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Year 2020, Volume: 4 Issue: 1, 38 - 43, 01.03.2020
https://doi.org/10.30621/jbachs.2020.837

Abstract

References

  • Nozawa N, Hibi K, Endo M, et al. Association Between Circulating Monocytes and Coronary Plaque Progression in Patients with Acute Myocardial Infarction. Circ J 2010;74:1384–1391. [CrossRef]
  • Afiune Neto A, Mansur Ade P, Avakian SD, Gomes EP, Ramires JA. Monocytosis is an Independent Risk Marker for Coronary Artery Disease. Arq Bras Cardiol 2006;86:240–244. [CrossRef]
  • Parthasarathy S, Barnett J, Fong LG. High-density lipoprotein inhibits the oxidative modification of low-density lipoprotein. Biochim Biophys Acta 1990;1044;275–283. [CrossRef]
  • Arısoy A, Altunkaş F, Karaman K, et al. Association of the Monocyte to HDL Cholesterol Ratio With Thrombus Burden in Patients With ST-Segment Elevation Myocardial Infarction. Clin Appl Thromb 2017;23:992–997. [CrossRef]
  • You S, Zhong C, Zheng D, et al. Monocyte to HDL cholesterol ratio is associated with discharge and 3-month outcome in patients with acute intracerebral hemorrhage. J Neurol Sci 2017;372:157–161. [CrossRef]
  • Bolayir A, Gokce SF, Cigdem B,, et al. Monocyte/high-density lipoprotein ratio predicts the mortality in ischemic stroke patients. Neurol Neurochir Pol 2018;52:150–155. [CrossRef]
  • Nşñez J, Nşñez E, Bodí V, et al. Low lymphocyte count in acute phase of ST-segment elevation myocardial infarction predicts long- term recurrent myocardial infarction. Coron Artery Dis 2010;21:1–7. [CrossRef]
  • van der Laan AM, Hirsch A, Robbers LFHJ, et al. A proinflammatory monocyte response is associated with myocardial injury and impaired functional outcome in patients with ST-segment elevation myocardial infarction: Monocytes and myocardial infarction. Am Heart J 2012;163:57–65.e2. [CrossRef]
  • Wang Q, Ma J, Jiang Z, Wu F, Ping J, Ming L. Association of lymphocyte- to-monocyte ratio with in-hospital and long-term major adverse cardiac and cerebrovascular events in patients with ST-elevated myocardial infarction. Med (United States) 2017;96:e7897. [CrossRef]
  • Ren H, Liu X, Wang L, Gao Y. Lymphocyte-to-Monocyte Ratio: A Novel Predictor of the Prognosis of Acute Ischemic Stroke. J Stroke Cerebrovasc Dis 2017;26:2595–2602. [CrossRef]
  • Lv P, Jin H, Liu Y, et al. Comparison of risk factor between lacunar stroke and large artery atherosclerosis stroke: A cross-sectional study in China. PLoS One 2016;11:e0149605. [CrossRef]
  • Matz K, Tatschl C, Sebek K, Dachenhausen A, Brainin M. Dyslipidemia, elevated LDL cholesterol and reduced nocturnal blood pressure dipping denote lacunar strokes occurring during nighttime. Eur J Neurol 2004;11:742–748. [CrossRef]
  • Cui R, Iso H, Yamagishi K, et al. High serum total cholesterol levels is a risk factor of ischemic stroke for general Japanese population: The JPHC study. Atherosclerosis 2012;221:565–569. [CrossRef]
  • Zhang B, Zhang WZ, Li X, et al. Admission markers predict lacunar and non-lacunar stroke in young patients. Thromb Res 2011;128:14– 17. [CrossRef]
  • Hatamian H, Saberi A, Pourghasem M. The relationship between stroke mortality and red blood cell parameters. Iran J Neurol 2014;13:237–240. [CrossRef]
  • Ani C, Ovbiagele B. Elevated red blood cell distribution width predicts mortality in persons with known stroke. J Neurol Sci 2009;277:103– 108. [CrossRef]
  • Lee HB, Kim J, Oh SH, et al. Red blood cell distribution width is associated with severity of leukoaraiosis. PLoS One 2016;11:e0150308. [CrossRef]
  • Nayak AR, Kashyap RS, Kabra D, et al. Evaluation of routinely performed hematological and biochemical parameters for the prognosis of acute ischemic stroke patients. Neurol Sci 2011;32:855– 860. [CrossRef]
  • Niazi GA, Awada A, Rajeh S, Larbi E. Hematological values and their assessment as risk factor in Saudi patients with stroke. Acta Neurol Scand 1994;89:439–445. [CrossRef]
  • Kleinig TJ, Vink R. Suppression of inflammation in ischemic and hemorrhagic stroke: Therapeutic options. Curr Opin Neurol 2009;22:294–301. [CrossRef]
  • Jin R, Yang G, Li G. Inflammatory mechanisms in ischemic stroke: role of inflammatory cells. J Leukoc Biol 2010;87:779–789. [CrossRef]
  • Kim E, Yang J, Beltran CD, Cho S. Role of spleen-derived monocytes/ macrophages in acute ischemic brain injury. J Cereb Blood Flow Metab 2014;34:1411–1419. [CrossRef]
  • Li GZ, Zhong D, Yang LM, et al. Expression of interleukin-17 in ischemic brain tissue. Scand J Immunol 2005;62:481–486. [CrossRef]
  • Zhao L, Dai Q, Chen X, et al. Neutrophil-to-Lymphocyte Ratio Predicts Length of Stay and Acute Hospital Cost in Patients with Acute Ischemic Stroke. J Stroke Cerebrovasc Dis 2016;25:739–744. [CrossRef]
  • Tokgoz S, Kayrak M, Akpinar Z, Seyithanoğlu A, Güney F, Yürüten B. Neutrophil lymphocyte ratio as a predictor of stroke. J Stroke Cerebrovasc Dis 2013;22:1169–1174. [CrossRef]
  • Xue P, Kanai M, Mori Y, et al. Neutrophil-to-lymphocyte ratio for predicting palliative chemotherapy outcomes in advanced pancreatic cancer patients. Cancer Med 2014;3:406–415. [CrossRef]
  • Chamorro Á, Urra X, Planas AM. Infection after acute ischemic stroke: A manifestation of brain-induced immunodepression. Stroke 2007;38:1097–1103. [CrossRef]
  • Liesz A, Dalpke A, Mracsko E, et al. DAMP Signaling is a Key Pathway Inducing Immune Modulation after Brain Injury. J Neurosci 2015;35:583–598. [CrossRef]
  • Park MG, Kim MK, Chae SH, Kim HK, Han J, Park KP. Lymphocyte- to-monocyte ratio on day 7 is associated with outcomes in acute ischemic stroke. Neurol Sci 2018;39:243–249. [CrossRef]
  • Putaala J, Strbian D, Mustanoja S, Haapaniemi E, Kaste M, Tatlisumak T. Functional outcome in young adult ischemic stroke: Impact of lipoproteins. Acta Neurol Scand 2013;127:61–69. [CrossRef]
  • Nardi K, Engelter S, Strbian D, et al. Lipid profiles and outcome in patients treated by intravenous thrombolysis for cerebral ischemia. Neurology 2012;79:1101–1108. [CrossRef]
  • Makihara N, Okada Y, Koga M, et al. Effect of serum lipid levels on stroke outcome after rt-PA therapy: SAMURAI rt-PA registry. Cerebrovasc Dis 2012;33:240–247. [CrossRef]
  • Hindy G, Engström G, Larsson SC, et al. Role of blood lipids in the development of ischemic stroke and its subtypes: A Mendelian randomization study. Stroke 2018;49:820–827. [CrossRef]

Are Monocyte/HDL, Lymphocyte/Monocyte and Neutrophil/Lymphocyte Ratios Prognostic or Follow-up Markers in Ischemic Cerebrovascular Patients?

Year 2020, Volume: 4 Issue: 1, 38 - 43, 01.03.2020
https://doi.org/10.30621/jbachs.2020.837

Abstract

Background: We investigated the association of monocyte to high-density lipoprotein cholesterol HDL ratio MHR , neutrophil to lymphocyte ratio NLR and lymphocyte to monocyte ratio LMR with prognostic value and infarct types in patients with acute ischemic cerebrovascular disease CVD .Matherial and Methods: The study was carried out retrospectively in 223 patients, but after the exclusion criterion, 150 patients with acute ischemic CVD were included to the study. The complete blood count and lipid profile were examined at the admission of the patients. For initial neurologic status, National Institutes of Health Stroke Scale NIHSS score and for following-up, modified Rankin Scale mRS score were evaluated. After the etiological investigations and neuroimaging, infarct types were defined.Results: We found that as the NIHSS score increased, LMR values decreased and NLR values increased statistically p=0.02, p=0.013 . Additionally, statistical significant differences were determined between MHR values and mRS scores p=0.045 . According to the results of regression analysis, it was observed that the increase of MHR was statistically significant on the MRS of people with cardioembolic infarction p=0.004, StB=0.383 .Conclusion: Our study provides, LMR and NLR values are related with the initial neurologic state, and they would be prognostic markers for the neurological deficit of acute cerebrovascular disease. MHR can be a follow-up marker for CVD and also a predictable marker for cardioembolic infarct type

References

  • Nozawa N, Hibi K, Endo M, et al. Association Between Circulating Monocytes and Coronary Plaque Progression in Patients with Acute Myocardial Infarction. Circ J 2010;74:1384–1391. [CrossRef]
  • Afiune Neto A, Mansur Ade P, Avakian SD, Gomes EP, Ramires JA. Monocytosis is an Independent Risk Marker for Coronary Artery Disease. Arq Bras Cardiol 2006;86:240–244. [CrossRef]
  • Parthasarathy S, Barnett J, Fong LG. High-density lipoprotein inhibits the oxidative modification of low-density lipoprotein. Biochim Biophys Acta 1990;1044;275–283. [CrossRef]
  • Arısoy A, Altunkaş F, Karaman K, et al. Association of the Monocyte to HDL Cholesterol Ratio With Thrombus Burden in Patients With ST-Segment Elevation Myocardial Infarction. Clin Appl Thromb 2017;23:992–997. [CrossRef]
  • You S, Zhong C, Zheng D, et al. Monocyte to HDL cholesterol ratio is associated with discharge and 3-month outcome in patients with acute intracerebral hemorrhage. J Neurol Sci 2017;372:157–161. [CrossRef]
  • Bolayir A, Gokce SF, Cigdem B,, et al. Monocyte/high-density lipoprotein ratio predicts the mortality in ischemic stroke patients. Neurol Neurochir Pol 2018;52:150–155. [CrossRef]
  • Nşñez J, Nşñez E, Bodí V, et al. Low lymphocyte count in acute phase of ST-segment elevation myocardial infarction predicts long- term recurrent myocardial infarction. Coron Artery Dis 2010;21:1–7. [CrossRef]
  • van der Laan AM, Hirsch A, Robbers LFHJ, et al. A proinflammatory monocyte response is associated with myocardial injury and impaired functional outcome in patients with ST-segment elevation myocardial infarction: Monocytes and myocardial infarction. Am Heart J 2012;163:57–65.e2. [CrossRef]
  • Wang Q, Ma J, Jiang Z, Wu F, Ping J, Ming L. Association of lymphocyte- to-monocyte ratio with in-hospital and long-term major adverse cardiac and cerebrovascular events in patients with ST-elevated myocardial infarction. Med (United States) 2017;96:e7897. [CrossRef]
  • Ren H, Liu X, Wang L, Gao Y. Lymphocyte-to-Monocyte Ratio: A Novel Predictor of the Prognosis of Acute Ischemic Stroke. J Stroke Cerebrovasc Dis 2017;26:2595–2602. [CrossRef]
  • Lv P, Jin H, Liu Y, et al. Comparison of risk factor between lacunar stroke and large artery atherosclerosis stroke: A cross-sectional study in China. PLoS One 2016;11:e0149605. [CrossRef]
  • Matz K, Tatschl C, Sebek K, Dachenhausen A, Brainin M. Dyslipidemia, elevated LDL cholesterol and reduced nocturnal blood pressure dipping denote lacunar strokes occurring during nighttime. Eur J Neurol 2004;11:742–748. [CrossRef]
  • Cui R, Iso H, Yamagishi K, et al. High serum total cholesterol levels is a risk factor of ischemic stroke for general Japanese population: The JPHC study. Atherosclerosis 2012;221:565–569. [CrossRef]
  • Zhang B, Zhang WZ, Li X, et al. Admission markers predict lacunar and non-lacunar stroke in young patients. Thromb Res 2011;128:14– 17. [CrossRef]
  • Hatamian H, Saberi A, Pourghasem M. The relationship between stroke mortality and red blood cell parameters. Iran J Neurol 2014;13:237–240. [CrossRef]
  • Ani C, Ovbiagele B. Elevated red blood cell distribution width predicts mortality in persons with known stroke. J Neurol Sci 2009;277:103– 108. [CrossRef]
  • Lee HB, Kim J, Oh SH, et al. Red blood cell distribution width is associated with severity of leukoaraiosis. PLoS One 2016;11:e0150308. [CrossRef]
  • Nayak AR, Kashyap RS, Kabra D, et al. Evaluation of routinely performed hematological and biochemical parameters for the prognosis of acute ischemic stroke patients. Neurol Sci 2011;32:855– 860. [CrossRef]
  • Niazi GA, Awada A, Rajeh S, Larbi E. Hematological values and their assessment as risk factor in Saudi patients with stroke. Acta Neurol Scand 1994;89:439–445. [CrossRef]
  • Kleinig TJ, Vink R. Suppression of inflammation in ischemic and hemorrhagic stroke: Therapeutic options. Curr Opin Neurol 2009;22:294–301. [CrossRef]
  • Jin R, Yang G, Li G. Inflammatory mechanisms in ischemic stroke: role of inflammatory cells. J Leukoc Biol 2010;87:779–789. [CrossRef]
  • Kim E, Yang J, Beltran CD, Cho S. Role of spleen-derived monocytes/ macrophages in acute ischemic brain injury. J Cereb Blood Flow Metab 2014;34:1411–1419. [CrossRef]
  • Li GZ, Zhong D, Yang LM, et al. Expression of interleukin-17 in ischemic brain tissue. Scand J Immunol 2005;62:481–486. [CrossRef]
  • Zhao L, Dai Q, Chen X, et al. Neutrophil-to-Lymphocyte Ratio Predicts Length of Stay and Acute Hospital Cost in Patients with Acute Ischemic Stroke. J Stroke Cerebrovasc Dis 2016;25:739–744. [CrossRef]
  • Tokgoz S, Kayrak M, Akpinar Z, Seyithanoğlu A, Güney F, Yürüten B. Neutrophil lymphocyte ratio as a predictor of stroke. J Stroke Cerebrovasc Dis 2013;22:1169–1174. [CrossRef]
  • Xue P, Kanai M, Mori Y, et al. Neutrophil-to-lymphocyte ratio for predicting palliative chemotherapy outcomes in advanced pancreatic cancer patients. Cancer Med 2014;3:406–415. [CrossRef]
  • Chamorro Á, Urra X, Planas AM. Infection after acute ischemic stroke: A manifestation of brain-induced immunodepression. Stroke 2007;38:1097–1103. [CrossRef]
  • Liesz A, Dalpke A, Mracsko E, et al. DAMP Signaling is a Key Pathway Inducing Immune Modulation after Brain Injury. J Neurosci 2015;35:583–598. [CrossRef]
  • Park MG, Kim MK, Chae SH, Kim HK, Han J, Park KP. Lymphocyte- to-monocyte ratio on day 7 is associated with outcomes in acute ischemic stroke. Neurol Sci 2018;39:243–249. [CrossRef]
  • Putaala J, Strbian D, Mustanoja S, Haapaniemi E, Kaste M, Tatlisumak T. Functional outcome in young adult ischemic stroke: Impact of lipoproteins. Acta Neurol Scand 2013;127:61–69. [CrossRef]
  • Nardi K, Engelter S, Strbian D, et al. Lipid profiles and outcome in patients treated by intravenous thrombolysis for cerebral ischemia. Neurology 2012;79:1101–1108. [CrossRef]
  • Makihara N, Okada Y, Koga M, et al. Effect of serum lipid levels on stroke outcome after rt-PA therapy: SAMURAI rt-PA registry. Cerebrovasc Dis 2012;33:240–247. [CrossRef]
  • Hindy G, Engström G, Larsson SC, et al. Role of blood lipids in the development of ischemic stroke and its subtypes: A Mendelian randomization study. Stroke 2018;49:820–827. [CrossRef]
There are 33 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Selma Tekin This is me

Esin Avcı This is me

Rukiye Nar This is me

Eylem Değirmenci This is me

Süleyman Demir This is me

Hande Şenol This is me

Publication Date March 1, 2020
Published in Issue Year 2020 Volume: 4 Issue: 1

Cite

APA Tekin, S., Avcı, E., Nar, R., Değirmenci, E., et al. (2020). Are Monocyte/HDL, Lymphocyte/Monocyte and Neutrophil/Lymphocyte Ratios Prognostic or Follow-up Markers in Ischemic Cerebrovascular Patients?. Journal of Basic and Clinical Health Sciences, 4(1), 38-43. https://doi.org/10.30621/jbachs.2020.837
AMA Tekin S, Avcı E, Nar R, Değirmenci E, Demir S, Şenol H. Are Monocyte/HDL, Lymphocyte/Monocyte and Neutrophil/Lymphocyte Ratios Prognostic or Follow-up Markers in Ischemic Cerebrovascular Patients?. JBACHS. March 2020;4(1):38-43. doi:10.30621/jbachs.2020.837
Chicago Tekin, Selma, Esin Avcı, Rukiye Nar, Eylem Değirmenci, Süleyman Demir, and Hande Şenol. “Are Monocyte/HDL, Lymphocyte/Monocyte and Neutrophil/Lymphocyte Ratios Prognostic or Follow-up Markers in Ischemic Cerebrovascular Patients?”. Journal of Basic and Clinical Health Sciences 4, no. 1 (March 2020): 38-43. https://doi.org/10.30621/jbachs.2020.837.
EndNote Tekin S, Avcı E, Nar R, Değirmenci E, Demir S, Şenol H (March 1, 2020) Are Monocyte/HDL, Lymphocyte/Monocyte and Neutrophil/Lymphocyte Ratios Prognostic or Follow-up Markers in Ischemic Cerebrovascular Patients?. Journal of Basic and Clinical Health Sciences 4 1 38–43.
IEEE S. Tekin, E. Avcı, R. Nar, E. Değirmenci, S. Demir, and H. Şenol, “Are Monocyte/HDL, Lymphocyte/Monocyte and Neutrophil/Lymphocyte Ratios Prognostic or Follow-up Markers in Ischemic Cerebrovascular Patients?”, JBACHS, vol. 4, no. 1, pp. 38–43, 2020, doi: 10.30621/jbachs.2020.837.
ISNAD Tekin, Selma et al. “Are Monocyte/HDL, Lymphocyte/Monocyte and Neutrophil/Lymphocyte Ratios Prognostic or Follow-up Markers in Ischemic Cerebrovascular Patients?”. Journal of Basic and Clinical Health Sciences 4/1 (March 2020), 38-43. https://doi.org/10.30621/jbachs.2020.837.
JAMA Tekin S, Avcı E, Nar R, Değirmenci E, Demir S, Şenol H. Are Monocyte/HDL, Lymphocyte/Monocyte and Neutrophil/Lymphocyte Ratios Prognostic or Follow-up Markers in Ischemic Cerebrovascular Patients?. JBACHS. 2020;4:38–43.
MLA Tekin, Selma et al. “Are Monocyte/HDL, Lymphocyte/Monocyte and Neutrophil/Lymphocyte Ratios Prognostic or Follow-up Markers in Ischemic Cerebrovascular Patients?”. Journal of Basic and Clinical Health Sciences, vol. 4, no. 1, 2020, pp. 38-43, doi:10.30621/jbachs.2020.837.
Vancouver Tekin S, Avcı E, Nar R, Değirmenci E, Demir S, Şenol H. Are Monocyte/HDL, Lymphocyte/Monocyte and Neutrophil/Lymphocyte Ratios Prognostic or Follow-up Markers in Ischemic Cerebrovascular Patients?. JBACHS. 2020;4(1):38-43.