Comparative Study of Erythrocyte Sedimentation Rate after Aminoglycoside and Aminocyclitol Treatment in Goats (Capra hircus)

Abstract

The aim of the present study was to follow up the erythrocyte sedimentation rate (ESR) in healthy female goats during and after 5-day parenteral treatment with amikacin (10 mg/kg), tobramycin (5 mg/kg), apramycin (20 mg/kg), gentamicin (4 mg/kg), kanamycin (10 mg/kg) and spectinomycin (20 mg/kg). Gentamicin and tobramycin caused an initial increase followed by a significant decrease of ESR on the 5th day for gentamicin and the 10th day for tobramycin, respectively, followed by recovery after the treatment. Reversely, amikacin and especially spectinomycin produced an increase of ESR without recovery several days post treatment. Kanamycin caused decrease of ESR on the 5th day without recovery in the subsequent days. Only apramycin did not give rise to increasing of ESR. In conclusion the aminoglycosides, especially tobramycin and gentamicin, caused more severe alterations of ESR than the aminocyclitols.

References

1. Brion, N., Barge, J., Godefroy, I., Dromer, F., Dubois, C., Contrepois A., Carbon, C., 1984. Gentamicin, netilmicin, dibekacin, and amikacin nephrotoxicity and its relationship to tubular reabsorption in rabbits. Antimicrobial Agents and Chemotherapy 25, 168-172.
2. Dhar, H., Shah, K., Ghongane, B., Rane, S., 2013. Nephroprotective activity of crocus sativus extract against gentamicin and/or ceftazidime-induced nephrotoxicity in rats. International Journal of Pharma and Bio Sciences 4, 864-870.
3. Dinev, T., 2007. Comparative investigations on side effects, antimicrobial activity and pharmacokinetics of aminoglycosides and aminocyclitols in goats and goat´s isolated microorganisms. PhD Thesis, Trakia University, Stara Zagora, Bulgaria.
4. Dinev, T., Kanakov, D., Zapryanova, D., 2005. Investigations on some biochemical and haematological parameters after tobramycin and amikacin treatment in female goats. Trakia Journal of Sciences 3, 14-16.
5. Dowling, P., 2013. Amİnoglycosides and Aminocyclitols. In: Giguere, S. (Ed.), Antimicrobial Therapy in Veterinary Medicine, Ames, USA, pp. 233-256.
6. Hottendorf, G., Gordon, L., 1980. Comparative low-dose nephrotoxicities of gentamicin, tobramycin, and amikacin. Antimicrobial Agents and Chemotherapy 18, 176-181.
7. Lacy, M.K., Nicolau, D.P., Nightingale, C.H., Quintiliani, R., 1998. The Pharmacodynamics of Aminoglycosides. Clinical Infectious Diseases 27, 23-27.
8. Lashev, L., Lasarova, S., 2001. Pharmacokinetics and sideeffects of gentamicin in healthy and Pseudomonas aeruginosa infected sheep. Journal of Veterinary Pharmacology and Therapeutics 24, 237-240.

9. Liu, S., Ren, J., Xia, Q., Wu, X., Han, G., Ren, H., Yan, D., Wang, G., Gu, G., Li, J., 2013. Preliminary case-control study to evaluate diagnostic values of C-reactive protein and erythrocyte sedimentation rate in differentiating active Crohn’s disease from intestinal lymphoma, intestinal tuberculosis and Behcet’s syndrome. The American Journal of the Medical Sciences 346, 467-472.
10. Mumtaz, F., Khaliq, T., Rahman, Z., Javed, I., Iftikhar, A., Aslam, B., Ali, A., Ahmad, Z., 2014. Effects of Rosa damascena mill flowers, Cichorium intybus linn roots and their mixtures on serum electrolytes and hematological parameters against gentamicin induced toxicity in albino rabbits. Indo American Journal of Pharmaceutical Research 4, 236-241.
11. Novak, E., Gray, J.E., Pfeifer, R.T., 1974. Animal and human tolerance of high-dose intramuscular therapy with spectinomycin. The Journal of Infectious Diseases 130, 50-55.
12. Rankin, L.I., Luft, F.C., Yum, M.N., Isaacs, L.L., 1980. Comparative nephrotoxicities of dibekacin, amikacin, and gentamicin in a rat model. Antimicrobial Agents and Chemotherapy 18, 983-985.
13. Sayarifard, A., Javadilarijani, F., Mousavi Movahhed, S., Moghtaderi, M., Javadilarijani, F., 2015. Amikacininduced Nephrotoxicity in a Child with Idiopathic Nephrotic Syndrome in Iran: A Case Report. Journal of Pediatric Nephrology 3, 31-34.
14. Schentag, J.J., Plaut, M.E., Cerra, F.B., 1981. Comparative nephrotoxicity of gentamicin and tobramycin: pharmacokinetic and clinical studies in 201 patients. Antimicrobial Agents and Chemotherapy 19, 859-866.
15. Sumano, H., Gutierrez, L., Velazquez, C., Hayashida, S., 2005. Pharmacokinetics and renal toxicity of three once-aday doses of amikacin in cows. Acta Veterinaria Hungarica 53, 231-240.
16. Yazar, E., Elmas, M., Altunok, V., Sivrikaya, A., Oztekin, E., Birdane, Y.O., 2003. Effects of aminoglycoside antibiotics on renal antioxidants, malondialdehyde levels, and some serum biochemical parameters. The Canadian Journal of Veterinary Research 67, 239-240.