Parvovirus ile Enfekte Köpeklerde Nötrofil/Lenfosit, Monosit/Lenfosit ve Platelet/Lenfosit Oranlarının Belirlenmesi

Year 2021, Volume: 6 Issue: 4, 585 - 591, 31.12.2021

Didem Pekmezci , Zeynep Nurselin Çolak

https://doi.org/10.35229/jaes.993377

Cited By: 2

Abstract

Nötrofil/lenfosit oranı (NEU/LYM), monosit/lenfosit oranı (MONO/LYM), ve platelet/lenfosit oranı (PLT/LYM) inflamasyonunun ucuz, tekrar kullanılabilen biyobelirteçlerini oluşturmaktadır. Bu çalışma ilk defa parvovirus enfeksiyonu (PVE) şekillenmiş köpeklerde NEU/LYM, MONO/LYM ve PLT/LYM değerlerini ortaya koymaktadır. Çalışmanın amacını ise tedavi öncesi PVE ile pozitif köpeklerin NEU/LYM, MONO/LYM ve PLT/LYM değerlerinin, sağlıklı kontrollere göre karşılaştırılması oluşturmuştur. On sekiz sahipli, 2-8 aylık, PVE pozitif köpek, çalışma grubunu oluşturmuştur. Yedi sahipli, aynı yaş aralığında sağlıklı köpek ise kontrol grubunu oluşturmuştur. Gruplar arasında tedavi öncesi NEU/LYM, MONO/LYM karşılaştırılmasında PVE pozitif grubu ortalama NEU (P<0,001), LYM (P<0,05) değerleri kontrol grubuna istatistiksel olarak düşük bulunmuştur. Bununla birlikte, PVE pozitif grubunda tedavi öncesi ortalama PLT/LYM seviyeleri kontrol grubuna göre istatistiksel olarak yüksek (P<0,001) tespit edilmiştir. PVE pozitif ve kontrol gruplarında ortalama PLT/LYM düzeyleri ise sırasıyla 1120,94 ve 135,26 olarak bulunmuştur. Sonuç olarak, bu ön çalışma PLT/LYM oranın, PVE ile doğal olarak enfekte olmuş köpeklerde kolay, uygun maliyetli, objektif ve invazif olmayan yeni bir prognostik belirteç adayı olabileceğini göstermektedir. NEU/LYM, MONO/LYM, PLT/LYM ile ilgili çalışmaların kısıtlı varlığına rağmen, özellikle veteriner hekimlikte bulaşıcı hastalıklarda daha ileri çalışmalara ihtiyaç duyulmaktadır.

Keywords

Nötrofil/lenfosit oranı, Monosit/lenfosit oranı, Platelet/lenfosit oranı, Parvovirus, Köpek

Supporting Institution

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Project Number

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Thanks

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Determination of Neutrophil/Lymphocyte, Monocyte/Lymphocyte and Platelet/Lymphocyte Ratios in Dogs with Occurring Parvovirus Infection

Abstract

Neutrophil/lymphocyte ratio (NEU/LYM), monocyte/lymphocyte ratio (MONO/LYM), and platelet/lymphocyte ratio (PLT/LYM) are inexpensive and reproducible biomarkers of inflammation. This is the first study that explores NEU/LYM, MONO/LYM, and PLT/LYM in dogs with Parvovirus infection (PVI). This study aims to determine whether the pretreatment NEU/LYM, MONO/LYM, and PLT/LYM differs in dogs with PVI against healthy controls. Eighteen client-owned dogs aged 2-8 months that were found positive with PVI were enrolled as the study group. Seven client-owned, healthy dogs of the same age formed the control group. Pretreatment NEU/LYM, MONO/LYM, and PLT/LYM were compared between groups. The pretreatment mean NEU (P< 0.001) and LYM (P<0.05) levels were found to be significantly lower in the study group when compared to the control group. However, pretreatment mean PLT/LYM levels in the PVI positive group was significantly higher (P<0.001) than in the control group. The mean PLT/LYM levels in the PVI positive and control groups were found as 1120.94 and 135.26, respectively. In summary, this preliminary study demonstrates that pretreatment PLT/LYM in dogs with PVI positive is an easy, cost-effective, objective, and non-invasive biomarker that could be the new prognostic marker candidates in dogs naturally infected with PVI. Although limited studies on NEU/LYM, MONO/LYM, PLT/LYM are existed, especially further studies in veterinary medicine with infectious diseases are needed.

Keywords

Neutrophil/lymphocyte ratio, Monocyte/lymphocyte ratio, Platelet/lymphocyte ratio, Parvovirus, Dog

Project Number

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