PİSA SENDROMU; BİR OLGU SUNUMU

Year 2015, Volume: 19 Issue: 3, 165 - 167, 01.09.2015

Dursun Hakan Delibaş Esin Erdoğan Murat Acar Abdurrahman Şeref Gülseren

Abstract

Pisa sendromu PS , ilk kez 1972 yılında Ekbom ve arkadaşları tarafından bildirilen, gövdede gelişen nadir bir geç distoni türüdür. PS gelişmesi sıklıkla uzamış antipsikotik tedavisiyle ilişkilidir, ancak diğer ilaçları kullanan hastalarda kolinesteraz inhibitörleri, antiemetikler gibi , ilaç kullanmayan bireylerde idyopatik PS ve nörodejeneratif bozukluklarda da bildirilmiştir. Bu yazında, risperidon kullanımına bağlı olarak PS gelişen şizofreni tanılı bir olgu tartışılacaktır. PS özellikle D2 reseptörlerine etkin antipsikotiklerin uzun süreli ve yüksek dozda kullanımında görülmektedir. PS gelişirse kullanılan antipsikotik tedavisi kesilmeli, ekstrapiramidal sistem yan etki profili düşük antipsikotiklere geçilmelidir. PS’e sebep olabilecek diğer tıbbı durumlar dışlanmalıdır. Baklofen ve klozapin tedavi seçenekleri arasında düşünülmelidir

Keywords

tardiv distoni, risperidon, baklofen, klozapin

PISA SYNDROME; A CASE REPORT

Abstract

Pisa syndrome PS is rare type of tardive truncal dystonia which were first reported by Ekbom et al in 1972. The development of PS is most commonly associated with prolonged treatment with antipsychotics; however, it has also been reported, although less frequently, in patients who are receiving other medications such as cholinesterase inhibitors and antiemetics , in those not receiving medication idiopathic PS and in those with neurodegenerative disorders. In this article, a case of a shizophrenia in which PS induced by the use of risperidone will be discussed. PS is seen particularly in long-term and high doses of administration of D2 reseptor sensitive antipsychotics. If PS is diagnosed antipsychotic treatment must be discontinued and switching to other antipsyhotics which have low potential of extrapyramidal side effect profile is a better choice. The other medical conditions which can cause PS should be excluded. Options of baclofen and clozapine treatment should also be considered

Keywords

Tardive dystonia, risperidone, baclofen, clozapine

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