SUBKLİNİK HİPOTROİDİLİ HASTALARDA LEVOTİROKSİN TEDAVİSİ ÖNCESİ VE SONRASI SCD40L DÜZEYLERİNİN KARŞILAŞTIRILMASI

Abstract

Çalışmanın amacı Subklinik Hipotroidide SHO inflamasyon, tromboz ve ateroskleroz işareti olan sCD40L düzeyinin belirlenmesi ve levotiroksin tedavisi ile değişip değişmediğini göstermektir. Subklinik Hipotroidi tanısı alan 32 hasta ile 30 sağlıklı kontrol grubu çalışmaya alındı. SHO’lu hastaların 3 ay levotiroksin tedavisi aldıktan sonra kan örnekleri tekrar alındı. TSH,FT3,FT4 ve sCD40L düzeyleri belirlenerek gruplar arası karşılaştırıldı. sCD40L düzeyleri SHO hasta grubunda kontrol grubuna göre anlamlı ölçüde yüksek bulundu p=0.0001 . sCD40Ldüzeyindeki artış 3 aylık 50µg/gün levotiroksin tedavisi verildikten sonrasında da gözlendi ancak bu sonuç istatistiksel olarak anlamlı değildi p=0.587 . sCD40Lile trombosit düzeyleri arasındaki ilgi Pearson Correlation ile analizi yapıldı ve anlamlı korelasyon yoktu t= -0,07, p=0,955 . Sağlıklı kontrol grubu ile karşılaştırıldığında SHO’lu grupta sCD40L düzeyi yüksek bulundu ve 3 aylık levotiroksin tedavisi sonrasında da devam ediyordu, bu bize hormon replasman tedavisinin hastalık riskini azaltmadığını, yeni tedavi stratejileri geliştirilmesi gerektirdiğini düşündürmektedir

COMPARISON OF SCD40L LEVELS IN PATIENTS WITH SUBCLINICAL HYPOTHYROIDISM BEFORE AND AFTER LEVOTHYROXINE TREATMENT

Abstract

The aim of the study is to determine sCD40L levels which is the sign for inflammation, thrombosis, atherosclerosis in common subclinical hypothyroidism SHO and if there is change in sCD40L levels after levothyroxine treatment. Thirty-two patients diagnosed with subclinical hypothyroidism and 30 healthy control group is enrolled in the study. In patients with SHO, blood samples were re-collected after a 3 months treatment of levothyroxine. TSH, FT3, FT4 and sCD40L levels were determined and levels were compared between groups. sCD40L levels were found significantly high in SHO patient group than control group p=0.0001 . Increase in sCD40L levels are observed after 3 months treatment of 50 µg/day levothyroxine but this result was not statistically significant p=0.587 . The relation between sCD40L levels and platelet count were analysed with Pearson Correlation analysis but no significant correlation could be determined. t= -0,07, p=0,955 . As sCD40L levels are found to be high in SHO patients compared with healthy control group, and continuation of being high after levothyroxine treatment for 3 months makes us think that, the hormone replacemant therapy does not reduce the risk of disease and new treatment strategies should be improved

Keywords

• Subclinical hypothyroidism,sCD40L,levothyroxine

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