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Morphological and Functional Changes in Rat Brain under Total Sleep Deprivation

Year 2015, Volume: 41 Issue: 2, 138 - 142, 01.07.2015

Babak Abushov Atilla Temur , Mehmet Ali Temiz

Abstract

In this article the effect of 36 h total sleep deprivation (TSD) on behavioural reactions of rats (rearing, grooming and sexual activity) and on ultrastructure of brain neurons have been studied. A group of somnogenic structures (III-V layers of the frontal limbic cortex, CA1 area of the dorsal hippocampus, reticular formation of pons varolli, nucleus raphe dorsalis and locus coeruleus) of the brain of 6 month-old Wistar rats has been analized in this study. It has been revealed that dystrophic changes (chromatolysis of cytoplasm and vacuolization) enveloping a group of medium-sized neurons (20-30 (μ) micron in diameter) are accompanied by decrease of numbers of rearing, grooming and sexual activity. It is supposed that dystrophic changes revealed in medium-sized neurons result in partial disturbances of integrative and behavioral reactions of animals.

Keywords

Total sleep deprivation neurons behavioral reactions

References

  • Abusov, B.M., 1984. Neyroni i Mejneyronalnie Svyazi Lateralnoy Gipotalamiceskoy Oblasti Mozga Kris Pri Pisevoy Deprivasii i Posle Yeyo Otmeni (in Rus). Dissertasii kandidata biologicheskix nauk. Moskva, pp. 221-230.
  • Abusov, B.M., 2011. Vliyanie deprivasii paradoksalnogo sna na neyronov ultrastrukturu povedenceskie reaksii kris. Annali Eksperimentalnoy i Kliniceskoy Nevrologii (in Rus) 5, 29-33. mozga i
  • Adrianov, O.S., 1995. Organizovanniy mozg (Ocerk o prinsipax konstruksii i funksionalnoy organizasii mozga. sооbs. I). Uspexi Fiziologicheskix Nauk (in Rus) 26, 25-45.
  • Ancoli-Israel, S., Bliwise, D.L., Norgaard, J.P., 2012. The effect of nocturia on sleep. Sleep Medicine Reviews 15, 91- 97.
  • Babayeva, A.G., 2009. Reqenerasiya: Fakti i Perspektiva (in Rus). Moskva: Izdatelstvo RAMN, pp. 336-341.
  • Chowdhury, A., Chandra, R., Sushil, K., Jha, S.K., 2011. Total sleep deprivation impairs the encoding of trace- conditioned memory in the rat. Neurobiology Learning and Memory 95, 355-360.
  • Eliava, M.I., Aristakesyan, E.A., 1998. Effekti sesticasovoy totalnoydeprivasii sna na tsikl bodrstvovanie-son kris v raznie sroki ontoqeneza (in Rus). Jurnal Evolyusionnoy Bioximii I Fiziologii 34, 202-211.
  • Elmenhorst, D., Basheer, R., McCarley, R.W., Bauer, A., 2009. Sleep deprivation increases A1 adenosine reseptor density in the rat brain. Brain Research 1258, 53-58.
  • Frumkina, L.Y., Bogolepov, N.N., Xaspekov, L.G., 2012. Ultrastrukturnie Osobennosti Patologiceskix Izmeneniy Neyronov Golovnogo Mozga in vitro i in vivo. Funksionalnaya Plasticnost Mozga. pp. 407-410. Asimmetriya i
  • Lakin, G.F., 1980. Biometriya (in Rus). Moskva: Vissaya skola, pp. 293-302.
  • Levin, Y.I., 2011. Neyrofizioloqiceskie. neyroximiceskie. vegetativnie i xronobiologiceskie ocnovi medisini sna. Rossiyskiy Fiziologi.eskiy Jurnal imeni I.M.Secenova 97, 388-402.
  • Lopez, N., Previc, F.H., Fischer, J., Heitz, R.P., Randall, W., Engle, R.W., 2012. Effects of sleep deprivation on cognitive performance by United States Air Force pilots. Journal of Applied Research in Memory and Cognition 1, 27-33.
  • Romanov, A.I., Resetnyak, B.K., 2003. Сон и его нарушения (in Rus). Мoskva: Firma “Slovo”, pp. 271-275.
  • Sarkisov, D.S., 1987. Strukturniye Osnovi Adaptasii i Kompensasii Narusennix Funksiy (in Rus). Мoskva: Меdisina, pp. 446-456.
  • Sarris, J., Byrne, G.J., 2011. A systematic review of insomnia and complementary medicine. Sleep Medicine Reviews 15, 99-106.
  • Semcenko, V.V., Stepanov, S.S., Bogolepov, N.N., 2008. Plasticnost Sinapsov Golovnogo Mozga (in Rus). Omsk: Omskaya oblastnaya tipoqrafiya, pp. 404-409.
  • Sunsova, N.B., Dyorgachova, O.Y., 2003. Rol medialnoy preopticheskoy oblasti gipotalamusa v organizasii paradoksalnoy fazi sna. Jurnal Visshiy nervnoy deyatelnosti (in Rus) 53, 62-69.
  • Veyn, A.M., Xext, K., 1989. Son Cheloveka. Fiziologiya i patologiya (in Rus). Мoskva: Меdisina, pp. 272-275.
  • Vgontzas, A.N., Pejovic, S., Karataraki, M., 2007. Sleep, Sleep Disorders and Stress. Encyclopedia of Stress. N.Y. Elsevier Inc., pp. 506-514.
  • Weakley, B., 1972. A Beginner’s Handbook in Biological Electron Microskopy. Edinburg and London, pp. 320- 322.

Total Uyku Yokluğunda Sıçanların Beyinlerinde Meydana Gelen Morfolojik ve Fonksiyonal Değişiklikler

Year 2015, Volume: 41 Issue: 2, 138 - 142, 01.07.2015

Babak Abushov Atilla Temur , Mehmet Ali Temiz

Abstract

Bu makalede, 36 saatlik Total Uyku Yokluğunun (TUY) sıçanların, davranış reaksiyonlarına (etrafa dikkat kesilmeleri, kendilerini kaşımaları ve cinsel aktiviteleri) ve beyin nöronlarının yapısına olan etkisi araştırıldı. Bir grup orta büyüklükteki nöronlarda (20-30 μ) meydana gelen distrofik değişikliklerin (sitoplazmalarının kromatilizi ve vakuolizisi), sıçanların etrafa dikkat kesilmeleri, kendilerini kaşımaları ve cinsel faaliyetlerin yavaşlamasına neden olduğunu göstermiştir. Hayvanların interaktif proseslerinin ve davranış reaksiyonlarının bozulmasının da, orta çaptaki nöronlarda meydana gelen distrofik değişikliklerden kaynaklandığı düşünülmektedir.

Keywords

Toplam uyku yoksunluğu nöronlar davranış reaksiyonları

References

  • Abusov, B.M., 1984. Neyroni i Mejneyronalnie Svyazi Lateralnoy Gipotalamiceskoy Oblasti Mozga Kris Pri Pisevoy Deprivasii i Posle Yeyo Otmeni (in Rus). Dissertasii kandidata biologicheskix nauk. Moskva, pp. 221-230.
  • Abusov, B.M., 2011. Vliyanie deprivasii paradoksalnogo sna na neyronov ultrastrukturu povedenceskie reaksii kris. Annali Eksperimentalnoy i Kliniceskoy Nevrologii (in Rus) 5, 29-33. mozga i
  • Adrianov, O.S., 1995. Organizovanniy mozg (Ocerk o prinsipax konstruksii i funksionalnoy organizasii mozga. sооbs. I). Uspexi Fiziologicheskix Nauk (in Rus) 26, 25-45.
  • Ancoli-Israel, S., Bliwise, D.L., Norgaard, J.P., 2012. The effect of nocturia on sleep. Sleep Medicine Reviews 15, 91- 97.
  • Babayeva, A.G., 2009. Reqenerasiya: Fakti i Perspektiva (in Rus). Moskva: Izdatelstvo RAMN, pp. 336-341.
  • Chowdhury, A., Chandra, R., Sushil, K., Jha, S.K., 2011. Total sleep deprivation impairs the encoding of trace- conditioned memory in the rat. Neurobiology Learning and Memory 95, 355-360.
  • Eliava, M.I., Aristakesyan, E.A., 1998. Effekti sesticasovoy totalnoydeprivasii sna na tsikl bodrstvovanie-son kris v raznie sroki ontoqeneza (in Rus). Jurnal Evolyusionnoy Bioximii I Fiziologii 34, 202-211.
  • Elmenhorst, D., Basheer, R., McCarley, R.W., Bauer, A., 2009. Sleep deprivation increases A1 adenosine reseptor density in the rat brain. Brain Research 1258, 53-58.
  • Frumkina, L.Y., Bogolepov, N.N., Xaspekov, L.G., 2012. Ultrastrukturnie Osobennosti Patologiceskix Izmeneniy Neyronov Golovnogo Mozga in vitro i in vivo. Funksionalnaya Plasticnost Mozga. pp. 407-410. Asimmetriya i
  • Lakin, G.F., 1980. Biometriya (in Rus). Moskva: Vissaya skola, pp. 293-302.
  • Levin, Y.I., 2011. Neyrofizioloqiceskie. neyroximiceskie. vegetativnie i xronobiologiceskie ocnovi medisini sna. Rossiyskiy Fiziologi.eskiy Jurnal imeni I.M.Secenova 97, 388-402.
  • Lopez, N., Previc, F.H., Fischer, J., Heitz, R.P., Randall, W., Engle, R.W., 2012. Effects of sleep deprivation on cognitive performance by United States Air Force pilots. Journal of Applied Research in Memory and Cognition 1, 27-33.
  • Romanov, A.I., Resetnyak, B.K., 2003. Сон и его нарушения (in Rus). Мoskva: Firma “Slovo”, pp. 271-275.
  • Sarkisov, D.S., 1987. Strukturniye Osnovi Adaptasii i Kompensasii Narusennix Funksiy (in Rus). Мoskva: Меdisina, pp. 446-456.
  • Sarris, J., Byrne, G.J., 2011. A systematic review of insomnia and complementary medicine. Sleep Medicine Reviews 15, 99-106.
  • Semcenko, V.V., Stepanov, S.S., Bogolepov, N.N., 2008. Plasticnost Sinapsov Golovnogo Mozga (in Rus). Omsk: Omskaya oblastnaya tipoqrafiya, pp. 404-409.
  • Sunsova, N.B., Dyorgachova, O.Y., 2003. Rol medialnoy preopticheskoy oblasti gipotalamusa v organizasii paradoksalnoy fazi sna. Jurnal Visshiy nervnoy deyatelnosti (in Rus) 53, 62-69.
  • Veyn, A.M., Xext, K., 1989. Son Cheloveka. Fiziologiya i patologiya (in Rus). Мoskva: Меdisina, pp. 272-275.
  • Vgontzas, A.N., Pejovic, S., Karataraki, M., 2007. Sleep, Sleep Disorders and Stress. Encyclopedia of Stress. N.Y. Elsevier Inc., pp. 506-514.
  • Weakley, B., 1972. A Beginner’s Handbook in Biological Electron Microskopy. Edinburg and London, pp. 320- 322.
There are 20 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Babak Abushov This is me

Atilla Temur

Mehmet Ali Temiz This is me

Publication Date July 1, 2015
Published in Issue Year 2015 Volume: 41 Issue: 2

Cite

APA Abushov, B., Temur, A., & Temiz, M. A. (2015). Morphological and Functional Changes in Rat Brain under Total Sleep Deprivation. İstanbul Üniversitesi Veteriner Fakültesi Dergisi, 41(2), 138-142. https://doi.org/10.16988/iuvfd.2015.45988
AMA Abushov B, Temur A, Temiz MA. Morphological and Functional Changes in Rat Brain under Total Sleep Deprivation. iuvfd. August 2015;41(2):138-142. doi:10.16988/iuvfd.2015.45988
Chicago Abushov, Babak, Atilla Temur, and Mehmet Ali Temiz. “Morphological and Functional Changes in Rat Brain under Total Sleep Deprivation”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 41, no. 2 (August 2015): 138-42. https://doi.org/10.16988/iuvfd.2015.45988.
EndNote Abushov B, Temur A, Temiz MA (August 1, 2015) Morphological and Functional Changes in Rat Brain under Total Sleep Deprivation. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 41 2 138–142.
IEEE B. Abushov, A. Temur, and M. A. Temiz, “Morphological and Functional Changes in Rat Brain under Total Sleep Deprivation”, iuvfd, vol. 41, no. 2, pp. 138–142, 2015, doi: 10.16988/iuvfd.2015.45988.
ISNAD Abushov, Babak et al. “Morphological and Functional Changes in Rat Brain under Total Sleep Deprivation”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 41/2 (August 2015), 138-142. https://doi.org/10.16988/iuvfd.2015.45988.
JAMA Abushov B, Temur A, Temiz MA. Morphological and Functional Changes in Rat Brain under Total Sleep Deprivation. iuvfd. 2015;41:138–142.
MLA Abushov, Babak et al. “Morphological and Functional Changes in Rat Brain under Total Sleep Deprivation”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi, vol. 41, no. 2, 2015, pp. 138-42, doi:10.16988/iuvfd.2015.45988.
Vancouver Abushov B, Temur A, Temiz MA. Morphological and Functional Changes in Rat Brain under Total Sleep Deprivation. iuvfd. 2015;41(2):138-42.