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Ovine Theileriosis Enhances Cardiovascular Disease Biomarkers in Naturally Infected Sheep (Ghezel breed) in West Azerbaijan, Iran

Year 2017, Volume: 43 Issue: 1, 61 - 66, 01.01.2017
https://doi.org/10.16988/iuvfd.268662

Abstract

    This study was aimed to evaluate the plasma levels of cardiovascular disease biomarkers in naturally infected theileriosis in sheep (Ghezel breed). Theileria species are known to be ruminant blood parasites and involves deleterious effects in the livestock. Blood samples were collected from 30 selected sheep (Ghezel breed), naturally infected with theileriosis (infected group) and same number non-infected ones. Hematological parameters and the plasma concentrations of cardiac troponin I (cTnI), creatine kinase-MB (CK-MB) and homocysteine (Hcy) were determined in all samples. The results revealed that significant increase (P>0.01) in the level of cTnI, CK-MB, and Hcy concentrations in infected sheep compared with non-infected ones. In addition, cardiovascular biomarkers levels increased with aging and parasitemia rate (P<0.01). In conclusion, theileriosis provides evidence of the progression of cardiovascular biomarkers by aging and following elevation of parasitemia rate in Ghezel breed sheep and seems that further attention should be paid on this issue.

References

  • Andrade, Z.A., Andrade, S.G., Correa, R., Sadiqursky, M., Ferrans, V.J., 1994. Myocardial changes in acute Trypanosoma cruzi infection. American Journal of Pathology 144, 1403-1410.
  • Boswood, A., 2009. Biomarkers in cardiovascular disease: Beyond natriuretic peptides. Journal of Veterinary Cardiology 11, 23-32.
  • Chango, A., Abdennebi-Najar, L., 2011. Folate metabolism pathway and Plasmodium falciparum malaria infection in pregnancy. Nutrition Reviews 69, 34-40.
  • Chillemi, R., Zappacosta, B., Simporè, J., Persichilli, S., Musumeci, M., Musumeci, S., 2004. Hyperhomocysteinemia in acute Plasmodium falciparum malaria: an effect of host-parasite interaction. Clinica Chimica Acta 348, 113-120.
  • Col, R., Uslu, U., 2007. Changes in selected serum components in cattle naturally infected with Theileria annulata. Bulletin of the Veterinary Institute in Pulawy 51, 15-18.
  • Diana, A., Guglielmini, C., Candini, D., Pietra, M., Cipone, M., 2007. Cardiac arrhythmias associated with piroplasmosis in the horse: A case report. Veterinary Journal 174, 193-195.
  • Diniz, P.P.V.P., Morais, H.S.A., Breitschwerdt, E.B., Schwartz, D.S., 2008. Serum cardiac troponin I concentration in dogs with ehrlichiosis. Journal of Veterinary Internal Medicine 22, 1136-1143.
  • Fartashvand, M., Nadalian, M.G., Sakha, M., Safi, S., 2013. Elevated Serum Cardiac Troponin I in Cattle with Theileriosis. Journal of Veterinary Internal Medicine 27, 194-199.
  • Ganguly, P., Alam, S.F., 2015. Role of homocysteine in the development of cardiovascular disease. Nutrition Journal 14, 6.
  • Ghanem, M.M., Omnia, M.A., Balir, M.A.N., 2013. Clinico-biochemical, serological and molecular study on tropical Theileriosis in Egyptian water buffaloes (Bubalus bubalis). Alexandria Journal of Veterinary Sciences, 39, 1-11.
  • Hamacher, L., Dorfelt, R., Muller, M., Wess, G., 2015. Serum Cardiac Troponin I Concentrations in Dogs with Systemic Inflammatory Response Syndrome. Journal of Veterinary Internal Medicine 29, 164-170.
  • Hashemi-Fesharki, R., 1988. Control of Theileria annulata in Iran. Parasitology Today 4, 36-40.
  • Hervas, J., Carrasco, L., Gomkl-Viliamandofs, J.C., De Lara, F.C., Sierra, M.A., 1998. Myocarditis associated with Theileria spp. in calves. Journal of Veterinary Medicine B 45, 401-405.
  • Jacobsen, D.W., 2000. Hyperhomocysteinemia and Oxidative Stress Time for a Reality Check? Arteriosclerosis Thrombosis Vascular Biology 20, 1182-1184.
  • Khaki, Z., Jalali, S.M., Kazemi, B., Jalali, M.R., Yasini, S.P., 2015. A study of hematological changes in sheep naturally infected with Anaplasma spp. and Theileria ovis: Molecular diagnosis. Iranian Journal of Veterinary Medicine 9, 19-26.
  • Kinnaird, J.H., Weir, W., Durrani, Z., Pillai, S.S., Baird, M., Shiels, B.R., 2013. A Bovine Lymphosarcoma Cell Line Infected with Theileria annulata Exhibits an Irreversible Reconfiguration of Host Cell Gene Expression. PLoS One 8, e66833.
  • Lai, W.K.C., Kan, M.Y., 2015. Homocysteine-Induced Endothelial Dysfunction. Annals of Nutrition and Metabolism 67, 1-12.
  • Leonardi, F., Passeri, B., Fusari, A., De Razza, P., Beghi, C., Lorusso, R., 2008. Cardiac Troponin I (cTnI) concentration in an ovine model of myocardial ischemia. Research in Veterinary Science 85, 141-144.
  • Lobetti, R., Dvir, E., Pearson, J., 2002. Cardiac troponins in canine babesiosis. Journal of Veterinary Internal Medicine 16, 63-68.
  • Lobetti, R.G., 2005. Cardiac involvement in canine babesiosis. Journal of South African Veterinary Association 76, 4-8.
  • Mehta, H.K., Sisodia, R.S., Misraula, R.S., 1988. Clinical and haematological observations in experimentally induced cases of bovine theileriosis. Indian Journal of Animal Science 58, 584-587.
  • Miranda, R.C., Machado, M., Takakura, I.T., DaMata, P.F., DaFonseca, C.G., Mouco, O.M., Hernandes, M.E., Lemos, M.A., Maia, L.N., 2006. Elevated troponin levels after prolonged supraventricular tachycardia in patient with normal coronary angiography. Cardiology 106, 10-13.
  • Modi, D.V., Bhadesiya, C.M., Mandali, G.C., 2015. Hematobiochemical changes in crossbred cattle infected with Theileria annulata in Banaskantha district of Gujarat. International Journal of Scientific and Research Publication. 5, 1-4.
  • Nazifi, S., Razavi, S.M., Safi, N., Rakhshandehroo, E., 2012. Malignant Ovine Theileriosis: Alterations in the Levels of Homocysteine, Thyroid Hormones and Serum Trace Elements. Journal of Bacteriology and Parasitology 3, 1-4.
  • O’Brien, P.J., Smith, D.E.C., Knechtel, T.J., Marchak, M.A., Pruimboom-Brees, I., Brees, D.J., 2006. Cardiac troponin I is a sensitive, specific biomarker of cardiac injury in laboratory animals. Laboratory Animal 40, 153-571.
  • O'Brien, P.J., 2008. Cardiac troponin is the most effective translational safety biomarker for myocardial injury in cardiotoxicity. Toxicology 245, 206-218.
  • Omer, O.H., Haroun, E.M., Mahmoud, O.M., Abdel-Magiet, E.M., El-Malik, K.H., Magzoub, M., 2003. Parasitological and clinico–pathological profiles in friesian cattle naturally infected with Theileria annulata in Saudi Arabia. Journal of Veterinary Medicine B 50, 200-203.
  • Perna, A.F, Ingrosso, D., De Santo, N.G., 2003. Homocysteine and oxidative stress. Amino Acids 25, 409-417.
  • Phillips, W., Gigue`re, S., Franklin, R.P., Hernandez, J., Adin, D., Peloso, J.G., 2003. Cardiac troponin I in pastured and race-training thoroughbred horses. Journal of Veterinary Internal Medicine 17, 597-99.
  • Radostitis, O.M., Gay, C.C., Hinchcliff, K.W., 2007. Theileriosis. In: Radostitis OM, Gay CC Hinchcliff KW, et al, eds. Veterinary Medicine, a Text Book of the Disease of Cattle, Sheep, Pigs and Horses. 10th ed. PA: Elsevier. pp. 1526-1532.

Ovine Theileriosis Enhances Cardiovascular Disease Biomarkers in Naturally Infected Sheep (Ghezel breed) in West Azerbaijan, Iran

Year 2017, Volume: 43 Issue: 1, 61 - 66, 01.01.2017
https://doi.org/10.16988/iuvfd.268662

Abstract

    This study was aimed to evaluate the plasma levels of cardiovascular disease biomarkers in naturally infected theileriosis in sheep (Ghezel breed). Theileria species are known to be ruminant blood parasites and involves deleterious effects in the livestock. Blood samples were collected from 30 selected sheep (Ghezel breed), naturally infected with theileriosis (infected group) and same number non-infected ones. Hematological parameters and the plasma concentrations of cardiac troponin I (cTnI), creatine kinase-MB (CK-MB) and homocysteine (Hcy) were determined in all samples. The results revealed that significant increase (P>0.01) in the level of cTnI, CK-MB, and Hcy concentrations in infected sheep compared with non-infected ones. In addition, cardiovascular biomarkers levels increased with aging and parasitemia rate (P<0.01). In conclusion, theileriosis provides evidence of the progression of cardiovascular biomarkers by aging and following elevation of parasitemia rate in Ghezel breed sheep and seems that further attention should be paid on this issue.

References

  • Andrade, Z.A., Andrade, S.G., Correa, R., Sadiqursky, M., Ferrans, V.J., 1994. Myocardial changes in acute Trypanosoma cruzi infection. American Journal of Pathology 144, 1403-1410.
  • Boswood, A., 2009. Biomarkers in cardiovascular disease: Beyond natriuretic peptides. Journal of Veterinary Cardiology 11, 23-32.
  • Chango, A., Abdennebi-Najar, L., 2011. Folate metabolism pathway and Plasmodium falciparum malaria infection in pregnancy. Nutrition Reviews 69, 34-40.
  • Chillemi, R., Zappacosta, B., Simporè, J., Persichilli, S., Musumeci, M., Musumeci, S., 2004. Hyperhomocysteinemia in acute Plasmodium falciparum malaria: an effect of host-parasite interaction. Clinica Chimica Acta 348, 113-120.
  • Col, R., Uslu, U., 2007. Changes in selected serum components in cattle naturally infected with Theileria annulata. Bulletin of the Veterinary Institute in Pulawy 51, 15-18.
  • Diana, A., Guglielmini, C., Candini, D., Pietra, M., Cipone, M., 2007. Cardiac arrhythmias associated with piroplasmosis in the horse: A case report. Veterinary Journal 174, 193-195.
  • Diniz, P.P.V.P., Morais, H.S.A., Breitschwerdt, E.B., Schwartz, D.S., 2008. Serum cardiac troponin I concentration in dogs with ehrlichiosis. Journal of Veterinary Internal Medicine 22, 1136-1143.
  • Fartashvand, M., Nadalian, M.G., Sakha, M., Safi, S., 2013. Elevated Serum Cardiac Troponin I in Cattle with Theileriosis. Journal of Veterinary Internal Medicine 27, 194-199.
  • Ganguly, P., Alam, S.F., 2015. Role of homocysteine in the development of cardiovascular disease. Nutrition Journal 14, 6.
  • Ghanem, M.M., Omnia, M.A., Balir, M.A.N., 2013. Clinico-biochemical, serological and molecular study on tropical Theileriosis in Egyptian water buffaloes (Bubalus bubalis). Alexandria Journal of Veterinary Sciences, 39, 1-11.
  • Hamacher, L., Dorfelt, R., Muller, M., Wess, G., 2015. Serum Cardiac Troponin I Concentrations in Dogs with Systemic Inflammatory Response Syndrome. Journal of Veterinary Internal Medicine 29, 164-170.
  • Hashemi-Fesharki, R., 1988. Control of Theileria annulata in Iran. Parasitology Today 4, 36-40.
  • Hervas, J., Carrasco, L., Gomkl-Viliamandofs, J.C., De Lara, F.C., Sierra, M.A., 1998. Myocarditis associated with Theileria spp. in calves. Journal of Veterinary Medicine B 45, 401-405.
  • Jacobsen, D.W., 2000. Hyperhomocysteinemia and Oxidative Stress Time for a Reality Check? Arteriosclerosis Thrombosis Vascular Biology 20, 1182-1184.
  • Khaki, Z., Jalali, S.M., Kazemi, B., Jalali, M.R., Yasini, S.P., 2015. A study of hematological changes in sheep naturally infected with Anaplasma spp. and Theileria ovis: Molecular diagnosis. Iranian Journal of Veterinary Medicine 9, 19-26.
  • Kinnaird, J.H., Weir, W., Durrani, Z., Pillai, S.S., Baird, M., Shiels, B.R., 2013. A Bovine Lymphosarcoma Cell Line Infected with Theileria annulata Exhibits an Irreversible Reconfiguration of Host Cell Gene Expression. PLoS One 8, e66833.
  • Lai, W.K.C., Kan, M.Y., 2015. Homocysteine-Induced Endothelial Dysfunction. Annals of Nutrition and Metabolism 67, 1-12.
  • Leonardi, F., Passeri, B., Fusari, A., De Razza, P., Beghi, C., Lorusso, R., 2008. Cardiac Troponin I (cTnI) concentration in an ovine model of myocardial ischemia. Research in Veterinary Science 85, 141-144.
  • Lobetti, R., Dvir, E., Pearson, J., 2002. Cardiac troponins in canine babesiosis. Journal of Veterinary Internal Medicine 16, 63-68.
  • Lobetti, R.G., 2005. Cardiac involvement in canine babesiosis. Journal of South African Veterinary Association 76, 4-8.
  • Mehta, H.K., Sisodia, R.S., Misraula, R.S., 1988. Clinical and haematological observations in experimentally induced cases of bovine theileriosis. Indian Journal of Animal Science 58, 584-587.
  • Miranda, R.C., Machado, M., Takakura, I.T., DaMata, P.F., DaFonseca, C.G., Mouco, O.M., Hernandes, M.E., Lemos, M.A., Maia, L.N., 2006. Elevated troponin levels after prolonged supraventricular tachycardia in patient with normal coronary angiography. Cardiology 106, 10-13.
  • Modi, D.V., Bhadesiya, C.M., Mandali, G.C., 2015. Hematobiochemical changes in crossbred cattle infected with Theileria annulata in Banaskantha district of Gujarat. International Journal of Scientific and Research Publication. 5, 1-4.
  • Nazifi, S., Razavi, S.M., Safi, N., Rakhshandehroo, E., 2012. Malignant Ovine Theileriosis: Alterations in the Levels of Homocysteine, Thyroid Hormones and Serum Trace Elements. Journal of Bacteriology and Parasitology 3, 1-4.
  • O’Brien, P.J., Smith, D.E.C., Knechtel, T.J., Marchak, M.A., Pruimboom-Brees, I., Brees, D.J., 2006. Cardiac troponin I is a sensitive, specific biomarker of cardiac injury in laboratory animals. Laboratory Animal 40, 153-571.
  • O'Brien, P.J., 2008. Cardiac troponin is the most effective translational safety biomarker for myocardial injury in cardiotoxicity. Toxicology 245, 206-218.
  • Omer, O.H., Haroun, E.M., Mahmoud, O.M., Abdel-Magiet, E.M., El-Malik, K.H., Magzoub, M., 2003. Parasitological and clinico–pathological profiles in friesian cattle naturally infected with Theileria annulata in Saudi Arabia. Journal of Veterinary Medicine B 50, 200-203.
  • Perna, A.F, Ingrosso, D., De Santo, N.G., 2003. Homocysteine and oxidative stress. Amino Acids 25, 409-417.
  • Phillips, W., Gigue`re, S., Franklin, R.P., Hernandez, J., Adin, D., Peloso, J.G., 2003. Cardiac troponin I in pastured and race-training thoroughbred horses. Journal of Veterinary Internal Medicine 17, 597-99.
  • Radostitis, O.M., Gay, C.C., Hinchcliff, K.W., 2007. Theileriosis. In: Radostitis OM, Gay CC Hinchcliff KW, et al, eds. Veterinary Medicine, a Text Book of the Disease of Cattle, Sheep, Pigs and Horses. 10th ed. PA: Elsevier. pp. 1526-1532.
There are 30 citations in total.

Details

Subjects Health Care Administration
Journal Section Research Article
Authors

Kaveh Azımzadeh

Publication Date January 1, 2017
Published in Issue Year 2017 Volume: 43 Issue: 1

Cite

APA Azımzadeh, K. (2017). Ovine Theileriosis Enhances Cardiovascular Disease Biomarkers in Naturally Infected Sheep (Ghezel breed) in West Azerbaijan, Iran. İstanbul Üniversitesi Veteriner Fakültesi Dergisi, 43(1), 61-66. https://doi.org/10.16988/iuvfd.268662
AMA Azımzadeh K. Ovine Theileriosis Enhances Cardiovascular Disease Biomarkers in Naturally Infected Sheep (Ghezel breed) in West Azerbaijan, Iran. iuvfd. January 2017;43(1):61-66. doi:10.16988/iuvfd.268662
Chicago Azımzadeh, Kaveh. “Ovine Theileriosis Enhances Cardiovascular Disease Biomarkers in Naturally Infected Sheep (Ghezel Breed) in West Azerbaijan, Iran”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 43, no. 1 (January 2017): 61-66. https://doi.org/10.16988/iuvfd.268662.
EndNote Azımzadeh K (January 1, 2017) Ovine Theileriosis Enhances Cardiovascular Disease Biomarkers in Naturally Infected Sheep (Ghezel breed) in West Azerbaijan, Iran. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 43 1 61–66.
IEEE K. Azımzadeh, “Ovine Theileriosis Enhances Cardiovascular Disease Biomarkers in Naturally Infected Sheep (Ghezel breed) in West Azerbaijan, Iran”, iuvfd, vol. 43, no. 1, pp. 61–66, 2017, doi: 10.16988/iuvfd.268662.
ISNAD Azımzadeh, Kaveh. “Ovine Theileriosis Enhances Cardiovascular Disease Biomarkers in Naturally Infected Sheep (Ghezel Breed) in West Azerbaijan, Iran”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 43/1 (January 2017), 61-66. https://doi.org/10.16988/iuvfd.268662.
JAMA Azımzadeh K. Ovine Theileriosis Enhances Cardiovascular Disease Biomarkers in Naturally Infected Sheep (Ghezel breed) in West Azerbaijan, Iran. iuvfd. 2017;43:61–66.
MLA Azımzadeh, Kaveh. “Ovine Theileriosis Enhances Cardiovascular Disease Biomarkers in Naturally Infected Sheep (Ghezel Breed) in West Azerbaijan, Iran”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi, vol. 43, no. 1, 2017, pp. 61-66, doi:10.16988/iuvfd.268662.
Vancouver Azımzadeh K. Ovine Theileriosis Enhances Cardiovascular Disease Biomarkers in Naturally Infected Sheep (Ghezel breed) in West Azerbaijan, Iran. iuvfd. 2017;43(1):61-6.