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LARİNGEAL NÖROFİBROM: OLGU SUNUMU

Year 2015, Volume: 19 Issue: 1, 41 - 45, 01.03.2015

Abstract

Laringeal nörofibrom, benign laringeal tümörler arasında çok nadirdir. Sıklıkla, supraglottik ariepiglottik fold yerleşimli, çocuklarda ve nörofibromatozis tip 1 ile ilişkili olarak görülmektedir. Biz soliter laringeal nörofibrom sebebiyle opere edilen 60 yaşındaki erkek olgumuzu oldukça nadir görülmesi nedeniyle paylaştık. Tümörde immunhistokimyasal olarak S100 pozitifliğine ek olarak CD34 ve bcl2 pozitifliği varlığı nörofibrom tanısını destekledi. Larinkste nonepitelyal bir tümör ile karşılaşıldığında nadir olmakla birlikte nörofibrom akla getirilmeli, tanının immunhistokimyasal olarak S100, CD34 ve bcl2 pozitifliği ile desteklenebileceği akılda tutulmalıdır

References

  • ) Rebecca AL, David AS, Jane LW, Joshua SS. Diffuse Subglottic Laryngeal Neurofibroma in an Adult. Otolaryngology Head and Neck Surgery 2009;141(4):545-7.
  • ) Chen YW, Fang TJ, Li HY. A Solitary Laryngeal Neurofibroma in A Pediatric Patient. Chang Gung Med J 2004;27(12): 3.
  • ) Liu J, Wong CF, Lim F, Kanagalingam J. Glottic neurofibroma in an elderly patient: a case report. J Voice 2013;27(6):644-6.
  • ) Chinn SB, Collar RM, McHugh JB, Hogikyan ND, neurofibroma: case report and review of the literature. Int J Pediatr Otorhinolaryngol ;78(1):142-7. Pediatric laryngeal ) Gstöttner M, Galvan O, Gschwendtner A, Neher A. Solitary subglottic neurofibroma: a report of an unusual manifestation. Eur Arch Otorhino laryngol 2005;262(9):705-7.
  • ) Hirose T, Tani T, Shimada T, Ishizawa K, Shimada S, Sano T. Immunohistochemical demonstration of EMA/Glut1-positive peri- neurial cells and CD34-positive fibroblastic cells in peripheral nerve sheath tumors. Mod Pathol 2003;16(4):293-8.
  • ) Cunha KS, Caruso AC, Faria PA, Silva LE, Fonseca EC, Geller M, de Moura-Neto RS, Lopes VS. Evaluation of Bcl-2, Bcl-x and cleaved caspase-3 in malignant peripheral nerve sheath tumors and neurofibromas. An Acad Bras Cienc 2013;85(4):1497-511.
  • ) Cihangiroglu M, Yilmaz S, Topsakal C, Gok U, Altinsoy B, Cobanoglu B. Laryngeal neurofibroma associated with neurofibroma tosis type 2. AJNR Am J Neuroradiol 2002; (10):1637-9.
  • ) Izadi F, Arbabi, Ahmadzad-Asl M, Doroudinia A. Endolaryngeal Neurofibroma. Acta Medica Iranica 2008;46(4):345 -8.
  • ) Youseml MD, Oberholtzef JC. Neurofibroma of the Aryepiglottic Fold. AJNR ;12(6):1176-8.
  • ) Son HY, Shim HS, Kim JP, Woo SH. Synchronous plexiform neurofibroma in the arytenoids and neurofibroma parapharynx in a patient with non- neurofibromatosis: a case report. J Med Case Rep. 2013;7:15-6. in the ) Fine SW, McClain SA, Li M.
  • Immunohistochemical staining for calretinin is useful for differentiating schwannomas from neurofibromas. Am J Clin Pathol. 2004;122 (4):552-9.

LARYNGEAL NEUROFIBROMA: CASE REPORT

Year 2015, Volume: 19 Issue: 1, 41 - 45, 01.03.2015

Abstract

Laryngeal neurofibroma are extremely rare among benign laryngeal tumors. Most of these lesions are located in the supraglottis, aryepiglottic fold, in the pediatric population and in association with neurofibromatosis type 1 NF1 . We report a an extremely rare case of an 60-year-old man who operated because of solitary laryngeal neurofibroma. In this tumor, presence of CD34 and bcl2 positivity in addition to the immunohistochemical positivity S100, supported the diagnosis of neurofibroma. Althought it is rarely, when encountering aneurofibromas should be considered and keep in mind that the immunohistochemical S100, CD34 and bcl2 staining help to confirm diagosis of a neurofibroma. nonepithelial tumor in the larynx

References

  • ) Rebecca AL, David AS, Jane LW, Joshua SS. Diffuse Subglottic Laryngeal Neurofibroma in an Adult. Otolaryngology Head and Neck Surgery 2009;141(4):545-7.
  • ) Chen YW, Fang TJ, Li HY. A Solitary Laryngeal Neurofibroma in A Pediatric Patient. Chang Gung Med J 2004;27(12): 3.
  • ) Liu J, Wong CF, Lim F, Kanagalingam J. Glottic neurofibroma in an elderly patient: a case report. J Voice 2013;27(6):644-6.
  • ) Chinn SB, Collar RM, McHugh JB, Hogikyan ND, neurofibroma: case report and review of the literature. Int J Pediatr Otorhinolaryngol ;78(1):142-7. Pediatric laryngeal ) Gstöttner M, Galvan O, Gschwendtner A, Neher A. Solitary subglottic neurofibroma: a report of an unusual manifestation. Eur Arch Otorhino laryngol 2005;262(9):705-7.
  • ) Hirose T, Tani T, Shimada T, Ishizawa K, Shimada S, Sano T. Immunohistochemical demonstration of EMA/Glut1-positive peri- neurial cells and CD34-positive fibroblastic cells in peripheral nerve sheath tumors. Mod Pathol 2003;16(4):293-8.
  • ) Cunha KS, Caruso AC, Faria PA, Silva LE, Fonseca EC, Geller M, de Moura-Neto RS, Lopes VS. Evaluation of Bcl-2, Bcl-x and cleaved caspase-3 in malignant peripheral nerve sheath tumors and neurofibromas. An Acad Bras Cienc 2013;85(4):1497-511.
  • ) Cihangiroglu M, Yilmaz S, Topsakal C, Gok U, Altinsoy B, Cobanoglu B. Laryngeal neurofibroma associated with neurofibroma tosis type 2. AJNR Am J Neuroradiol 2002; (10):1637-9.
  • ) Izadi F, Arbabi, Ahmadzad-Asl M, Doroudinia A. Endolaryngeal Neurofibroma. Acta Medica Iranica 2008;46(4):345 -8.
  • ) Youseml MD, Oberholtzef JC. Neurofibroma of the Aryepiglottic Fold. AJNR ;12(6):1176-8.
  • ) Son HY, Shim HS, Kim JP, Woo SH. Synchronous plexiform neurofibroma in the arytenoids and neurofibroma parapharynx in a patient with non- neurofibromatosis: a case report. J Med Case Rep. 2013;7:15-6. in the ) Fine SW, McClain SA, Li M.
  • Immunohistochemical staining for calretinin is useful for differentiating schwannomas from neurofibromas. Am J Clin Pathol. 2004;122 (4):552-9.
There are 11 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Enver Vardar This is me

Tolgahan Çatlı This is me

Tulu Kebat This is me

Asuman Argon This is me

Çağrı Çelik This is me

Didem Ersöz This is me

Publication Date March 1, 2015
Published in Issue Year 2015 Volume: 19 Issue: 1

Cite

APA Vardar, E., Çatlı, T., Kebat, T., Argon, A., et al. (2015). LARİNGEAL NÖROFİBROM: OLGU SUNUMU. İzmir Eğitim Ve Araştırma Hastanesi Tıp Dergisi, 19(1), 41-45.
AMA Vardar E, Çatlı T, Kebat T, Argon A, Çelik Ç, Ersöz D. LARİNGEAL NÖROFİBROM: OLGU SUNUMU. İzmir EAH Tıp Der. March 2015;19(1):41-45.
Chicago Vardar, Enver, Tolgahan Çatlı, Tulu Kebat, Asuman Argon, Çağrı Çelik, and Didem Ersöz. “LARİNGEAL NÖROFİBROM: OLGU SUNUMU”. İzmir Eğitim Ve Araştırma Hastanesi Tıp Dergisi 19, no. 1 (March 2015): 41-45.
EndNote Vardar E, Çatlı T, Kebat T, Argon A, Çelik Ç, Ersöz D (March 1, 2015) LARİNGEAL NÖROFİBROM: OLGU SUNUMU. İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi 19 1 41–45.
IEEE E. Vardar, T. Çatlı, T. Kebat, A. Argon, Ç. Çelik, and D. Ersöz, “LARİNGEAL NÖROFİBROM: OLGU SUNUMU”, İzmir EAH Tıp Der, vol. 19, no. 1, pp. 41–45, 2015.
ISNAD Vardar, Enver et al. “LARİNGEAL NÖROFİBROM: OLGU SUNUMU”. İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi 19/1 (March 2015), 41-45.
JAMA Vardar E, Çatlı T, Kebat T, Argon A, Çelik Ç, Ersöz D. LARİNGEAL NÖROFİBROM: OLGU SUNUMU. İzmir EAH Tıp Der. 2015;19:41–45.
MLA Vardar, Enver et al. “LARİNGEAL NÖROFİBROM: OLGU SUNUMU”. İzmir Eğitim Ve Araştırma Hastanesi Tıp Dergisi, vol. 19, no. 1, 2015, pp. 41-45.
Vancouver Vardar E, Çatlı T, Kebat T, Argon A, Çelik Ç, Ersöz D. LARİNGEAL NÖROFİBROM: OLGU SUNUMU. İzmir EAH Tıp Der. 2015;19(1):41-5.