KRONİK LENFOSİTİK LÖSEMİ/LENFOMA TANILI HASTALARIMIZIN RETROSPEKTİF DEĞERLENDİRİLMESİ

Year 2016, Volume: 20 Issue: 3, 87 - 94, 01.09.2016

Şerife Solmaz Medeni Tugba Çetintepe Sinem Namdaroğlu Rumeysa Sarı Merve Koçar Ebru Özden Oktay Bilgir

Abstract

Giriş: Çalışmamızda Bozyaka Eğitim ve Araştırma Hastanesi Hematoloji Kliniğinde takip edilen 91 kronik lenfositik lösemili hastanın demografik verileri, tedavi endikasyonları, tedavi yanıtları ile sağkalım analizlerinin yapılması amaçlandı. Gereç ve Yöntem: Kronik Lenfositik Lösemi/Lenfoma tanısı ile izlenen 91 olgunun verileri geriye dönük olarak değerlendirildi. Bulgular: Çalışmaya alınan 91 hastadan 48'i erkek, 43'ü kadındı. Ortanca yaş 67 olarak saptandı.57 hasta tedavisiz izlenirken, 34 hasta tedavi aldı. 21 hasta Ritüksimab, fludarabin, siklofosfomid R- FC , 6 hasta Fludarabin, sikolofosfomid FC , 5 hasta Ritüksimab-Klorombusil, 1 hasta Fludarabin, mitaksantron, siklofosfomid FMC ve 1 hasta Ritüksimab, siklofosfomid, vinkristin, prednizolon R-CVP tedavisi aldı. Hastaların 18 tanesi ölmüş, 74 tanesi ise yaşıyor olarak saptandı. Tüm KLL hastalarında ortalama sağkalım süresi 45 ay olarak bulundu. 1 yıllık sağkalım %95, 5 yıllık sağkalım % 41 olarak saptandı. Sonuç: Hastalarımızın demografik özellikleri diğer çalışmalar ile benzerdir. Tedavi alan gruptaki sağkalım daha yüksek bulunuştur. Bununla beraber çalışmamızda toplam sağkalım süresi literatürdekilerden daha kısa bulunmuştur

Keywords

Kronik lenfositik lösemi/lenfoma, prognoz

RETROSPECTIVE EVALUATION OF OUR PATIENTS WITH DIAGNOSIS CHRONIC LYMPHOCYTIC LEUKEMIA/LYMPHOMA

Abstract

Introduction: Demografic features, treatment endications, respond the treatment of 91 chronic lymphocytic leukemia CLL patients observed at depertman of hematology, Bozyaka Traning and Research Hospital in our study. Material and Method: Data of 91 CLL patients were evaluated retrospectively. Results: We found that 43 of the patients were women and 48 of the patients and were men and median age were 67. While 34 patients received treatment, 57 patients were observed. 21 patients were treated by R-FC , 6 patients by FC, 5 patients by R-Klorombucil, 2 patients by FMC and R-CVP.18 patients died, and 74 of them lived.We found the median survival 45 months all of the patients. All patients survival OS was 95% of one year and 5 years overall survival rates 41%. Conclusion: Demografic features of patients are similar to another studies. The survival were higher in the treatment group. However, in our study was significantly shorter overall survival than those in the literature

Keywords

Chronic lymphocytic leukemia/ lymphoma, prognosis

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• İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi (Medical Journal of İzmir Hospital)