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Melanocortine System: Appetite and Energy Homeostasis Mechanisms

Year 2021, Volume 3, Issue 3, 212 - 219, 30.12.2021
https://doi.org/10.47769/izufbed.1027766

Abstract

The appetite and energy balance has been tried to be exposed with researches for many years. Melanocortin system has an important role in maintaining this balance in the brain. It provides its functions with different mechanisms. The mechanisms; it is associated with hormones, dopamine, AMPK, exercise, diet, immunoglobulins and lipocalin-2. Malfunctions in the functioning of the melanocortin system cause many metabolic syndromes, especially childhood obesity. It may be important for many diseases to develop treatment methods for these conditions caused by diet-related or genetic variations. In this review, the working principles of the melanocortin system in appetite and energy balance and its relations with foods are examined.

References

  • Greenhill, C. (2017). Osteoblast-derived lipocalin 2 suppresses appetite. Nature Reviews Endocrinology, 13(5), 250. https://doi.org/10.1038/nrendo.2017.30
  • Morell-Azanza, Ojeda-Rodríguez, Giuranna, Azcona-SanJulián, Hebebrand, Marti, & Hinney. (2019). Melanocortin-4 Receptor and Lipocalin 2 Gene Variants in Spanish Children with Abdominal Obesity: Effects on BMI-SDS After a Lifestyle Intervention. Nutrients, 11(5), 960. https://doi.org/10.3390/nu11050960
  • Butler, A. A., Girardet, C., Mavrikaki, M., Trevaskis, J. L., Macarthur, H., Marks, D. L., & Farr, S. A. (2017). A Life without Hunger: The Ups (and Downs) to Modulating Melanocortin-3 Receptor Signaling. Frontiers in Neuroscience, 11. Published. https://doi.org/10.3389/fnins.2017.00128
  • Yeo, G. S., Chao, D. H. M., Siegert, A. M., Koerperich, Z. M., Ericson, M. D., Simonds, S. E., . . . Adan, R. A. (2021). The melanocortin pathway and energy homeostasis: From discovery to obesity therapy. Molecular Metabolism, 48, 101206. https://doi.org/10.1016/j.molmet.2021.101206
  • Mosialou, I., Shikhel, S., Liu, J. M., Maurizi, A., Luo, N., He, Z., . . . Kousteni, S. (2017). Erratum: Corrigendum: MC4R-dependent suppression of appetite by bone-derived lipocalin 2. Nature, 546(7658), 440. https://doi.org/10.1038/nature22808
  • Gava, F. N., da Silva, A. A., Dai, X., Harmancey, R., Ashraf, S., Omoto, A. C., . . . do Carmo, J. M. (2021b). Restoration of Cardiac Function After Myocardial Infarction by Long-Term Activation of the CNS Leptin-Melanocortin System. JACC: Basic to Translational Science, 6(1), 55–70. https://doi.org/10.1016/j.jacbts.2020.11.007
  • Petropoulou, P. I., Mosialou, I., Shikhel, S., Hao, L., Panitsas, K., Bisikirska, B., . . . Kim, J. (2021). Lipocalin-2 is an anorexigenic signal in primates. Yearbook of Paediatric Endocrinology. Published. https://doi.org/10.1530/ey.18.14.2

Melanokortin Sistemi: İştah ve Enerji Homeostazı Etki Mekanizmaları

Year 2021, Volume 3, Issue 3, 212 - 219, 30.12.2021
https://doi.org/10.47769/izufbed.1027766

Abstract

İştah ve enerji dengesi uzun yıllardır araştırmalarla aydınlatılmaya çalışılmaktadır. Beyindeki melanokortin sistemi bu dengenin korunmasında önemli bir role sahiptir. İşlevlerini vücuttaki farklı mekanizmalarla sağlar. Bu mekanizmalar; hormonlar, dopamin, AMPK, egzersiz, diyet, immünoglobülinler ve lipokalin-2 ile ilişkilidir. Melanokortin sisteminin işleyişindeki bozukluklar başta çocukluk çağı obezitesi olmak üzere birçok metabolik sendroma sebep olur. Diyete bağlı veya genetik varyasyonların sebep olduğu bu durumların tedavi yollarını geliştirmek birçok hastalık için önemli olabilir. Bu derlemede, melanokortin sisteminin iştah ve enerji dengesindeki çalışma prensipleri ve besinlerle olan ilişkileri incelenmiştir.

References

  • Greenhill, C. (2017). Osteoblast-derived lipocalin 2 suppresses appetite. Nature Reviews Endocrinology, 13(5), 250. https://doi.org/10.1038/nrendo.2017.30
  • Morell-Azanza, Ojeda-Rodríguez, Giuranna, Azcona-SanJulián, Hebebrand, Marti, & Hinney. (2019). Melanocortin-4 Receptor and Lipocalin 2 Gene Variants in Spanish Children with Abdominal Obesity: Effects on BMI-SDS After a Lifestyle Intervention. Nutrients, 11(5), 960. https://doi.org/10.3390/nu11050960
  • Butler, A. A., Girardet, C., Mavrikaki, M., Trevaskis, J. L., Macarthur, H., Marks, D. L., & Farr, S. A. (2017). A Life without Hunger: The Ups (and Downs) to Modulating Melanocortin-3 Receptor Signaling. Frontiers in Neuroscience, 11. Published. https://doi.org/10.3389/fnins.2017.00128
  • Yeo, G. S., Chao, D. H. M., Siegert, A. M., Koerperich, Z. M., Ericson, M. D., Simonds, S. E., . . . Adan, R. A. (2021). The melanocortin pathway and energy homeostasis: From discovery to obesity therapy. Molecular Metabolism, 48, 101206. https://doi.org/10.1016/j.molmet.2021.101206
  • Mosialou, I., Shikhel, S., Liu, J. M., Maurizi, A., Luo, N., He, Z., . . . Kousteni, S. (2017). Erratum: Corrigendum: MC4R-dependent suppression of appetite by bone-derived lipocalin 2. Nature, 546(7658), 440. https://doi.org/10.1038/nature22808
  • Gava, F. N., da Silva, A. A., Dai, X., Harmancey, R., Ashraf, S., Omoto, A. C., . . . do Carmo, J. M. (2021b). Restoration of Cardiac Function After Myocardial Infarction by Long-Term Activation of the CNS Leptin-Melanocortin System. JACC: Basic to Translational Science, 6(1), 55–70. https://doi.org/10.1016/j.jacbts.2020.11.007
  • Petropoulou, P. I., Mosialou, I., Shikhel, S., Hao, L., Panitsas, K., Bisikirska, B., . . . Kim, J. (2021). Lipocalin-2 is an anorexigenic signal in primates. Yearbook of Paediatric Endocrinology. Published. https://doi.org/10.1530/ey.18.14.2

Details

Primary Language Turkish
Subjects Health Care Sciences and Services
Journal Section Articles
Authors

Ela ALTUN> (Primary Author)
It is not affiliated with an institution
0000-0003-4129-6955
Türkiye


Sabiha Zeynep Aydenk KÖSEOĞLU>
İSTANBUL SABAHATTİN ZAİM ÜNİVERSİTESİ
0000-0001-7936-8462
Türkiye

Publication Date December 30, 2021
Application Date November 24, 2021
Acceptance Date December 30, 2021
Published in Issue Year 2021, Volume 3, Issue 3

Cite

APA Altun, E. & Köseoğlu, S. Z. A. (2021). Melanokortin Sistemi: İştah ve Enerji Homeostazı Etki Mekanizmaları . İstanbul Sabahattin Zaim Üniversitesi Fen Bilimleri Enstitüsü Dergisi , 3 (3) , 212-219 . DOI: 10.47769/izufbed.1027766

20503

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