Protective Effect of Melatonin on Aluminum Accumulation in Some Organs of Rats

Abstract

This study emphasizes the protective effect of melatonin against the aluminum accumulation in some organs of rats. Twenty eight male Wistar rats were divided into four groups (n=7 animals for each), one control and three experimental, and aluminum sulphate and melatonin were applied in drinking water for three months as follows: group I: aluminum sulphate (1000 ppb in water), group II: aluminum sulphate (1000 ppb in water) and melatonin (10 mg in 100 mL water) and group III: melatonin (10 mg in100 mL water). Control group: water. Aluminum was accumulated in liver, kidney, heart, spleen and brain of exposed rats in significantly higher amounts compared to the control group. The findings showed that melatonin administration reduced the aluminum level in studied organs and melatonin had a protective effect against aluminum accumulation.

Keywords

• Aluminum, organ accumulation, melatonin, rats

Sıçanlarda Melatoninin Bazı Organlarda Alüminyum Birikmesi Üzerine Koruyucu Etkisi

Abstract

Bu çalışma, sıçanların bazı organlarında alüminyum birikmesine karşı melatoninin koruyucu etkisini vurgulamaktadır. Yirmi sekiz erkek Wistar faresi biri kontrol, üçü deneysel olmak üzere dört gruba ayrılmıştır (her grupta n=7 hayvan); üç ay süreyle içme suyu içinde alüminyum sülfat ve melatonin belirtilen şekilde uygulanmıştır; grup I: alüminyum sülfat (suda 1000 ppb), grup II: alüminyum sülfat (suda 1000 ppb) ve melatonin (100 mL suda 10 mg), grup III: melatonin (100 mL suda 10 mg). Kontrol grup: su. Alüminyum uygulaması yapılan sıçanların karaciğer, böbrek, kalp, dalak ve beyinlerinde kontrol grubuna oranla anlamlı olarak daha yüksek miktarlarda alüminyum birikmiştir. Bulgular uygulanan melatoninin araştırılan organlarda alüminyum düzeylerini azalttığını ve melatoninin alüminyum birikmesine karşı koruyucu etkisinin olduğunu göstermiştir.

Keywords

• Aluminyum, organ birikimi, melatonin, sıçan

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