SERUM HAPTOGLOBIN AND CERULOPLASMIN CONCENTRATIONS IN DOGS WITH VARIOUS DISEASES

Pınar Ulutaş; Bülent Ulutaş; Murat Sarıerler; Göksel Bayramlı

doi:10.16988/iuvfd.02607

SERUM HAPTOGLOBIN AND CERULOPLASMIN CONCENTRATIONS IN DOGS WITH VARIOUS DISEASES

Abstract

ABSTRACT

Acute phase proteins are plasma proteins which increase in concentration following infection, inflammation or trauma. In this study serum haptoglobin and ceruloplasmin levels were determined in dogs with various diseases in order to determine their potential value in the diagnosis and prognosis. Totally 97 dogs with various diseases and traumas, 2-7 years old, mixed breed and mixed sex were used in this study. According to the results of this study serum haptoglobin and ceruloplasmin concentrations in dogs with various diseases were changed to compare with the control group. The results of this study it seems that serum haptoglobin and ceruloplasmin levels are raised in dogs with variety of disease. As a result of this study it thought to be serum haptoglobin and ceruloplasmin levels should prove to be valuable diagnostic tool providing evidence of an inflammatory or infectious process.

Key Words: Acute phase proteins, haptoglobin, ceruloplasmin, dog.

FARKLI HASTALIKLI KÖPEKLERDE SERUM HAPTOGLOBİN VE SERULOPLAZMİN DÜZEYLERİ

ÖZET

Akut faz proteinleri infeksiyon, inflamasyon veya travmayı takiben kanda konsantrasyonları artan plazma proteinleridir. Bu çalışmada, farklı hastalıklı köpeklerde serum haptoglobin ve seruloplazmin düzeyleri, farklı hastalıklarda prognoz ve diyagnozdaki potansiyel önemlerini belirlenmek için incelenmiştir. Bu çalışmada 2-7 yaşlarında karışık ırk ve cinsiyette, farklı hastalık ve travmalı, toplam 97 köpek kullanılmıştır. Bu çalışmanın sonucunda köpeklerde çeşitli hastalıklarda serum haptoglobin ve seruloplazmin konsantrasyonlarının yükseldiği gözlenmiştir. Bu çalışmanın sonucunda serum haptoglobin ve seruloplazmin düzeylerinin bir inflamatorik ya da infeksiyoz durumun varlığında tanı amaçlı kullanılabileceği görüşüne varılmıştır.

Anahtar Kelimeler: Akut faz proteinleri, haptoglobin, seruloplazmin, köpek.

Keywords

Akut faz proteinleri, haptoglobin, seruloplazmin, köpek

References

Batchelor, J., Fuller, J., Woodman, D.D.: A simple method for measurement of the hemoglobin binding capacity of canine haptoglobin. Lab. Anim., 1989; 23, 365-369.
Caspi, D., Snel, W.J.J., Batt, R.M.: C-reactive protein in dogs. Am. J. Vet. Res., 1987; 48, 919-921.
Ceron, J.J., Eckersal, P.D., Martinez-Subiela, S.: Acute phase proteins in dogs and cats: current knowledge and future perspective. Vet. Clin. Path., 2005; 34, 85-99.
Ceron, J.J., Martinez-Subiela, S.: An outamated spectrophotometric method for measuring canine ceruloplasmin in serum. Vet. Res., 2004; 35, 671-679.
Ceron, J.J., Para, M.D., Tecles, F.: Recent advanced in methodology for acute phase measurements in dogs. In proceeding of the XI Congress of the Internationally Society of Animal Clinical Chemistry. 2004; Valdivia, Chile: 76.
Conner, J.G., Eckersall, P.D., Ferguson, J., Douglas, T.A.: Acute phase response in the dog following surgical trauma. Res. Vet. Sci., 1988; 45, 107-110
Eckersal, P.D., Duthie, S., Safi, S., Moffat, D., Horadogada, N.U., Doyle, S., Patron, R., Bennett, D., Fitzpatrick, J.L.: An automated biochemical assay for haptoglobin: prevention of interference from albumin. Comp. Haemotol. Int., 1999; 9, 117-124.
Eckersall, P.D.: Recent advances and future prospects for the use of acute phase proteins as markers of disease in animals. Revue Med. Vet., 2000; 151, 7, 577-584.

Elson, E.C.: Quantitative determination of serum haptoglobin. A simple and rapid method. Am. J. Clin. Path., 1974; 62, 655-663.
Glass, E.J., Craigmile, S.C., Sprinbett, A. :The protozoon parasite, theleria annulata induces a distinc acute phase protein response in cattle that is associated with pathology. Int. J. Pathol., 2003; 33: 1409-1418.
Gruys, E., Oblovo, M.J., Toussaint, M.J.M.: Diagnostic significance of major acute phase proteins in veterinary clinical chemistry: a review. Veterinary Bulltein, 1994; 64: 11, 1009- 1015.
Jain, N.C.: Schalm’s Veterinary Hematology. 4th ed. Lea&Febiger, 1986; Phledelphia.
Kent, J.: Acute phase proteins: Their use in veterinary diagnosis. Br. Vet. J. 1992; 148, 279 - 282.
Kjelgaard-Hansen, M., Kristensen, A.T., Jensen, A.L.: Evaluation of a commercially available enzyme-linked immunoabsorbent assay (ELISA) for the determination of for the determination of C-reactive protein in canine serum. J. Vet. Med., 2003; 50, 164-168.
Martinez-Subiela, S., Tecles, F., Eckersall, P.D., Ceron, J.J.: Serum concentaration of acute phase proteins in dogs with leismaniasis. Vet. Rec., 2002; 150, 241-244.
Martinez-Subiela, S., Tecles, F., Ceron, J.J.: Critical differences of acute phase proteins in canine serum samples. Vet. J., 2003; 166: 233-237.
McGrotty, Y.L., Knottenbelt, C.M., Ramsey, I.K., Reid, S.W., Eckersall, P.D.: Haptoglobin concentration in a canine hospital population. Vet. Rec., 2003; 152, 562-564.
Rikihisa, Y., Yamamato, S., Kwak, I.: C-reactive protein and alpha-1 acid glycoprotein levels in dogs infected with Erlichia canis. J. Clin. Microbiol., 1994; 32, 912-917.
Solter, P.F., Hoffman, W.E., Hungerford, L.L., Siegel, J.P., Denis, S.H., Dorner, J.L.: Haptoglobin and ceruloplasmin as determinants of inflammation in dogs. Am. J. Vet. Res., 1991; 52, 10: 1738-1742.
Sunderman, F.W., Nomoto, S.: Measurement of human serum ceruloplasmin by its p- phenylenediamine oxidase activity. Clin. Chem., 1970; 16, 903–910.
Ulutaş, B., Bayramlı. G., Ulutaş, P.A., Karagenç, T.: Serum concentration of some acute phase proteins in naturally ocuuring canine babesiosis: a preliminary study. Vet. Clin. Path., 2005; 34(2), 144-147.
Yamamato, S., Shida, T., Miyaji, S., Santsuka, H., Fujıse, H., Mukawa, K., Furuka, E., Nagae, T., Naiki, M.: Changes in serum C-reactive protein levels in dogs with various disorders and surgical traumas. Vet. Res. Commun., 1993; 17, 85 – 93.
Yamamato, S., Miyadi, S., Ashida, Y.: Preperation of anticanine serum amiloid A serum and purification of SAA canine high density lipoprotein. Vet. Immunol. Immunopathol., 1994; 41, 41-53.

Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Pınar Ulutaş

Bülent Ulutaş This is me

Murat Sarıerler This is me

Göksel Bayramlı This is me

Publication Date

November 26, 2012

Submission Date

November 26, 2012

Acceptance Date

-

Published in Issue

Year 2007 Volume: 33 Number: 2

DOI

https://doi.org/10.16988/iuvfd.02607

IZ

https://izlik.org/JA85JN49DP

Cite

RIS / Bibtex

APA

Ulutaş, P., Ulutaş, B., Sarıerler, M., & Bayramlı, G. (2012). SERUM HAPTOGLOBIN AND CERULOPLASMIN CONCENTRATIONS IN DOGS WITH VARIOUS DISEASES. İstanbul Üniversitesi Veteriner Fakültesi Dergisi, 33(2), 35-42. https://doi.org/10.16988/iuvfd.02607

AMA

1.Ulutaş P, Ulutaş B, Sarıerler M, Bayramlı G. SERUM HAPTOGLOBIN AND CERULOPLASMIN CONCENTRATIONS IN DOGS WITH VARIOUS DISEASES. iuvfd. 2012;33(2):35-42. doi:10.16988/iuvfd.02607

Chicago

Ulutaş, Pınar, Bülent Ulutaş, Murat Sarıerler, and Göksel Bayramlı. 2012. “SERUM HAPTOGLOBIN AND CERULOPLASMIN CONCENTRATIONS IN DOGS WITH VARIOUS DISEASES”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 33 (2): 35-42. https://doi.org/10.16988/iuvfd.02607.

EndNote

Ulutaş P, Ulutaş B, Sarıerler M, Bayramlı G (November 1, 2012) SERUM HAPTOGLOBIN AND CERULOPLASMIN CONCENTRATIONS IN DOGS WITH VARIOUS DISEASES. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 33 2 35–42.

IEEE

[1]P. Ulutaş, B. Ulutaş, M. Sarıerler, and G. Bayramlı, “SERUM HAPTOGLOBIN AND CERULOPLASMIN CONCENTRATIONS IN DOGS WITH VARIOUS DISEASES”, iuvfd, vol. 33, no. 2, pp. 35–42, Nov. 2012, doi: 10.16988/iuvfd.02607.

ISNAD

Ulutaş, Pınar - Ulutaş, Bülent - Sarıerler, Murat - Bayramlı, Göksel. “SERUM HAPTOGLOBIN AND CERULOPLASMIN CONCENTRATIONS IN DOGS WITH VARIOUS DISEASES”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 33/2 (November 1, 2012): 35-42. https://doi.org/10.16988/iuvfd.02607.

JAMA

1.Ulutaş P, Ulutaş B, Sarıerler M, Bayramlı G. SERUM HAPTOGLOBIN AND CERULOPLASMIN CONCENTRATIONS IN DOGS WITH VARIOUS DISEASES. iuvfd. 2012;33:35–42.

MLA

Ulutaş, Pınar, et al. “SERUM HAPTOGLOBIN AND CERULOPLASMIN CONCENTRATIONS IN DOGS WITH VARIOUS DISEASES”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi, vol. 33, no. 2, Nov. 2012, pp. 35-42, doi:10.16988/iuvfd.02607.

Vancouver

1.Pınar Ulutaş, Bülent Ulutaş, Murat Sarıerler, Göksel Bayramlı. SERUM HAPTOGLOBIN AND CERULOPLASMIN CONCENTRATIONS IN DOGS WITH VARIOUS DISEASES. iuvfd. 2012 Nov. 1;33(2):35-42. doi:10.16988/iuvfd.02607