Are Monocyte/HDL, Lymphocyte/Monocyte and Neutrophil/Lymphocyte Ratios Prognostic or Follow-up Markers in Ischemic Cerebrovascular Patients?

Abstract

Background: We investigated the association of monocyte to high-density lipoprotein cholesterol HDL ratio MHR , neutrophil to lymphocyte ratio NLR and lymphocyte to monocyte ratio LMR with prognostic value and infarct types in patients with acute ischemic cerebrovascular disease CVD .Matherial and Methods: The study was carried out retrospectively in 223 patients, but after the exclusion criterion, 150 patients with acute ischemic CVD were included to the study. The complete blood count and lipid profile were examined at the admission of the patients. For initial neurologic status, National Institutes of Health Stroke Scale NIHSS score and for following-up, modified Rankin Scale mRS score were evaluated. After the etiological investigations and neuroimaging, infarct types were defined.Results: We found that as the NIHSS score increased, LMR values decreased and NLR values increased statistically p=0.02, p=0.013 . Additionally, statistical significant differences were determined between MHR values and mRS scores p=0.045 . According to the results of regression analysis, it was observed that the increase of MHR was statistically significant on the MRS of people with cardioembolic infarction p=0.004, StB=0.383 .Conclusion: Our study provides, LMR and NLR values are related with the initial neurologic state, and they would be prognostic markers for the neurological deficit of acute cerebrovascular disease. MHR can be a follow-up marker for CVD and also a predictable marker for cardioembolic infarct type

Keywords

• Acute ischemic cerebrovascular disease,monocyte to high-density lipoprotein cholesterol ratio,neutrophil to lymphocyte ratio,lymphocyte to monocyte ratio,prognosis

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