TİROİD NODÜLLERİNDE MALİGNİTE RİSKLERİ VE BU RİSKLERİN OPERASYON KARARINDAKİ ROLÜ NE OLMALIDIR?

Mehmet Tahsin Tekeli; Mehmet Akif Üstüner; Emrah Dadalı; Uğur Gökçelli; Hilmi Güngör; Enver İlhan; Orhan Üreyen

TİROİD NODÜLLERİNDE MALİGNİTE RİSKLERİ VE BU RİSKLERİN OPERASYON KARARINDAKİ ROLÜ NE OLMALIDIR?

Year 2014, Volume: 18 Issue: 3, 58 - 65, 01.09.2014

Mehmet Tahsin Tekeli Mehmet Akif Üstüner Emrah Dadalı Uğur Gökçelli Hilmi Güngör Enver İlhan Orhan Üreyen

Abstract

Son yıllarda tiroid nodül saptanma oranı ve prevelansı yıldan yıla artmaktadır. Artan bu tiroid nodülü oranına sekonder olarak da nodül nedeniyle tiroid cerrahisi sayısı hızla artmaktadır. Bu çalışmada nodüler guatr nedeniyle tiroidektomi yapılan olguları analiz ederek hangi durumlarda cerrahi yapmamız gerektiğinin yanısıra gereksiz tiroidektomilerden nasıl kaçınabiliriz sorusunun yanıtını araştırdık. Kliniğimizde Haziran 2012 – Mayıs 2014 tarihleri arasında benign yada malign nedenlerle erişkin yaş grubunda nodüler guatr nedeniyle tiroidektomi operasyonu uygulanan olgular malignite ile ilişkili faktörler araştırılmak üzere retrospektif olarak kaydedildi Çalışmaya yaşları 23-84 arasında değişen 102 kadın 19 erkek olmak üzere toplam 121 olgu dahil edildi. Yaş, ultrasonografide US nodül sayısı ve major nodül çapları açısından gruplar arasında istatistiksel olarak anlamlı fark bulunmadı p>0,05 . Hormonal durum ve nodül yapıları açısından gruplar arasında istatistiksel olarak anlamlı fark bulundu p

Keywords

Tiroid nodül, tiroid cancer, tiroid neoplazi, risk faktör

References

) Huang TW, Lai JH,Wu MY, Chen SL, Wu CH, Tam KW. Systematic review of clinical practice guidelines in thediagnosis and management of thyroid nodules and cancer. BMC Medicine 2013; 11:191.
) Ferraz C, Eszlınger M, Paschke R: Current state andf uture perspective of molecular diagnosis of fine-needle aspiration biopsy of thyroid nodules. J Clin Endocrinol Matab ; 96:2016-26
) Kratky J, Vitkova H, BartakovaJ, Telicka Z, Antosova M, Limanova Z, Et al. Thyroid nodules: pathophysiological ınsight on oncogenesis and novel diagnostic techniques. Physiol Res 2014;63:263-75.
) Qin H, Kun W, Fuchen L, Li Z, Qingxian H, Yunfeng H, Et al. Epidemiological characteristics of thyroid nodules and risk factors for malignant nodules: a retrospective study from 6 304 surgical cases.Chin Med J ;127:2286-92.
) Choi YJ, Jung İ, Min SJ, Kim HJ, Kim J, Kim S, Thyroid nodule with benign cytology: is clinical follow- up enough? Plos one 2013; 8: 4.
) Wang CC, Friedman L, Kennedy GC, Wang H, Kebebew E, Stewart DL, et al. A large multicenter correlation study of thyroid nodule cytopathology and histopathology. Thyroid 2011;21: 243–51.
) Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, et al. Reviseda merican thyroid association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid ; 19:1167–214.
) Mohammadi A, Hajizadeh T. Evaluation of diagnostic efficacy of ultrasounds coring system to select thyroid nodules requiring fine needle aspiration biopsy.Int J Clin Exp Med 2013; 6:641-8.
) Coleman MP, Estève J, Damiecki P, Arslan A, Renard H. Trends in cancer incidence and mortality. IARC 1993;121:1–806.
) Suvak Ö, Salyam B, Çoşkun F, Oktay M, Albayrak A, Suvak B et al. Tiroid nodülü tanısıyla takip edilen hastalarımızdaki tiroid kanser insidansı: bir referans merkez çalışması. Yeni Tıp Dergisi 2012;29:37-42.
) Mandel SJ. A 64-year-old woman with a thyroid nodule. JAMA 2004;292:2632-42.
) Haymart MR, Repplinger DJ, Leverson GE, Elson DF, Sippel RS, Jaume JC, et al. Higher serum thyroid stimulating hormone level in thyroid nodüle patients is associated with greater risks of differentiated thyroid cancer and advancedt umor stage. J Clin Endocrinol Metab 2008;93:809-14.
) Lee ES, Kim J, Gyuna D, Paeng JC, Min HS, Choi SH, et al. Hyperfunction thyroid nodules: their risk for becomingor being associated with thyroid cancers. Korean J Radiol 2013;14:643-52.
) Rago T, Fiore E, Scutari M, Santini F, DiCoscio G, Romani R, et al. Male sex, single nodularity, and young age are associated with the risk of finding a papillary thyroid cancer on fine needle aspiration cytology in a large series of patients with nodular thyroid disease. Eur J Endocrinol 2010; 162:763-70.
) Lin JD, Chao TC, Huang BY, Chen ST, Chang HY, Hsueh C. Thyroid cancer in the thyroid nodulese valuated by ultrasonography and fine-needle aspiration cytology. Thyroid ; 15:708-17. ) Campanella P, Ianni F, Rota CA, Corsello SM, Pontecorvi A. Quantification of cancer risk of each clinical and ultrasonographic suspicious feature of thyroid nodules: a systematic review and meta-analysis. European Journal of Endocrinology 2014; :203–11.
) Mazzaferri EL. Management of a solitary thyroid nodule. N Engl J Med 1993; 328:553
) Kamran SC, Marqusee E, Kım MI, Frates MC, Ritner J, Peters H, Et al. Thyroid nodule size and prediction of cancer. J Clin Endocrinol Metab 2013;98: 564-70.
) Lumachi F, Varotto L, Borsato S, Tregnaghi A, Zucchetta P,Marzola MC, et al. Usefulness of 99mTc-pertechnetate scintigraphy and fine-needle aspiration cytology in patients withs olitary thyroid nodules and thyroid cancer. Anticancer Res ; 24:2531-34.
) Imani EF, Aminorroaya A, Soheilipour F, Adibi A, Sirous M, RoohiE, et al. Sonographic and functional characteristics of thyroid nodules in apopulation of adult people in Isfahan. Endokrynol Pol 2010; 61:188-91.
) Gupta S, Reddy CV, Chettri ST, Karki S. Clinicopathological features and complications of thyroid operations: a single centre experience. Indian J Otolaryngol Head Neck Surg 2013; 65140–5.
) Gharib H, Goellner JR, Johnson DA. Fine- needle aspiration cytology of the thyroid: a year experience with 11,000 biopsies. Clin Lab Med 1993;13:699–709.
) Delbridge L. Solitary thyroid nodule: current management. ANZ J Surg 2006; 76: 6.
) Renuka IV, Bala GS,Aparna C, Kumari R, Sumalatha K. The bethesda system for reporting thyroid cytopathology: ınterpretation and guidelines in surgical treatment. Indian J Otolaryngol Head Neck Surg 2012; 64:305–11.
) Alves Filho GJ, Kowalski LP. Surgical complications after thyroid surgery performed in a cancer hospital. Otolaryngol Head Neck Surg 2005;132:490–4.
) Alves Filho GJ, Kowalski LP. Postoperative complications of thyroidectomy for differentiated thyroid carcinoma. Am J Otolaryngol 2004; 25:225–30.
Yazının alınma tarihi:25.07.2014 Kabül tarihi:06.08.2014 Online basım:14.08.2014

THE RISK FACTORS FOR MALIGNANCY IN THYROID NODULES; HOW SHOULD THESE RISK FACTORS AFFECT THE DECISION FOR SURGERY?

Year 2014, Volume: 18 Issue: 3, 58 - 65, 01.09.2014

Mehmet Tahsin Tekeli Mehmet Akif Üstüner Emrah Dadalı Uğur Gökçelli Hilmi Güngör Enver İlhan Orhan Üreyen

Abstract

In the recent years, the incidence and prevalence of thyroid nodules has gradually increased. Due to the increasing occurrence of thyroid nodules, the number of thyroid surgeries has rapidly increased as well. In this study, we analyzed cases that underwent thyroidectomy due to nodular goiter in order to identify the conditions/cases in which surgery became necessary. We thus aimed to determine how unnecessary thyroidectomies can be avoided

Keywords

Thyroid nodule, thyroid cancer, thyroid neoplasia, risk factor

References

) Huang TW, Lai JH,Wu MY, Chen SL, Wu CH, Tam KW. Systematic review of clinical practice guidelines in thediagnosis and management of thyroid nodules and cancer. BMC Medicine 2013; 11:191.
) Ferraz C, Eszlınger M, Paschke R: Current state andf uture perspective of molecular diagnosis of fine-needle aspiration biopsy of thyroid nodules. J Clin Endocrinol Matab ; 96:2016-26
) Kratky J, Vitkova H, BartakovaJ, Telicka Z, Antosova M, Limanova Z, Et al. Thyroid nodules: pathophysiological ınsight on oncogenesis and novel diagnostic techniques. Physiol Res 2014;63:263-75.
) Qin H, Kun W, Fuchen L, Li Z, Qingxian H, Yunfeng H, Et al. Epidemiological characteristics of thyroid nodules and risk factors for malignant nodules: a retrospective study from 6 304 surgical cases.Chin Med J ;127:2286-92.
) Choi YJ, Jung İ, Min SJ, Kim HJ, Kim J, Kim S, Thyroid nodule with benign cytology: is clinical follow- up enough? Plos one 2013; 8: 4.
) Wang CC, Friedman L, Kennedy GC, Wang H, Kebebew E, Stewart DL, et al. A large multicenter correlation study of thyroid nodule cytopathology and histopathology. Thyroid 2011;21: 243–51.
) Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, et al. Reviseda merican thyroid association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid ; 19:1167–214.
) Mohammadi A, Hajizadeh T. Evaluation of diagnostic efficacy of ultrasounds coring system to select thyroid nodules requiring fine needle aspiration biopsy.Int J Clin Exp Med 2013; 6:641-8.
) Coleman MP, Estève J, Damiecki P, Arslan A, Renard H. Trends in cancer incidence and mortality. IARC 1993;121:1–806.
) Suvak Ö, Salyam B, Çoşkun F, Oktay M, Albayrak A, Suvak B et al. Tiroid nodülü tanısıyla takip edilen hastalarımızdaki tiroid kanser insidansı: bir referans merkez çalışması. Yeni Tıp Dergisi 2012;29:37-42.
) Mandel SJ. A 64-year-old woman with a thyroid nodule. JAMA 2004;292:2632-42.
) Haymart MR, Repplinger DJ, Leverson GE, Elson DF, Sippel RS, Jaume JC, et al. Higher serum thyroid stimulating hormone level in thyroid nodüle patients is associated with greater risks of differentiated thyroid cancer and advancedt umor stage. J Clin Endocrinol Metab 2008;93:809-14.
) Lee ES, Kim J, Gyuna D, Paeng JC, Min HS, Choi SH, et al. Hyperfunction thyroid nodules: their risk for becomingor being associated with thyroid cancers. Korean J Radiol 2013;14:643-52.
) Rago T, Fiore E, Scutari M, Santini F, DiCoscio G, Romani R, et al. Male sex, single nodularity, and young age are associated with the risk of finding a papillary thyroid cancer on fine needle aspiration cytology in a large series of patients with nodular thyroid disease. Eur J Endocrinol 2010; 162:763-70.
) Lin JD, Chao TC, Huang BY, Chen ST, Chang HY, Hsueh C. Thyroid cancer in the thyroid nodulese valuated by ultrasonography and fine-needle aspiration cytology. Thyroid ; 15:708-17. ) Campanella P, Ianni F, Rota CA, Corsello SM, Pontecorvi A. Quantification of cancer risk of each clinical and ultrasonographic suspicious feature of thyroid nodules: a systematic review and meta-analysis. European Journal of Endocrinology 2014; :203–11.
) Mazzaferri EL. Management of a solitary thyroid nodule. N Engl J Med 1993; 328:553
) Kamran SC, Marqusee E, Kım MI, Frates MC, Ritner J, Peters H, Et al. Thyroid nodule size and prediction of cancer. J Clin Endocrinol Metab 2013;98: 564-70.
) Lumachi F, Varotto L, Borsato S, Tregnaghi A, Zucchetta P,Marzola MC, et al. Usefulness of 99mTc-pertechnetate scintigraphy and fine-needle aspiration cytology in patients withs olitary thyroid nodules and thyroid cancer. Anticancer Res ; 24:2531-34.
) Imani EF, Aminorroaya A, Soheilipour F, Adibi A, Sirous M, RoohiE, et al. Sonographic and functional characteristics of thyroid nodules in apopulation of adult people in Isfahan. Endokrynol Pol 2010; 61:188-91.
) Gupta S, Reddy CV, Chettri ST, Karki S. Clinicopathological features and complications of thyroid operations: a single centre experience. Indian J Otolaryngol Head Neck Surg 2013; 65140–5.
) Gharib H, Goellner JR, Johnson DA. Fine- needle aspiration cytology of the thyroid: a year experience with 11,000 biopsies. Clin Lab Med 1993;13:699–709.
) Delbridge L. Solitary thyroid nodule: current management. ANZ J Surg 2006; 76: 6.
) Renuka IV, Bala GS,Aparna C, Kumari R, Sumalatha K. The bethesda system for reporting thyroid cytopathology: ınterpretation and guidelines in surgical treatment. Indian J Otolaryngol Head Neck Surg 2012; 64:305–11.
) Alves Filho GJ, Kowalski LP. Surgical complications after thyroid surgery performed in a cancer hospital. Otolaryngol Head Neck Surg 2005;132:490–4.
) Alves Filho GJ, Kowalski LP. Postoperative complications of thyroidectomy for differentiated thyroid carcinoma. Am J Otolaryngol 2004; 25:225–30.
Yazının alınma tarihi:25.07.2014 Kabül tarihi:06.08.2014 Online basım:14.08.2014

There are 26 citations in total.

Details

Primary Language	Turkish
Journal Section	Research Article
Authors	Mehmet Tahsin Tekeli This is me Mehmet Akif Üstüner This is me Emrah Dadalı This is me Uğur Gökçelli This is me Hilmi Güngör This is me Enver İlhan This is me Orhan Üreyen This is me
Publication Date	September 1, 2014
Published in Issue	Year 2014 Volume: 18 Issue: 3

Cite

APA	Tekeli, M. T., Üstüner, M. A., Dadalı, E., Gökçelli, U., et al. (2014). TİROİD NODÜLLERİNDE MALİGNİTE RİSKLERİ VE BU RİSKLERİN OPERASYON KARARINDAKİ ROLÜ NE OLMALIDIR?. İzmir Eğitim Ve Araştırma Hastanesi Tıp Dergisi, 18(3), 58-65.
AMA	Tekeli MT, Üstüner MA, Dadalı E, Gökçelli U, Güngör H, İlhan E, Üreyen O. TİROİD NODÜLLERİNDE MALİGNİTE RİSKLERİ VE BU RİSKLERİN OPERASYON KARARINDAKİ ROLÜ NE OLMALIDIR?. İzmir EAH Tıp Der. September 2014;18(3):58-65.
Chicago	Tekeli, Mehmet Tahsin, Mehmet Akif Üstüner, Emrah Dadalı, Uğur Gökçelli, Hilmi Güngör, Enver İlhan, and Orhan Üreyen. “TİROİD NODÜLLERİNDE MALİGNİTE RİSKLERİ VE BU RİSKLERİN OPERASYON KARARINDAKİ ROLÜ NE OLMALIDIR?”. İzmir Eğitim Ve Araştırma Hastanesi Tıp Dergisi 18, no. 3 (September 2014): 58-65.
EndNote	Tekeli MT, Üstüner MA, Dadalı E, Gökçelli U, Güngör H, İlhan E, Üreyen O (September 1, 2014) TİROİD NODÜLLERİNDE MALİGNİTE RİSKLERİ VE BU RİSKLERİN OPERASYON KARARINDAKİ ROLÜ NE OLMALIDIR?. İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi 18 3 58–65.
IEEE	M. T. Tekeli, M. A. Üstüner, E. Dadalı, U. Gökçelli, H. Güngör, E. İlhan, and O. Üreyen, “TİROİD NODÜLLERİNDE MALİGNİTE RİSKLERİ VE BU RİSKLERİN OPERASYON KARARINDAKİ ROLÜ NE OLMALIDIR?”, İzmir EAH Tıp Der, vol. 18, no. 3, pp. 58–65, 2014.
ISNAD	Tekeli, Mehmet Tahsin et al. “TİROİD NODÜLLERİNDE MALİGNİTE RİSKLERİ VE BU RİSKLERİN OPERASYON KARARINDAKİ ROLÜ NE OLMALIDIR?”. İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi 18/3 (September 2014), 58-65.
JAMA	Tekeli MT, Üstüner MA, Dadalı E, Gökçelli U, Güngör H, İlhan E, Üreyen O. TİROİD NODÜLLERİNDE MALİGNİTE RİSKLERİ VE BU RİSKLERİN OPERASYON KARARINDAKİ ROLÜ NE OLMALIDIR?. İzmir EAH Tıp Der. 2014;18:58–65.
MLA	Tekeli, Mehmet Tahsin et al. “TİROİD NODÜLLERİNDE MALİGNİTE RİSKLERİ VE BU RİSKLERİN OPERASYON KARARINDAKİ ROLÜ NE OLMALIDIR?”. İzmir Eğitim Ve Araştırma Hastanesi Tıp Dergisi, vol. 18, no. 3, 2014, pp. 58-65.
Vancouver	Tekeli MT, Üstüner MA, Dadalı E, Gökçelli U, Güngör H, İlhan E, Üreyen O. TİROİD NODÜLLERİNDE MALİGNİTE RİSKLERİ VE BU RİSKLERİN OPERASYON KARARINDAKİ ROLÜ NE OLMALIDIR?. İzmir EAH Tıp Der. 2014;18(3):58-65.

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