Radiological and Ultrasound Imaging Scores in Experimental Sodium Monoiodoacetate Model of Knee Osteoarthritis in Dogs

Year 2013, Volume: 39 Issue: 1, 67 - 75, 16.11.2012

Nikolay Goranov Mihail Paskalev Dian Kanakov

Abstract

ABSTRACT

Experimental osteoarthritis was induced in six adult dogs by intraarticular injection of sodium monoiodoacetate in left knee joints. The contralateral knees served as control. The changes occurring in joints were followed out by radiography and ultrasound imaging in the beginning (day 0), and on post injection days 30, 60, and 105. Two assessment systems were used to generate individual scores for each time interval. The results evidenced dynamic and consistently increased scores for left joints in both diagnostic imaging techniques used with statistically significant differences between left and right joints. Radiological and ultrasound scores were closely correlated (r=0.55, P<0.001) suggesting that the combined use of both imaging techniques was more advantageous for diagnostics of osteoarthritis.

Key Words: Dogs, knee joint, sodium monoiodoacetate model, radiography, ultrasonography, osteoarthritis

 

 ÖZET

KÖPEKLERDE DİZ OSTEOARTRİTİNİN DENEYSEL SODYUM MONOİYODOASETAT MODELİ İLE RADYOLOJİK VE ULTRASONOGRAFİK GÖRÜNTÜLEME SKORLARI

 

Çalışmada, sodyum monoiyodoasetatın altı adet yetişkin köpeğin sol diz eklemine intraartiküler enjeksiyonu ile deneysel osteoartrit oluşturuldu. Kontralateral dizler kontrol olarak ayrıldı. Başlangıçta (gün 0) ve enjeksiyonu takip eden 30., 60. ve 105. günlerde radyografi ve ultrasonografik görüntülemelerle eklemlerde meydana gelen değişiklikler incelendi. Bireysel skorlar elde edilmesinde her bir zaman aralığı için iki değerlendirme sistemi kullanıldı. Kullanılan her iki diagnostik görüntüleme tekniklerinde istatistiksel olarak sağ ve sol eklemlerde önemli farklılıkların olduğu ve sonuçlar sol eklemlerdeki skorun istikrarlı bir şekilde artış gösterdiği ortaya çıkardı. Radyolojik ve ultrasonografik skorlarının korelasyon (r=0,55; P<0,001) sonuçlarına göre görüntüleme tekniklerinin birlikte kullanılmasının osteoartrit tanısı için daha avantajlı olduğunu saptanmıştır.

Anahtar Kelimeler: Köpek, diz eklemi, sodyum monoiyodoasetat modeli, radyografi, ultrasonografi, osteoartirit

 

Keywords

Köpek, diz eklemi, sodyum monoiyodoasetat modeli, radyografi, ultrasonografi, osteoartirit

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