TEK TARAFLI HERPETİK STROMAL KERATİTLİ HASTALARIN SAĞLIKLI GÖZLERİNDE GÖZYAŞI İŞLEVİ

Year 2013, Volume: 17 Issue: 3, 150 - 157, 01.09.2013

Ferişte Öztürk Sevgi Onat Hilal Batı Sinem Karabulut Bora Yüksel

Abstract

Bu çalışmanın amac tek taraflı latent stromal herpetik keratitli hastaların sağlıklı gözlerindeki gözyaşı işlevinin değerlendirilmesidir. Kornea bölümünden unilateral latent stromal herpetic keratitli 42 hasta ele alındı. Kontrol gurubu sağlıklı 25 kadın, 19 erkekten oluşmaktaydı. 5 dk geleneksel Schirmer I testi anestezisiz olarak kapaklar kapalıyken uygulandı. Her iki gurupta BUT süresi ölçüldü ve korneanın floressein boyanma özelliği değerlendirildi. Kontrol ve test grubunun yaş ortalamalarının karşılaştırmasında t testi kullanıldı. Cinsiyet,sigara alışkanlığı ve gözyaşı işlevi ile ilgili değerlerin karşılaştırılmasında ise ki kare testi kullanıldı.İki gurup arasında ortalama yaş, cinsiyet ve sigara içme oranları arasında istatistiksel anlamlı bir fark yoktu. Korneada floressein boyanma herpes gurubunda %31.7, kontrol gurubunda %6.8 oranında görüldü. Aradaki fark istatistiksel olarak anlamlı idi χ2: 8,604, p:0,005 . Ortalama Schirmer değeri herpes gurubunda 9.0±8.2mm, kontrol gurubunda 19.0±9.8mm p:0.000 . Ortalama BUT herpes gurubunda 13.8±14.5, kontrol gurubunda 21.8±12.7mm idi p:0.009 . İki gurup arasında HSV-1IgG,M or HSV-2IgG,M seropozitifliği açısından istatistiksel anlamlı fark bulunmadı. Unilateral latent stromal herpetic keratitli hastaların sağlıklı gözlerinde istirahat hali gözyaşı salgısında azalma, gözyaşı kırılma zamanında kısalma BUT , korneanın floressein boyanmasında artış saptanmıştır. Özetle bu gözler de kuru göz bulguları taşımaktadır

Keywords

Herpetik keratit, karşı göz, gözyaşı işlevi

TEAR FUNCTION IN THE HEALTHY EYES OF UNILATERAL LATENT HERPETIC STROMAL KERATITIS PATIENTS

Abstract

This study was conducted to evaluate the tear function in the healthy eye of the patients with unilateral latent stromal herpetic keratitis. Fourty two patients with unilateral latent stromal herpetic keratitis were acquired from the cornea department. Control group consisted of 44 people including 25 women and 19 men. A 5-minute conventional Schirmer I test without anesthesia was performed on closed eyes. Tear BUT was measured and corneal fluorescein staining pattern evaluated in both groups. t test was used for comparison of the mean age of the two groups. Chi square test was used for the comparison of sex, smoking habits and tear function values of control and test groups. t test for was used for independent groups and chi square test was used for the comparisons. p:0.000 . Mean BUT was 13.8±14.5 in herpes group and 21.8±12.7mm p:0.009 . No statistically significant difference was found between two groups in terms of HSV-1IgG,M or HSV-2IgG,M positivity. The healthy eyes of the patients with herpetic stromal keratitis showed a decrease in tear secretion and tear film stability

Keywords

Herpetic keratitis, contrlateral eye, tear function

References

• ) Keijser S, van Best JA, van der Lelij A, Jager MJ. Reflex and steady state tears in patients with latent stromal herpetic keratitis. Invest Ophthalmol Vis Sci. 2002; 43:87–91.
• ) Kaufman HE. Can we prevent recurrences of herpes infections without antiviral drugs? The Weisenfeld Lecture. Invest 43:1325-9. Vis Sci. 2002
• management of herpes simplex virus keratitis. Eye 2003; 17:919-22.
• and 4) Liesegang TJ. Herpes simplex virus epidemiology and ocular importance. Cornea 2001; 20:1–13.
• ) De Paiva CS, Corrales RM, Villarreal AL, Farley W, Li DQ, Stern ME, Pflugfelder SC. Apical corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline. Invest Ophthalmol Vis Sci. 2006; 47:2847-56.
• ) Posavad CM, Koelle DM, Corey L. Tipping the scales of herpes simplex virus responses are local. Nat Med 1998; 4:381–2. the
• important 7) Khanal S, Tomlinson A, McFayden A, Diaper C, Ramaesh K. Dry eye diagnosis. Inv Ophthalmol Vis Sci 2008; 49:1407- 1414. 8)
• Schmut O, Floegel I, Solhdju V, Bodner E, Schwantzer G, Haller-Schober EM. Evaluation of the clinical course of dry eye syndrome. Arch Ophthalmol. 2003; 121:1364-8. J, Berghold
• A, 9) Moss SE, Klein R, Klein BE. Prevalence of and risk factors for dry eye syndrome. Arch Ophthalmol 2000; 118:1264-8.
• ) Lee-Wing MW, Hodge WG, Diaz- Mitoma F. Investigating a viral etiology for keratoconjunctivitis sicca among patients who are positive for human immunodeficiency 1999;18:671-4. virus.
• Cornea 11)Shimeld C, Tullo AB, Hill TJ, Blyth WA, Easty DL. Spread of herpes simplex virus and distribution of latent infection after intraocular infection of the mouse. Arch Virol. 1985;85:175–187.
• ) Akpek E K, GottschJ D. Immune defense at the ocular surface. Eye 2003; 17, 949–956.
• ) Sheppard JD, Wertheimer ML, Scoper SV. Modalities to decrease stromal reactivation 2009; 127:852-56. simplex Arch rates.
• )Herpetic Eye Disease Study Group. Psychological stress and other potential triggers for recurrences of herpes simplex virus eye infections. Arch Ophthal mol 2000;118:1617-25.