Investigation of Creatine Levels in Glial Tumors Using MR Spectroscopy

Year 2024, Volume: 8 Issue: 2, 262 - 270, 31.05.2024

Nadir Moustafa , Berrin Çavuşoğlu , Reşat Serhat Erbayraktar , Emel Ada

https://doi.org/10.30621/jbachs.1223385

Abstract

Purpose: The present study examines the efficacy of Creatine (Cr) levels in the determination of tumor grade on single-voxel (SV) and multi-voxel (MV) magnetic resonance spectroscopy (MRS) in patients with glial tumors.
Material and Methods: A retrospective review was made of 20 SV and 20 MV MRS PDF images of patients with a pathological diagnosis of glial tumor. Cr values and metabolite ratios were measured in the tumor and compared with those in the healthy symmetrical brain parenchyma of the contralateral hemisphere.
Results: A significant difference was noted in the (Cho+Cr)/NAA and Cho/NAA ratios on SV MRS between the high-grade tumors and the healthy contralateral hemisphere. On MV MRS, Cho/NAA ratios within the minimum and maximum Cr(h) voxels (Cho/NAAmin-Cr(h), Cho/NAAmax-Cr(h), respectively) were higher in high-grade tumors compared to healthy tissue. ROC analysis showed that the max-Cr(h) metabolite on MV MRS was successful in distinguishing low-grade tumors from high-grade tumors.
Conclusion: Using the minimum and maximum values of Cr as a reference can improve the overall diagnostic accuracy in the diagnosis and grading of glial tumors. Our findings showed that Cr tended to be low in high-grade tumors and further that the max-Cr(h) metabolite may help in the differentiation of glial tumors on MV MRS.

Keywords

Magnetic resonance imaging, spectroscopy, glial tumors, creatine

Investigation of Creatine Levels in Glial Tumors Using MR Spectroscopy

Abstract

Keywords

Magnetic resonance imaging, spectroscopy, glial tumors, creatine

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