Serum Fetuin A and Secreted Phosphoprotein 24 as Diagnostic Markers in Inflammatory Bowel Disease

Abstract

Purpose: A completely satisfactory biomarker has yet to be identified for the diagnosis and characterization of inflammatory bowel disease IBD . This study evaluated the utility of fetuin A and secreted phosphoprotein 24 kDa Spp24 as novel biomarkers in IBD. Methods: Ninety IBD patients, 54 with ulcerative colitis UC and 36 with Crohn’s disease CD , and 41 healthy controls HC were included. Serum fetuin A, Spp24, TNF-α, and IFN-γ levels were analyzed by ELISA. Serum C-reactive protein CRP levels were determined turbidimetrically by an automated procedure. Results: There were no significant differences in serum Spp24 levels among the UC 17.15 pg/mL, mean , CD 18.88 pg/mL , and HC 14.77 pg/mL groups P>0.05 . Median fetuin A levels were significantly lower in the UC 249 mg/L and CD 254 mg/L groups compared to HC 352 mg/L UC vs. HC P

Keywords

• Fetuin A, inflammatory bowel disease, secreted phosphoprotein 24

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