Abstract
Acut intra-abdominal hypertansion IAH may lead to abdominal compartment syndrome ACS . Ischaemia/reperfusion I/R injury plays an important role on ACS. The aim of management of ACS is to lower pressure despite reperfusion. The study was performed to investigate whether octretid improves the reperfusion injury and bacteriel translocation in rat model. We analysed liver blood enzymes,bacterial samples in vena porta and bacteria in the intestinal lymph nodes.Under ketamin anesthesia, a percutan catheter was inserted intraperitoneally. Catheter was connected to a manoneter. Gruops were divided as follows: İschaemia groups: IA pressure was kept at 20 mmHg for 1h. I/R group: 1 hour pressure +decompression+ 1 hour reperfusion. I/R +octreotid:1 hour pressure+ octreotid 100 microg/kg i.p.+ decompression. In results liver enzymes levels were not elevated and also bacteriel transformation was not found in the I/R +octreotid group. In conclusion, we found that octretid is an effective drug to prevent I/R injury at the ACS. We believe that the further investigations will show more definite effects of octretid at the IAH and ACS
Keywords
References
- ) Eddy V, Nunn C, Morris JA; Abdominal compartmant syndrome. The Nashville experience. Sur Clin North Am ; 77: 801-12. ) Ivatury RR, Diebel L, Porter JM, Simon RJ, Intraabdominal hypertension and syndrome. Surg Clin N Am 1990; :783-800. compartment
- ) Ivatury RR, Porter MJ, Simon RJ, İslam Intraabdominal hypertension after life- threating trauma: Prophylaxis, incidence, and clinical relevance to gastric mucosal pH and abdominal compartment syndrome. The J Trauma: Injury, Infection, and Critical Care 1998; 44:1016-23. WM. penetrating abdominal
- ) Saggi B H, Sugerman H J, Ivatury R R, compartment syndrome. The J Trauma: Injury, Infection, and Critical Care ;45: 597-606. L. Abdominal ) Alexander WJ, Boyce ST, Babcock GF, Gianotti L, Peck MD, Dunn DL et al. The process of microbial translocation. Ann Surg 1990; 212: 496-512.
- ) Pape HC, Dwenger A, Regel G, Auf Kolck M, Gollub F; Wisner D et al. Increased gut permeability after multipl trauma. Br J Surg 1999; 81:850-2.
- ) Saadia R, Schein M, Mac Farlene C, Boffard KD. Gut barrier function and surgeon. Br J Surg 1990; 77: 487-92.
- ) Saggi BH, Harvey JS, Ivatury RR, Bloomfield GL. Abdominal compartment syndrome. J Trauma 1998; 45:597-606.
- ) Burch JM,Moore EE. The abdominal compartment syndrome. Surg Clin N Am ; 76:833-42. ) Gutt CN, Schmandra TC. Portal venous pneumoperitoneum in the rat. Surg Endosc 1999; 13:902-5. CO2 ) Pathophysiology reperfusion ;190:256-66. Granger DN. of ischamaemia- injury. J Pathol
- ) Bloomfield GL, Ridings PC; Proposed relationship between increased intrathorasic and ) Yokoyoma Y, Alterman DM, Sarmadi AH, Baveja R. Hepatic vascular response to elevated intraperitoneal presure in the rat. J Surg Research 2002;105:86
- ) Granger DN, Rutili G, Mc Cord JM. Superoxide radicals infeline intesinal ischemia Gastroenterology 1981; 81
- ) Nillsson UA, Aberg J, Aneman A, Lundgren O. Feline intestinal ischemia and radical formation and tissue damage. Eur Surg Res 1993; 25:20. between
- ) Park PO, Haglund U, Bulkley GB, Falt K. The seguence of development of intestinal strangulation ischemia and reperfusion. Surgery 1990; 107: 574. after )
- Reperfusion injury. Surg Clin N Am ;72:65-83. BJ, Granger N. ) Mitsudo S, Lawrence JB. Pathology of intestinal ischemia. Surg Clin N Am ; 72: 43-65. ) nonhormonal cytoprotective effect by somatostatins. Hormone Res 1988; :83-85. Hormonal and ) Vale W, Rivier J, Ling N, Brown M.
- Biologic and immunologic activities and applications of somatostatin analogs. Metabolism 1978; 27: 1391-1401.
Abstract
Akut karın içi basınç KİB artışı abdominal kompartman sendromuna AKS yol açabilir. İskemi/Re-perfüzyon İ/R hasarı AKS patogenezinde önemli bir role sahiptir. AKS’da tedavinin temel amacı re-perfüzyon hasarına rağmen KİB’ın acilen düşürülmesidir. Bu çalışmanın amacı, akut abdominal hipertansiyonun dekompresyonunda oktreotid’in reperfüzyon hasarını ve bakteriyel translokasyonu azaltıp azaltmayacağını belirlemektir. Bu amaçla sıçanlara ketamin anestezisi altında, perkutan intraperitoneal kateter yerleştirilerek manometre sistemine bağlandı. Ratlar aşağıdaki gruplara ayrıldı. KİB 1 saat boyunca iskemi İ grubunda 20 mmHg düzeyinde tutuldu. İ/R grubunda 1 saatlik bu basıncı+ dekompresyon +1 saat re-perfüzyon İ/R grubu+ 100 mikrogram/kg oktreotid+dekompresyon İ/R grubuna oktreotid uygulanması ile serum karaciğer enzimleri düzeylerindeki yükselme olmamış ve bakteriyel translokasyon daha az olmuştur. Sonuç olarak oktreotid AKS de I/R grubunda etkili bulunmuştur. Daha ileri çalışmaların oktreotidin KİB ve AKS da daha kesin etkilerini göstereceğine inanmaktayız
Keywords
References
- ) Eddy V, Nunn C, Morris JA; Abdominal compartmant syndrome. The Nashville experience. Sur Clin North Am ; 77: 801-12. ) Ivatury RR, Diebel L, Porter JM, Simon RJ, Intraabdominal hypertension and syndrome. Surg Clin N Am 1990; :783-800. compartment
- ) Ivatury RR, Porter MJ, Simon RJ, İslam Intraabdominal hypertension after life- threating trauma: Prophylaxis, incidence, and clinical relevance to gastric mucosal pH and abdominal compartment syndrome. The J Trauma: Injury, Infection, and Critical Care 1998; 44:1016-23. WM. penetrating abdominal
- ) Saggi B H, Sugerman H J, Ivatury R R, compartment syndrome. The J Trauma: Injury, Infection, and Critical Care ;45: 597-606. L. Abdominal ) Alexander WJ, Boyce ST, Babcock GF, Gianotti L, Peck MD, Dunn DL et al. The process of microbial translocation. Ann Surg 1990; 212: 496-512.
- ) Pape HC, Dwenger A, Regel G, Auf Kolck M, Gollub F; Wisner D et al. Increased gut permeability after multipl trauma. Br J Surg 1999; 81:850-2.
- ) Saadia R, Schein M, Mac Farlene C, Boffard KD. Gut barrier function and surgeon. Br J Surg 1990; 77: 487-92.
- ) Saggi BH, Harvey JS, Ivatury RR, Bloomfield GL. Abdominal compartment syndrome. J Trauma 1998; 45:597-606.
- ) Burch JM,Moore EE. The abdominal compartment syndrome. Surg Clin N Am ; 76:833-42. ) Gutt CN, Schmandra TC. Portal venous pneumoperitoneum in the rat. Surg Endosc 1999; 13:902-5. CO2 ) Pathophysiology reperfusion ;190:256-66. Granger DN. of ischamaemia- injury. J Pathol
- ) Bloomfield GL, Ridings PC; Proposed relationship between increased intrathorasic and ) Yokoyoma Y, Alterman DM, Sarmadi AH, Baveja R. Hepatic vascular response to elevated intraperitoneal presure in the rat. J Surg Research 2002;105:86
- ) Granger DN, Rutili G, Mc Cord JM. Superoxide radicals infeline intesinal ischemia Gastroenterology 1981; 81
- ) Nillsson UA, Aberg J, Aneman A, Lundgren O. Feline intestinal ischemia and radical formation and tissue damage. Eur Surg Res 1993; 25:20. between
- ) Park PO, Haglund U, Bulkley GB, Falt K. The seguence of development of intestinal strangulation ischemia and reperfusion. Surgery 1990; 107: 574. after )
- Reperfusion injury. Surg Clin N Am ;72:65-83. BJ, Granger N. ) Mitsudo S, Lawrence JB. Pathology of intestinal ischemia. Surg Clin N Am ; 72: 43-65. ) nonhormonal cytoprotective effect by somatostatins. Hormone Res 1988; :83-85. Hormonal and ) Vale W, Rivier J, Ling N, Brown M.
- Biologic and immunologic activities and applications of somatostatin analogs. Metabolism 1978; 27: 1391-1401.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | March 1, 2013 |
| Published in Issue | Year 2013 Volume: 17 Issue: 1 |