RUMİNANTLARDA SÜT PROTEİNLERİ VE POLİMORFİZMİ

Year 2008, Volume: 34 Issue: 3, 29 - 35, 21.11.2012

Hasret Yardibi

Abstract

ÖZET

Mendel kanunlarına göre, sığırlarda dominant olmayan otosomal genler tarafından  kontrol edilen 6 büyük süt proteini fraksiyonu, farklı allel formlarında mevcuttur; αs1 kazein, αs2 kazein, β kazein, κ kazein, α-LA, β-LG. Sığırlarda süt protein genlerini içeren DNA bölgelerinde polimorfizm belirlenmiştir. Bu derlemeyle,  ruminantlarda süt verimi ve kalitesi gibi ekonomik verim özelliklerine etki eden süt protein genleri hakkında araştırıcılara bilgi verilmesi amaçlanmıştır.

Anahtar Kelimeler: Sığır, süt proteinleri, polimorfizm.

 

MILK PROTEINS AND POLYMORPHISM ON RUMINANTS

ABSTRACT

According to Mendels Laws, genetic variations of major six milk proteins in ruminants were identified;αs1 casein, αs2 casein, β casein, κ casein, α-lactalbumin, β-lactoglobulin. Polymorphisms were detected in the DNA region containing milk protein genes in ruminants. In this review, it is aimed to determine the milk protein genes which effect the milk production traits and milk quality.

 

Key words: Cattle, milk proteins,polymorphism.

Keywords

Sığır, süt proteinleri, polimorfizm

References

• Aschaffenburg,R., Drewy,J.: Occurrence of different beta lactoglobulins in cow's milk. Nature, 1955; 176: 218-219.
• Bylund G.: Dairy Processing Handbook 2n d Ed., 2003; 440. Tetrapak, Sweden.
• Ceriott G., Chessa S., Bolla P., Budelli E., Bianchi L., Duranti E., Caroli A.: Single Nucleotide Polymorphisms in the Ovine Casein Genes Detected by Polymerase Chain reaction-single Strand Conformation Polymorphism. J. Dairy Sci., 2004; 87 (8): 2606-2613.
• Chianese L., Garro G., Addeo F., Lopez G., Ramos M. :Discovery of an ovine a-S2 casein variat. J. Dairy Research, 1993; 60: 485-493.
• Doğan, M.,Kaygısız, A.: Türkiye'deki İsviçre Esmer Sığırlarda Süt Protein polimorfizmi ile Süt Verim Özellikleri Arasındaki İlişkiler. Tr.J.of Veterinary and Animal Sciences, 1999; 23ı 1: 47-49.
• Ehrmann, S., Bartenschlager, H., Geldermann, H.: Polymorhism in the 5' flanking region of the bovine lactoglobulin-encoding gene and its association with beta lactoglobulin in the milk. Fachgebiet Tierzüchtung, Institut für Tierhaltung, Universitat Hohenheim, Stuttgart, 1997.
• Erhardt, G., Juszczak, J., Panicke, L., Krick-Saleck, H.: Genetic polymorphism of milk proteins in polish red cattle: a new genetic variant of beta lactoglobulin. J.Anim.Breed.Gen, 1997; 115: 63- 71.
• Erhardt, G.: Evidence for a third allele at the beta lactoglobulin locus of sheep milk and its occurence in different breeds. Animal Genetics, 1989; 20: 197-204.
• Folch, J.M., Coll, A., Hayes, H.C., Sanchez, A.: Charecterization of a caprine beta lactoglobulin pseudogene identification and chromosomal location by in stu hybridisation in goat, shep and cow. Gene , 1996; 177: 87-91.
• Folch, J.M., Dova, M., Medrano, J.F.: Differential expression of bovine beta lactoglobuln A and B promoter variants in transiently transfected HC 11 cells. J. Dairy Research, 1999; 66: 537-544.
• Ford, C.A., Connett, M.B., Wilkins, R.J.: Beta lactoglobulin expression in bovine mammary tissue. Proceed New Zeland Soc. Anim. Produc, 1993; 53: 167-169.
• Geldermann, H., Gogol, J . , Kock, M., Tacea, G.: DNA variants within the 5' flanking region of bovine milk protein encoding genes. Fachgebiet Tierzüchtung, Institut für Tierhaltung, Universitat Hohenheim, Stuttgart,1996.
• Ginger M.R., Grigor M.R.: Comparative aspects of milk caseins. Comp.Biochem.Phys.B., 1999; 124: 133-145.
• Godavac, Z., Conti, A., Liberatori, J., Braunitzer, G.: The amino acide sequence of beta lactoglobulin I I from horse colostrum; beta lactoglobulins are retinol binding proteins. Biolog Chem, 1985; 366: 601-608.
• Gustafsson, V., Lunden, A.: Strong linkage disequilibrium between polymorphisms in the 5' flanking region and the coding part of the bovine ß-lactoglobulin gene. Department of Animal Breeding and Genetics, Sweedish University of Agricultural Sciences, Uppsala, Sweeden, 2003.
• Haenlein G.F., Gonyon, Mather., R.E., Hines H.C.: Association of Bovine Blood and Milk Polymorphism with Lactation Traits:Guernsey. J.Dairy Sci., 1987; 70: 2599- 2609.
• Hill, J.P.: The relationship between beta lactoglobulin phenotypes and milk composition in new Zeleand dairy cattle. J. Dairy Sci, 1993; 76: 281- 286.
• Mele M., Conte G., Serra A., Buccioni A., Seccshiari P.: Relationship between beta- lactoglobulin polymorphism and milk fatty acid composition in milk of Massese dairy ewes. Small Ruminant Research., 2007; 73 (1-3): 37-44.
• Mercier J.C., Violette J.L.: Structure and function of milk protein genes. J. Dairy Sci., 1993; 76: 3079-3098.
• Mioli, B., Pilla, F., Tripaldi, C.: Detection of milk protein genetic polymorphisms in order to improve dairy traits in sheep ad goats: a review. Small Ruminant Research, 1998; 27: 185-195.
• Mitra, A., Sashikanth., Yadav, B.R.: Alpha lactalbumin polymorphism in three breeds of Indian zebu cattle. J.anim.Breed.Gen., 1998; 115: 403-405.
• N.G., Hanh K.F., Kim, S.: Differents amount of beta lactoglobulin A and B in milk from heterozygous AB cows. International Dairy J., 1996; 6: 689- 695.
• Özbeyaz C., Bayraktar M., Alpan O., Akcan A.: Jerseylerde süt protein polimorfizmi ve ilk laktasyon süt verimiyle İlişkisi. Lalahan Hayvancılık araştırma Enstitüsü Dergisi, 1991; 31: 27-33.
• Passey, R.J., Mackinlay, A.G.: Characterizaton of a second apparently inactive, copy of the bovine beta lactoglobulin. European J. Biochem., 1995; 233: 736-743.
• Perez, M.D., Sanchez, L., Aranda, P., Ena, J . , Oria, D., Calvo, M.: Effect of beta lactoglobulin on the activity of pregastric lipase. Apossible role fort his protein in ruminant . Biochim.Biophys.Acta., 1992; 1123: 151-155.
• Prosser, C.G., Turner, S.A., McLareen, R.D., Langley, B., Huillier, P.J., Molan, P., Auldist, M.: Milk whey protein concentration and mRNA associated with beta lactoglobulin phenotype . J. Dairy Research, 2000; 67: 287-293.
• Trujillo,A.J., Jordana, J., Guamis, B., Serradilla., J.M., Amills, M.: El polimorfismo del gen dela caseina a-S1 caprina y su efecto sobre la produccio'n, la composicio'n y las
• Ruminantlarda Silt Proteinleri ve Polimorfizmi
• propiedades tecnolo'gicas de la leche y sobre la fabricacio'n y la maduracio'n del queso.
• Food.Sci.Tech.Int., 1998; 4: 217-235.
• Violette J.L., Soulier S., Printz C., Mercier J.C.: Sequence of the goat alfa-lactalbumin encoding gene: Comparision with the bovine gene and evidence of related sequences in the goat genome. Gene, 1991; 98: 271-276.
• Wagner V.A., Schild T.A., Gelderman H.: DNA variants within 5' flanking region of milk-protein-encoding genes.II.The P-Lactoglobulin-encoding gene. Theor. Appl. Genet., 1994; 89: 121-126.