APPENDİKSİN PRİMER ADENOKARSİNOMU – OLGU SUNUMU

Abstract

Appendiksin primer adenokarsinomu nadir bir tümör tipi olup tüm gastrointestinal tümörlerin %0,5’inden azını oluşturur. Tanı genellikle postoperatif dönemde histopatolojik inceleme ile konur. Akut appandisit kliniği ile hastanemize başvuran 43 yaşındaki erkek hastada appendiksin diferansiye kolonik tip adenokarsinomu saptanmıştır. Postoperatif evresi Duke’s B olan olguya ikinci bir operasyonla sağ hemikolektomi uygulanmış olup postopertif dönemde kemoterapi görmüştür. Appendiksin primer adenokarsinom tanısını pre veya intraoperatif olarak koymak güç olup, postoperatif olarak tanısı konan hastalarda appendektomiyi takiben sağ hemikolektomi önerilmektedir

Keywords

• Appendiks, adenokarsinom

PRİMARY ADENOCARCİNOMA OF APPENDİX – CASE REPORT

Abstract

Primary adenocarcinoma of appendix is a rare tumor and occuring less than %0,5 of all gastrointestinal tumors. Diagnosis was usually achieved by histopathological investigation during postoperative period. 43 years of old male patient who had symptoms of acute appendicitis admitted to our hospital and the patient differentiated primary adenocarsinoma of appendix with colonic type. Postoperative staging was Duke’s B and chemotherapy was done after right hemicolectomy had been performed as second operation. Pre or intraoperative diagnosis of primary adenocarcinoma of appendix is usually difficult and once diagnosis is made, right hemicolectomy is recommended surgical procedure

Keywords

• Appendix,adenocarcinoma

References

1. Chen V, Qizilbash AH: Goblet cell carcinoid tumor of the appendix. Report of five cases and review of the literature. Arch Pathol Lab Med; 103(4): 180-2, 1979
2. Chiou YY, Pitman MB, Hahn PF, Kim YH, Rhea JJ, Mueller PR: Rare benign and malignant appendiceal lesions: spectrum of computed tomography findings with pathologic correlation . J Comput Assist Tomogr. 27(3): 297-306, 2003
3. Edmonds P, Merino PJ, Livolsi VA, Duray PH: Adenocarcinoid (mucinous carcinoid) of the appendix. Gastroenterology (2):302-9, 1984
4. Eriquchi N et al: Appendicitis caused by caecal carcinoma: report of a case. Kurume Med. J. 49(4): 217-9,2002
5. Fero M, Anthony PP: Adenocarcinoma of the appendix. Dis Colon Rectum 28(6): 457-9, 1985
6. Garin C, Carbinais S, Boucher E, Blanchet J, Le Guilcher P, Raoul JL: Adenocarcinoid of the appendix vermiformis, complete and persistant remission after chemotheraphy (folfox) of a metastatic case Dig. Dis. Scie. 47(12): 2760-2, 2002
7. Hata K, Tamaha N: Early appendiceal carcinoma. J. Gastroenterol. 37(3): 210-4,2002
8. Harry S. Cooper: Intestınal Neoplasms, Diagnostic Surgical Pathology Third Edition (Ed: Stephan S. Steinberg), Lippincott Williams&Wilkins Company 1999, Chapter 34, 1444

9. Kabbani W, Houlihan PS, Luthra R, Hamilton SR, Rashid A: Mucinous and non mucinous appendiceal adenocarcinomas: different clinicopathological features but similar genetic alterations. Mod Pathol. 15(6):599-605, 2002
10. Kelm C et al : Dificult diagnosis : acute appendicitis and appendiceal/ cecal carcinoma. Chirurg. German 72(4):444-7, 2001
11. McCusker ME et al: Primary malignant neoplasms of the appendix. Cancer 94 (12): 3307-12, 2002
12. Misdraji J, Yantiss RK, Graeme-Cook FM, Dalis UJ, Young RH: Appendiceal mucinous neoplasms; a clinicopathological analysis of 107 cases. Am J. Surg. Pathol. 27(8):1089-13, 2003.
13. Mohamed F, Chang D, Sugarbaker PH: Third look surgery and beyond for appendiceal malignancy with peritoneal dissemination. J Surg Oncol. 83(1): 5-12,2003
14. Nitecki SS, Wolf BG, Schlinkert R, Sarr MG: The natural history of surgically treated primary adenocarcinoma of the appendix. Ann Surg 219(1):51-7, 1994
15. Panov TS et al: Tumors of appendix. Chirurgiia (Sofia) 55(6):24-5,1999
16. Panton ON, Bell GA, Quen DA: Adenocarcinoma of the vermiform appendix is a rare clinical entity. Can J. Surg 26(39):276- ,1983.
17. Pickardt PJ, Levy AD, Rohrmann CA Jr, Kenda AL: Primary neoplasms of appendix: Radiologic spectrum of disease. Radiographics 23(39): 645-62, 2003
18. Qizilbash AH: Primary adenocarcinoma of appendix . A clinicopathological study of 11 cases. Arch Pathol 99:556-562,1975
19. Rasu PC et al: Primary adenocarcinoma of appendix. Case report and review of literature. Minerva Chir. 57(5):695-8 Oct 2002
20. Rosemary A., Kozar and Joel J. Roselyn : Tumors of appendix. Principles of Surgery 7th edition (Ed: Seymour I. Schwartz) Mc Graw Hill Company, 1999, Chapter 27, 1392-1393
21. Wolff M, Ahmed N: Epithelial neoplasms of the vermiform appendix (exclusive of carcinoid), Ackerman’s Surgical Pathology 8th edition (Ed: Juan Rosai), A Times Mirror Company, 1996, Chapter 11, 722.