Background and Aim: To evaluate the effects of trehalose and sodium hyaluronate solution on ocular comfort and tear-film instability after cataract surgery Materials and Methods: This prospective study was conducted between May 2017 and January 2018. Patients over the age of 18 years who underwent unilateral cataract surgery were included in the study. Preoperatively, all patients underwent Schirmer test and tear film break-up time (TBUT) measurement. At postoperative month 1, the ocular surface was evaluated using the Ocular Surface Disease Index (OSDI), Schirmer test, TBUT, and corneal fluorescein staining. patients were asked to rate the severity of their dry eye symptoms (foreign body sensation, burning and stinging, desire to close the eyes, increased blinking frequency) on a visual analogue scale (VAS). Results: The study group showed no statistically significant change in Schirmer test results between baseline and postoperative 1 month in the study group (p=0.086), Preoperative TBUT was equivalent in the two groups (11 s for both, p>0.05). TBUT at postoperative 1 month was longer in the study group than the control group (12 s vs. 9 s, p <0.001). At postoperative 1 month, OSDI scores were significantly lower in the study group than the control group (2.27 vs. 20, p<0.001) .Foreign body sensation and burning and stinging sensation were significantly lower in the study group than in the control group (p=0.002 and p=0.004, respectively). Fluorescein corneal staining scores were also significantly lower in the study group than in the control group (p=0.005) . Conclusion: This study indicates that 3% trehalose and 0.15% sodium hyaluronate solution reduces dry eye symptoms, stabilized tear film layer, and increased corneal cell viability after cataract surgery. Key words: Hyaluronate solution , trehalose solution , ocular comfort, tear-film instability
Primary Language | English |
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Subjects | Health Care Administration |
Journal Section | Articles |
Authors | |
Publication Date | August 12, 2020 |
Submission Date | August 20, 2020 |
Acceptance Date | September 23, 2020 |
Published in Issue | Year 2020 Volume: 3 Issue: 1 |