Anticancer Efficiency of Curcumin on Ovarian Cancer

Year 2019, , 78 - 82, 01.06.2019

Gizem Calibasi Kocal

https://doi.org/10.30621/jbachs.2019.610

Abstract

Objectives: Ovarian cancer is one of the most common malignancies in women, and it is quite difficult to cure. In order to treat the disease, chemotherapy is often performed as adjuvant therapy following the surgery or neo-adjuvant cure for the pre-operative purpose. While the strategy is an effective way to destroy the tumor, it also affects healthy cells thus it causes side effects leading to even multiple organ failure and death. So that to minimize the disadvantage of chemotherapeutics, phytochemicals have been studied as chemotherapeutic agents. Curcumin is an orange-yellow nutraceutical, which is isolated from turmeric Curcuma longa L. . This phyto-polyphenolic compound has various roles in bio-industry such as textile and food dye as well as a wide range of medicinal properties especially the anticancer feature.Methods: The aim of this study is to investigate the anti-proliferative and anti-migrative effects of curcumin on ovarian adenocarcinoma. Cell proliferation rates on ONCO-DG-1 cell line were examined in five different doses of curcumin. Wound healing assay was performed to evaluate the anti-migrative effect on curcumin on this cell line.Results: The results showed that curcumin inhibits tumor cell proliferation at 5, 10, 20, 30 and 40 µM doses at 24- and 48-hours incubation time p

Keywords

Curcumin, Ovarian Cancer, Anticancer, Antiproliferative, Antimigrative, ONCO-DG-1

References

• Rath KS, McCann GA, Cohn DE, Rivera BK, Kuppusamy P, Selvendiran K. Safe and targeted anticancer therapy for ovarian cancer using a novel class of curcumin analogs. J Ovarian Res 2013;6:35. https://doi. org/10.1186/1757-2215-6-35
• Vallianou NG, Evangelopoulos A, Schizas N, Kazazis C. Potential anticancer properties and mechanisms of action of curcumin. Anticancer Res 2015;35:645–651.
• Kunnumakkara AB, Anand P, Aggarwal BB. Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett 2008;269:199–225. [CrossRef]
• Duvoix A, Blasius R, Delhalle S, et al. Chemopreventive and therapeutic effects of curcumin. Cancer Lett 2005;223:181–190. [CrossRef]
• Sharma RA, Gescher AJ, Steward WP. Curcumin: the story so far. Eur J Cancer 2005;41:1955–1968. [CrossRef]
• Epstein J, Sanderson IR, Macdonald TT. Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies. Br J Nutr 2010;103:1545–1557. [CrossRef]
• Aggarwal S, Ichikawa H, Takada Y, Sandur SK, Shishodia S, Aggarwal BB. Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation. Mol Pharmacol 2006;69:195–206. [CrossRef]
• Bharti AC, Donato N, Aggarwal BB. Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells. J Immunol 2003;171:3863–3871. [CrossRef]
• Ravindran J, Prasad S, Aggarwal BB. Curcumin and Cancer Cells: How Many Ways Can Curry Kill Tumor Cells Selectively? AAPS J 2009;11:495–510. [CrossRef]
• Ghosh S, Banerjee S, Sil PC. The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update. Food Chem Toxicol 2015;83:111–124. [CrossRef]
• Khosropanah MH, Dinarvand A, Nezhadhosseini A, et al. Analysis of the Antiproliferative Effects of Curcumin and Nanocurcumin in MDA- MB231 as a Breast Cancer Cell Line. Iran J Pharm Res 2016;15:231–239.
• Sakuma S, Maruyama C, Kohda T, Fujimoto Y. Curcumin inhibits the proliferation of a human colorectal cancer cell line Caco-2 partially by both apoptosis and G2/M cell cycle arrest. Int J Pharmacol Res 2014;4:84–90. Available at: https://pdfs.semanticscholar.org/ db9f/0f665457169456d053b44602b154859f1eb2.pdf
• Chang R, Sun L, Webster TJ. Short communication: selective cytotoxicity of curcumin on osteosarcoma cells compared to healthy osteoblasts. Int J Nanomedicine 2014;9:461–465. [CrossRef]
• Syng-Ai C, Kumari LA, Khar A. Effect of curcumin on normal and tumor cells: Role of glutathione and bcl-2. Mol Cancer Ther 2004;3:1101–1108.
• Shi M, Cai Q, Yao L, Mao Y, Ming Y, Ouyang G. Antiproliferation and apoptosis induced by curcumin in human ovarian cancer cells. Cell Biol Int 2006;30:221–226. [CrossRef]
• Lin YG, Kunnumakkara AB, Nair A, et al. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor- kB pathway. Clin Cancer Res 2007;13:3423–3430. [CrossRef]