The association of diesel vehicle emissions and diesel passenger car preferences with cancer and chronic respiratory airway disease deaths in Türkiye: an ecological study

Yıl 2024, Cilt: 9 Sayı: 4, 703 - 710

Ömür Güngör , Özge Özata Güngör

https://doi.org/10.35229/jaes.1558892

Öz

The first aim of this study was to investigate the relationship of increased emissions from diesel vehicles with the ratios of chronic respiratory disease and cancer deaths. Secondly, this study aims to investigate the types of cancer deaths associated with the increase in diesel passenger cars. The fuel types and engine types of cars in traffic since 2004 were obtained from national statistics data (TurkStat) and Automotive Distributors and Mobility Association data. Chronic respiratory disease and cancer death rates were calculated using the TurkStat data. Time-lag correlation analysis was examined to evaluate the relationship between the increase in the number of diesel vehicles and deaths from diseases (5-year lag). The increase in diesel vehicles correlated with deaths from colon (r: 0.81), pancreas (r: 0.83), rectum (r: 0.79), bladder (r: 0.83), and skin (r: 0.59) cancers in males. For females, there was a correlation between the increase in diesel vehicles and deaths from lung and larynx (r: 0.73), colon (r: 0.66), pancreas (r: 0.85), bladder (r: 0.66), breast (r: 0.85), uterus (r: 0.91), and ovarian (r: 0.81) cancers. The increase in diesel car preference was associated with deaths from lung and larynx (r: 0.57), colon (r: 0.59), and bladder (r: 0.63) cancers in females. The outcomes underscore the potential public health impact of diesel vehicle emissions and the need for regulatory policies to mitigate these harmful effects. Promoting cleaner alternatives can be a supportive step in the fight against cancer.

Anahtar Kelimeler

air pollution, cancer, diesel exposure, environment

Türkiye'de dizel araç emisyonları ve dizel binek araç tercihlerinin kanser ve kronik solunum yolu hastalığı ölümleriyle ilişkisi: ekolojik bir çalışma

Öz

Ulaştırma sektöründeki artan taleplere yanıt olarak dizel araçların kullanımı son 20 yılda hızla artmıştır. Dizel motorlar çeşitli avantajları nedeniyle binek otomobiller için popüler bir tercih haline gelmiştir. Bu çalışmanın ilk amacı dizel araçlardan kaynaklanan artan emisyonların kronik solunum yolu hastalığı ve kanser ölüm hızlarıyla ilişkisini araştırmaktır. İkinci olarak, bu çalışma dizel binek otomobillerdeki artışla ilişkili kanser ölüm türlerini araştırmayı amaçlamaktadır. Trafikteki araçların yakıt türleri ve motor türleri 2004 yılını kapsayacak şekilde Türkiye İstatistik Kurumu (TÜİK) verilerinden ve Otomotiv Distribütörleri ve Mobilite Derneği verilerinden elde edilmiştir. Kronik solunum yolu hastalığı ve kanser ölüm oranları TÜİK verileri kullanılarak hesaplanmıştır. Dizel araç sayısındaki artış ile hastalıklardan kaynaklanan ölümler arasındaki ilişkiyi değerlendirmek için time-lag korelasyon analizi yapılmıştır. Time-lag semi-partial korelasyon testi kullanılarak dizel araç tercihiyle ilişkili kanser türlerinden kaynaklanan ölümler analiz edilmiştir. Dizel araçlardaki artış erkeklerde kolon (r: 0.81), pankreas (r: 0.83), rektum (r: 0.79), mesane (r: 0.83) ve cilt (r: 0.59) kanserlerinden kaynaklanan ölümlerle ilişkiliydi. Kadınlarda dizel araçlardaki artış ile akciğer ve gırtlak (r: 0.73), kolon (r: 0.66), pankreas (r: 0.85), mesane (r: 0.66), meme (r: 0.85), uterus (r: 0.91) ve yumurtalık (r: 0.81) kanserlerinden kaynaklanan ölümler arasında bir ilişki vardı. Dizel araç tercihindeki artış kadınlarda akciğer ve gırtlak (r: 0.57), kolon (r: 0.59) ve mesane (r: 0.63) kanserlerinden kaynaklanan ölümlerle ilişkiliydi. Sonuçlar, dizel araç emisyonlarının potansiyel halk sağlığı etkisini ve bu zararlı etkileri azaltmak için düzenleyici politikalara olan ihtiyacı vurgulamaktadır. Daha temiz alternatifleri teşvik etmek, kansere karşı mücadelede destekleyici bir adım olabilir.

Anahtar Kelimeler

çevre, dizel maruziyeti, hava kirliliği, kanser

Kaynakça

• Aghapour, M., Ubags, N.D., Bruder, D., Hiemstra, P.S., Sidhaye, V. & Rezaee, F. (2022). Role of air pollutants in airway epithelial barrier dysfunction in asthma and COPD. Eur Respir Rev, 23, (163), 210112. PMID: 35321933, PMCID: PMC9128841. DOI: 10.1183/16000617.0112- 2021
• Andrés, L. & Padilla, E. (2018). Driving factors of GHG emissions in the EU transport activity. Transp Policy, 61, 60-74.
• Attfield, M.D., Schleiff, P.L., Lubin, J.H., Blair, A., Stewart, P.A. & Vermeulen, R. (2012). The diesel exhaust in miners study: a cohort mortality study with emphasis on lung cancer. Journal of the National Cancer Institute, 104(11), 869-883. DOI: 10.1093/jnci/djs035
• Boffetta, P., Harris, R.E. & Wynder, E.L. (1990). Case- control study on occupational exposure to diesel exhaust and lung cancer risk. American Journal Of Industrial Medicine, 17(5), 577-591. DOI: 10.1002/ajim.4700170504
• Candela, A., Sandrini, G., Gadola, M., Chindamo, D. & Magri, P. (2024). Lightweighting in the automotive industry as a measure for energy efficiency: Review of the main materials and methods. Heliyon, 10(8), DOI: 10.1016/j.heliyon.2024.e29728
• D'Agostini, M., Collatuzzo, G., Teglia, F. & Boffetta, P. (2024). Risk of skin cancer in workers exposed to diesel exhaust: a systematic review and meta- analysis of cohort studies. La Med del Lav, 115(2), DOI: 10.23749/mdl.v1
• Drizik, E., Corbett, S., Zheng, Y., Vermeulen, R., Dai, Y. & Hu, W. (2020). Transcriptomic changes in the nasal epithelium associated with diesel engine exhaust exposure. Environ Int, 137, 105506; DOI: 10.1016/j.envint.2020.105506
• European Commission. (2024a). CO₂ emission performance standards for cars and vans. Available: https://climate.ec.europa.eu/eu- action/transport/road-transport-reducing-co2- emissions-vehicles/co2-emission-performance- standards-cars-and-vans_en [Accessed 14 June 2024].
• European Commission. (2024b). Reducing CO₂ emissions from heavy-duty vehicles. Available: https://climate.ec.europa.eu/eu-action/transport/ road-transport-reducing-co2-emissions-vehicles/ reducing-co2-emissions-heavy-duty-vehicles_en [Accessed 14 June 2024].
• Fang, R., Le, N. & Band, P. (2011). Identification of occupational cancer risks in British Columbia, Canada: A population-based case–control study of 1,155 cases of colon cancer. Int J Environ Res Public Health, 8, 3821–3843. DOI: 10.3390/ijerp Font, A., Hedges, M. & Han, Y. (2024). Air quality on UK diesel and hybrid trains. Environ Int, 187, 108682. DOI: 10.1016/j.envint.2024.108682
• Guo, J., Kauppinen, T., Kyyrönen, P., Heikkilä, P., Lindbohm, M.,L. & Pukkala, E. (2004). Risk of esophageal, ovarian, testicular, kidney and bladder cancers and leukemia among finnish workers exposed to diesel or gasoline engine exhaust. Int J Cancer, 20, 111(2), 286-92, PMID: 15197784. DOI: 10.1002/ijc.20263
• IARC. (International Agency for Research on Cancer); working group on the evaluation of carcinogenic risks to humans (2014). Diesel and gasoline engine exhausts and some nitroarenes. IARC Monogr Eval Carcinog Risks Hum, 105, 9- 699.
• Karthikeyan, S., Breznan, D., Thomson, E.M., Blais, E., Vincent, R. & Kumarathasan, P. (2024). Concordance between in vitro and in vivo relative toxic potencies of diesel exhaust particles from different biodiesel blends. Toxics, 12, 290. DOI: 10.3390/toxics12040290
• Kim, S. (2015). Package ‘ppcor’. Commun Stat Appl Methods, 22(6), 665-674.
• Koutros, S., Kogevinas, M., Friesen, M.C., Stewart, P.A., Baris, D., Karagas, M. R. & Silverman, D. T. (2020). Diesel exhaust and bladder cancer risk by pathologic stage and grade subtypes. Environ Int, 135, 105346. DOI: 10.1016/j.envint.2019.105346
• Koutros, S., Graubard, B., Bassig, B.A., Vermeulen, R., Appel, N., Hyer, M. & Silverman, D.T. (2023). Diesel exhaust exposure and cause-specific mortality in the Diesel Exhaust in Miners Study II (DEMS II) cohort. Environ Health Perspect, 131(8), 87003. DOI: 10.1289/EHP12840
• Li, T., Yang, H.L., Xu, L.T., Zhou, Y.T., Min, Y.J. & Yan, S.C. (2023). Comprehensive treatment strategy for diesel truck exhaust. Environ. Sci. Pollut. Res. Int., 30(19), 54324-54332, DOI: 10.1007/s11356-023-26506-3
• Li, X., Zhao, P., Fang, M. & Huang, Z. (2024). Organic carbon, elemental carbon, and particulate semivolatile organic compound emissions from a common-rail diesel engine: Insight into effect of fuel injection pressure at different loads. Sci Total Environ, 912, 169465.
• Lloyd, A.C. & Cackette, T.A. (2001). Diesel engines: environmental impact and control. J. Air. Waste Manag. Assoc., 51(6), 809-847. DOI: 10.1080/10473289.2001.10464315
• McCreanor, J., Cullinan, P., Nieuwenhuijsen, M.J., Stewart-Evans, J., Malliarou, E. & Jarup L. (2007). Respiratory effects of exposure to diesel traffic in persons with asthma. N. Engl. J. Med., 357(23), 2348-58. PMID: 18057337, DOI: 10.1056/NEJMoa071535
• Möhner, M. & Wendt, A. (2017). A critical review of the relationship between occupational exposure to diesel emissions and lung cancer risk. Crit Rev Toxicol, 47(3), 185-224. DOI: 10.1080/10408444.2016.1266598
• Muscat, J.E. & Wynder, E.L. (1995). Diesel exhaust, diesel fumes, and laryngeal cancer. Otolaryngology–Head and Neck Surgery, 112(3), 437-440. DOI: 10.1016/s0194-5998(95)70280-6
• Neophytou, A.M., Ferguson, J.M., Costello, S., Picciotto, S., Balmes, J.R. & Koutros, S. (2024). Diesel exhaust and respiratory dust exposure in miners and chronic obstructive pulmonary disease (COPD) mortality in DEMS II. Environ. Int., 185, 108528. PMID: 38422874, PMCID: PMC10961191. DOI: 10.1016/j.envint.2024.108528
• ODMD. [Otomotiv Distribütörleri ve Mobilite Derneği (in English: Automotive Distributors and Mobility Association)] (2024). Available: https://www.odmd.org.tr/web_2837_1/rss.aspx [Accessed 14 June 2024].
• Pedersen, J.E. & Hansen, J. (2023). Parental occupational exposure to chemicals and risk of breast cancer in female offspring. Environ Res., 227, 115817; Epub 1, April 2023. PMID: 37011793. DOI: 10.1016/j.envres.2023.115817
• Pedersen, J.E., Strandberg-Larsen, K., Andersson, M. & Hansen, J. (2012). Breast cancer among Danish women occupationally exposed to diesel exhaust and polycyclic aromatic hydrocarbons, 1964-2016. Scand J Work Environ Health, 47(2), 154-162. DOI: 10.5271/sjweh.3920
• Peyre-Costa, D., Stjernbrandt, A., Wahlström, J., Ikäheimo, T.M. & Höper, A.C. (2024). Self- reported exposure to dust and diesel exhaust, respiratory symptoms, and use of respiratory protective equipment among Arctic miners. Int J Circumpolar Health, 83(1), 2343125. PMID: 38626426; PMCID: PMC11022915. DOI: 10.1080/22423982.2024.2343125
• Petersen, A., Hansen, J., Olsen, J. H. & Netterstrøm, B. (2010). Cancer morbidity among Danish male urban bus drivers: a historical cohort study. American Journal of Industrial Medicine, 53(7), 757-761.
• Pirhadi, M., Krasowsky, T.S., Gatt, G. & Quiros, D.C. (2024). Criteria pollutant and greenhouse gas emissions from cargo handling equipment operating at the Ports of Los Angeles and Long Beach. Science of the Total Environment, 927, 172084.
• Ptak, M., Neneman, J. & Roszkowska, S. (2024). The impact of petrol and diesel oil taxes in EU member states on CO2 emissions from passenger cars. Scientific Reports, 14(1), 52. DOI: 10.1038/s41598-023-50456-y
• Richiardi, L., Mirabelli, D., Calisti, R., Ottino, A., Ferrando, A., Boffetta, P. & Merletti, F. (2006). Occupational exposure to diesel exhausts and risk for lung cancer in a population-based case–control study in Italy. Annals of Oncology, 17(12), 1842- 1847.
• Romero, S.K., Bolm-Audorff, U., Reissig, D. & Seidler, A. (2024). Dose-response-relationship between occupational exposure to diesel engine emissions and lung cancer risk: A systematic review and meta-analysis. International Journal Of Hygiene And Environmental Health, 256, 114299. DOI: 10.1016/j.ijheh.2023.114299
• Sabanov, S., Qureshi, A.R., Korshunova, R. & Kurmangazy, G. (2024). Analysis of Experimental Measurements of Particulate Matter (PM) and Lung Deposition Surface Area (LDSA) in Operational Faces of an Oil Shale Underground Mine. Atmosphere, 15, 200. DOI: 10.3390/atmos15020200
• Saini, N., Negi, M., Yadav, P. & Singh, R. (2024). Oxidative desulfurization of fuels using alcohol- based DESs. Environ Sci Pollut Res Int, 1, 22. DOI: 10.1007/s11356-024-33093-4
• Sassano, M., Collatuzzo, G., Teglia, F. & Boffetta P. (2024). Occupational exposure to diesel exhausts and liver and pancreatic cancers: a systematic review and meta-analysis. Eur J Epidemiol, 39(3), 241-255. DOI: 10.1007/s10654-024-01099-4.
• Seo, J., Park, J., Oh, Y. & Park, S. (2016). Estimation of total transport CO2 emissions generated by medium- and heavy-duty vehicles (MHDVs) in a sector of Korea. Energies, 9, 638.
• Shammut, M., Cao, M., Zhang, Y., Papaix, C., Liu, Y. & Gao, X. (2019). Banning diesel vehicles in London: Is 2040 too late? Energies, 12(18), 3495. DOI: 10.3390/en12183495
• Soll-Johanning H., Bach, E. & Jensen, S.S. (2003). Lung and bladder cancer among Danish urban bus drivers and tramway employees: a nested case- control study. Occupational Medicine, 53(1), 25- 33. DOI: 10.1093/occmed/kqg004
• Talibov, M., Sormunen, J., Weiderpass, E., Kjaerheim, K., Martinsen, J.I. & Sparen P. (2019). Workplace Diesel Exhausts and Gasoline Exposure and Risk of Colorectal Cancer in Four Nordic Countries. Safety And Health at Work, 10(2), 141-150. DOI: 10.1016/j.shaw.2019.01.001
• Tian, S., Liu, Q., Ge, S., Luo, L., Yang, M. & An, Y. (2024). Characteristics of Polycyclic Aromatic Hydrocarbons in Size-Re solved Particles in the Roadside Environment of Beijing: Seasonality, Source, and Toxicological Effects. Atmosphere, 15, 346. DOI: 10.3390/atmos15030346
• TurkStat. (Turkish Statistical Institute) (2022). Death and Death Causes Statistics. Available: https://data.tuik.gov.tr/Bulten/Index?p=Olum-ve- Olum-Nedeni-Istatistikleri-2022-49679 [Accessed 14 June 2024].
• TurkStat (Turkish Statistical Institute) (2023a). Road motor vehicles, July 2023. Available: https://data.tuik.gov.tr/Bulten/Index?p=Road- Motor-Vehicles-July-2023-49428&dil=2 [Accessed 14 June 2024].
• TurkStat (Turkish Statistical Institute) (2023b). Turkish Greenhouse Gas Inventory 1990–2021. National Inventory Report for Submission Under the United Nations Framework Convention on Climate Change. https://enerji.gov.tr/Media/Dizin/EVCED/tr/%C3 %87evreVe%C4%B0klim/%C4%B0klimDe%C4 %9Fi%C5%9Fikli%C4%9Fi/UlusalSeraGaz%C4 %B1EmisyonEnvanteri/Belgeler/Ek-1.pdf
• Vahter, M., Gochfeld, M., Casati, B., Thiruchelvam, M., Falk-Filippson, A. & Kavlock, R. (2007). Implications of gender differences for human health risk assessment and toxicology. Environmental Research, 104(1), 70-84. DOI: 10.1016/j.envres.2006.10.001
• Zhang, H., Taya, K., Nagaoka, K., Yoshida, M. & Watanabe, G. (2017). 4-Nitrophenol (PNP) inhibits the expression of estrogen receptor β and disrupts steroidogenesis during the ovarian development in female rats. Environmental Pollution, 229, 1-9. DOI: 10.1016/j.envpol.2017.04.088.