Which Polymorphism Is The Distinguishing Factor For Fitness Athletes: The Ace Indel or Actn3 rs1815739?

Year 2024, Volume: 8 Issue: 2, 319 - 326, 31.05.2024

Onur Eroğlu , Raif Zileli , Muhammed Ali Nalbant , Tolga Polat , Özlem Özge Yılmaz , Beste Tacal Aslan , Korkut Ulucan

https://doi.org/10.30621/jbachs.1264683

Cited By: 1

https://izlik.org/JA99KX89CR

Abstract

Project Number

(2015-02.XXXX.13-01)

Which Polymorphism Is The Distinguishing Factor For Fitness Athletes: The Ace Indel or Actn3 rs1815739?

https://izlik.org/JA99KX89CR

Abstract

Purpose: The purpose of this research is to investigate the occurrence of ACE I/D and ACTN3 rs1815739 variations in sub-elite fitness athletes and to determine which gene is distinctive by comparing genotype and allele frequencies with sedentary individuals.
Material and Methods: 41 sub-elite fitness athletes and 41 sedentary volunteers participated in the study. Genetic analyzes of the athletes were determined using molecular-based methods such as DNA isolation using a commercial kit, Real-time polymerase chain reaction (Real-Time PCR), and Polymerase chain reaction (PCR) after blood collection in EDTA tubes. The Chi-Square test was used to compare the genotype distribution and I, D, C, and T allele frequencies of ACE I/D and ACTN3 rs1815739 polymorphisms for statistical significance.
Results: Analysis of data from our study revealed no statistically significant differences in ACE I/D polymorphisms between groups (p=0.4438), but statistically significant differences in ACTN3 rs1815739 polymorphisms significant difference (p=0.0313).
Conclusion: In conclusion, in our study, it can be said that the ACTN3 gene is a distinguishing factor in fitness.

Keywords

ACE , ACTN3 , fitness , gene , polymorphism , power

Supporting Institution

This work was supported by the Scientific Research Organization of Xxxxxxx Xxxx Xxxxxxxx University.

Project Number

(2015-02.XXXX.13-01)

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