BibTex RIS Cite

Serum Levels of Trace Elements, Vitamin D and Oxidant Status in Children with Asthma

Year 2019, , 63 - 68, 01.06.2019
https://doi.org/10.30621/jbachs.2019.580

Abstract

Purpose: The aim of this study was to detect serum levels of trace elements, vitamin D and oxidant status in asthmatic children and to understand whether these elements reduce the number of attacks or use them as supplementation.Methods: Fifty children with asthma and 50 healthy children were included in the study. We studied serum levels of vitamin D, selenium Se , manganese Mn , chromium Cr , chlorine Cl , iron Fe , calcium Ca , zinc Zn , sodium Na , magnesium Mg , potassium K , copper Cu , total antioxidant capacity TAS , total oxidative status TOS and oxidative stress index OSI in both group.Results: In asthmatic group, the serum level of Cr, Se, Zn and TAS levels were lower p=0.040, p=0.000, p=0.000, p=0.000 respectively and serum Cu, TOS and OSI levels were higher than controls p=0.000, p=0.000, p=0.000 respectively . Serum TAS level showed negative correlation with TOS, OSI, Fe, Cu, Mn, Se, Zn and positive correlation with Se and Vitamin D.Conclusion: The supplementation of Se, Zn and Cr may provide better control of attacks and can be use treatment of asthma in children and modulating plasma antioxidants may have a beneficial effect on asthma progression

References

  • Bousquet J, Jeffery PK, Busse WW, Johnson M, Vignola AM. Asthma. From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med 2000;161:1720–1745. [CrossRef]
  • Landrigan PJ, Carlson JE, Bearer CF, et al. Children’s health and the environment: a new agenda for prevention research. Environ Health Persp 1998;106:787–794. [CrossRef]
  • Van der Zee S, Hoek G, Boezen HM, Schouten JP, van Wijnen JH, Brunekreef B. Acute effects of urban air pollution on respiratory health of children with and without chronic respiratory symptoms. Occup Environ Med 1999;56:802–812. [CrossRef]
  • Van Oeffelen AA, Bekkers MB, Smit HA, et al. Serum micronutrient concentrations and childhood asthma: the PIAMA birth cohort study. Pediatr Allergy Immunol 2011;22:784–793. [CrossRef]
  • Soutar A, Seaton A, Brown K. Bronchial reactivity and dietary antioxidants. Thorax 1997;52:166–170. [CrossRef]
  • Riedl MA, Nel AE. Importance of oxidative stress in the pathogenesis and treatment of asthma. Curr Opin Allergy Clin Immunol 2008;8:49– 56. [CrossRef]
  • Sackesen C, Ercan H, Dizdar E, et al. A comprehensive evaluation of the enzymatic and nonenzymatic antioxidant systems in childhood asthma. J Allergy Clin Immunol 2008;122:78–85. [CrossRef]
  • el-Kholy MS, Gas Allah MA, el-Shimi S, el-Baz F, el-Tayeb H, Abdel- Hamid MS. Zinc and copper status in children with bronchial asthma and atopic dermatitis. J Egypt Public Health Assoc 1990;65:657–668.
  • JL Malo, A Cartier, J Dolovich. Occupational asthma due to zinc. Eur Respir J 1993;6:447–450.
  • Sprietsma JE. Zinc-controled Th1/Th2 switch significantly determines development of disease. Med Hypotheses 1997;49:1–14. [CrossRef]
  • Kocabaş CN, Adalioglu G, Coşkun T, Tuncer A, Sekerel BE. The relationship between serum selenium levels and frequent wheeze in children. Turk J Pediatr 2006;48:308–312.
  • Prasad AS. Zinc and immunity. Mol Cell Biochem 1998;188:63–69.
  • Flatt A, Pearce N, Thomson CD, Sears MR, Robinson MF, Beasley R. Reduced selenium in asthmatic subjects in New Zealand. Thorax 1990;45:95–99. [CrossRef]
  • Hasselmark L, Malmgren R, Zetterström O, Unge G. Selenium supplementation in intrinsic asthma. Allergy 1993;48:30–36.
  • Bast A, Haenen G, Doelman C. Oxidants and antioxidants. Am J Med 1991;91:S2–S13. [CrossRef]
  • Akinkube FM, Ette SI. Role of zinc, copper and ascorbic acid in some common clinical pediatric problems. J Trop Paediatr 1987;33:337– 342. [CrossRef]
  • Uysalol M, Uysalol EP, Yilmaz Y, et al. Serum level of vitamin D and trace elements in children with recurrent wheezing: a cross-sectional study. BMC Pediatr 2014;14:270. [CrossRef]
  • Greene LS. Asthma and oxidant stress: nutritional, environmental, and genetic risk factors. J Am Coll Nutr 1995;14:317–324. [CrossRef]
  • Kocyigit A, Armutcu F, Gurel A, Ermis B. Alterations in plasma essential trace elements selenium, manganese, zinc, copper, and iron concentrations and the possible role of these elements on oxidative status in patients with childhood asthma. Biol Trace Elem Res 2004;97:31–42. [CrossRef]
  • Pearce N, Douwes J. Lifestyle changes and childhood asthma. Indian J Pediatr 2013;80:S95–S99. [CrossRef]
  • Razi CH, Akin O, Harmanci K, Akin B, Renda R. Serum heavy metal and antioxidant element levels of children with recurrent wheezing. Allergol Immunopathol (Madr) 2011;39:85–89. [CrossRef]
  • Chinellato I, Piazza M, Sandri M, Peroni D, Piacentini G, Boner AL. Vitamin D serum levels and markers of asthma control in Italian children. J Pediatr 2011;158:437–441. [CrossRef]
  • Afzal S, Lange P, Bojesen SE, Freiberg JJ, Nordestgaard BG. Plasma 25-hydroxyvitamin D, lung function and risk of chronic obstructive pulmonary disease. Thorax 2014;69:24–31. [CrossRef]
  • van Oeffelen AA, Bekkers MB, Smit HA, et al. Serum micronutrient concentrations and childhood asthma: The PIAMA birth cohort study. Pediatr Allergy Immunol 2011;22:784–793. [CrossRef]
  • Kerley CP, Elnazir B, Faul J, Cormican L. Vitamin D as an adjunctive therapy in asthma. Part 2: A review of human studies. Pulmonary Pharm Therap 2015;32:75–92. [CrossRef]
  • Beaver LM, Stemmy EJ, Schwartz AM, et al. Lung inflammation, injury, and proliferative response after repetitive particulate hexavalent chromium exposure. Environ Health Perspect 2009;117:1896–1902. [CrossRef]
  • Huang X, Xie J, Cui X, et al. Association between Concentrations of Metals in Urine and Adult Asthma: A Case-Control Study in Wuhan, China. PLoS One 2016;11:e0155818. 10.1371/journal.pone.015581
  • Hannu T, Piipari R, Kasurinen H, Keskinen H, Tuppurainen M, Tuomi T. Occupational asthma due to manual metal-arc welding of special stainless steels. Eur Respir J 2005;26:736–739. [CrossRef]
Year 2019, , 63 - 68, 01.06.2019
https://doi.org/10.30621/jbachs.2019.580

Abstract

References

  • Bousquet J, Jeffery PK, Busse WW, Johnson M, Vignola AM. Asthma. From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med 2000;161:1720–1745. [CrossRef]
  • Landrigan PJ, Carlson JE, Bearer CF, et al. Children’s health and the environment: a new agenda for prevention research. Environ Health Persp 1998;106:787–794. [CrossRef]
  • Van der Zee S, Hoek G, Boezen HM, Schouten JP, van Wijnen JH, Brunekreef B. Acute effects of urban air pollution on respiratory health of children with and without chronic respiratory symptoms. Occup Environ Med 1999;56:802–812. [CrossRef]
  • Van Oeffelen AA, Bekkers MB, Smit HA, et al. Serum micronutrient concentrations and childhood asthma: the PIAMA birth cohort study. Pediatr Allergy Immunol 2011;22:784–793. [CrossRef]
  • Soutar A, Seaton A, Brown K. Bronchial reactivity and dietary antioxidants. Thorax 1997;52:166–170. [CrossRef]
  • Riedl MA, Nel AE. Importance of oxidative stress in the pathogenesis and treatment of asthma. Curr Opin Allergy Clin Immunol 2008;8:49– 56. [CrossRef]
  • Sackesen C, Ercan H, Dizdar E, et al. A comprehensive evaluation of the enzymatic and nonenzymatic antioxidant systems in childhood asthma. J Allergy Clin Immunol 2008;122:78–85. [CrossRef]
  • el-Kholy MS, Gas Allah MA, el-Shimi S, el-Baz F, el-Tayeb H, Abdel- Hamid MS. Zinc and copper status in children with bronchial asthma and atopic dermatitis. J Egypt Public Health Assoc 1990;65:657–668.
  • JL Malo, A Cartier, J Dolovich. Occupational asthma due to zinc. Eur Respir J 1993;6:447–450.
  • Sprietsma JE. Zinc-controled Th1/Th2 switch significantly determines development of disease. Med Hypotheses 1997;49:1–14. [CrossRef]
  • Kocabaş CN, Adalioglu G, Coşkun T, Tuncer A, Sekerel BE. The relationship between serum selenium levels and frequent wheeze in children. Turk J Pediatr 2006;48:308–312.
  • Prasad AS. Zinc and immunity. Mol Cell Biochem 1998;188:63–69.
  • Flatt A, Pearce N, Thomson CD, Sears MR, Robinson MF, Beasley R. Reduced selenium in asthmatic subjects in New Zealand. Thorax 1990;45:95–99. [CrossRef]
  • Hasselmark L, Malmgren R, Zetterström O, Unge G. Selenium supplementation in intrinsic asthma. Allergy 1993;48:30–36.
  • Bast A, Haenen G, Doelman C. Oxidants and antioxidants. Am J Med 1991;91:S2–S13. [CrossRef]
  • Akinkube FM, Ette SI. Role of zinc, copper and ascorbic acid in some common clinical pediatric problems. J Trop Paediatr 1987;33:337– 342. [CrossRef]
  • Uysalol M, Uysalol EP, Yilmaz Y, et al. Serum level of vitamin D and trace elements in children with recurrent wheezing: a cross-sectional study. BMC Pediatr 2014;14:270. [CrossRef]
  • Greene LS. Asthma and oxidant stress: nutritional, environmental, and genetic risk factors. J Am Coll Nutr 1995;14:317–324. [CrossRef]
  • Kocyigit A, Armutcu F, Gurel A, Ermis B. Alterations in plasma essential trace elements selenium, manganese, zinc, copper, and iron concentrations and the possible role of these elements on oxidative status in patients with childhood asthma. Biol Trace Elem Res 2004;97:31–42. [CrossRef]
  • Pearce N, Douwes J. Lifestyle changes and childhood asthma. Indian J Pediatr 2013;80:S95–S99. [CrossRef]
  • Razi CH, Akin O, Harmanci K, Akin B, Renda R. Serum heavy metal and antioxidant element levels of children with recurrent wheezing. Allergol Immunopathol (Madr) 2011;39:85–89. [CrossRef]
  • Chinellato I, Piazza M, Sandri M, Peroni D, Piacentini G, Boner AL. Vitamin D serum levels and markers of asthma control in Italian children. J Pediatr 2011;158:437–441. [CrossRef]
  • Afzal S, Lange P, Bojesen SE, Freiberg JJ, Nordestgaard BG. Plasma 25-hydroxyvitamin D, lung function and risk of chronic obstructive pulmonary disease. Thorax 2014;69:24–31. [CrossRef]
  • van Oeffelen AA, Bekkers MB, Smit HA, et al. Serum micronutrient concentrations and childhood asthma: The PIAMA birth cohort study. Pediatr Allergy Immunol 2011;22:784–793. [CrossRef]
  • Kerley CP, Elnazir B, Faul J, Cormican L. Vitamin D as an adjunctive therapy in asthma. Part 2: A review of human studies. Pulmonary Pharm Therap 2015;32:75–92. [CrossRef]
  • Beaver LM, Stemmy EJ, Schwartz AM, et al. Lung inflammation, injury, and proliferative response after repetitive particulate hexavalent chromium exposure. Environ Health Perspect 2009;117:1896–1902. [CrossRef]
  • Huang X, Xie J, Cui X, et al. Association between Concentrations of Metals in Urine and Adult Asthma: A Case-Control Study in Wuhan, China. PLoS One 2016;11:e0155818. 10.1371/journal.pone.015581
  • Hannu T, Piipari R, Kasurinen H, Keskinen H, Tuppurainen M, Tuomi T. Occupational asthma due to manual metal-arc welding of special stainless steels. Eur Respir J 2005;26:736–739. [CrossRef]
There are 28 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Esra Akyüz Özkan This is me

Ayşe Yeşim Göçmen This is me

Yusuf Küçükbağrıaçık This is me

Melike Akyüz This is me

Publication Date June 1, 2019
Published in Issue Year 2019

Cite

APA Özkan, E. A., Göçmen, A. Y., Küçükbağrıaçık, Y., Akyüz, M. (2019). Serum Levels of Trace Elements, Vitamin D and Oxidant Status in Children with Asthma. Journal of Basic and Clinical Health Sciences, 3(2), 63-68. https://doi.org/10.30621/jbachs.2019.580
AMA Özkan EA, Göçmen AY, Küçükbağrıaçık Y, Akyüz M. Serum Levels of Trace Elements, Vitamin D and Oxidant Status in Children with Asthma. JBACHS. June 2019;3(2):63-68. doi:10.30621/jbachs.2019.580
Chicago Özkan, Esra Akyüz, Ayşe Yeşim Göçmen, Yusuf Küçükbağrıaçık, and Melike Akyüz. “Serum Levels of Trace Elements, Vitamin D and Oxidant Status in Children With Asthma”. Journal of Basic and Clinical Health Sciences 3, no. 2 (June 2019): 63-68. https://doi.org/10.30621/jbachs.2019.580.
EndNote Özkan EA, Göçmen AY, Küçükbağrıaçık Y, Akyüz M (June 1, 2019) Serum Levels of Trace Elements, Vitamin D and Oxidant Status in Children with Asthma. Journal of Basic and Clinical Health Sciences 3 2 63–68.
IEEE E. A. Özkan, A. Y. Göçmen, Y. Küçükbağrıaçık, and M. Akyüz, “Serum Levels of Trace Elements, Vitamin D and Oxidant Status in Children with Asthma”, JBACHS, vol. 3, no. 2, pp. 63–68, 2019, doi: 10.30621/jbachs.2019.580.
ISNAD Özkan, Esra Akyüz et al. “Serum Levels of Trace Elements, Vitamin D and Oxidant Status in Children With Asthma”. Journal of Basic and Clinical Health Sciences 3/2 (June 2019), 63-68. https://doi.org/10.30621/jbachs.2019.580.
JAMA Özkan EA, Göçmen AY, Küçükbağrıaçık Y, Akyüz M. Serum Levels of Trace Elements, Vitamin D and Oxidant Status in Children with Asthma. JBACHS. 2019;3:63–68.
MLA Özkan, Esra Akyüz et al. “Serum Levels of Trace Elements, Vitamin D and Oxidant Status in Children With Asthma”. Journal of Basic and Clinical Health Sciences, vol. 3, no. 2, 2019, pp. 63-68, doi:10.30621/jbachs.2019.580.
Vancouver Özkan EA, Göçmen AY, Küçükbağrıaçık Y, Akyüz M. Serum Levels of Trace Elements, Vitamin D and Oxidant Status in Children with Asthma. JBACHS. 2019;3(2):63-8.