Effectiveness of Cream Containing Medicinal Plants in the Treatment of Second Degree Burns: Biochemical and Histopathological Investigation

Seda Aşkın; Esra Palabıyık; Handan Uğuz Bayrakçeken; Bahri Avcı; Ayşe Nurseli Sulumer; Harika Derya Tamer; Hakan Aşkın

doi:10.35229/jaes.1659982

TR EN

İkinci Derece Yanıkların Tedavisinde Tıbbi Bitkiler İçeren Kremlerin Etkinliği: Biyokimyasal ve Histopatolojik Araştırma

Abstract

Yanık yaralanmaları, artan oksidatif stres ve bozulmuş doku bütünlüğü ile karakterize edilen ciddi patofizyolojik durumları temsil eder ve etkili terapötik müdahaleleri gerektirir. Bu çalışma, Juglans regia yaprak özütü, Argania spinosa çekirdeği yağı, Prunus dulcis yağı ve Lavandula angustifolia yağı içeren yeni bir krem formülasyonunun ikinci derece yanık yaraları üzerindeki biyokimyasal ve histopatolojik etkilerini değerlendirir. Bir Wistar-albino sıçan modeli kullanılarak, formülasyonun terapötik potansiyelini belirlemek için süperoksit dismutaz (SOD) ve malondialdehit (MDA) dahil olmak üzere oksidatif stres belirteçleri histopatolojik değerlendirmelerle birlikte analiz edildi. Sonuçlar, tedavi grubunda SOD seviyelerinde önemli bir artış ve MDA seviyelerinde eş zamanlı bir azalma olduğunu göstererek, gelişmiş bir antioksidan tepkisi ve azalmış lipid peroksidasyonunu düşündürmektedir. Histopatolojik değerlendirmeler, yanık kontrol ve gümüş sülfadiazin gruplarına kıyasla hızlandırılmış epitelizasyon, artmış fibroblast aktivitesi ve iyileştirilmiş keratinizasyon ortaya koydu. Bu bulgular, test edilen formülasyonun doku rejenerasyonunu desteklerken oksidatif hasarı etkili bir şekilde azalttığını göstermektedir. Geleneksel yanık tedavilerine potansiyel bir alternatif olarak, bu bitki bazlı formülasyon ikinci derece yanıkları yönetmek için yenilikçi ve uygun maliyetli bir terapötik strateji sunabilir. Ancak, insan uygulamalarında etkinliğini doğrulamak için daha fazla klinik çalışmaya ihtiyaç vardır.

Keywords

Antioksidan aktivite, bitkisel yanık tedavisi, histopatolojik değerlendirme

Effectiveness of Cream Containing Medicinal Plants in the Treatment of Second Degree Burns: Biochemical and Histopathological Investigation

Abstract

Burn injuries represent severe pathophysiological conditions characterized by increased oxidative stress and impaired tissue integrity, necessitating effective therapeutic interventions. This study evaluates the biochemical and histopathological effects of a novel cream formulation containing Juglans regia leaf extract, Argania spinosa kernel oil, Prunus dulcis oil, and Lavandula angustifolia oil on second-degree burn wounds. Using a Wistar-albino rat model, oxidative stress markers, including superoxide dismutase (SOD) and malondialdehyde (MDA), were analyzed alongside histopathological assessments to determine the formulation’s therapeutic potential. The results demonstrated a significant increase in SOD levels and a concurrent reduction in MDA levels in the treatment group, suggesting an enhanced antioxidant response and reduced lipid peroxidation. Histopathological evaluations revealed accelerated epithelialization, increased fibroblast activity, and improved keratinization compared to the burn control and silver sulfadiazine groups. These findings indicate that the tested formulation effectively mitigates oxidative damage while promoting tissue regeneration. As a potential alternative to conventional burn treatments, this plant-based formulation may offer an innovative and cost-effective therapeutic strategy for managing second-degree burns. However, further clinical studies are required to confirm its efficacy in human applications.

Keywords

Antioxidant activity, herbal burn therapy, histopathological evaluation

Ethical Statement

This study was conducted in accordance with the decision of the Atatürk University Medical Experimental Application and Research Center (ATADEM) Ethics Committee, numbered E-75296309-050.01.04-2400427040 and dated 26.12.2024.

Thanks

We would like to thank ATADEM, the Faculty of Science Molecular Biology and Genetics Laboratory, and the Faculty of Medicine Medical Pathology Laboratory where our experimental studies were carried out.

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Details

Primary Language

English

Subjects

Zoology (Other)

Journal Section

Research Article

Authors

Seda Aşkın
0000-0001-6133-9065
Türkiye

Esra Palabıyık ^*
0000-0002-3066-1921
Türkiye

Handan Uğuz Bayrakçeken
0000-0001-5444-1459
Türkiye

Bahri Avcı
0000-0001-8451-5463
Türkiye

Ayşe Nurseli Sulumer
0000-0002-2001-2186
Türkiye

Harika Derya Tamer
0009-0000-6016-0039
Türkiye

Hakan Aşkın
0000-0003-3248-759X
Türkiye

Early Pub Date

September 22, 2025

Publication Date

September 30, 2025

Submission Date

March 18, 2025

Acceptance Date

September 16, 2025

Published in Issue

Year 2025 Volume: 10 Number: 5

DOI

https://doi.org/10.35229/jaes.1659982

IZ

https://izlik.org/JA39WH78TC

APA

Aşkın, S., Palabıyık, E., Uğuz Bayrakçeken, H., Avcı, B., Sulumer, A. N., Tamer, H. D., & Aşkın, H. (2025). Effectiveness of Cream Containing Medicinal Plants in the Treatment of Second Degree Burns: Biochemical and Histopathological Investigation. Journal of Anatolian Environmental and Animal Sciences, 10(5), 693-702. https://doi.org/10.35229/jaes.1659982

AMA

1.Aşkın S, Palabıyık E, Uğuz Bayrakçeken H, et al. Effectiveness of Cream Containing Medicinal Plants in the Treatment of Second Degree Burns: Biochemical and Histopathological Investigation. JAES. 2025;10(5):693-702. doi:10.35229/jaes.1659982

Chicago

Aşkın, Seda, Esra Palabıyık, Handan Uğuz Bayrakçeken, et al. 2025. “Effectiveness of Cream Containing Medicinal Plants in the Treatment of Second Degree Burns: Biochemical and Histopathological Investigation”. Journal of Anatolian Environmental and Animal Sciences 10 (5): 693-702. https://doi.org/10.35229/jaes.1659982.

EndNote

Aşkın S, Palabıyık E, Uğuz Bayrakçeken H, Avcı B, Sulumer AN, Tamer HD, Aşkın H (September 1, 2025) Effectiveness of Cream Containing Medicinal Plants in the Treatment of Second Degree Burns: Biochemical and Histopathological Investigation. Journal of Anatolian Environmental and Animal Sciences 10 5 693–702.

IEEE

[1]S. Aşkın et al., “Effectiveness of Cream Containing Medicinal Plants in the Treatment of Second Degree Burns: Biochemical and Histopathological Investigation”, JAES, vol. 10, no. 5, pp. 693–702, Sept. 2025, doi: 10.35229/jaes.1659982.

ISNAD

Aşkın, Seda - Palabıyık, Esra - Uğuz Bayrakçeken, Handan - Avcı, Bahri - Sulumer, Ayşe Nurseli - Tamer, Harika Derya - Aşkın, Hakan. “Effectiveness of Cream Containing Medicinal Plants in the Treatment of Second Degree Burns: Biochemical and Histopathological Investigation”. Journal of Anatolian Environmental and Animal Sciences 10/5 (September 1, 2025): 693-702. https://doi.org/10.35229/jaes.1659982.

JAMA

1.Aşkın S, Palabıyık E, Uğuz Bayrakçeken H, Avcı B, Sulumer AN, Tamer HD, Aşkın H. Effectiveness of Cream Containing Medicinal Plants in the Treatment of Second Degree Burns: Biochemical and Histopathological Investigation. JAES. 2025;10:693–702.

MLA

Aşkın, Seda, et al. “Effectiveness of Cream Containing Medicinal Plants in the Treatment of Second Degree Burns: Biochemical and Histopathological Investigation”. Journal of Anatolian Environmental and Animal Sciences, vol. 10, no. 5, Sept. 2025, pp. 693-02, doi:10.35229/jaes.1659982.

Vancouver

1.Seda Aşkın, Esra Palabıyık, Handan Uğuz Bayrakçeken, Bahri Avcı, Ayşe Nurseli Sulumer, Harika Derya Tamer, Hakan Aşkın. Effectiveness of Cream Containing Medicinal Plants in the Treatment of Second Degree Burns: Biochemical and Histopathological Investigation. JAES. 2025 Sep. 1;10(5):693-702. doi:10.35229/jaes.1659982

Cited By

Investıgatıon of the In vıtro and In vıvo Effect of A Mıxture Of Ficus carica L. and Hippophae rhamnoides L. on Experımentally Induced Burns in Rats

Burns

https://doi.org/10.1016/j.burns.2026.107921

EBSCOHost Scilit CABI

JAES/AAS-Journal of Anatolian Environmental and Animal Sciences/Anatolian Academic Sciences&Anadolu Çevre ve Hayvancılık Dergisi/Anadolu Akademik Bilimler-AÇEH/AAS