Serum Inflammatory Biomarkers To Discriminate The Cervical Squamous Intraepithelial Lesions

Year 2026, Volume: 10 Issue: 1, 97 - 103, 31.01.2026

Orkun İlgen , Sibel Ejder Tekgündüz , Nurcan Yoruk , Nazım Ozan Çelebioğlu , Berrin Göktuğ Kadıoğlu

https://doi.org/10.30621/jbachs.1775019

Abstract

Objectives: The aim of this study was to evaluate the relationship between platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR), serum, systemic immune-inflammation index (SII), and cervical squamous intraepithelial pathologies
Material and methods: The database of our institution was reviewed. Cases with cervical pathology including high grade squamous intraepithelial lesion (HSIL), and low grade squamous intraepithelial lesion (LSIL), between January 2024 to December 2024, were collected. Their CBC results and clinicopathologic data were determined. The relation between the NLR, PLR, MLR, SII, and cervical pathologies was evaluated.
Results: There was no statistically significant difference between NLR, PLR, MLR, and cervical squamous intraepithelial lesions, However, SII values were determined significantly higher in patients with HSIL compared to LSIL cases. SII cut-off value was determined to be 845.10 to discriminate HSIL from LSIL.
Conclusion: SII seems to be an effective, simple, and promising marker to discriminate HSIL from LSIL in cervical squamous intraepithelial lesions by contrast with widely known simple markers such as NLR, PLR, and MLR.

Keywords

Neutrophil to lymphocyte ratio , platelet to lymphocyte ratio , systemic immune-inflammation index , cervical squamous intraepithelial pathologies

Ethical Statement

The ethics committee approval was obtained for this study (Approval no: B.30.2.ATA.0.01.00/280-21).

Serum Inflammatory Biomarkers To Discriminate The Cervical Squamous Intraepithelial Lesions

Abstract

Amaç: Bu çalışmanın amacı, trombosit/lenfosit oranı (PLR), nötrofil/lenfosit oranı (NLR), monosit/lenfosit oranı (MLR), serum, sistemik immün-inflamasyon indeksi (Sİİ) ve servikal skuamöz intraepitelyal patolojiler arasındaki ilişkiyi değerlendirmektir.
Gereç ve yöntemler: Kurumumuzun veri tabanı tarandı. Ocak 2024 ile Aralık 2024 tarihleri ​​arasında yüksek dereceli skuamöz intraepitelyal lezyon (HSIL) ve düşük dereceli skuamöz intraepitelyal lezyon (LSIL) dahil olmak üzere servikal patolojisi olan vakalar toplandı. Tam kan sayımı sonuçları ve klinikopatolojik verileri belirlendi. NLR, PLR, MLR, SII ve servikal patolojiler arasındaki ilişki değerlendirildi.
Bulgular: NLR, PLR, MLR ve servikal skuamöz intraepitelyal lezyonlar arasında istatistiksel olarak anlamlı bir fark bulunmamıştır. Ancak, SII değerleri HSIL'li hastalarda LSIL vakalarına kıyasla anlamlı derecede yüksek bulunmuştur. HSIL'i LSIL'den ayırt etmek için SII kesme değeri 845.10 olarak belirlenmiştir.
Sonuç: SII, NLR, PLR ve MLR gibi yaygın olarak bilinen basit belirteçlerin aksine, servikal skuamöz intraepitelyal lezyonlarda HSIL'i LSIL'den ayırt etmede etkili, basit ve umut verici bir belirteç gibi görünmektedir.

Keywords

Nötrofil/lenfosit oranı , trombosit/lenfosit oranı , sistemik immün-inflamasyon indeksi , servikal skuamöz intraepitelyal patolojiler

Ethical Statement

Bu çalışma için etik kurul onayı alındı ​​(Onay no: B.30.2.ATA.0.01.00/280-21).

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