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B 12 VİTAMİN EKSİKLİĞİNİN NÖROLOJİK KOMPLİKASYONLARINA DAİR BİR OLGU SUNUMU

Year 2014, Volume: 18 Issue: 3, 66 - 70, 01.09.2014

Abstract

Beş ay önce kolelitiyazis nedeniyle operasyon öyküsü olan otuz dokuz yaşında erkek hasta yürümede güçlük, denge bozukluğu şikayetleri ile kliniğimize başvurdu. B12 vitamin düzeyi düşük saptandı. Servikal torakal vertebra manyetik rezonans görüntülemede; subakut kombine dejenerasyon ile uyumlu sinyal artışı izlendi. Elektromiyografide sensoriyel polinöropati saptandı. Vizüel ve somatosensoriyel evoked potansiyellerde total ileti bloğu gözlendi. Hastaya parenteral olarak B12 vitamin replasmanı verildi. Tedavi sonrası klinik bulgularda düzelme gözlendi. Bu olgu, B12 vitamin eksikliğine bağlı elektrofizyolojik çalışmalar ve nörogörüntülemelerle kanıtlanmış optik nöropati, miyelopati, periferik nöropati ile giden nöroanemik sendrom olması nedeniyle tartışmaya uygun bulduk

References

  • ) Aminoff JM. Hematolojik hastalıkları nörolojik belirtileri. Çeviri editörleri; Sara Zarko Bahar, Oğuzhan Çoban. Neurology and General Medicine Türkçe. 4. Baskı, Ankara, Güneş Tıp Kitabevleri 2010. Sayfa;228-9.
  • ) Maamar M, Tazi-Mezalek Z, Harmouche H, Ammouri W, Zahlane M , Adnaoui M ve ark. Neurological manifestations of vitamin B12 deficiency: a retrospective study of 26 cases. Rev Med Interne 2006;27:442-7
  • ) Sharma V, Biswas D. Cobalamin defi- ciency presenting as obsessive compulsive disorder: case report. Gen Hosp Psychiatry. 2012;34:578.e7-8. )
  • AN, Harzallah O, Bekir S ve ark.. Neuro- psychiatric disorders revealed pernicious disease without anemia. About three cases. Tunis Med ;82(6):555-9. ) Miscusi M, Testaverde L, Rago A, Raco A, Colonnese C. degeneration without nutritional anemia. J Clin Neurosci. 2012;19(12):1744-5. )
  • KV, Narahari MG.Helicobacter pylori associated vitamin B12 deficiency, pernicious anaemia and subacute combined degenerationof the spinal cord. BMJ Case Rep. 2013;30.
  • ) Renard D, Anais D, Remy A, Castelnovo G, Labauge P. Subacute combined degeneration of the spinal cord caused by nitrous oxide anaesthesia. Neurol Sci 2009;30:75-6.
  • ) Senol MG, Sonmez G, Ozdağ F, Saracoğlu M. Reversible myelopathy with vitamin B 12 deficiency. Singapore Med J 2008; 49: e 330
  • ) Sen A, Chandrasekhar K. Spinal MR imaging in Vitamin B12 deficiency: Case series; differential diagnosis of symmetrical posterior spinal cord lesions. Ann Indian Acad Neurol 2013; 16: 255–8.
  • ) de Medeiros FC, de Albuquerque LA, de Souza RB, Gomes Neto AP, Christo PP. Vitamin B12 extensive thoracic myelopathy: clinical, radiological and prognostic aspects. Two cases report and literature review. Neurol Sci. 2013;34:1857-60.
  • ) Marshall R, Milburn JM. Clinical Images - A Quarterly Column: Subacute Combined Degeneration of the spinal kord. Ochsner J. 2013 Summer; 13: 183–5.
  • )Yang JW, Han JY, Seong MW, Sung JJ, Park SS, Lee KW. Hereditary Spastic Paraplegia with a Novel SPAST Mutation Misdiagnosed with Subacute Combined Degeneration. Exp Neurobiol. 2013;22:128-31.
  • ) Chu C, Scanlon P. Vitamin B12 deficiency optic neuropathy detected by asymptomatic screening. bcr0220113823.
  • ) Chavala SH, Kosmorsky GS, Lee MK, Lee MS. Optic neuropathy in vitamin B12 deficiency. Eur J Intern Med. 2005;16:447-8.
  • ) Gürsoy AE, Kolukısa M, Yıldız GB, Çelebi A. Subacute Combined Degeneration of the Spinal Cord due to Different Etiologies and Improvement of MRI Findings. Case Rep Neurol Med. 2013; 159649.
  • Yazının alınma tarihi:18.03.2014 Kabül tarihi:25.06.2014 Online basım:14.08.2014

THE RISK FACTORS FOR MALIGNANCY IN THYROID NODULES;HOW SHOULD THESE RISK FACTORS AFFECT THE DECISION FOR SURGERY?

Year 2014, Volume: 18 Issue: 3, 66 - 70, 01.09.2014

Abstract

Thirty nine years old male patient having cholelithiasis operation five months ago complaining walking difficulty, balance problems has been admitted to our hospital. Vit B12 level was found low. Subacute combined degeneration findings including increased signal intensity in cervical and thoracal magnetic resonance imaging were detected. In electromyography sensorial polyneuropathy was found. Visual and somatosensorial evoked potentials were all blocked. Parenteral Vit B12 replation therapy was given to the patient. After treatment, clinical findings were improved. Because this case has got neuroanemic syndrome proven with optic neuropathy, myelopathy, peripheral neuropathy with electrophysiology and neuroimaging techniques, we prefered to discuss here

References

  • ) Aminoff JM. Hematolojik hastalıkları nörolojik belirtileri. Çeviri editörleri; Sara Zarko Bahar, Oğuzhan Çoban. Neurology and General Medicine Türkçe. 4. Baskı, Ankara, Güneş Tıp Kitabevleri 2010. Sayfa;228-9.
  • ) Maamar M, Tazi-Mezalek Z, Harmouche H, Ammouri W, Zahlane M , Adnaoui M ve ark. Neurological manifestations of vitamin B12 deficiency: a retrospective study of 26 cases. Rev Med Interne 2006;27:442-7
  • ) Sharma V, Biswas D. Cobalamin defi- ciency presenting as obsessive compulsive disorder: case report. Gen Hosp Psychiatry. 2012;34:578.e7-8. )
  • AN, Harzallah O, Bekir S ve ark.. Neuro- psychiatric disorders revealed pernicious disease without anemia. About three cases. Tunis Med ;82(6):555-9. ) Miscusi M, Testaverde L, Rago A, Raco A, Colonnese C. degeneration without nutritional anemia. J Clin Neurosci. 2012;19(12):1744-5. )
  • KV, Narahari MG.Helicobacter pylori associated vitamin B12 deficiency, pernicious anaemia and subacute combined degenerationof the spinal cord. BMJ Case Rep. 2013;30.
  • ) Renard D, Anais D, Remy A, Castelnovo G, Labauge P. Subacute combined degeneration of the spinal cord caused by nitrous oxide anaesthesia. Neurol Sci 2009;30:75-6.
  • ) Senol MG, Sonmez G, Ozdağ F, Saracoğlu M. Reversible myelopathy with vitamin B 12 deficiency. Singapore Med J 2008; 49: e 330
  • ) Sen A, Chandrasekhar K. Spinal MR imaging in Vitamin B12 deficiency: Case series; differential diagnosis of symmetrical posterior spinal cord lesions. Ann Indian Acad Neurol 2013; 16: 255–8.
  • ) de Medeiros FC, de Albuquerque LA, de Souza RB, Gomes Neto AP, Christo PP. Vitamin B12 extensive thoracic myelopathy: clinical, radiological and prognostic aspects. Two cases report and literature review. Neurol Sci. 2013;34:1857-60.
  • ) Marshall R, Milburn JM. Clinical Images - A Quarterly Column: Subacute Combined Degeneration of the spinal kord. Ochsner J. 2013 Summer; 13: 183–5.
  • )Yang JW, Han JY, Seong MW, Sung JJ, Park SS, Lee KW. Hereditary Spastic Paraplegia with a Novel SPAST Mutation Misdiagnosed with Subacute Combined Degeneration. Exp Neurobiol. 2013;22:128-31.
  • ) Chu C, Scanlon P. Vitamin B12 deficiency optic neuropathy detected by asymptomatic screening. bcr0220113823.
  • ) Chavala SH, Kosmorsky GS, Lee MK, Lee MS. Optic neuropathy in vitamin B12 deficiency. Eur J Intern Med. 2005;16:447-8.
  • ) Gürsoy AE, Kolukısa M, Yıldız GB, Çelebi A. Subacute Combined Degeneration of the Spinal Cord due to Different Etiologies and Improvement of MRI Findings. Case Rep Neurol Med. 2013; 159649.
  • Yazının alınma tarihi:18.03.2014 Kabül tarihi:25.06.2014 Online basım:14.08.2014
There are 15 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Zehra Özde Akkiraz This is me

Behiye Özer This is me

Ayşegül Karatepe This is me

Şehnaz Arıcı This is me

Publication Date September 1, 2014
Published in Issue Year 2014 Volume: 18 Issue: 3

Cite

APA Akkiraz, Z. Ö., Özer, B., Karatepe, A., Arıcı, Ş. (2014). B 12 VİTAMİN EKSİKLİĞİNİN NÖROLOJİK KOMPLİKASYONLARINA DAİR BİR OLGU SUNUMU. İzmir Eğitim Ve Araştırma Hastanesi Tıp Dergisi, 18(3), 66-70.
AMA Akkiraz ZÖ, Özer B, Karatepe A, Arıcı Ş. B 12 VİTAMİN EKSİKLİĞİNİN NÖROLOJİK KOMPLİKASYONLARINA DAİR BİR OLGU SUNUMU. İzmir EAH Tıp Der. September 2014;18(3):66-70.
Chicago Akkiraz, Zehra Özde, Behiye Özer, Ayşegül Karatepe, and Şehnaz Arıcı. “B 12 VİTAMİN EKSİKLİĞİNİN NÖROLOJİK KOMPLİKASYONLARINA DAİR BİR OLGU SUNUMU”. İzmir Eğitim Ve Araştırma Hastanesi Tıp Dergisi 18, no. 3 (September 2014): 66-70.
EndNote Akkiraz ZÖ, Özer B, Karatepe A, Arıcı Ş (September 1, 2014) B 12 VİTAMİN EKSİKLİĞİNİN NÖROLOJİK KOMPLİKASYONLARINA DAİR BİR OLGU SUNUMU. İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi 18 3 66–70.
IEEE Z. Ö. Akkiraz, B. Özer, A. Karatepe, and Ş. Arıcı, “B 12 VİTAMİN EKSİKLİĞİNİN NÖROLOJİK KOMPLİKASYONLARINA DAİR BİR OLGU SUNUMU”, İzmir EAH Tıp Der, vol. 18, no. 3, pp. 66–70, 2014.
ISNAD Akkiraz, Zehra Özde et al. “B 12 VİTAMİN EKSİKLİĞİNİN NÖROLOJİK KOMPLİKASYONLARINA DAİR BİR OLGU SUNUMU”. İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi 18/3 (September 2014), 66-70.
JAMA Akkiraz ZÖ, Özer B, Karatepe A, Arıcı Ş. B 12 VİTAMİN EKSİKLİĞİNİN NÖROLOJİK KOMPLİKASYONLARINA DAİR BİR OLGU SUNUMU. İzmir EAH Tıp Der. 2014;18:66–70.
MLA Akkiraz, Zehra Özde et al. “B 12 VİTAMİN EKSİKLİĞİNİN NÖROLOJİK KOMPLİKASYONLARINA DAİR BİR OLGU SUNUMU”. İzmir Eğitim Ve Araştırma Hastanesi Tıp Dergisi, vol. 18, no. 3, 2014, pp. 66-70.
Vancouver Akkiraz ZÖ, Özer B, Karatepe A, Arıcı Ş. B 12 VİTAMİN EKSİKLİĞİNİN NÖROLOJİK KOMPLİKASYONLARINA DAİR BİR OLGU SUNUMU. İzmir EAH Tıp Der. 2014;18(3):66-70.