ST ELEVASYONLU MİYOKARD İNFARKTÜS HASTALARINDA HEMATOLOJİK PARAMETRELER VE BAŞARISIZ TROMBOLİTİK

Öz

Trombolitik ajanlardaki son gelişmelere rağmen reperfüzyon kriterlerini sağlayan hastaların bir kısmında halen infarkt ilişkili damar İİD açıklığı sağlanamamaktadır. Hastaneye başvurudaki hematolojik parametrelerin trombolitik tedavi başarısı ile ilişkisi net değildir. Çalışmamızda akut ST elevasyonlu miyokard infarktüsü STEMİ hastalarında hastaneye başvuru hematolojik parametreleri ile trombolitik tedavi başarısı arasındaki ilişkinin incelenmesi amaçlanmıştır. Akut STEMİ hastalarında, hastaneye başvuru esnasında saptanan yüksek OPH ve nötrofil sayısı anlamlı olarak başarısız tromboliz ile ilişkili bulunmuştur

Anahtar Kelimeler

• Akut ST elevasyonlu miyokard infarktüsü,tromboliz,ortalama platelet hacmi,nötrofil

HEMATOLOGICAL PARAMETERS AND THROMBOLYTIC FAILURE IN ACUTE ST ELEVATION MYOCARDIAL INFARCTION PATIENTS

Abstract

Despite recent advances in thrombolytic agents, a significant number of patients fulfilling the reperfusion criteria still fail to accomplish complete patency of infarct related artery IRA . Therelationshipof hospital admission hematological parameters with thrombolytic outcome is not clear. We aimed to evaluate the relationship of hospital admission hematological parameters with thrombolytic outcome in acute ST elevation myocardial infarction STEMI patients

Keywords

• Acute ST elevation myocardial infarction,thrombolysis,mean platelet volume,neutrophil

References

1. ) LP, Blömstrom-Lundqvist C, Borger MA, et al. Task Force on the management of ST- segment elevation acute myocardial infarction of the European Society of Cardiology (ESC), ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J. 2012; 33:2569-619. )
2. Casey DE Jr, Chung MK, de Lemos JA, et al. ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013;29;61(4):e78-140. )
3. Badimon JJ, Fuster V. Coronary artery disease: pathogenesis and acute coronary syndromes. Mt Sinai J Med. 2001;68:167-81. )
4. Acute myocardial infarction: failed thrombolysis. Heart. 2001;85:104-12. )
5. White HD, Rutsch WR, Vahanian A, et al, for the GUSTO-I Investigators. Link between the angiographic substudy and mortality out- comes in a large randomized trial of myocardial reperfusion. Importance of early and complete infarct artery reperfusion. GUSTO-I Investigators. Circulation. ;91:1923–8.
6. White HD, Braunwald E. Applying the open artery theory: use of predictive survival markers. Eur Heart J. 1998;19:1132–9. )
7. Woodlief LH, Granger CB, Armstrong PW, et al. Variations in patient management and outcomes for acute myocardial infarction in the United States and other countries. Results from the GUSTO trial. Global utilization of streptokinase and tissue plasminogen activator for occluded coronary arteries. J Am Med Assoc. 1995;273:1586– )
8. Baumann G, Wolfe S, Maino J, et al. Community hospital administration of intravenous tissue plasminogen activator in acute myocardial infarction: improved timing,thrombolytic efficacy and ventricular function. J Am Coll Cardiol. 1987;10:1173–7. )

9. CP, Guo W, Murphy SA, Gibson CM, et al. Association between baseline neutrophil count, clopidogrel therapy, and clinical and angiographic outcomes in patients with ST- elevation myocardial infarction receiving fibrinolytic therapy. Eur Heart J. ;29:984-91. ) platelet volume on admission correlates with impaired response to thrombolysis in patients with ST-elevation myocardial infarction. Platelets. 2010;21:117-21.
10. ) Yaşar AS, Bilen E, Yüksel IO, Arslantaş U, Karakaş F, Kirbaş O, et al.Association between admission mean platelet volume and coronary patency after thrombolytic therapy for acute myocardial infarction. Turk Kardiyol Dern Ars. 2010;38:85-9. )
11. Recent advances in platelet- polymorphonuclear leukocyte interaction. Haemostasis. 1999;29:41–9. )
12. Braunwald E, Gibson CM. Association between white blood cell count, epicardial blood flow, myocardial perfusion, and clinical outcomes in the setting of acute myocardial infarction: a thrombolysis in myocardial infarction 10 substudy. Circulation. ;102:2329-34. )
13. DL, Eikelboom JW, Konkle B, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost. ;8:148-56. ) coronary intervention: does the concept make sense? Heart. 2007;93:632-8. )
14. H, Balli M, Cakici M, Abus S, Akturk E, Ozgul S. Increased Platelet Distribution Width Is Associated With ST-Segment Elevation Myocardial Infarction and Thrombolysis Failure. Angiology. 2014 Feb 12. [Epub ahead of print]
15. Varasteh-Ravan HR, Ali-Hassan- Sayegh S, Shokraneh S, Mozayan MR, Karimi-Bondarabadi AA. Relationship of admission mean platelet volume, platelet distribution width and white blood cells with ST resolution in patients with acute ST segment elevation myocardial infarction treated with streptokinase without history of previous cardiovascular surgery.Perspect Clin Res. 2013 Apr;4(2):125-9.
16. ) Greisenegger S, Endler G, Hsieh K, Tentschert S, Mannhalter C, Lalouschek W. Is elevated mean platelet volume associated with a worse outcome in patients with acute ischemic cerebrovascular events? Stroke. ;35:1688-91.
17. ) Dastjerdi MS, Emami T, Najafian A, Amini M.Mean platelet volume measurement, EDTA or citrate? Hematology. 2006;11:317
18. Yazının alınma tarihi: 10.03.2014 Kabül tarihi: 22.04.2014 Online basım: 24.04.2014