effect of L-carnitine supplementation in hemodialysis patients. Nephron 88 (3), 218-223.
Visioli, O., Pasini, E . , de Giuli, F., Ferrari, R., 1992. Molecular Mechanism of Action of L-carnitine in Treatment of Myocardial Disorders at the Experimental Levels. In: Ferrari, R., DiMauro, S., Sherwood, G., (Eds.), L-carnitine and Its Role in Medicine: From Function to Therapy. Academic Press, London, pp. 237-263.
Wächter, S., Vogt, M., Kreis, R., Boesch, C , Bigler, P., Hoppeler, H., Krähenbühl, S., 2002. Long- term administration of L-carnitine to humans: Effect on skeletal muscle carnitine content and physical performance. Clinica Chimica Acta 318 (1-2), 51-61.
Zelnik, N., Fridkis, S., Gruener, N., 1995. Reduced carnitine and antiepileptic drugs cause relationship or co-existance. Acta Pediatrica 84, 93-95.

Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Halil Yavuz This is me

Firuze Kurtoğlu This is me

Publication Date

November 15, 2012

Submission Date

November 15, 2012

Acceptance Date

-

Published in Issue

Year 2012 Volume: 38 Number: 2

DOI

https://doi.org/10.16988/iuvfd.34399

IZ

https://izlik.org/JA23DX89UN

Cite

RIS / Bibtex

APA

Yavuz, H., & Kurtoğlu, F. (2012). Biyokimyasal Özellikleri ile L - Karnitin. İstanbul Üniversitesi Veteriner Fakültesi Dergisi, 38(2), 207-218. https://doi.org/10.16988/iuvfd.34399

AMA

1.Yavuz H, Kurtoğlu F. Biyokimyasal Özellikleri ile L - Karnitin. iuvfd. 2012;38(2):207-218. doi:10.16988/iuvfd.34399

Chicago

Yavuz, Halil, and Firuze Kurtoğlu. 2012. “Biyokimyasal Özellikleri Ile L - Karnitin”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 38 (2): 207-18. https://doi.org/10.16988/iuvfd.34399.

EndNote

Yavuz H, Kurtoğlu F (November 1, 2012) Biyokimyasal Özellikleri ile L - Karnitin. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 38 2 207–218.

IEEE

[1]H. Yavuz and F. Kurtoğlu, “Biyokimyasal Özellikleri ile L - Karnitin”, iuvfd, vol. 38, no. 2, pp. 207–218, Nov. 2012, doi: 10.16988/iuvfd.34399.

ISNAD

Yavuz, Halil - Kurtoğlu, Firuze. “Biyokimyasal Özellikleri Ile L - Karnitin”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 38/2 (November 1, 2012): 207-218. https://doi.org/10.16988/iuvfd.34399.

JAMA

1.Yavuz H, Kurtoğlu F. Biyokimyasal Özellikleri ile L - Karnitin. iuvfd. 2012;38:207–218.

MLA

Yavuz, Halil, and Firuze Kurtoğlu. “Biyokimyasal Özellikleri Ile L - Karnitin”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi, vol. 38, no. 2, Nov. 2012, pp. 207-18, doi:10.16988/iuvfd.34399.

Vancouver

1.Halil Yavuz, Firuze Kurtoğlu. Biyokimyasal Özellikleri ile L - Karnitin. iuvfd. 2012 Nov. 1;38(2):207-18. doi:10.16988/iuvfd.34399