Vertebral Malformations in French Bulldogs

Abstract

The aim of this study was to detect vertebral malformations among French Bulldogs admitted between the years 2011 – 2016 due to the high popularity of the breed and the intentions to increase the breed welfare by reducing the occurrence of congenital anomalies. Besides, we aimed to look for gender predisposition, possible vertebral predisposition, occurrence of clinical symptoms and radiographic findings. A total of 73 French Bulldogs met the inclusion criteria (radiographs of the whole spine). In 67.12% (49) dogs we confirmed a vertebral anomaly and 32.88% (24) dogs were free of any vertebral anomaly. We identified a total of 67 abnormal vertebrae in 49 dogs, 13 cervical vertebrae (19.4%), 43 thoracic vertebrae (64.2%), and 11 abnormal lumbar vertebrae (16.4%). In this study, we found 44 hemivertebrae (65.7%) out of 67 abnormal vertebrae. We identified 64.4% (47/73) dogs with clinical signs (30 males, 17 females) and 36.6% (26/73) dogs without clinical signs (19 males, 7 females). Although the incidence of male dogs was higher in this study, the statistical evaluation did not confirm any predisposed gender, and we found no statistically significant predisposition for any particular abnormal vertebra.

Keywords

• Chondrodystrophy,dog,hemivertebrae,spinal cord compression,vertebral anomalies

References

1. Aikawa, T., Kanazono, S., Yoshigae, Y., Sharp, N.J.H., Muñana, K.R., 2007. Vertebral stabilization using positively threaded profile pins and polymethylmethacrylate, with or without laminectomy, for spinal canal stenosis and vertebral instability caused by congenital thoracic vertebral anomalies. Veterinary Surgery 36, 432-441.
2. Aikawa, T., Shibata, M., Asano, M., Hara, Y., Tagawa, M., Orima, H., 2014. A comparison of thoracolumbar intervertebral disc extrusion in French Bulldogs and Dachshunds and association with congenital vertebral anomalies. Veterinary Surgery 43, 301-307.
3. Bailey, C.S., Morgan, J.P., 1992. Congenital spinal malformations. Veterinary Clinics of North America: Small Animal Practice 22, 985-1015.
4. Bellumori, T.P., Famula, T.R., Bannasch, D.L., Belanger, J.M., Oberbauer, A.M., 2013. Prevalence of inherited disorders among mixed-breed and purebred dogs: 27, 254 cases (1995–2010). Journal of American Veterinary Medical Association 242, 1549-1555.
5. Berlanda, M., Zotti, A., Brandazza, G., Poser, H., Calò, P., Bernardini, M., 2011. Magnetic resonance and computed tomographic features of 4 cases of canine congenital thoracic vertebral anomalies. Canadian Veterinary Journal 52, 1334-1338.
6. Carvallo, F.R., Domínguez, A.S., Morales, P.C., 2010. Bilateral ectrodactyly and spinal deformation in a mixed-breed dog. Canadian Veterinary Journal 51, 47-49.
7. Charalambous, M., Jeffery, N.D., Smith, P.M., Goncalves, R., Barker, A., Hayes, G., Ives, E., Vanhaesebrouck, A.E., 2014. Surgical treatment of dorsal hemivertebrae associated with kyphosis by spinal segmental stabilisation, with or without decompression. The Veterinary Journal 202, 267-273.
8. Gough, A., Thomas, A., 2011. Breed Predispositions to Disease in Dogs and Cats. 2nd ed., Chicago, Wiley-Blackwell Press, p. 352.

9. De Decker, S., De Risio, L., Lowrie, M., Mauler, D., Beltran, E., Giedja, A., Kenny, P.J., Gielen, I., Garosi, L., Volk, H., 2012. Cervical vertebral stenosis associated with a vertebral arch anomaly in the Basset Hound. Journal of Veterinary Internal Medicine 26, 1374-1382.
10. Dennis, R., Kirberger, R.M., Barr, F., Wrigley, R.H., 2010. Handbook of Small Animal Radiology and Ultrasound: Techniques and Differential Diagnoses, 2nd ed., London, WB Saunders, p. 370.
11. Falzone, Ch., 2011. Lumbosacral Spine: Surgical Decision Making, In: Baines, S., Proceedings – Small Animals, 20th Annual Scientific Meeting, Ghent, Belgium, pp. 140-141.
12. Grenn, H.H., Lindo, D.E., 1969. Hemivertebrae with severe kypho-scoliosis and accompanying deformities in a dog. The Canadian Veterinary Journal 10, 214-216.
13. Guevar, J., Penderis, J., Faller, K., Yeamans, C., Stalin, C., Gutierrez-Quintana, R., 2014. Computer-assisted radiographic calculation of spinal curvature in brachycephalic “screw-tailed” dog breeds with congenital thoracic vertebral malformations: Reliability and clinical evaluation. Plos One, 9, e106957.
14. Gutierrez‐Quintana, R., Guevar, J., Stalin, C., Faller, K., Yeamans, C., Penderis, J., 2014. A proposed radiographic classification scheme for congenital thoracic vertebral malformations in brachycephalic “screw‐tailed” dog breeds. Veterinary Radiology and Ultrasound 55, 585-591.
15. Hopkins, N., 2015. Pedigree dog welfare: whose responsibility? Veterinary Nursing Journal 30, 108-110.
16. Jeffery, N.D., Smith, P.M., Talbot, C.E., 2007. Imaging findings and surgical treatment of hemivertebrae in three dogs. Journal of American Veterinary Medical Association 230, 532-536.
17. McDonald, J. H., 2008. Handbook of Biological Statistics. Baltimore, Sparky House Publishing, pp. 313. Moissonnier, P., Gossot, P., Scotti, S., 2011. Thoracic kyphosis associated with hemivertebra. Veterinary Surgery 40, 1029-1032.
18. Morris, A., 2009. Animal Welfare: whose responsibility? Veterinary Record 164, 705-707.
19. Olby, N., Thrall, D.E., 2004. Neuroradiology. In: Platt S. R., Olby N, (Eds.) BSAVA Manual of Canine and Feline Neurology. 3rd ed., Chicago, Wiley-Blackwell Press, pp. 70-83.
20. Schlensker, E., Distl, O., 2013. Prevalence, grading and genetics of hemivertebrae in dogs. European Journal of Companion Animal Practice 23, 119-123.
21. Schlensker, E., Distl, O., 2016. Heritability of hemivertebrae in the French bulldog using an animal threshold model. Veterinary Journal 207, 188-189.
22. Thompson, P.C., Wilson, B.J., Wade, C.M., Shariflou, M.R., James, J.W., Tammen, I., Raadsma, H.W., Nicholas, F.W., 2010. The utility of estimated breeding values for inherited disorders of dogs. Veterinary Journal 183, 243-244.
23. Walker, M.A., 2002. The Vertebrae - Canine and Feline. In: Thrall, D. E. (Ed.), Textbook of Veterinary Diagnostic Radiology. 4th ed., Philadelphia, W.B. Saunders Company, pp. 98-109.
24. Westworth, D.R., Sturges, B.K., 2010. Congenital spinal malformations in small animals. Veterinary Clinics of North America Small Animal Practice 40, 951-981.